Best TWAS P=7.83e-09 · Best GWAS P=2.07e-09 conditioned to 0.00463
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CDC42BPA | 0.10 | 0.05 | lasso | 5 | 0.02 | 3.6e-03 | 4.2 | -5.3 | 9.8e-08 | 0.65 | 0.43 | 0.48 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | RNF187 | 0.17 | 0.01 | enet | 34 | 0.06 | 4.7e-05 | -4.1 | 5.1 | 3.1e-07 | -0.11 | 0.07 | 0.14 | TRUE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | PSEN2 | 0.15 | 0.05 | lasso | 7 | 0.04 | 1.7e-03 | -4.9 | 5.3 | 9.0e-08 | -0.23 | 0.42 | 0.27 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | PSEN2 | 0.10 | 0.04 | lasso | 7 | 0.02 | 7.9e-03 | 5.1 | 5.5 | 4.0e-08 | -0.12 | 0.28 | 0.22 | TRUE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSEN2 | 0.14 | 0.06 | lasso | 4 | 0.07 | 5.4e-05 | -4.9 | 5.6 | 2.2e-08 | -0.42 | 0.02 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PSEN2 | 0.02 | 0.02 | blup | 51 | 0.02 | 1.6e-03 | -4.9 | 5.3 | 1.0e-07 | -0.39 | 0.01 | 0.77 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PSEN2 | 0.08 | 0.00 | blup | 51 | 0.04 | 2.6e-03 | -4.3 | 5.2 | 1.8e-07 | -0.43 | 0.01 | 0.26 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CABC1 | 0.08 | 0.02 | enet | 6 | 0.05 | 6.6e-06 | -4.9 | -5.8 | 7.8e-09 | 0.54 | 0.45 | 0.32 | TRUE |