Best TWAS P=1.26e-11 · Best GWAS P=2.29e-09 conditioned to 6.81e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | KREMEN1 | 0.19 | 0.13 | enet | 22 | 0.13 | 9.2e-11 | 5.9 | 6.8 | 1.3e-11 | 0.16 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Adrenal Gland | KREMEN1 | 0.38 | 0.26 | lasso | 3 | 0.22 | 1.7e-08 | 5.9 | 5.5 | 3.5e-08 | 0.02 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | KREMEN1 | 0.14 | 0.06 | enet | 10 | 0.10 | 6.9e-06 | 4.6 | 5.7 | 1.2e-08 | 0.17 | 0.02 | 0.96 | FALSE |
| 4 | GTEx | Heart Left Ventricle | KREMEN1 | 0.47 | 0.32 | lasso | 6 | 0.34 | 5.0e-19 | 5.6 | 5.8 | 5.6e-09 | 0.05 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Ovary | KREMEN1 | 0.28 | 0.18 | enet | 5 | 0.19 | 1.7e-05 | 5.6 | 5.7 | 1.1e-08 | 0.08 | 0.03 | 0.85 | FALSE |
| 6 | GTEx | Pancreas | KREMEN1 | 0.33 | 0.24 | lasso | 7 | 0.23 | 4.2e-10 | 5.8 | 6.1 | 1.4e-09 | 0.06 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Thyroid | KREMEN1 | 0.10 | 0.09 | lasso | 3 | 0.08 | 1.3e-06 | 5.9 | 5.9 | 4.4e-09 | 0.05 | 0.01 | 0.99 | FALSE |
| 8 | METSIM | Adipose | KREMEN1 | 0.12 | 0.12 | lasso | 8 | 0.11 | 1.7e-16 | 5.8 | 5.6 | 1.9e-08 | 0.05 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KREMEN1 | 0.13 | 0.10 | lasso | 5 | 0.11 | 3.3e-12 | 5.6 | 6.3 | 2.2e-10 | 0.09 | 0.03 | 0.97 | FALSE |