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chr17:61,087,073-62,694,738

Best TWAS P=1.63e-11 · Best GWAS P=4.58e-11 conditioned to 0.027

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	STRADA	0.04	0.03	lasso	1	0.03	2.7e-04	-5.4	-5.4	7.9e-08	-0.52	0.43	0.42	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TCAM1P	0.05	0.03	enet	8	0.04	4.1e-06	6.3	-5.9	3.8e-09	-0.83	0.04	0.96	FALSE
3	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	6.1	-5.9	3.1e-09	-0.77	0.06	0.94	FALSE
4	GTEx	Adipose Visceral Omentum	CD79B	0.15	0.00	lasso	6	0.02	4.1e-02	6.1	-5.6	1.8e-08	-0.68	0.05	0.62	FALSE
5	GTEx	Artery Aorta	DDX42	0.08	0.01	enet	4	0.01	9.1e-02	-5.3	-5.4	6.2e-08	-0.50	0.37	0.11	FALSE
6	GTEx	Brain Hypothalamus	FTSJ3	0.23	0.26	lasso	5	0.23	4.6e-06	-5.3	5.5	3.7e-08	0.59	0.64	0.31	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	FTSJ3	0.22	0.29	lasso	7	0.25	1.8e-07	-5.3	5.3	9.5e-08	0.51	0.76	0.21	FALSE
8	GTEx	Breast Mammary Tissue	FTSJ3	0.25	0.34	lasso	5	0.33	1.1e-17	-5.5	5.1	2.8e-07	0.44	0.80	0.20	FALSE
9	GTEx	Breast Mammary Tissue (Male)	PSMC5	0.19	0.08	lasso	6	0.07	1.1e-02	-5.3	5.4	7.1e-08	0.50	0.12	0.40	FALSE
10	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	6.4	-5.9	3.2e-09	-0.93	0.02	0.57	FALSE
11	GTEx	Esophagus Mucosa	PSMC5	0.11	0.09	lasso	4	0.14	1.1e-09	-5.3	6.5	1.0e-10	0.76	0.16	0.84	FALSE
12	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	6.1	6.1	9.3e-10	0.93	0.03	0.91	FALSE
13	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	6.4	6.0	2.0e-09	0.92	0.01	0.97	FALSE
14	GTEx	Heart Left Ventricle	FTSJ3	0.27	0.35	lasso	5	0.33	3.0e-18	-5.4	5.2	1.5e-07	0.50	0.81	0.19	FALSE
15	GTEx	Liver	FTSJ3	0.13	0.05	lasso	3	0.07	4.6e-03	-5.4	5.4	6.7e-08	0.48	0.38	0.34	FALSE
16	GTEx	Lung	PSMC5	0.04	0.00	enet	5	0.01	4.1e-02	-5.3	5.7	1.5e-08	0.80	0.05	0.85	FALSE
17	GTEx	Nerve Tibial	DDX42	0.07	0.08	enet	5	0.06	3.7e-05	-5.4	-5.2	2.1e-07	-0.48	0.80	0.20	FALSE
18	GTEx	Pituitary	FTSJ3	0.26	0.32	lasso	7	0.34	3.1e-09	-5.4	5.4	8.7e-08	0.51	0.80	0.20	FALSE
19	GTEx	Prostate	FTSJ3	0.18	0.07	lasso	3	0.08	3.7e-03	-5.3	5.2	1.6e-07	0.51	0.43	0.25	FALSE
20	GTEx	Skin Sun Exposed Lower leg	PSMC5	0.07	0.02	enet	23	0.02	1.6e-02	-4.3	5.1	2.7e-07	0.58	0.07	0.70	FALSE
21	GTEx	Thyroid	PSMC5	0.04	0.01	lasso	4	0.01	4.5e-02	-5.4	5.4	6.2e-08	0.50	0.25	0.20	FALSE
22	GTEx	Thyroid	DDX42	0.07	0.07	lasso	1	0.05	1.1e-04	-5.4	-5.4	7.9e-08	-0.51	0.60	0.19	FALSE
23	GTEx	Uterus	FTSJ3	0.30	0.37	lasso	3	0.38	1.1e-08	-5.4	5.5	4.3e-08	0.50	0.76	0.19	FALSE
24	GTEx	Whole Blood	FTSJ3	0.09	0.07	lasso	4	0.09	1.2e-08	-4.6	5.1	2.8e-07	0.46	0.85	0.15	FALSE
25	GTEx	Whole Blood	DDX42	0.05	0.03	lasso	6	0.01	1.7e-02	-5.5	-5.7	1.5e-08	-0.51	0.32	0.11	FALSE
26	YFS	Blood	FTSJ3	0.02	0.01	bslmm	318	0.01	6.4e-04	-5.5	5.6	2.0e-08	0.38	0.73	0.19	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FTSJ3	0.04	0.04	blup	30	0.04	5.4e-04	-5.5	5.1	2.8e-07	0.46	0.38	0.20	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	6.2	-5.9	3.5e-09	-0.70	0.02	0.43	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	TCAM1P	0.04	0.07	blup	26	0.07	4.9e-15	-5.4	-6.2	5.3e-10	-0.66	0.77	0.23	FALSE
30	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CSH2	0.09	0.01	blup	37	0.08	5.7e-05	-5.4	-6.5	7.7e-11	-0.74	0.12	0.79	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FTSJ3	0.06	0.04	blup	30	0.04	4.9e-03	-5.5	5.2	2.0e-07	0.49	0.09	0.15	FALSE
