Best TWAS P=1.7e-08 · Best GWAS P=2.03e-11 conditioned to 0.0245
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | REEP2 | 0.24 | 0.15 | lasso | 6 | 0.13 | 2.0e-06 | 5.4 | 5.4 | 6.4e-08 | -0.48 | 0.76 | 0.08 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | WNT8A | 0.05 | 0.01 | blup | 300 | 0.03 | 1.0e-04 | 1.3 | 5.6 | 1.7e-08 | -0.75 | 0.09 | 0.86 | TRUE |
| 3 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EGR1 | 0.02 | 0.01 | blup | 41 | 0.02 | 1.9e-03 | 5.4 | 5.4 | 8.7e-08 | -0.44 | 0.10 | 0.22 | TRUE |