TWAS hub - CTSO

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3640	0.0490	0.0e+00	0.162	0.229	0.273	0.289	0.290	2.8e-19	1.7e-27	2.8e-33	1.9e-35	1.7e-35
2	GTEx	Adipose Subcutaneous	0.1130	0.0430	3.0e-03	0.051	NA	0.012	NA	0.031	5.1e-05	NA	3.5e-02	NA	1.4e-03
3	GTEx	Cells Transformed fibroblasts	0.1790	0.0440	4.8e-06	0.108	NA	0.137	NA	0.136	1.8e-08	NA	1.8e-10	NA	2.2e-10
4	GTEx	Thyroid	0.1590	0.0480	4.7e-04	0.019	NA	0.030	NA	0.041	1.3e-02	NA	2.2e-03	NA	3.9e-04
5	METSIM	Adipose	0.0580	0.0202	6.9e-04	0.026	0.019	0.035	0.028	0.031	7.0e-05	5.3e-04	5.3e-06	3.6e-05	1.6e-05
6	ROSMAP	Brain Pre-frontal Cortex	0.0347	0.0197	4.5e-02	0.063	0.007	0.059	0.051	0.061	1.6e-08	3.9e-02	4.7e-08	3.4e-07	2.6e-08
7	YFS	Blood	0.0617	0.0173	2.7e-06	0.030	0.025	0.034	0.032	0.039	4.2e-10	9.1e-09	2.4e-11	9.5e-11	7.4e-13
8	TCGA	Breast Invasive Carcinoma	0.0308	0.0182	7.5e-04	0.019	0.016	0.015	NA	0.018	8.1e-05	2.3e-04	3.7e-04	NA	1.0e-04
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0980	0.0560	3.8e-03	0.051	0.023	0.022	NA	0.023	6.5e-04	1.7e-02	2.0e-02	NA	1.8e-02
10	TCGA	Brain Lower Grade Glioma	0.1921	0.1161	2.2e-03	0.018	0.014	0.031	NA	0.014	3.6e-03	8.1e-03	1.6e-04	NA	9.6e-03
11	TCGA	Lung Adenocarcinoma	0.0948	0.0483	6.0e-07	0.062	0.049	0.055	NA	0.056	9.9e-08	1.9e-06	5.2e-07	NA	3.4e-07
12	TCGA	Lung Squamous Cell Carcinoma	0.0816	0.0483	3.3e-05	0.050	0.037	0.046	NA	0.048	2.4e-06	4.1e-05	5.2e-06	NA	3.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Medication: Amlodipine	6.4	9.0	13.3	-1.7	-3.4	-3.1	-3.6	-3.6	-3.4	-1.8	-3.3	-2.7	-2.2	-3.2	-3.1
Impedance of arm (right)	4.9	22.7	31.1	1.3	4.9	4.9	4.8	5.4	5.6	3.2	5.5	5.5	2.9	5.5	5.6
Handedness (chirality/laterality): Left-handed	4.6	5.6	9.0	0.4	-3.0	-2.3	-1.7	-2.3	-2.7	-1.1	-2.9	-2.5	-2.1	-2.9	-2.8
Impedance of arm (left)	4.4	20.3	28.1	1.3	4.8	4.7	4.5	5.1	5.3	3.1	5.1	5.1	2.9	5.1	5.1
Ever highly irritable/argumentative for 2 days	4.4	5.3	8.2	0.2	-2.5	-2.4	-2.3	-2.5	-2.9	-0.7	-2.8	-2.6	-0.9	-2.8	-2.8
Allergy	4.0	9.3	14.7	-2.0	-3.0	-3.2	-3.8	-3.2	-3.3	-2.0	-3.4	-3.2	-1.9	-3.4	-3.4
Supplements: Calcium	3.7	4.1	8.0	0.5	-1.8	-1.9	-2.1	-2.5	-1.8	-0.6	-2.3	-2.8	-1.6	-2.4	-2.6
Impedance of whole body	3.7	18.9	25.3	0.9	4.7	4.5	4.4	5.0	5.0	3.2	4.9	4.8	2.8	4.9	4.9
Hayfever, allergic rhinitis or eczema	3.6	7.8	11.8	2.3	2.8	2.9	3.4	2.5	3.4	1.6	3.2	2.9	1.3	3.2	3.1
Systolic Blood Pressure	3.4	17.0	28.5	-2.1	-4.1	-3.6	-5.1	-5.3	-4.9	-2.0	-4.6	-4.3	-2.4	-4.6	-4.6
Smoking status: Previous	3.2	4.8	9.1	0.9	-2.3	-1.7	-1.4	-2.9	-2.1	-1.8	-2.2	-3.0	-2.2	-2.3	-2.5
Medication: Blood pressure	3.1	5.6	9.0	0.4	-2.5	-2.4	-1.4	-3.0	-2.9	-0.7	-2.9	-2.7	-1.5	-2.9	-2.9
Crohns Disease (2012)	2.7	4.4	7.3	0.2	-2.2	-1.7	-2.1	-2.7	-2.1	-2.2	-2.4	-2.2	-1.3	-2.4	-2.4
Number of live births	2.7	3.8	6.0	-1.1	-2.0	-2.4	-2.4	-1.5	-2.4	-0.7	-2.2	-2.4	-0.2	-2.2	-2.3
Allergy or Eczema	2.6	6.9	10.9	2.5	2.7	2.8	3.3	2.2	3.2	1.5	2.9	2.7	1.2	2.9	2.8
High blood pressure	2.6	7.4	12.2	0.1	-2.7	-2.8	-1.9	-3.5	-3.5	-0.6	-3.0	-3.3	-2.7	-3.0	-3.0
Systolic blood pressure, automated reading	2.5	7.2	14.6	-0.1	-2.4	-2.5	-2.6	-3.0	-3.8	-0.8	-3.0	-3.2	-2.2	-3.0	-3.1
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	4.5	1.3	1.8	1.4	2.1	1.7	1.2	1.9	1.8	1.8	0.2	1.8	1.9
Hypertension (Self-reported)	2.5	6.8	11.6	0.3	-2.6	-2.6	-1.7	-3.4	-3.2	-0.4	-3.0	-3.2	-2.4	-3.0	-3.0
Vascular/heart problems diagnosed by doctor	2.5	6.9	11.3	-0.3	2.5	2.4	1.7	3.2	3.4	-0.2	3.2	3.2	2.2	3.2	3.2
Chronotype (morning person)	2.4	5.5	9.1	1.2	2.3	2.2	2.4	2.5	2.8	1.3	2.7	3.0	0.9	2.7	2.8
Trunk fat percentage	2.4	9.8	16.9	1.4	3.6	3.1	4.1	3.9	2.9	2.1	3.3	3.3	2.0	3.3	3.4
Fractured/broken bones in last 5 years	2.4	3.1	5.8	1.3	1.8	2.2	1.8	1.9	2.4	1.1	1.7	1.7	1.5	1.7	1.6
Schizophrenia (2018)	2.3	4.8	8.1	0.8	2.3	2.4	2.0	2.7	2.8	1.7	2.0	2.5	2.2	2.0	2.1
Alzheimer’s Disease (in mother)	2.3	2.7	4.4	-1.4	-1.8	-2.1	-1.5	-1.7	-1.9	-2.0	-1.1	-2.0	-1.3	-1.1	-1.3
Mineral and other dietary supplements	2.3	3.1	6.8	-0.9	2.1	1.7	0.9	2.4	1.7	1.0	1.7	1.8	2.6	1.7	1.7
Major Depression (MDD)	2.2	2.6	4.9	2.1	1.5	1.9	2.2	1.7	1.4	2.1	1.4	1.1	-0.2	1.4	1.4
Serious illness, injury or assault to yourself	2.2	2.6	6.5	2.5	1.6	1.3	2.5	1.5	1.6	0.5	1.6	1.3	-0.0	1.6	1.6
Comparative body size at age 10	2.2	6.0	10.0	-1.6	-2.9	-3.2	-2.6	-2.8	-2.7	-2.0	-2.0	-2.7	-2.6	-2.0	-2.1
