Best TWAS P=2.33e-09 · Best GWAS P=1.3e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | RNF185 | 0.06 | 0.09 | lasso | 4 | 0.07 | 1.5e-07 | -6.1 | -6.0 | 2.3e-09 | 1.00 | 0.00 | 1.00 | TRUE |
| 1 | GTEx | Esophagus Gastroesophageal Junction | SFI1 | 0.15 | 0.07 | lasso | 3 | 0.06 | 3.7e-03 | -5.4 | 5.9 | 4.3e-09 | -0.93 | 0.02 | 0.88 | FALSE |
| 7 | The Cancer Genome Atlas | Rectum Adenocarcinoma | RNF185 | 0.18 | 0.10 | enet | 6 | 0.12 | 9.7e-04 | -5.9 | -5.6 | 2.6e-08 | 0.95 | 0.00 | 0.88 | FALSE |
| 4 | NTR | Blood | DEPDC5 | 0.02 | 0.02 | lasso | 5 | 0.01 | 2.4e-05 | -5.3 | 5.5 | 2.9e-08 | -0.60 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Muscle Skeletal | SFI1 | 0.13 | 0.09 | enet | 22 | 0.10 | 1.7e-10 | 4.2 | 5.5 | 5.1e-08 | -0.70 | 0.82 | 0.18 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIMK2 | 0.06 | 0.06 | blup | 47 | 0.06 | 9.3e-08 | -4.6 | 5.4 | 5.9e-08 | -0.91 | 0.06 | 0.94 | FALSE |
| 2 | GTEx | Esophagus Muscularis | LIMK2 | 0.08 | 0.03 | lasso | 4 | 0.01 | 4.3e-02 | -5.4 | 5.3 | 1.4e-07 | -0.84 | 0.04 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RNF185 | 0.06 | 0.05 | blup | 54 | 0.05 | 4.7e-06 | -5.9 | -5.2 | 2.0e-07 | 0.82 | 0.00 | 0.99 | FALSE |