32	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TCAM1P	0.06	0.06	lasso	1	0.06	8.4e-04	-5.5	-5.5	4.2e-08	-0.52	0.09	0.17	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC5	0.06	0.07	blup	27	0.07	9.4e-05	-5.4	5.2	2.2e-07	0.48	0.58	0.26	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	TCAM1P	0.05	0.03	blup	26	0.05	6.0e-04	-5.3	-6.7	1.6e-11	-0.77	0.04	0.77	TRUE
35	The Cancer Genome Atlas	Esophageal Carcinoma	TCAM1P	0.09	0.11	lasso	3	0.10	4.5e-04	-5.3	-5.4	6.7e-08	-0.41	0.04	0.23	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FTSJ3	0.05	0.08	lasso	13	0.08	7.4e-09	-5.5	5.5	5.0e-08	0.52	0.72	0.28	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	6.2	6.2	6.7e-10	0.93	0.00	0.91	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FTSJ3	0.24	0.30	blup	30	0.28	3.7e-32	-5.5	5.2	2.3e-07	0.45	0.67	0.33	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMARCD2	0.04	0.06	enet	3	0.05	8.3e-07	-5.5	5.5	3.5e-08	0.51	0.67	0.32	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRADA	0.07	0.01	blup	57	0.03	5.5e-04	-4.3	-6.3	2.3e-10	-0.87	0.01	0.88	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TCAM1P	0.04	0.06	lasso	7	0.07	3.3e-08	-5.4	-5.5	3.7e-08	-0.48	0.77	0.23	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FTSJ3	0.16	0.20	lasso	4	0.19	6.8e-11	-5.5	5.3	1.1e-07	0.49	0.71	0.29	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TCAM1P	0.17	0.14	lasso	4	0.11	6.5e-07	-5.4	-5.1	2.6e-07	-0.43	0.72	0.26	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	6.2	-6.5	6.4e-11	-0.91	0.00	0.83	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	TCAM1P	0.02	0.03	blup	26	0.02	9.4e-04	-5.4	-6.7	1.8e-11	-0.78	0.03	0.58	FALSE
46	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FTSJ3	0.07	0.10	lasso	10	0.10	2.7e-05	-5.4	5.4	6.7e-08	0.51	0.50	0.28	FALSE
47	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TCAM1P	0.10	0.13	enet	12	0.13	1.2e-06	-5.4	-5.2	1.5e-07	-0.49	0.72	0.23	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	TCAM1P	0.05	0.05	lasso	1	0.05	2.0e-06	-5.5	-5.5	4.9e-08	-0.51	0.72	0.26	FALSE
49	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FTSJ3	0.30	0.12	enet	10	0.18	6.7e-08	-5.4	6.3	3.5e-10	0.71	0.20	0.79	FALSE
50	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PSMC5	0.12	0.05	enet	19	0.07	6.2e-04	6.4	5.4	6.3e-08	0.76	0.01	0.82	FALSE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TCAM1P	0.13	0.14	blup	26	0.13	5.1e-06	-5.5	-5.9	3.4e-09	-0.60	0.57	0.37	FALSE
52	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FTSJ3	0.30	0.35	lasso	11	0.36	3.2e-15	-5.4	5.5	4.5e-08	0.52	0.72	0.28	FALSE
53	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TCAM1P	0.11	0.10	enet	13	0.11	5.2e-05	-5.4	-5.4	6.5e-08	-0.52	0.39	0.21	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	6.4	6.4	1.7e-10	0.95	0.01	0.95	FALSE
55	The Cancer Genome Atlas	Rectum Adenocarcinoma	FTSJ3	0.37	0.34	lasso	16	0.34	1.1e-08	-5.5	5.4	7.7e-08	0.50	0.66	0.30	FALSE
56	The Cancer Genome Atlas	Soft Tissue Sarcoma	FTSJ3	0.17	0.22	blup	30	0.23	9.0e-14	-5.4	5.7	1.1e-08	0.58	0.72	0.28	FALSE
57	The Cancer Genome Atlas	Soft Tissue Sarcoma	TCAM1P	0.05	0.05	blup	26	0.05	4.3e-04	-5.4	-5.7	9.2e-09	-0.57	0.21	0.22	FALSE
58	The Cancer Genome Atlas	Stomach Adenocarcinoma	FTSJ3	0.14	0.21	lasso	2	0.20	1.9e-14	-5.4	5.2	2.0e-07	0.46	0.72	0.28	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	FTSJ3	0.18	0.28	lasso	16	0.27	1.4e-26	-5.4	5.4	8.4e-08	0.51	0.73	0.27	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	TCAM1P	0.07	0.07	blup	26	0.08	2.8e-08	-5.5	-6.6	3.6e-11	-0.80	0.06	0.94	FALSE