Best TWAS P=2.46e-16 · Best GWAS P=3.93e-17 conditioned to 0.00141
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | RQCD1 | 0.13 | 0.04 | lasso | 11 | 0.01 | 2.1e-01 | -4.3 | -5.2 | 1.7e-07 | 0.09 | 0.04 | 0.41 | TRUE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RP11-316O14.1 | 0.52 | 0.34 | lasso | 4 | 0.35 | 6.1e-10 | 8.4 | 8.2 | 2.5e-16 | 0.94 | 0.00 | 1.00 | TRUE |
| 3 | GTEx | Brain Cerebellum | RP11-316O14.1 | 0.39 | 0.29 | enet | 10 | 0.30 | 1.7e-09 | 8.4 | 7.8 | 5.1e-15 | 0.97 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Brain Hypothalamus | RP11-316O14.1 | 0.28 | 0.26 | lasso | 4 | 0.17 | 8.1e-05 | 8.1 | 8.1 | 8.2e-16 | 0.95 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP11-316O14.1 | 0.19 | 0.16 | lasso | 3 | 0.12 | 1.3e-09 | 8.1 | 7.8 | 6.6e-15 | 0.95 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Prostate | ABCB6 | 0.32 | -0.01 | enet | 28 | 0.05 | 2.6e-02 | 3.9 | 5.7 | 1.4e-08 | 0.30 | 0.06 | 0.16 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | DIRC3 | 0.08 | 0.06 | lasso | 5 | 0.07 | 2.7e-07 | 5.5 | -5.2 | 1.9e-07 | -0.03 | 0.48 | 0.52 | TRUE |