TWAS
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Traits
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Traits
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Impedance of arm (right)
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chr5:136,723,696-138,474,788
Best TWAS P=1.7e-08 · Best GWAS P=2.03e-11 conditioned to 0.0245
136.8M
137M
137.2M
137.4M
137.6M
137.8M
138M
138.2M
138.4M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
WNT8A
0.05
0.01
blup
300
0.03
1.0e-04
1.3
5.6
1.7e-08
-0.75
0.09
0.86
TRUE
3
The Cancer Genome Atlas
Prostate Adenocarcinoma
EGR1
0.02
0.01
blup
41
0.02
1.9e-03
5.4
5.4
8.7e-08
-0.44
0.10
0.22
TRUE
1
GTEx
Heart Atrial Appendage
REEP2
0.24
0.15
lasso
6
0.13
2.0e-06
5.4
5.4
6.4e-08
-0.48
0.76
0.08
FALSE