Best TWAS P=1.07e-10 · Best GWAS P=6.19e-20 conditioned to 1.01e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | PPARG | 0.23 | 0.09 | lasso | 12 | 0.07 | 2.1e-03 | 4.3 | 5.9 | 4.3e-09 | 0.75 | 0.10 | 0.77 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | HRH1 | 0.20 | 0.00 | lasso | 3 | 0.01 | 1.1e-01 | -5.5 | 5.4 | 7.7e-08 | -0.01 | 0.04 | 0.57 | TRUE |
| 3 | GTEx | Esophagus Mucosa | ATG7 | 0.12 | 0.04 | enet | 10 | 0.05 | 2.2e-04 | -5.9 | 5.5 | 2.9e-08 | 0.06 | 0.00 | 0.99 | TRUE |
| 4 | GTEx | Heart Left Ventricle | PPARG | 0.25 | 0.07 | enet | 36 | 0.10 | 5.1e-06 | 9.0 | 6.5 | 1.1e-10 | 0.67 | 0.01 | 0.98 | TRUE |
| 5 | GTEx | Muscle Skeletal | SYN2 | 0.18 | 0.10 | enet | 28 | 0.14 | 5.3e-14 | 6.0 | 5.7 | 1.5e-08 | 0.48 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Nerve Tibial | ATG7 | 0.11 | 0.04 | lasso | 6 | 0.04 | 8.9e-04 | -4.4 | 5.5 | 5.1e-08 | -0.01 | 0.02 | 0.92 | FALSE |
| 7 | GTEx | Thyroid | ATG7 | 0.11 | 0.02 | lasso | 3 | 0.02 | 1.1e-02 | -5.9 | 5.3 | 1.2e-07 | 0.00 | 0.01 | 0.94 | FALSE |