TWAS hub - WNT8A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0496	0.0232	0.00026	0.008	0.029	0.026	0.029	0.023	0.0270	0.0001	0.00024	0.00011	0.00054
2	TCGA	Brain Lower Grade Glioma	0.0219	0.0145	0.00580	0.016	0.020	0.018	NA	0.010	0.0056	0.0019	0.00310	NA	0.02200

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Diabetes (self-reported)	9.6	14.8	16.7	-4.1	-3.6
Emphysema/chronic bronchitis	9.0	10.1	12.3	2.8	3.5
Diabetes diagnosed by doctor	8.9	14.6	15.0	-3.9	-3.8
Type 2 Diabetes (T2D) (2018)	6.6	12.3	13.3	-3.7	-3.4
Body Mass Index (BMI) (2010)	6.3	8.6	15.4	-3.9	-1.4
Number of live births	6.1	8.6	9.9	3.2	2.7
Eye problems/disorders: Diabetes related eye disease	5.7	6.3	7.2	-2.3	-2.7
Impedance of whole body	5.1	25.8	45.7	6.8	2.4
Impedance of leg (left)	4.9	23.6	43.0	6.6	2.0
Arm fat-free mass (left)	4.9	25.0	46.0	-6.8	-2.0
Whole body fat-free mass	4.6	26.3	48.3	-7.0	-2.1
Trunk fat-free mass	4.5	25.6	44.7	-6.7	-2.5
Trunk predicted mass	4.5	25.4	44.6	-6.7	-2.5
Arm predicted mass (left)	4.5	22.7	42.2	-6.5	-1.8
Arm predicted mass (right)	4.4	22.4	41.9	-6.5	-1.7
Whole body water mass	4.4	25.0	46.2	-6.8	-1.9
Leg predicted mass (right)	4.4	23.2	44.4	-6.7	-1.4
Leg fat-free mass (left)	4.3	22.7	43.7	-6.6	-1.3
Leg predicted mass (left)	4.3	22.6	43.4	-6.6	-1.3
Impedance of leg (right)	4.2	20.4	38.1	6.2	1.6
Peak expiratory flow (PEF)	4.2	9.7	10.7	-3.3	-3.0
Arm fat-free mass (right)	4.2	21.7	41.0	-6.4	-1.6
Leg fat-free mass (right)	4.2	22.6	43.3	-6.6	-1.4
Eye problems/disorders: Cataract	4.1	4.7	5.4	2.0	2.3
Basal metabolic rate	4.0	22.3	42.2	-6.5	-1.6
Triglycerides	3.8	6.3	7.2	2.7	2.3
Impedance of arm (right)	3.8	17.8	31.8	5.6	2.0
Other serious medical condition/disability diagnosed by doctor	3.6	4.7	6.0	-2.5	-1.8
Medication: Metformin	3.6	5.0	6.5	-2.6	-1.9
Qualifications: A levels/AS levels or equivalent	3.6	8.0	9.7	-2.5	-3.1
Impedance of arm (left)	3.6	16.6	29.4	5.4	2.0
Medication: Allopurinol	3.4	4.5	5.5	1.9	2.3
Illnesses of siblings: Diabetes	3.3	4.0	4.5	-2.1	-1.9
Myopia	3.2	4.7	6.8	1.6	2.6
Hair/balding pattern: Pattern 2	3.1	4.0	6.0	-1.4	-2.4
Pain all over the body in last month	3.1	3.3	3.5	-1.8	-1.9
Medication for cholesterol, blood pressure or diabetes	3.1	5.2	7.5	2.7	1.7
Birth weight	3.1	6.7	8.2	2.3	2.9
Sitting height	3.0	21.5	28.7	-5.4	-3.8
Bilateral oophorectomy (both ovaries removed)	2.9	3.4	4.2	-2.1	-1.6
Commuting to job workplace: Cycle	2.8	3.4	3.6	-1.9	-1.8
Schizophrenia vs Biploar Disorder	2.7	3.6	6.4	2.5	0.9
Prostate Cancer	2.7	3.8	4.1	-2.0	-1.9
Heart disease (siblings)	2.7	3.3	3.4	-1.8	-1.8
Stomach or abdominal pain in last month	2.6	3.3	6.3	0.6	2.5
Weight	2.6	12.8	25.3	-5.0	-0.5
Smoking Status	2.5	6.1	6.7	2.3	2.6
Eye problems/disorders: None of the above	2.5	2.8	3.1	-1.8	-1.6
Ever had hysterectomy (womb removed)	2.4	2.7	4.6	-2.1	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	3.5	-1.7	-1.9
Handedness (chirality/laterality): Left-handed	2.4	2.9	4.8	-2.2	-1.0
