TWAS
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Traits
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Traits
:
Impedance of arm (right)
:
←
→
chr2:225,574,650-227,217,161
Best TWAS P=1.23e-20 · Best GWAS P=4.83e-45 conditioned to 4.55e-27
225.6M
225.8M
226M
226.2M
226.4M
226.6M
226.8M
227M
227.2M
0
10
20
30
40
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
NYAP2
0.02
0.01
lasso
4
0.01
0.029
11
-9.3
1.2e-20
-0.53
0.06
0.73
TRUE