Illnesses of siblings: Diabetes	2.2	2.6	4.5	1.4	2.0	1.1	1.8	2.1	1.1	1.8	1.2	1.8	2.0	1.2	1.4
Schizophrenia vs Biploar Disorder	2.1	2.8	4.3	1.4	1.7	1.8	1.9	2.1	1.8	1.1	1.5	2.0	1.5	1.6	1.6
Severe depression (siblings)	2.1	2.4	4.0	-0.8	1.7	0.9	1.2	1.8	1.2	1.0	2.0	1.4	1.8	2.0	1.9
Illness, injury, bereavement, stress in last 2 years	2.1	2.5	8.0	-0.8	-1.3	-0.5	-2.8	-2.3	-1.3	-0.2	-1.8	-1.5	-0.5	-1.8	-1.9
Supplements: Vitamin C	2.1	2.4	3.7	0.9	1.4	1.8	1.5	1.9	1.6	1.1	1.9	1.2	1.4	1.9	1.7
Bipolar Disorder (2011)	2.0	2.0	4.7	-0.7	-1.1	-0.4	-2.2	-1.6	-1.0	-0.4	-1.9	-1.7	-0.4	-1.8	-1.9
Supplements: Glucosamine	2.0	2.6	4.8	-0.3	-1.9	-1.8	-1.9	-2.2	-1.3	-1.6	-1.5	-1.2	-2.0	-1.4	-1.4
Age started oral contraceptive pill	2.0	2.5	3.9	1.9	-1.3	-0.8	-0.7	-1.4	-1.7	0.9	-1.9	-2.0	-1.6	-2.0	-2.0
Asthma	1.9	3.7	6.8	0.5	2.1	2.3	2.0	2.6	2.2	1.7	1.7	1.8	1.9	1.7	1.7
Tinnitus: Yes, now most or all of the time	1.9	2.2	4.0	0.2	-1.5	-1.2	-1.3	-1.6	-1.6	0.3	-2.0	-1.7	-0.9	-2.0	-2.0
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	2.7	-0.7	-1.6	-1.6	-1.7	-1.6	-1.2	-0.8	-1.5	-1.5	-1.1	-1.5	-1.5
Medication: Atenolol	1.8	2.3	5.2	0.8	-1.4	-1.6	0.3	-1.7	-2.3	-0.5	-1.7	-1.8	-1.6	-1.7	-1.6
Past tobacco smoking	1.8	3.3	6.0	-0.8	2.1	1.4	0.9	2.4	1.9	1.6	1.8	2.5	1.9	1.8	2.0
Number of children fathered	1.8	2.0	3.3	1.0	1.4	1.8	1.0	1.7	1.7	1.2	1.3	1.4	1.6	1.3	1.3
Other serious medical condition/disability diagnosed by doctor	1.7	2.1	4.8	0.4	1.5	1.3	2.2	1.8	1.9	0.8	1.6	1.2	-0.1	1.6	1.6
Supplements: Zinc	1.7	1.9	4.3	-0.9	-1.4	-1.7	-1.3	-1.6	-1.3	-1.2	-0.7	-1.8	-2.1	-0.8	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	5.9	0.9	1.4	0.9	2.4	2.3	0.8	1.0	1.3	0.9	1.5	1.3	1.2
Medication: Paracetamol	1.7	2.8	5.2	0.1	1.6	1.4	1.5	1.8	2.3	0.7	1.9	2.1	1.5	2.0	2.0
Angina (self-reported)	1.7	2.3	4.5	1.1	-1.3	-1.5	0.0	-1.5	-1.8	0.5	-1.8	-2.1	-1.4	-1.8	-1.9
Medication: Blood pressure	1.7	3.2	8.4	-0.3	-1.7	-2.4	-0.4	-2.1	-2.5	-0.8	-1.2	-2.2	-2.9	-1.3	-1.4
Bipolar Disorder (2018)	1.6	2.6	9.3	-2.0	-1.1	-0.9	-3.1	-1.5	-0.8	-0.9	-1.3	-2.0	-1.4	-1.4	-1.6
Angina	1.6	2.1	4.0	0.9	-1.3	-1.5	0.0	-1.3	-1.7	0.4	-1.8	-2.0	-1.1	-1.8	-1.9
Impedance of leg (left)	1.6	7.8	10.8	-0.0	3.0	2.9	2.4	3.1	3.0	2.4	3.3	3.1	1.9	3.3	3.3
Pain all over the body in last month	1.6	1.7	3.2	-1.2	1.1	0.6	0.9	1.1	1.4	-0.3	1.7	1.8	1.3	1.8	1.8
Trunk fat-free mass	1.6	9.1	13.9	0.3	-3.1	-2.5	-3.4	-3.7	-3.1	-1.6	-3.7	-3.5	-1.6	-3.7	-3.7
Trunk predicted mass	1.6	9.3	14.2	0.3	-3.1	-2.6	-3.4	-3.8	-3.2	-1.7	-3.7	-3.5	-1.6	-3.7	-3.8
Body fat percentage	1.6	6.5	12.5	1.2	3.0	2.3	3.5	3.2	2.2	1.8	2.7	2.7	1.5	2.7	2.7
Ever had bowel cancer screening	1.6	1.8	3.2	0.0	-1.4	-1.1	-1.2	-1.7	-1.7	-1.4	-1.1	-1.8	-1.5	-1.1	-1.2
Wears glasses or contact lenses	1.6	1.8	3.6	-0.5	-0.9	-1.5	-1.9	-1.7	-1.3	-0.1	-1.3	-1.8	-1.0	-1.4	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	3.4	1.4	1.2	1.4	1.8	1.7	1.6	1.0	1.2	1.8	0.3	1.2	1.4
Alzheimer’s Disease (including proxy)	1.5	2.2	4.3	-0.5	-1.9	-1.9	-1.3	-2.1	-1.5	-1.7	-1.2	-1.6	-1.2	-1.2	-1.2
Impedance of leg (right)	1.5	7.1	9.9	0.1	2.9	3.0	1.8	3.0	3.1	2.6	3.0	2.8	1.9	3.0	3.0
Medication: Ramipril	1.5	2.0	3.2	-0.7	-1.8	-1.8	-1.2	-1.7	-1.8	-1.2	-1.3	-1.3	-1.3	-1.2	-1.2
Illnesses of siblings	1.5	2.1	7.9	-1.4	-1.6	-1.8	-1.2	-1.7	-0.6	-2.8	-0.1	-0.6	-2.2	-0.0	-0.0
Asthma (self-reported)	1.5	3.0	5.4	0.7	1.9	2.1	2.1	2.3	2.0	1.4	1.6	1.6	1.4	1.6	1.6
Had other major operations	1.4	1.7	4.2	0.2	-1.4	-0.9	-0.8	-1.6	-1.1	-1.8	-0.8	-1.8	-2.0	-0.8	-1.0
Arm fat-free mass (right)	1.4	7.3	10.7	-0.1	-2.7	-2.4	-2.7	-3.2	-2.9	-1.9	-3.2	-3.2	-1.8	-3.2	-3.3
Arm predicted mass (right)	1.4	7.2	11.4	0.0	-2.6	-2.2	-2.7	-3.1	-2.9	-1.7	-3.2	-3.3	-1.5	-3.3	-3.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.3	0.8	1.1	1.3	1.8	1.3	1.6	0.8	1.6	1.5	0.6	1.6	1.6
Alcohol intake versus 10 years previously	1.3	2.0	4.6	0.7	1.6	1.0	1.7	2.1	1.6	0.4	1.4	1.6	1.1	1.4	1.5
Commuting to job workplace: Walk	1.3	1.4	2.7	-0.9	0.9	1.2	1.4	1.1	0.8	-0.4	1.6	1.4	0.6	1.6	1.6
Back pain experienced in last month	1.3	1.9	3.7	1.4	1.3	1.0	1.9	1.5	0.9	0.8	1.2	1.9	1.2	1.2	1.5
HbA1C	1.2	1.3	2.6	0.3	-1.2	-1.0	-1.2	-1.1	-1.0	-0.2	-1.5	-1.4	-0.2	-1.6	-1.6
Schizophrenia (2014)	1.2	2.7	5.8	1.8	1.8	2.4	1.1	1.5	2.1	2.0	0.6	1.4	2.2	0.6	0.6
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	2.4	0.8	1.4	1.3	1.5	1.4	1.4	1.2	0.9	1.1	1.4	0.9	0.9