Taking other prescription medications	2.3	3.5	5.9	-2.4	-1.0
Medication: Ventolin 100micrograms inhaler	2.3	3.0	5.0	1.0	2.2
Relative age of first facial hair	2.2	4.4	4.8	2.2	2.0
Age when periods started (menarche)	2.2	5.3	7.1	2.7	1.8
Medication: Cholesterol lowering	2.2	3.5	3.9	-2.0	-1.8
Blood clot in the leg (DVT)	2.2	2.9	5.1	-2.3	-0.8
Breast Cancer	2.1	5.1	7.0	1.8	2.6
Comparative body size at age 10	2.1	5.9	11.4	-3.4	0.6
Number of self-reported non-cancer illnesses	2.1	3.6	6.7	-2.6	-0.7
Hip circumference	2.0	8.8	17.6	-4.2	0.3
Hair/balding pattern: Pattern 4	2.0	4.9	5.9	-2.4	-2.0
Medication: Blood pressure	2.0	3.6	6.7	-2.6	-0.7
Pulse rate, automated reading	2.0	6.3	9.4	1.8	3.1
Fractured/broken bones in last 5 years	1.9	2.4	4.7	-2.2	-0.3
Smoking status: Current	1.8	2.8	3.6	1.4	1.9
Relative age voice broke	1.7	2.6	4.8	2.2	0.6
Body mass index (BMI)	1.7	7.4	14.7	-3.8	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	3.6	-1.9	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	4.9	-2.2	-1.4
Ever had prostate specific antigen (PSA) test	1.7	2.0	2.1	-1.4	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	4.0	-2.0	-0.5
Mean Putamen Volume	1.6	1.8	3.3	0.6	1.8
Diabetes (father)	1.6	2.0	3.5	-1.9	-0.7
Medication: Atenolol	1.6	2.1	2.4	-1.3	-1.5
Medication: Levothyroxine sodium	1.6	2.8	4.3	-2.1	-1.1
Medication: Ramipril	1.6	2.1	3.3	-1.8	-0.9
Depressed Affect (Nagel 2018)	1.5	3.2	5.0	-2.2	-1.2
Current tobacco smoking	1.5	2.5	3.2	1.4	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.7	5.6	-2.0	-2.4
Comparative height size at age 10	1.5	8.1	10.9	-3.3	-2.3
Commuting to job workplace: Car/motor vehicle	1.5	1.8	3.5	-1.9	-0.1
Hypertension (Self-reported)	1.5	4.3	7.7	-2.8	-0.9
Average weekly red wine intake	1.5	2.3	4.3	-0.5	-2.1
Medication: Bendroflumethiazide	1.5	2.3	3.4	-1.9	-1.1
Blood Red Count	1.4	13.3	18.6	2.8	4.3
BMI	1.4	8.3	16.6	-4.1	0.1
Pulse rate	1.4	2.4	3.8	1.0	1.9
Health satisfaction	1.4	1.8	2.7	-1.6	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	2.5	0.9	1.6
Arm fat mass (left)	1.4	5.6	10.6	-3.3	0.7
Sensitivity / hurt feelings	1.3	2.2	2.7	-1.6	-1.4
Serious illness, injury or assault to yourself	1.3	1.6	1.8	-1.3	-1.2
High blood pressure (mother)	1.3	1.8	3.5	-1.9	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.6	-1.9	-0.6
Gout (self-reported)	1.3	1.7	2.1	1.2	1.4
Age at last live birth	1.3	1.9	2.6	1.1	1.6
Supplements: Vitamin C	1.3	1.5	2.7	0.5	1.6
Guilty feelings	1.3	1.9	2.3	-1.5	-1.2
Ever taken oral contraceptive pill	1.3	1.4	2.1	-0.8	-1.4
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.0	-1.7	-0.6
Crohns Disease (2017)	1.2	2.6	3.1	-1.8	-1.5
Ovarian Cancer	1.2	1.6	3.0	-1.7	-0.5
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.6	-0.1	1.6
Arm fat mass (right)	1.2	4.9	9.2	-3.0	0.8
Long-standing illness, disability or infirmity	1.2	1.8	3.3	-1.8	-0.4
Ever had bowel cancer screening	1.2	1.4	1.7	1.3	1.0
Medication: Aspirin	1.2	1.6	2.6	-1.6	-0.8
