Best TWAS P=2.51e-08 · Best GWAS P=2.56e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | CTSO | 0.06 | 0.03 | enet | 8 | 0.03 | 5.3e-06 | -4.1 | 5.4 | 7.5e-08 | -0.84 | 0.03 | 0.97 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | CTSO | 0.03 | 0.06 | lasso | 1 | 0.06 | 2.6e-08 | -5.6 | 5.6 | 2.7e-08 | -0.83 | 0.00 | 1.00 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CTSO | 0.03 | 0.02 | lasso | 3 | 0.02 | 1.0e-04 | -5.6 | 5.5 | 4.9e-08 | -0.99 | 0.00 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TDO2 | 0.02 | 0.00 | blup | 26 | 0.00 | 5.2e-02 | -5.6 | -5.1 | 3.1e-07 | 0.57 | 0.00 | 0.31 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CTSO | 0.10 | 0.05 | blup | 8 | 0.02 | 1.7e-02 | -5.6 | 5.5 | 2.9e-08 | -0.90 | 0.00 | 0.86 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | CTSO | 0.09 | 0.06 | lasso | 2 | 0.06 | 3.4e-07 | -5.6 | 5.5 | 4.4e-08 | -0.99 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CTSO | 0.08 | 0.05 | lasso | 5 | 0.05 | 3.6e-06 | -5.6 | 5.6 | 2.5e-08 | -1.00 | 0.00 | 1.00 | TRUE |