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.7	0.8	1.3	1.3	1.0	1.6	1.4	0.4	1.4	1.1	0.8	1.4	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.0	-1.7	-1.3	-1.6	-1.4	-1.0	-1.0	-1.2	-0.8	-1.2	-0.8	-0.8	-0.9
Medication: Paracetamol	1.2	1.8	2.8	-0.3	1.1	1.0	1.2	1.3	1.6	0.8	1.5	1.7	1.7	1.6	1.6
Medication: Lisinopril	1.2	1.5	3.4	-0.8	-1.2	-1.2	-1.1	-1.8	-1.8	-0.7	-1.3	-0.9	-1.0	-1.2	-1.1
Sensitivity / hurt feelings	1.1	1.8	3.8	-1.1	-2.0	-1.5	-1.3	-1.7	-1.1	-1.4	-1.2	-1.1	-1.3	-1.1	-1.1
Medication: Simvastatin	1.1	1.6	3.6	1.9	-0.4	0.2	-0.1	-1.0	-0.7	1.8	-1.8	-0.7	0.7	-1.8	-1.7
Length of working week for main job	1.1	1.2	3.2	-1.3	-1.4	-1.2	-1.3	-1.1	-0.8	-1.8	-0.5	-0.5	-1.3	-0.4	-0.3
Pulse wave reflection index	1.1	1.4	2.6	-0.7	-1.4	-1.6	-1.3	-1.6	-1.3	-1.2	-0.8	-1.2	-0.8	-0.8	-0.9
Eye problems/disorders: None of the above	1.1	1.3	2.3	0.2	-0.9	-1.2	-1.2	-1.2	-1.1	-0.2	-1.5	-1.4	-0.2	-1.5	-1.5
Mouth/teeth dental problems: Loose teeth	1.1	1.3	5.2	-2.3	-0.4	-0.9	0.2	-0.0	-0.3	-1.8	1.0	0.3	-1.7	1.0	1.0
Medication: Omeprazole	1.1	1.3	2.3	1.2	1.1	1.2	1.3	1.2	1.4	0.7	1.0	1.5	0.4	1.1	1.2
Average weekly red wine intake	1.1	1.7	3.6	1.8	1.2	1.8	1.9	0.7	1.4	1.3	1.0	1.3	-0.1	0.9	1.1
Arm fat-free mass (left)	1.1	5.4	8.3	-0.2	-2.3	-2.0	-2.5	-2.8	-2.5	-1.5	-2.8	-2.8	-1.2	-2.8	-2.9
Coronary Artery Disease (CAD)	1.0	1.2	2.8	1.4	-0.0	0.4	-0.3	-0.9	-0.6	0.7	-1.7	-1.5	-0.2	-1.7	-1.7
Cardiovascular Disease	1.0	3.3	5.5	-0.6	-2.0	-2.0	-1.3	-2.3	-2.1	-0.3	-2.3	-1.9	-0.6	-2.3	-2.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.4	0.3	1.0	0.9	1.3	1.4	1.2	0.3	1.4	1.5	0.3	1.4	1.5
Arm fat percentage (right)	1.0	4.0	8.6	0.9	2.3	1.6	2.9	2.6	1.6	1.2	2.2	2.1	1.2	2.2	2.2
Noisy workplace	1.0	1.3	3.2	-1.7	-0.9	-1.1	-1.8	-1.3	-0.6	-0.9	-1.2	0.0	1.1	-1.1	-0.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.6	-0.1	1.2	1.0	1.0	1.0	1.4	0.6	1.6	1.1	0.6	1.6	1.5
Heart disease (mother)	1.0	1.2	2.6	-0.1	-0.8	-1.4	-0.8	-1.2	-1.5	-0.2	-1.1	-1.6	-0.9	-1.1	-1.2
Arm fat percentage (left)	1.0	4.1	8.9	0.9	2.4	1.6	3.0	2.7	1.6	1.2	2.2	2.1	1.1	2.2	2.2
Qualifications: nursing, teaching	1.0	1.6	2.7	1.1	1.6	0.6	1.5	1.7	1.0	1.4	1.4	1.1	0.7	1.3	1.3
Eye problems/disorders: Cataract	1.0	1.2	7.3	-2.7	-0.9	-0.5	-1.8	-0.6	-0.7	-1.1	-0.1	-0.3	-0.4	-0.1	-0.1
Supplements: Fish oil (including cod liver oil)	1.0	1.4	2.7	0.2	-1.3	-1.2	-0.6	-1.6	-1.5	-0.8	-1.1	-1.2	-1.4	-1.1	-1.1
Arm predicted mass (left)	1.0	5.2	8.0	-0.1	-2.3	-2.0	-2.3	-2.7	-2.6	-1.5	-2.8	-2.7	-1.3	-2.8	-2.8
Fasting Glucose	0.9	1.1	2.9	-0.8	-1.0	-1.4	-1.7	-1.1	-1.1	-0.2	-1.2	-0.6	0.6	-1.2	-1.2
Triglycerides	0.9	1.5	5.7	2.4	1.1	0.8	1.5	1.3	0.4	1.7	0.7	1.1	1.1	0.7	0.8
Number of treatments/medications taken	0.9	1.7	3.3	0.0	-1.3	-1.4	-0.3	-1.8	-1.5	0.2	-1.5	-1.4	-1.4	-1.5	-1.4
Average weekly fortified wine intake	0.9	1.1	6.7	2.6	-0.3	0.2	0.3	-0.9	-0.2	1.1	-0.8	-0.8	-1.0	-0.9	-0.9
Stomach or abdominal pain in last month	0.9	1.1	2.0	0.4	0.5	0.8	1.2	1.4	1.1	-0.3	1.4	0.6	-0.9	1.4	1.3
Trunk fat mass	0.9	4.1	8.3	1.5	2.4	2.1	2.9	2.4	1.8	1.5	1.9	2.0	1.3	1.9	2.0
Peak expiratory flow (PEF)	0.9	2.0	4.2	0.4	-1.4	-0.7	-1.4	-1.5	-1.3	-0.6	-1.9	-2.0	-0.1	-1.9	-2.1
Health satisfaction	0.9	1.2	2.7	-1.1	-1.2	-1.4	-0.2	-0.7	-1.2	-1.3	-0.6	-1.5	-1.6	-0.6	-0.7
Number of full sisters	0.9	1.1	2.5	0.7	1.2	0.5	1.4	1.6	0.7	1.4	0.7	0.9	1.1	0.7	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	4.2	2.0	0.9	0.8	0.7	0.5	0.5	1.0	0.5	1.1	1.7	0.6	0.6
Medication: Aspirin	0.9	1.2	2.2	-0.9	-1.0	-1.5	-0.2	-1.2	-1.3	-0.4	-1.1	-1.2	-1.2	-1.1	-1.1
Whole body fat-free mass	0.9	4.9	8.1	0.6	-2.2	-1.7	-2.1	-2.7	-2.2	-1.3	-2.8	-2.6	-1.2	-2.8	-2.8
Medication: Aspirin	0.9	1.2	2.0	-0.6	-1.1	-1.3	-0.1	-1.4	-1.2	-0.4	-1.3	-1.0	-1.4	-1.3	-1.2
Whole body water mass	0.9	5.4	8.7	0.5	-2.3	-1.9	-2.4	-2.8	-2.4	-1.4	-2.9	-2.7	-1.3	-2.9	-3.0
Ever smoked	0.9	1.6	4.1	1.0	-1.6	-0.9	-0.2	-1.7	-1.4	-1.2	-0.8	-1.4	-2.0	-0.8	-0.9
Mean Putamen Volume	0.8	0.9	2.3	-1.2	-1.5	-1.1	-0.6	-0.5	-1.5	-1.2	-0.7	-0.6	-0.6	-0.6	-0.5
Ever had hysterectomy (womb removed)	0.8	0.9	4.5	2.1	1.1	0.5	1.5	1.1	0.5	0.6	0.7	0.4	0.0	0.6	0.6
Mouth/teeth dental problems: Dentures	0.8	1.3	7.9	2.8	-0.2	-0.2	1.8	0.0	-1.0	1.0	-0.7	0.5	-0.8	-0.7	-0.3