Age started oral contraceptive pill	1.2	1.5	1.8	1.4	1.1
Hayfever, allergic rhinitis or eczema	1.1	2.4	3.3	1.2	1.8
Medication: Simvastatin	1.1	1.6	2.7	-1.6	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	2.7	-1.6	-0.9
Mood swings	1.1	1.9	3.3	-1.8	-0.7
Fed-up feelings	1.0	1.8	3.1	-1.8	-0.7
High blood pressure	1.0	2.8	5.6	-2.4	-0.3
Number of incorrect matches in round	1.0	1.7	2.9	-0.7	-1.7
Allergy	1.0	2.4	4.5	-0.5	-2.1
Illnesses of siblings	1.0	1.4	1.7	1.3	1.1
Leg fat mass (right)	1.0	3.8	6.9	-2.6	0.9
Medication: Aspirin	1.0	1.4	1.8	-1.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	3.7	-0.6	-1.9
Medication: Lisinopril	1.0	1.3	1.6	-1.2	-1.1
Diastolic blood pressure, automated reading	1.0	3.0	6.0	-0.2	2.5
Leg fat mass (left)	1.0	4.0	7.3	-2.7	0.8
Irritable Bowel Disease (IBD)	0.9	2.1	2.8	-1.7	-1.2
Crohns Disease (2012)	0.9	1.4	1.7	-1.0	-1.3
Schizophrenia (2014)	0.9	1.9	2.8	1.7	1.0
Waist Hip Ratio (WHR)	0.9	4.1	8.2	2.9	0.2
Hearing difficulty/problems with background noise	0.9	1.5	2.9	1.7	0.4
Alcohol intake versus 10 years previously	0.9	1.3	2.4	0.5	1.5
Length of working week for main job	0.9	1.0	2.0	-0.2	1.4
Whole body fat mass	0.9	3.8	6.3	-2.5	1.1
Alcohol intake frequency.	0.9	2.2	4.3	0.0	2.1
Number of full sisters	0.9	1.0	1.2	1.1	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.2	-0.9	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.1	0.2	1.5
Osteoporosis (self-reported)	0.9	1.1	1.1	1.1	1.0
Average weekly champagne plus white wine intake	0.9	1.2	2.3	-0.4	-1.5
Alcohol drinker status: Previous	0.9	1.1	1.6	0.8	1.2
Coronary Artery Disease (CAD)	0.8	0.9	1.8	0.2	1.4
Trunk fat mass	0.8	3.4	5.6	-2.4	1.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	2.7	-1.6	-1.5
Depression (self-reported)	0.8	1.0	1.5	-1.2	-0.7
Illnesses of mother	0.8	1.0	1.8	1.3	0.5
Forced vital capacity (FVC), Best measure	0.8	3.0	3.0	-1.7	-1.7
Leg pain on walking	0.8	1.0	1.6	-1.3	-0.6
Illnesses of father: High blood pressure	0.8	1.0	1.2	-1.1	0.9
Supplements: Calcium	0.8	0.9	1.6	0.4	1.3
Blood Eosinophil Count	0.7	5.6	10.6	0.8	3.3
Blood Platelet Count	0.7	8.2	12.9	3.6	1.9
Cardiovascular Disease	0.7	2.4	4.3	-2.1	-0.8
Average weekly fortified wine intake	0.7	0.8	1.1	-0.8	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.7	-1.3	0.5
Financial difficulties in last 2 years	0.7	0.9	1.7	-1.3	-0.3
Time employed in main current job	0.7	0.8	1.1	-0.7	-1.1
Standing height	0.7	7.1	10.8	-3.3	-1.9
Medication: Omeprazole	0.7	0.8	0.9	-0.9	0.9
Chest pain or discomfort	0.7	0.9	1.5	-1.2	-0.6
Knee pain experienced in last month	0.7	1.2	1.8	0.7	1.3
Illnesses of father: Heart disease	0.7	1.0	1.7	-0.5	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.1	1.0	1.1
Miserableness	0.7	1.2	2.5	-1.6	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.6	-0.4	1.3
Major Depression (MDD)	0.6	0.8	1.4	-0.3	-1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.1	-1.1	-0.5
