Best TWAS P=6.41e-13 · Best GWAS P=2.49e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PASK | 0.17 | 0.09 | enet | 13 | 0.09 | 8.3e-08 | 5.4 | -5.4 | 5.3e-08 | -0.40 | 0.98 | 0.02 | TRUE |
| 2 | GTEx | Artery Aorta | CAPN10-AS1 | 0.14 | 0.00 | lasso | 5 | 0.00 | 2.6e-01 | 6.1 | 6.2 | 7.8e-10 | -0.03 | 0.05 | 0.06 | TRUE |
| 3 | GTEx | Artery Tibial | HDLBP | 0.16 | 0.08 | enet | 15 | 0.12 | 8.4e-10 | 3.7 | -5.3 | 1.4e-07 | -0.04 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Esophagus Mucosa | PASK | 0.19 | 0.13 | lasso | 6 | 0.14 | 1.1e-09 | 5.5 | -5.8 | 5.1e-09 | -0.39 | 0.97 | 0.03 | FALSE |
| 5 | GTEx | Heart Left Ventricle | PASK | 0.10 | 0.03 | lasso | 6 | 0.03 | 9.4e-03 | -4.7 | -6.5 | 1.1e-10 | -0.45 | 0.11 | 0.28 | TRUE |
| 6 | GTEx | Nerve Tibial | PASK | 0.26 | 0.18 | enet | 12 | 0.22 | 1.0e-15 | 5.4 | -6.3 | 3.0e-10 | -0.47 | 0.97 | 0.03 | TRUE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | PASK | 0.28 | 0.16 | enet | 17 | 0.19 | 1.9e-10 | 4.7 | -5.7 | 1.6e-08 | -0.43 | 0.98 | 0.02 | TRUE |
| 8 | GTEx | Skin Sun Exposed Lower leg | PASK | 0.27 | 0.18 | enet | 10 | 0.18 | 4.5e-15 | 4.7 | -5.2 | 1.6e-07 | -0.36 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Small Intestine Terminal Ileum | MTERFD2 | 0.37 | 0.24 | lasso | 3 | 0.18 | 7.3e-05 | 6.7 | -6.7 | 2.8e-11 | -0.93 | 0.01 | 0.94 | FALSE |
| 10 | GTEx | Testis | MTERFD2 | 0.43 | 0.17 | enet | 32 | 0.25 | 1.4e-11 | 6.0 | 5.5 | 3.5e-08 | 0.88 | 0.06 | 0.94 | TRUE |
| 11 | GTEx | Thyroid | HDLBP | 0.16 | 0.14 | enet | 31 | 0.14 | 3.2e-11 | 3.9 | -5.2 | 1.8e-07 | -0.11 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Thyroid | MTERFD2 | 0.12 | 0.09 | lasso | 2 | 0.08 | 1.8e-06 | 7.0 | -6.2 | 6.0e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Whole Blood | PASK | 0.25 | 0.15 | enet | 10 | 0.21 | 4.4e-19 | 5.9 | -6.9 | 3.8e-12 | -0.89 | 0.10 | 0.90 | TRUE |
| 14 | GTEx | Whole Blood | MTERFD2 | 0.10 | 0.06 | enet | 16 | 0.06 | 3.0e-06 | 6.3 | -6.2 | 7.6e-10 | -0.67 | 0.17 | 0.81 | FALSE |
| 15 | NTR | Blood | PASK | 0.08 | 0.09 | bslmm | 437 | 0.09 | 1.0e-26 | 6.7 | -6.5 | 6.9e-11 | -0.94 | 0.02 | 0.98 | FALSE |
| 16 | YFS | Blood | PASK | 0.31 | 0.46 | lasso | 11 | 0.48 | 1.8e-181 | 7.0 | -7.2 | 6.4e-13 | -0.98 | 0.00 | 1.00 | TRUE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PASK | 0.04 | 0.00 | blup | 92 | 0.01 | 3.2e-02 | 6.1 | -5.7 | 1.1e-08 | -0.53 | 0.05 | 0.11 | FALSE |