Illnesses of mother	0.8	1.0	2.8	-0.4	0.7	0.9	0.9	1.2	0.9	0.2	0.8	1.7	1.3	0.9	1.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	1.9	0.9	1.4	1.0	1.3	1.2	0.7	1.2	1.4	1.0	0.5	1.3	1.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.6	-0.5	0.9	0.6	0.0	1.6	1.3	-0.4	1.5	1.5	0.3	1.6	1.6
Emphysema/chronic bronchitis	0.8	0.9	1.9	-0.1	-0.8	-0.8	-0.6	-1.0	-1.0	-1.2	-1.4	-0.6	0.7	-1.3	-1.2
Alcohol intake frequency.	0.8	1.8	4.7	-0.1	1.2	0.5	2.2	2.0	1.1	0.8	1.3	1.8	0.8	1.3	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.1	0.8	1.3	1.5	1.3	1.6	2.0	0.9	1.1	1.5	0.8	1.2	1.2
Medication for cholesterol	0.8	1.2	3.1	0.5	0.8	1.7	0.6	1.1	1.8	0.5	0.8	1.0	1.7	0.9	0.8
Osteoarthritis (self-reported)	0.8	1.1	3.5	-0.1	0.1	0.1	1.9	0.6	0.4	-0.6	1.3	0.6	-1.7	1.3	1.3
Number of operations (self-reported)	0.8	1.2	2.7	-0.3	-1.1	-1.2	-1.5	-1.5	-0.5	-1.6	-0.8	-1.1	-1.1	-0.8	-0.9
Unable to work because of sickness or disability	0.8	1.0	2.7	0.9	0.7	0.9	1.3	1.0	1.2	1.1	0.6	1.6	0.4	0.7	0.9
Basal cell carcinoma (self-reported)	0.8	1.0	2.7	-1.6	-1.0	-0.9	-1.1	-0.7	-1.0	-0.7	-0.7	-1.1	-1.1	-0.7	-0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	4.0	-2.0	-0.5	-0.8	-1.4	-0.5	-0.4	-1.2	0.1	-1.0	-0.7	0.0	-0.2
Alcohol usually taken with meals	0.7	1.1	2.0	-0.4	1.0	1.2	1.2	1.1	1.0	0.6	1.3	1.4	0.1	1.3	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	4.3	1.1	1.4	0.6	2.1	1.6	0.9	1.3	1.1	0.5	1.2	1.1	0.9
Medication: Cholesterol lowering	0.7	1.1	2.5	0.6	-0.5	-0.2	-0.3	-1.5	-0.8	0.5	-1.5	-1.2	0.6	-1.5	-1.6
Medication: Lansoprazole	0.7	0.8	1.9	-0.0	-1.0	-1.0	-0.4	-0.7	-1.1	0.1	-1.4	-0.9	0.1	-1.3	-1.3
Lung cancer (father)	0.7	0.8	1.7	-0.2	0.8	1.2	0.7	1.0	0.9	1.3	0.3	1.3	1.3	0.4	0.5
Tense / ‘highly strung’	0.7	1.1	4.2	-2.0	-1.3	-1.3	-1.7	-0.9	-0.2	-1.4	-0.3	0.2	-0.5	-0.2	-0.0
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.3	0.4	0.6	0.6	1.5	1.3	0.9	0.2	1.1	0.6	-0.8	1.1	1.1
Suffer from ‘nerves’	0.7	1.1	2.4	-1.4	0.3	0.8	0.3	0.8	1.5	-0.2	1.5	0.9	0.3	1.6	1.4
Illnesses of father: Heart disease	0.7	0.9	3.3	1.6	-0.5	-0.9	1.4	-0.7	-0.7	-0.2	-0.3	-0.8	-1.8	-0.4	-0.4
Illnesses of father: None of the above (group 1)	0.7	0.9	2.2	0.4	1.3	1.3	-0.3	0.8	1.0	0.7	0.7	1.0	1.5	0.7	0.7
Miserableness	0.7	1.3	2.0	0.7	1.0	1.1	1.4	1.1	1.4	0.8	1.4	1.1	0.1	1.4	1.4
Illnesses of father: High blood pressure	0.7	0.9	1.8	0.7	-1.0	-1.4	0.4	-0.9	-1.2	-0.2	-0.8	-1.2	-1.1	-0.8	-0.9
Alcohol drinker status: Never	0.7	0.8	2.3	0.7	0.6	0.7	1.2	1.1	0.2	0.7	0.6	1.5	1.3	0.6	0.9
Average weekly beer plus cider intake	0.7	1.0	2.4	-1.6	0.0	-0.3	-0.0	0.6	0.8	-1.4	1.5	0.2	-0.4	1.5	1.3
Irritability	0.7	1.2	2.4	-1.1	-1.3	-1.3	-1.5	-1.3	-0.7	-0.8	-1.2	-0.5	-0.5	-1.1	-1.0
Alcohol drinker status: Previous	0.7	0.8	3.0	-0.1	-0.4	-0.9	1.3	0.0	-0.3	-1.2	0.8	-0.1	-1.7	0.8	0.8
Pack years of smoking	0.7	1.0	3.1	-1.1	-1.2	-1.7	-1.0	-0.7	-1.7	-1.1	-0.9	0.2	0.0	-0.7	-0.4
Depression (Nagel 2018)	0.6	1.0	2.7	0.7	0.6	0.9	1.7	1.3	1.0	0.7	1.0	1.0	-0.2	1.0	1.1
Average weekly spirits intake	0.6	0.8	1.8	1.3	0.9	1.1	1.1	0.5	0.9	1.3	0.7	0.3	0.0	0.7	0.6
Age when periods started (menarche)	0.6	1.5	2.6	1.3	-0.9	0.2	-1.5	-1.5	-0.7	1.2	-1.6	-1.1	0.4	-1.6	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.0	-1.4	-1.4	-0.9	-0.6	-1.1	-0.3	-0.8	-0.3	-0.6	-1.7	-0.2	-0.2
Hair/balding pattern: Pattern 2	0.6	0.7	3.5	-0.9	0.9	0.5	-0.2	1.1	0.3	1.4	0.3	0.3	1.9	0.3	0.2
Mouth/teeth dental problems	0.6	1.0	4.3	-1.6	-0.5	-0.4	-2.1	-0.8	-0.3	-0.6	-0.6	-0.9	1.0	-0.6	-0.8
Falls in the last year	0.6	0.8	1.9	0.3	0.6	1.0	0.8	0.7	1.4	-0.6	1.2	0.9	-0.3	1.2	1.1
Leg fat percentage (right)	0.6	2.3	4.4	0.9	2.0	1.4	2.1	1.8	1.1	1.7	1.5	1.3	0.8	1.5	1.5
Whole body fat mass	0.6	2.5	6.3	1.5	1.9	1.5	2.5	1.9	1.1	1.3	1.4	1.3	1.0	1.4	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.1	1.4	-0.6	0.3	0.3	0.4	-0.1	0.4	-1.5	-0.1	-0.3	-1.4	-1.1
Medication: Bendroflumethiazide	0.6	0.9	3.7	1.8	-0.4	-0.5	1.1	-1.0	-0.7	0.4	-0.2	-0.7	-1.9	-0.2	-0.2
Leg fat percentage (left)	0.6	2.0	4.9	0.6	1.8	1.1	2.2	1.8	0.8	1.4	1.4	1.2	0.8	1.4	1.4
Reaction Time	0.5	1.0	2.2	0.5	0.9	1.0	1.5	0.4	1.0	0.8	1.0	1.5	0.6	1.1	1.2
Ovarian Cancer	0.5	0.7	2.3	-1.5	-0.7	-0.6	-1.5	-0.7	-0.9	-0.9	-0.4	-0.1	0.4	-0.3	-0.2
Age at First Birth	0.5	0.8	1.7	-0.2	-1.3	-0.7	-0.9	-1.2	-1.1	-0.9	-0.8	-0.6	-0.6	-0.8	-0.7
Neuroticism (2016)	0.5	0.8	3.8	-1.9	-0.6	-0.9	-1.7	-0.7	-0.4	-0.6	-0.2	-0.2	0.4	-0.1	-0.1