Number of treatments/medications taken	0.6	1.1	2.1	-1.4	0.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.6	0.1	1.2
Hearing difficulty/problems: Yes	0.6	1.0	1.5	1.2	0.7
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	1.1	0.5
Waist circumference	0.6	2.0	3.8	-2.0	0.5
Alcohol usually taken with meals	0.6	1.0	1.4	-0.7	-1.2
Hair/balding pattern: Pattern 3	0.6	0.8	1.0	-1.0	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.9	1.0	0.7
Asthma	0.6	1.2	2.1	-0.6	1.4
Headache pain in last month	0.6	1.0	1.5	-1.2	-0.6
Number of full brothers	0.6	0.7	1.2	0.5	1.1
Wheeze or whistling in the chest in last year	0.6	1.1	1.1	-1.1	1.1
Migraine (self-reported)	0.6	0.7	1.4	-0.2	1.2
Overall health rating	0.6	1.4	2.7	-1.7	0.1
Friendships satisfaction	0.6	0.8	1.5	1.2	0.0
Asthma (self-reported)	0.6	1.2	2.1	-0.5	1.5
Schizophrenia (2018)	0.5	1.0	1.1	0.9	1.1
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.9	-0.5
Height	0.5	10.0	14.4	-3.8	-2.4
Vitamin and mineral supplements	0.5	0.6	1.0	-0.5	-1.0
Trunk fat percentage	0.5	2.1	3.4	-0.9	1.9
Had other major operations	0.5	0.6	1.0	0.3	1.0
Forced vital capacity (FVC)	0.5	1.8	2.9	-1.7	-0.8
Neuroticism score	0.5	1.0	1.6	-1.3	-0.6
Arm fat percentage (right)	0.5	2.1	2.4	-1.3	1.6
Father’s age at death	0.5	0.7	0.9	1.0	0.7
Medication: Lansoprazole	0.5	0.6	0.8	0.6	0.9
Birth weight of first child	0.5	0.9	1.1	0.9	1.1
Body fat percentage	0.5	2.1	3.6	-0.7	1.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.8	-0.6	-0.9
Arm fat percentage (left)	0.5	2.1	2.2	-1.4	1.5
Mineral and other dietary supplements	0.5	0.7	0.9	0.9	-0.7
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.0	-1.0	-0.2
Medication: Atorvastatin	0.5	0.6	0.7	-0.8	-0.7
Leg fat percentage (left)	0.5	1.7	3.2	-0.4	1.8
Vascular/heart problems diagnosed by doctor	0.5	1.5	3.0	1.7	-0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	0.7	0.7	-0.8
Rheumatoid Arthritis	0.4	0.5	0.8	-0.4	-0.9
Allergy or Eczema	0.4	1.1	1.7	0.7	1.3
Respiratory disease	0.4	0.8	1.4	-0.5	1.2
Average weekly spirits intake	0.4	0.5	0.6	-0.8	-0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	-0.1	-1.0
Supplements: Glucosamine	0.4	0.6	0.9	-1.0	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	0.9	0.2
Nervous feelings	0.4	0.7	1.3	1.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	-0.3	1.0
Pulse wave reflection index	0.4	0.5	1.1	-0.2	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.3	-1.1	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	-0.4	0.9
Leg fat percentage (right)	0.4	1.5	2.8	-0.5	1.7
Exposure to tobacco smoke outside home	0.4	0.6	1.2	-1.1	-0.0
Family relationship satisfaction	0.4	0.5	1.0	-0.2	-1.0
Breast cancer (self-reported)	0.4	0.4	0.6	-0.5	-0.8
Mother’s age at death	0.4	0.5	0.8	0.9	0.3
Number of operations (self-reported)	0.4	0.5	1.0	-1.0	-0.3
Risk taking	0.4	0.5	0.6	-0.8	-0.7
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	0.3	0.9
Bipolar Disorder or Schizophrenia	0.3	0.7	0.9	0.7	1.0