Waist Hip Ratio (WHR)	0.5	2.3	3.7	-0.8	1.6	1.8	1.2	1.4	1.7	0.7	1.9	1.4	1.2	1.9	1.8
Smoking Status	0.5	1.3	2.3	-0.2	-1.3	-1.1	-1.2	-1.2	-1.5	-0.7	-1.1	-1.5	-0.8	-1.1	-1.2
Relative age of first facial hair	0.5	1.0	1.9	-0.5	-1.1	-0.9	-1.1	-1.2	-0.9	-1.4	-0.6	-1.3	-0.8	-0.6	-0.8
Diabetes (father)	0.5	0.7	1.6	-0.0	-0.7	-0.9	-0.2	-0.6	-1.2	0.1	-1.0	-1.3	0.1	-1.0	-1.1
Townsend deprivation index at recruitment	0.5	0.8	1.5	0.2	0.8	0.5	1.2	0.9	0.6	0.3	0.9	1.2	1.1	1.0	1.0
Taking other prescription medications	0.5	0.8	2.0	0.6	-1.1	-1.0	0.5	-0.7	-1.0	-0.4	-0.9	-0.7	-1.4	-0.9	-0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	0.7	-0.9	-1.1	-0.7	-0.9	-0.6	-0.7	-0.6	-0.6	-1.0	-0.6	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.2	1.3	1.2	0.4	1.8	1.6	0.8	1.0	1.1	0.7	0.8	1.0	1.0
Financial difficulties in last 2 years	0.5	0.6	1.9	-1.4	-0.1	-0.7	0.4	0.8	0.3	-0.5	1.0	-0.6	-1.0	1.0	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.7	-0.9	-0.1	-0.6	0.7	0.4	0.4	-0.7	1.2	0.6	-1.3	1.3	1.3
Pulse rate	0.5	0.8	2.2	0.3	0.6	1.1	0.8	1.0	0.6	0.6	0.7	1.5	1.1	0.8	1.0
High blood pressure (siblings)	0.5	0.8	4.9	0.4	0.8	1.1	0.2	1.0	0.4	2.2	-0.4	-0.1	0.9	-0.5	-0.5
Shortness of breath walking on level ground	0.5	0.6	3.2	-1.8	-0.6	-0.6	-0.8	-0.3	-0.8	-1.4	0.0	-0.1	-0.1	0.1	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.3	-0.4	0.5	0.9	-0.0	0.6	0.7	0.1	0.7	0.8	1.5	0.7	0.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	1.1	-0.9	-0.7	0.2	-0.8	-0.5	-0.4	-1.0	-0.7	-1.4	-1.1	-0.9
Breast cancer (self-reported)	0.5	0.6	1.4	0.1	-0.5	-0.6	-0.6	-0.5	-0.9	-0.5	-1.2	-0.5	1.0	-1.1	-1.1
High cholesterol (Self-reported)	0.5	0.9	2.0	0.8	-0.9	-1.0	-0.4	-1.1	-1.1	0.3	-1.4	-0.2	0.3	-1.4	-1.1
Medication: Atorvastatin	0.5	0.7	2.9	-0.1	-0.7	-1.1	-0.3	-0.5	-1.7	-0.0	-1.0	-0.6	0.4	-0.9	-0.8
Basal metabolic rate	0.5	2.7	4.8	0.8	-1.5	-1.2	-1.4	-1.9	-1.7	-0.8	-2.1	-2.0	-0.8	-2.2	-2.2
Risk taking	0.5	0.8	4.3	0.8	-0.9	-0.3	0.7	-0.7	-0.4	-1.3	0.2	-0.6	-2.1	0.2	0.1
Diastolic blood pressure, automated reading	0.5	1.7	4.1	-0.4	-0.9	-1.1	-1.8	-1.4	-2.0	0.4	-1.3	-1.7	-0.0	-1.4	-1.5
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.7	1.2	-0.3	0.0	0.3	-0.1	-0.8	0.9	-1.3	-0.5	0.3	-1.3	-1.2
Heart disease (siblings)	0.5	0.6	1.3	0.8	-0.4	0.1	-0.0	-0.8	-0.7	0.8	-1.1	-0.6	0.6	-1.1	-1.1
Bipolar Disorder or Schizophrenia	0.4	0.9	2.9	-0.6	1.1	1.3	-0.4	1.2	1.7	0.7	0.7	0.8	0.8	0.7	0.6
Ulcerative Colitis (UC)	0.4	0.7	2.9	-0.5	0.8	0.7	0.2	1.1	0.1	-1.0	0.5	0.9	1.7	0.5	0.6
Breast Cancer	0.4	0.8	2.2	-0.4	-0.3	-0.9	1.4	0.4	-0.1	-1.5	1.0	0.7	-0.7	1.1	1.2
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.3	-0.2	-0.7	-0.8	-1.2	-0.3	-1.5	0.1	-1.2	-0.6	0.4	-1.1	-1.0
Pack years adult smoking proportion	0.4	0.6	1.7	-1.3	-0.7	-1.3	-0.5	-0.2	-1.0	-0.9	-0.2	0.8	0.3	-0.1	0.2
Number of incorrect matches in round	0.4	0.6	4.2	0.5	0.2	1.0	0.9	0.7	0.2	2.1	-0.1	0.4	0.6	-0.1	0.0
Hearing difficulty/problems with background noise	0.4	0.6	3.6	1.5	0.4	0.6	0.2	0.4	-0.0	1.9	-0.2	-0.1	0.4	-0.2	-0.2
Qualifications: None of the above	0.4	0.8	3.9	-2.0	-1.0	-1.0	-0.1	-0.2	-0.4	-1.3	-0.1	-0.1	-1.2	-0.0	0.1
Heart attack	0.4	0.5	1.4	1.2	-0.2	0.1	0.4	0.1	-0.7	0.8	-1.1	-0.4	0.4	-1.1	-1.0
Father’s age at death	0.4	0.5	3.1	-0.4	0.3	0.5	-1.4	-0.5	-0.2	-0.3	0.1	0.2	1.8	0.1	-0.0
Worrier / anxious feelings	0.4	0.7	1.6	1.1	-1.2	-0.6	-0.4	-1.2	-0.5	0.0	-1.0	-0.7	-0.8	-0.9	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	1.0	0.8	0.9	0.2	0.4	0.5	0.7	0.9	1.1	0.1	0.9	1.0
Happiness	0.4	0.4	1.8	0.1	0.7	0.9	0.3	0.0	1.4	-0.0	0.7	0.7	0.5	0.7	0.6
Pulse wave Arterial Stiffness index	0.4	0.4	1.9	1.2	0.5	0.7	0.5	0.3	-0.2	1.4	0.1	0.1	0.8	0.1	0.1
Birth weight	0.4	0.8	2.3	0.6	-0.8	-0.2	-1.5	-1.0	-1.3	-0.2	-1.1	-0.1	0.8	-1.0	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	-1.2	0.2	-0.0	-0.5	0.6	0.5	-0.4	0.3	1.0	1.3	0.4	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	-0.0	-0.9	-0.8	-0.7	-0.3	-0.7	-0.3	-1.0	-0.6	0.4	-0.9	-0.9
Medication: Seretide 50 evohaler	0.4	0.5	1.6	0.1	0.7	0.8	1.3	0.6	1.0	0.8	0.6	0.2	-0.2	0.6	0.5
Family relationship satisfaction	0.4	0.4	1.2	0.7	-0.8	-1.0	0.1	-0.4	-0.2	-1.1	-0.3	-0.9	-0.7	-0.3	-0.4
Long-standing illness, disability or infirmity	0.4	0.7	3.3	1.3	0.6	0.5	1.8	1.0	0.4	0.7	0.2	0.2	-0.7	0.2	0.2
Ever taken oral contraceptive pill	0.4	0.5	0.9	-0.9	0.1	0.4	-0.8	-0.0	0.5	-0.9	0.9	0.5	0.8	0.9	0.8
Commuting to job workplace: Public transport	0.4	0.5	2.4	-1.6	-0.1	-0.1	0.4	0.0	-0.1	-1.1	0.9	0.1	-0.4	0.9	0.8
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.3	1.0	0.9	1.2	1.0	0.8	0.8	0.9	1.1	0.3	-0.1	1.0	0.9
Crohns Disease (2017)	0.3	0.7	3.3	-0.1	-0.6	-0.6	-1.1	-0.8	-0.8	-1.8	-0.8	-0.2	0.3	-0.7	-0.6
Prostate Cancer	0.3	0.4	1.4	-0.5	0.3	0.5	-0.0	1.2	0.5	-0.3	0.7	0.7	0.5	0.8	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	-1.0	-0.7	-1.2	0.0	-0.2	-0.6	-1.0	0.3	0.3	0.4	0.2	0.3
Primary Biliary Cirrhosis	0.3	0.4	2.2	-0.2	0.4	0.5	-0.0	1.0	0.3	1.5	0.3	0.3	0.5	0.3	0.3
Ulcerative Colitis	0.3	0.4	2.1	-0.1	0.7	1.0	-0.2	0.5	0.6	-0.1	-0.2	0.4	1.5	-0.2	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.2	0.2	0.1	1.1	0.7	0.8	0.5	0.6	0.6	-0.5	0.6	0.7
Relative age voice broke	0.3	0.5	1.6	-1.3	0.3	0.1	-0.7	0.4	0.1	-0.9	0.9	0.3	-0.3	0.9	0.8
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.6	-0.8	-0.6	-0.2	-0.5	-0.7	-0.9	-0.3	-0.8	-0.8	-0.3	-0.4
Nervous feelings	0.3	0.5	1.7	-1.3	-1.1	-0.7	-1.1	-0.7	-0.3	-0.8	-0.3	0.2	-0.4	-0.1	0.0
Forced vital capacity (FVC)	0.3	1.1	2.8	-0.5	-1.3	-0.8	-1.2	-1.0	-0.4	-1.7	-0.7	-1.6	-0.9	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.8	-0.5	-1.2	-0.6	-0.9	-1.0	-0.5	-1.2	-0.7	-1.9	-1.1	-0.8	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.8	0.6	1.2	1.0	0.0	0.6	0.9	1.7	0.1	0.0	1.1	-0.0	-0.2
Depression (self-reported)	0.3	0.4	2.2	-1.5	-0.3	0.3	-0.7	0.0	0.6	-0.8	0.5	0.2	0.4	0.6	0.5
Arm fat mass (right)	0.3	1.2	3.7	1.0	1.3	0.9	1.9	1.4	0.6	0.6	1.0	1.0	0.6	1.0	1.0
Exposure to tobacco smoke at home	0.3	0.3	0.8	-0.3	-0.1	-0.6	0.9	0.7	-0.2	0.2	0.6	0.1	-0.8	0.6	0.6
Birth weight of first child	0.3	0.6	1.8	-0.8	-0.3	-0.0	-0.0	-0.0	0.1	-1.3	0.9	1.1	0.3	1.1	1.2
Loud music exposure frequency	0.3	0.3	1.7	-1.3	-0.7	0.1	0.0	-0.0	0.2	-1.3	-0.2	0.5	-0.1	-0.1	0.1
Glaucoma (self-reported)	0.3	0.3	1.7	0.3	-0.7	-0.6	-0.0	-0.6	-0.5	-1.3	-0.4	0.1	-0.5	-0.3	-0.1
Pulse wave peak to peak time	0.3	0.4	1.8	-0.9	-0.5	-0.6	-0.5	-0.3	0.3	-1.4	-0.2	-0.0	-0.7	-0.1	-0.1
Qualifications: College or University degree	0.3	0.8	4.3	0.3	0.9	1.0	-0.4	0.5	1.0	1.0	0.2	0.8	2.1	0.2	0.2
Neck or shoulder pain in last month	0.3	0.4	0.7	0.8	-0.8	-0.8	-0.3	-0.7	-0.4	0.6	-0.8	-0.5	-0.3	-0.8	-0.7
Medication: Ibuprofen	0.3	0.3	1.3	-1.1	-0.4	0.1	-1.1	-0.8	0.2	-0.5	-0.2	-0.1	0.6	-0.2	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.7	-1.3	-0.4	-0.5	0.0	0.3	-0.5	-0.9	0.3	0.4	-0.9	0.4	0.5
Arm fat mass (left)	0.3	1.1	3.1	0.9	1.3	0.8	1.8	1.3	0.5	0.5	1.0	0.9	0.6	1.0	1.0
Guilty feelings	0.3	0.4	1.7	0.4	-0.6	0.1	0.8	0.0	0.5	-0.6	0.7	-0.2	-1.3	0.7	0.6
Commuting to job workplace: Cycle	0.3	0.3	1.2	-0.6	0.3	-0.0	-0.3	0.8	0.3	-0.5	0.3	0.9	1.1	0.4	0.5
Cholesterol lowering medication	0.3	0.5	1.2	0.8	-0.4	-0.5	0.9	0.2	-0.9	1.1	-0.8	0.5	-0.0	-0.7	-0.4
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	0.4	0.5	0.6	0.7	0.6	1.1	0.4	0.7	1.0	0.3	0.7	0.8
Worry (Nagel 2018)	0.2	0.5	1.5	-1.2	-0.8	-0.4	-0.8	-0.4	0.9	-1.1	0.1	0.6	0.2	0.2	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	3.6	-0.8	0.2	-0.0	-0.6	0.3	-0.3	-1.9	0.0	0.5	1.1	0.1	0.2
LDL Cholesterol	0.2	0.3	0.9	0.8	0.1	0.1	-0.2	-0.1	-0.4	0.7	-0.9	-0.3	0.2	-0.9	-0.8
Lupus	0.2	0.3	1.2	0.1	-0.4	-0.7	0.6	0.8	-0.1	-1.1	0.6	-0.2	-0.3	0.6	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.0	-0.3	0.1	0.8	0.6	0.1	0.5	1.0	0.4	0.2	0.4	0.4	0.4
Blood Platelet Count	0.2	2.7	5.1	-2.2	1.2	1.1	1.1	1.9	1.4	0.1	2.2	1.7	0.6	2.2	2.2
Hypothyroidism (self reported)	0.2	0.5	1.0	-0.6	0.6	0.5	0.8	0.7	0.8	0.4	1.0	0.6	-0.3	1.0	0.9
Respiratory disease	0.2	0.4	1.1	0.5	-0.5	0.1	-0.5	-0.4	-0.2	-0.2	-1.0	-0.5	0.4	-1.0	-1.0
Lung FVC	0.2	1.1	2.2	-0.3	-1.4	-1.1	-0.3	-0.8	-0.9	-1.2	-1.0	-1.5	-1.2	-1.1	-1.2
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.1	-0.3	-0.1	-0.2	0.4	-0.6	0.8	-0.8	-0.4	0.1	-0.8	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	0.9	0.1	-0.6	0.8	-0.1	-0.6	-0.3	0.3	-0.3	-1.0	0.2	0.2
Medication for hormone replacement therapy	0.2	0.2	1.0	-0.4	0.4	-0.6	0.0	-0.0	-0.1	-1.0	0.5	0.0	-0.4	0.5	0.4
Vitamin and mineral supplements	0.2	0.3	0.9	-0.1	-0.2	-0.5	-0.4	-0.6	-0.9	-0.4	-0.4	-0.9	-0.3	-0.5	-0.6
Medication: Co-codamol	0.2	0.2	1.5	0.1	-0.6	-0.4	-0.0	-0.7	0.1	0.1	-0.2	0.2	-1.2	-0.2	-0.0
Medication: Metformin	0.2	0.3	1.8	-0.3	-0.1	-0.9	-0.6	0.1	-1.4	0.4	-0.4	-0.1	0.7	-0.3	-0.2