Neuroticism (Nagel 2018)	0.3	0.7	0.7	-0.8	-0.8
Age at First Birth	0.3	0.5	1.0	-0.0	-1.0
Neuroticism (2016)	0.3	0.4	0.7	0.8	0.4
Lung FEV1/FVC ratio	0.3	1.6	3.2	1.8	0.1
Hand grip strength (left)	0.3	0.8	0.8	-0.9	0.9
Medication: Co-codamol	0.3	0.3	0.4	0.6	0.5
Prospective memory result	0.3	0.4	0.4	-0.6	-0.6
Pulse wave Arterial Stiffness index	0.3	0.3	0.4	-0.7	-0.5
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.7	0.3
Breastfed as a baby	0.3	0.4	0.8	0.2	0.9
Medication: Amlodipine	0.3	0.5	0.7	-0.9	-0.4
Age at first live birth	0.3	0.6	1.1	0.4	1.0
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.6	0.8	0.2
Smoking status: Previous	0.3	0.4	0.5	-0.7	-0.6
Commuting to job workplace: Walk	0.3	0.3	0.5	0.4	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	-0.3	-0.9
Medication: Gliclazide	0.3	0.4	0.4	-0.6	-0.6
Financial situation satisfaction	0.3	0.4	0.8	-0.9	-0.3
Medication: Paracetamol	0.3	0.5	0.9	1.0	0.2
Depression (Nagel 2018)	0.2	0.3	0.5	-0.3	0.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.0	-0.7
Ulcerative Colitis (UC)	0.2	0.3	0.4	-0.7	-0.5
Fasting Glucose	0.2	0.2	0.3	0.5	0.4
LDL Cholesterol	0.2	0.3	0.7	0.8	-0.1
Lupus	0.2	0.3	0.7	0.0	0.8
Neuroticism	0.2	0.5	0.5	-0.7	-0.7
Systolic blood pressure, automated reading	0.2	0.5	1.0	-1.0	0.0
Pack years adult smoking proportion	0.2	0.3	0.4	0.6	0.5
Hand grip strength (right)	0.2	0.7	0.9	-1.0	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	-0.3	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	0.9	-0.5	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.1	0.7
Happiness	0.2	0.2	0.4	0.6	-0.2
Tense / ‘highly strung’	0.2	0.3	0.5	-0.7	-0.3
Pulse wave peak to peak time	0.2	0.2	0.3	0.6	0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.3	0.6	0.5
Angina (self-reported)	0.2	0.2	0.4	-0.2	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.0	-0.6
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.7	0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	0.1	0.7
Hearing aid user	0.2	0.2	0.3	-0.1	-0.6
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.3	-0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.0	-0.7
Medication: Blood pressure	0.2	0.4	0.7	-0.9	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	-0.2	0.7
Ever smoked	0.2	0.3	0.3	0.5	0.5
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.8	-0.0
Pain experienced in last month	0.2	0.4	0.8	0.9	-0.0
Pack years of smoking	0.2	0.3	0.4	0.7	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.2	0.5	-0.4
Worry (Nagel 2018)	0.1	0.2	0.4	0.7	-0.1
Reaction Time	0.1	0.2	0.3	-0.6	-0.1
Bipolar Disorder (2011)	0.1	0.1	0.1	0.3	0.1
HDL Cholesterol	0.1	0.2	0.2	0.4	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.1	0.5
Blood White Count	0.1	1.0	2.0	1.4	0.1
Heel T-Score	0.1	0.6	1.0	1.0	0.4
Hypothyroidism (self reported)	0.1	0.1	0.2	-0.2	0.5
Chronotype (morning person)	0.1	0.2	0.4	-0.6	-0.2
Angina	0.1	0.2	0.4	-0.1	0.6
Supplements: Zinc	0.1	0.1	0.1	-0.2	0.3