Leg fat-free mass (left)	0.2	1.1	2.3	1.3	-0.8	-0.4	-0.4	-1.1	-0.7	-0.5	-1.5	-1.2	-0.5	-1.5	-1.5
Hand grip strength (right)	0.2	0.5	1.6	0.7	0.7	0.9	-0.8	0.8	0.1	1.2	-0.3	-0.3	1.3	-0.3	-0.5
Fed-up feelings	0.2	0.4	1.3	-0.6	-0.7	-0.8	0.1	-0.3	-0.0	-1.1	0.7	0.3	-0.8	0.7	0.7
Chronic bronchitis/emphysema (father)	0.2	0.3	0.7	0.2	0.2	0.6	0.6	0.8	0.8	0.1	0.5	0.6	-0.3	0.6	0.6
Leg predicted mass (left)	0.2	1.1	2.1	1.2	-0.8	-0.4	-0.4	-1.1	-0.7	-0.6	-1.4	-1.2	-0.6	-1.5	-1.5
Had menopause	0.2	0.3	1.0	-0.2	-0.2	-0.6	-0.4	0.3	-1.0	-0.6	-0.3	-0.6	-0.6	-0.4	-0.4
Diabetes (self-reported)	0.2	0.3	1.3	0.4	0.1	-0.7	-0.2	0.2	-1.1	1.0	-0.5	0.1	0.5	-0.4	-0.3
Time employed in main current job	0.2	0.2	1.4	-0.3	-0.4	-0.5	-0.1	-0.5	0.2	-0.4	0.4	-0.2	-1.2	0.4	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.1	-1.1	-0.0	0.2	-0.7	-0.3	0.5	-0.2	-0.1	0.3	0.8	-0.1	-0.1
Prospective memory result	0.2	0.3	1.9	0.8	-0.3	-0.3	1.4	0.3	0.1	0.2	-0.0	0.4	-0.4	0.1	0.2
Breastfed as a baby	0.2	0.3	0.8	-0.9	0.2	-0.4	0.2	0.5	0.2	-0.6	0.7	0.1	-0.3	0.7	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-1.0	0.2	-0.1	-0.4	0.6	0.6	0.3	0.3	0.9	0.8	0.3	0.5
Leg fat mass (right)	0.2	0.8	2.4	1.3	1.2	0.8	1.6	0.9	0.4	1.0	0.5	0.4	0.3	0.5	0.5
Chest pain or discomfort	0.2	0.2	1.0	-0.9	-0.4	-0.6	-0.1	-0.0	-0.1	-1.0	-0.1	-0.6	-0.1	-0.0	-0.2
Age at last live birth	0.2	0.3	0.9	-0.4	-0.5	0.0	-0.6	-0.7	-0.0	0.4	-0.4	-0.7	-1.0	-0.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.8	0.9	-0.1	-0.1	-0.4	-0.3	-0.5	0.5	-0.7	-0.5	0.3	-0.7	-0.7
Knee pain experienced in last month	0.2	0.3	1.2	0.2	-0.4	-0.5	0.9	-0.4	-0.3	-0.3	0.4	0.1	-1.1	0.5	0.5
Leg fat-free mass (right)	0.2	1.1	2.0	1.1	-0.9	-0.6	-0.2	-1.1	-0.8	-0.7	-1.4	-1.2	-0.7	-1.4	-1.4
Mood swings	0.2	0.3	0.7	-0.6	-0.2	-0.0	-0.4	0.3	0.5	-0.6	0.6	0.8	-0.1	0.7	0.8
Diabetes diagnosed by doctor	0.2	0.4	1.4	0.5	-0.1	-0.6	-0.3	-0.0	-1.2	0.9	-0.7	-0.1	0.3	-0.7	-0.5
Friendships satisfaction	0.2	0.3	1.0	-0.3	0.1	-0.1	-0.1	-0.2	0.9	-1.0	0.5	0.2	-0.8	0.4	0.4
Osteoporosis (self-reported)	0.2	0.3	1.0	0.1	0.2	0.4	1.0	0.6	0.6	-0.1	0.2	0.4	0.9	0.2	0.2
Smoking status: Current	0.2	0.3	1.5	-0.5	0.2	0.1	0.1	0.6	-0.0	0.7	-0.0	0.8	1.2	0.1	0.2
Leg predicted mass (right)	0.2	1.0	1.9	1.1	-0.9	-0.6	-0.2	-1.1	-0.8	-0.8	-1.4	-1.2	-0.7	-1.4	-1.4
Number of self-reported non-cancer illnesses	0.2	0.4	2.1	1.4	-0.4	-0.4	1.3	-0.3	-0.4	0.2	-0.1	0.2	-0.7	-0.1	0.1
Average weekly champagne plus white wine intake	0.2	0.3	1.0	-0.5	0.3	-0.0	0.1	0.8	0.2	-0.4	1.0	0.3	0.3	1.0	0.9
Hearing aid user	0.2	0.2	1.1	0.5	0.4	-0.1	0.7	0.5	0.0	0.4	-0.3	0.4	1.1	-0.3	-0.2
Mother’s age at death	0.2	0.2	0.7	0.5	0.5	0.2	0.2	0.3	-0.3	0.8	0.0	-0.8	0.5	-0.0	-0.3
Eye problems/disorders: Glaucoma	0.2	0.2	0.9	0.9	-0.1	-0.0	0.7	-0.3	0.0	-0.7	-0.1	0.3	0.3	-0.1	0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.7	-0.2	-0.3	-0.2	-0.1	-0.4	0.2	-0.6	-0.5	-0.1	-0.6	-0.6
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	-0.1	-0.4	0.3	-0.8	-0.6	-0.2	-0.4	-0.7	-0.4	0.3	-0.7	-0.7
Leg fat mass (left)	0.2	0.7	2.6	1.2	1.1	0.7	1.6	0.9	0.3	0.9	0.4	0.5	0.4	0.4	0.4
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.5	-0.6	-0.4	-0.1	-0.3	0.5	-0.6	0.0	0.2	-0.4	0.1	0.2
Alzheimer’s Disease (in father)	0.1	0.2	0.6	-0.2	-0.4	-0.2	0.3	0.1	0.3	-0.8	0.3	0.7	-0.2	0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.8	0.9	-0.1	0.0	-0.6	-0.9	-0.4	0.1	-0.7	-0.8	0.3	-0.7	-0.8
Rheumatoid Arthritis	0.1	0.2	0.9	0.9	0.0	-0.1	0.6	0.3	-0.1	0.4	-0.4	0.0	-0.2	-0.4	-0.3
Blood Eosinophil Count	0.1	1.1	3.0	0.5	1.1	0.9	1.1	1.3	0.3	1.7	0.8	1.3	1.3	0.8	0.9
Blood White Count	0.1	1.1	2.5	-1.6	0.6	0.5	1.1	1.3	0.8	0.6	1.2	1.1	0.3	1.2	1.2
Height	0.1	1.8	13.1	3.6	0.2	1.2	-0.0	-0.8	0.4	1.4	-1.1	-0.5	0.7	-1.1	-1.1
Lung FEV1/FVC ratio	0.1	0.6	1.3	0.2	1.0	0.9	1.1	0.7	0.5	1.0	0.8	0.5	-0.0	0.8	0.7
Neuroticism	0.1	0.2	1.1	-0.1	-0.1	0.2	-0.1	-0.0	1.1	0.1	0.1	0.6	0.8	0.2	0.2
Hair Pigment	0.1	1.5	3.3	0.3	1.3	1.2	1.3	1.8	1.2	0.7	1.3	1.3	0.3	1.3	1.4
Tanning	0.1	1.3	2.5	-1.2	-1.0	-1.3	-1.3	-1.2	-1.0	-1.6	-1.1	-1.1	-0.7	-1.1	-1.1
Hand grip strength (left)	0.1	0.4	1.0	-0.3	0.8	0.7	-0.8	0.9	0.3	0.8	0.3	-0.3	1.0	0.2	-0.0
Diabetes (mother)	0.1	0.1	0.3	-0.5	0.5	-0.2	-0.2	-0.1	0.4	-0.1	0.6	-0.2	0.0	0.5	0.4
Current tobacco smoking	0.1	0.2	1.4	-0.4	-0.0	-0.1	-0.3	0.3	-0.3	0.6	-0.2	0.7	1.2	-0.1	0.1
Maternal smoking around birth	0.1	0.1	0.3	-0.1	0.2	-0.4	0.1	0.4	0.6	-0.3	0.3	-0.2	-0.3	0.3	0.2
Multivitamins +/- minerals	0.1	0.1	0.4	0.2	-0.3	-0.4	-0.0	-0.2	0.1	0.2	-0.5	-0.1	-0.6	-0.5	-0.4
Medication: Levothyroxine sodium	0.1	0.1	0.6	-0.8	0.2	0.0	-0.1	0.4	0.4	0.6	0.3	0.0	-0.4	0.3	0.3
Sitting height	0.1	0.5	2.0	1.4	0.5	0.7	-0.1	-0.0	0.5	1.1	-0.3	-0.2	1.2	-0.3	-0.4
High blood pressure (mother)	0.1	0.1	0.4	-0.0	0.2	0.6	-0.0	-0.3	0.5	0.2	0.3	-0.6	-0.2	0.2	0.0
Fluid intelligence score	0.1	0.3	1.1	1.0	0.7	0.6	0.6	0.1	0.0	0.6	0.5	-0.1	0.2	0.5	0.3
Neuroticism score	0.1	0.2	0.6	-0.6	-0.8	-0.2	-0.3	-0.4	0.6	-0.4	0.3	0.4	-0.5	0.4	0.5
Hip circumference	0.1	0.3	1.3	1.1	0.7	0.6	0.9	0.4	0.1	0.6	0.3	0.0	0.3	0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.8	0.4	-0.5	0.2	0.2	-0.0	0.6	-0.4	-0.1	-0.9	-0.6	-0.2	-0.4
Standing height	0.1	0.6	2.9	1.7	-0.2	0.7	-0.9	-0.8	0.4	0.5	-0.7	-0.7	0.0	-0.7	-0.8
Blood clot in the leg (DVT)	0.1	0.1	0.8	0.2	-0.1	-0.5	-0.2	-0.3	-0.9	0.3	0.1	-0.3	0.1	0.1	0.0
Headache pain in last month	0.1	0.1	0.6	0.3	-0.0	0.2	-0.1	0.8	0.4	-0.2	-0.2	0.1	0.1	-0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.6	-0.7	0.3	0.0	0.6	0.6	0.4	0.4	0.7	0.3	-0.4	0.7	0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	1.5	0.4	-1.1	-0.3	-0.5	-0.5	0.1	-0.9	-0.6	-1.2	-0.4	-0.6	-0.8
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.4	-0.2	-0.4	-0.0	0.3	-0.4	-0.6	-0.1	-0.1	-0.1	-0.1	-0.0
Number of full brothers	0.1	0.2	1.0	-0.1	-0.1	-0.1	-0.1	0.5	-0.1	0.5	-0.3	-0.2	1.0	-0.3	-0.3
Worry too long after embarrassment	0.1	0.1	0.4	-0.5	-0.7	-0.1	0.1	0.3	0.3	0.0	0.1	-0.0	-0.5	0.1	0.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	-0.1	0.5	0.3	0.6	0.8	-0.1	0.5	0.2	0.2	0.8	0.2	0.2
Age at first live birth	0.1	0.2	1.2	0.7	-0.3	0.5	0.6	-0.3	0.2	-0.0	0.4	-0.2	-1.1	0.3	0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.6	-0.0	-0.2	-0.0	-0.7	-0.3	-0.5	-0.3	-0.1	-0.6	-0.2	-0.1	-0.2
Migraine (self-reported)	0.1	0.2	0.6	-0.6	-0.3	-0.0	0.2	0.1	0.4	-0.8	-0.4	0.1	0.2	-0.4	-0.3
Medication: Allopurinol	0.1	0.2	0.8	-0.1	-0.8	-0.1	-0.2	-0.1	-0.6	-0.1	-0.4	-0.3	-0.9	-0.4	-0.3
Mean time to correctly identify matches	0.1	0.3	1.0	1.0	0.1	0.2	1.0	-0.4	0.3	0.3	0.1	0.9	-0.1	0.1	0.3
Pulse rate, automated reading	0.1	0.4	1.3	-0.7	0.2	0.5	-0.1	0.7	0.0	0.5	0.4	1.1	1.2	0.5	0.7
Comparative height size at age 10	0.1	0.4	2.8	1.7	0.5	0.8	0.6	0.3	0.5	0.5	0.1	0.1	0.3	0.0	0.0
Overall health rating	0.1	0.3	2.0	-0.4	0.2	-0.2	1.4	0.5	-0.1	0.1	0.5	0.5	-0.0	0.5	0.6
Had major operations	0.1	0.2	0.5	0.4	0.3	-0.0	-0.6	-0.2	0.5	-0.2	0.3	0.6	0.7	0.3	0.3
Leg pain on walking	0.1	0.2	0.5	0.7	-0.3	0.3	0.6	0.4	-0.1	0.3	-0.5	-0.2	0.2	-0.4	-0.4
Medication: Gliclazide	0.1	0.1	0.3	-0.1	0.4	-0.2	-0.4	0.4	-0.3	0.3	-0.0	0.1	0.5	-0.1	-0.0
Financial situation satisfaction	0.1	0.1	0.5	-0.1	-0.1	-0.6	0.7	-0.2	0.1	-0.1	-0.2	-0.6	-0.4	-0.3	-0.4
Ever depressed for a whole week	0.1	0.1	0.1	0.3	0.0	-0.3	0.4	0.1	-0.1	0.2	-0.3	-0.4	-0.1	-0.4	-0.4
Myopia	0.1	0.2	0.8	0.6	0.1	0.1	0.5	0.2	0.4	0.3	-0.4	0.3	-0.9	-0.4	-0.2
Pain experienced in last month	0.1	0.2	0.8	-0.6	0.5	0.4	-0.9	-0.2	-0.0	0.3	0.0	-0.5	0.9	-0.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	1.0	0.4	-0.2	-0.7	-0.2	-0.4	-1.0	0.4	-0.1	-0.4	0.1	-0.1	-0.1
HDL Cholesterol	0.0	0.0	0.3	0.0	0.2	0.1	0.2	0.1	0.5	0.1	0.1	-0.2	-0.4	0.0	0.0
Blood Red Count	0.0	0.3	1.3	-1.1	0.3	0.1	-0.4	0.8	-0.1	0.7	-0.3	-0.1	0.7	-0.3	-0.4
Heel T-Score	0.0	0.3	1.1	0.5	0.2	-1.1	-0.2	0.1	-0.9	0.7	-0.4	-0.3	0.3	-0.4	-0.4
BMI	0.0	0.3	1.1	0.9	0.3	-0.1	1.0	0.5	-0.5	0.4	-0.4	-0.3	-0.2	-0.4	-0.4
Body mass index (BMI)	0.0	0.1	0.5	0.2	0.1	-0.3	0.6	0.2	-0.7	-0.2	-0.2	-0.2	0.1	-0.2	-0.2
Waist circumference	0.0	0.1	0.7	0.4	0.5	0.2	0.8	0.3	-0.3	0.4	0.1	-0.1	-0.0	0.1	0.1
Weight	0.0	0.2	0.7	0.8	-0.0	-0.1	0.1	-0.2	-0.5	0.0	-0.6	-0.5	-0.0	-0.6	-0.6
Hair/balding pattern: Pattern 4	0.0	0.1	0.5	0.3	-0.1	0.4	0.1	0.7	0.4	0.1	-0.0	0.7	0.0	-0.0	0.2
Gout (self-reported)	0.0	0.0	0.2	-0.4	-0.2	0.4	-0.1	0.4	0.1	-0.1	-0.1	0.1	0.1	-0.1	-0.1
Loneliness, isolation	0.0	0.1	0.2	0.1	-0.1	0.1	0.5	0.1	0.2	0.1	-0.2	0.4	0.3	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.4	0.3	0.1	0.1	0.4	0.2	0.6	0.4	0.2	-0.2	0.1	0.2	0.0

Hub : Genes

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Models

Trait associations