Diabetes (mother)	0.1	0.1	0.2	-0.4	0.1
Severe depression (siblings)	0.1	0.2	0.2	-0.4	0.4
Maternal smoking around birth	0.1	0.1	0.3	0.5	-0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.3	0.1	0.5
Past tobacco smoking	0.1	0.2	0.3	-0.3	-0.5
Had menopause	0.1	0.2	0.3	-0.1	-0.6
Qualifications: None of the above	0.1	0.2	0.3	0.4	0.6
Mouth/teeth dental problems	0.1	0.1	0.3	-0.5	0.1
Heart attack	0.1	0.2	0.4	-0.6	-0.1
Fluid intelligence score	0.1	0.2	0.3	-0.3	-0.5
Worrier / anxious feelings	0.1	0.2	0.3	0.5	-0.1
Noisy workplace	0.1	0.1	0.1	-0.3	0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.6	0.0
Lung cancer (father)	0.1	0.1	0.2	0.1	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.4	0.2
Loud music exposure frequency	0.1	0.1	0.2	-0.3	-0.4
Medication: Paracetamol	0.1	0.1	0.2	0.3	-0.5
Glaucoma (self-reported)	0.1	0.1	0.2	0.2	-0.4
High blood pressure (siblings)	0.1	0.2	0.3	-0.1	0.5
Number of children fathered	0.1	0.1	0.1	-0.4	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	-0.2	-0.3
Shortness of breath walking on level ground	0.1	0.1	0.2	0.2	-0.4
Qualifications: College or University degree	0.1	0.3	0.5	0.4	-0.7
Neck or shoulder pain in last month	0.1	0.1	0.2	0.2	0.5
Medication: Ibuprofen	0.1	0.2	0.3	0.5	-0.2
Heart disease (mother)	0.1	0.1	0.2	-0.5	0.0
Suffer from ‘nerves’	0.1	0.2	0.3	0.5	0.5
Had major operations	0.1	0.1	0.1	0.2	0.3
Loneliness, isolation	0.1	0.2	0.3	-0.5	0.2
Medication for cholesterol	0.1	0.2	0.2	0.4	-0.4
Back pain experienced in last month	0.1	0.2	0.3	0.5	0.3
Wears glasses or contact lenses	0.1	0.2	0.3	-0.5	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.2	0.4	-0.4
Alcohol drinker status: Never	0.1	0.1	0.2	-0.1	0.4
Irritability	0.1	0.1	0.3	-0.5	-0.1
Ever depressed for a whole week	0.1	0.1	0.1	-0.3	0.2
Cholesterol lowering medication	0.1	0.1	0.2	0.1	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	0.0
Bipolar Disorder (2018)	0.0	0.0	0.0	-0.0	0.2
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	0.3	0.2
HbA1C	0.0	0.0	0.0	-0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	-0.1	0.2
Systolic Blood Pressure	0.0	0.2	0.4	-0.6	0.1
Lung FVC	0.0	0.1	0.1	-0.0	-0.3
Hair Pigment	0.0	0.7	1.2	0.4	1.1
Tanning	0.0	0.6	0.8	-0.9	-0.6
Medication for hormone replacement therapy	0.0	0.0	0.1	0.2	0.2
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.2	-0.1
Multivitamins +/- minerals	0.0	0.0	0.0	-0.1	0.1
Falls in the last year	0.0	0.1	0.1	0.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.3	0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	0.0	0.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	-0.1	-0.2
Worry too long after embarrassment	0.0	0.1	0.1	0.2	-0.3
Medication: Seretide 50 evohaler	0.0	0.0	0.0	0.2	-0.1
Mean time to correctly identify matches	0.0	0.0	0.1	0.2	0.0
Qualifications: nursing, teaching	0.0	0.0	0.0	-0.2	-0.2
Average weekly beer plus cider intake	0.0	0.1	0.1	0.2	0.3

Hub : Genes

WNT8A

Models

Trait associations