TWAS hub - EGR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.3350	0.1380	0.0021	0.009	NA	-0.004	NA	-0.006	0.140	NA	0.460	NA	0.590
2	TCGA	Prostate Adenocarcinoma	0.0224	0.0134	0.0039	0.014	0.022	0.014	NA	0.013	0.011	0.0019	0.011	NA	0.013

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder or Schizophrenia	8.5	20.7	27.3	3.8	5.2
Schizophrenia (2014)	7.3	16.0	24.6	2.7	5.0
Number of children fathered	7.3	8.3	14.6	-1.4	-3.8
Schizophrenia (2018)	6.4	13.3	16.8	3.1	4.1
Commuting to job workplace: Walk	5.7	6.2	9.2	1.8	3.0
Waist Hip Ratio (WHR)	5.3	23.7	42.1	2.3	6.5
Medication: Ramipril	5.1	6.5	13.0	0.1	-3.6
Bipolar Disorder (2018)	5.0	7.9	10.5	2.3	3.2
Breast cancer (self-reported)	4.6	5.5	7.3	-2.7	-1.9
Allergy	4.4	10.0	18.6	-1.2	4.3
Mineral and other dietary supplements	4.4	5.9	11.7	-0.2	3.4
Miserableness	4.3	7.4	14.5	-0.5	-3.8
Exposure to tobacco smoke at home	4.2	4.7	8.7	0.9	2.9
Chronotype (morning person)	4.1	9.5	12.3	2.6	3.5
Supplements: Glucosamine	3.8	5.0	8.9	-1.0	-3.0
Pulse rate, automated reading	3.8	12.4	24.7	-0.2	5.0
Respiratory disease	3.7	8.2	12.5	2.0	-3.5
Ever unenthusiastic/disinterested for a whole week	3.6	4.4	5.5	-1.8	-2.4
Age at First Birth	3.5	5.2	9.5	-0.9	3.1
Alzheimer’s Disease (including proxy)	3.4	4.9	9.5	0.5	3.1
Bipolar Disorder (2011)	3.4	3.2	4.9	1.2	2.2
Frequency of depressed mood in last 2 weeks	3.4	4.8	4.9	2.2	-2.2
Qualifications: NVQ or HND or HNC or equivalent	3.3	3.9	7.3	0.8	-2.7
Ovarian Cancer	3.2	4.2	6.6	-2.6	-1.4
Impedance of arm (right)	3.2	14.8	28.6	1.0	5.4
Asthma (self-reported)	3.2	6.4	11.0	1.3	-3.3
Medication: Ventolin 100micrograms inhaler	3.0	3.9	7.6	-0.3	-2.8
Arm fat-free mass (right)	3.0	15.3	29.6	-1.0	-5.4
Loneliness, isolation	3.0	4.2	8.0	-0.6	-2.8
Hayfever, allergic rhinitis or eczema	2.9	6.3	12.3	0.6	-3.5
Impedance of arm (left)	2.9	13.3	25.3	1.1	5.0
Shortness of breath walking on level ground	2.9	3.4	5.4	1.2	2.3
Arm predicted mass (right)	2.9	14.7	28.3	-1.1	-5.3
Suffer from ‘nerves’	2.9	4.6	9.2	0.1	-3.0
Asthma	2.8	5.6	9.7	1.2	-3.1
Number of full brothers	2.8	3.6	4.1	-1.7	-2.0
Arm fat-free mass (left)	2.8	14.3	26.9	-1.3	-5.2
Pain type(s) experienced in last month: Hip pain	2.6	3.3	6.2	-0.6	-2.5
Trunk fat-free mass	2.5	14.3	25.3	-1.8	-5.0
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.7	7.4	0.0	-2.7
Number of live births	2.4	3.3	5.2	2.3	-1.2
Pulse rate	2.4	4.1	7.8	-0.6	2.8
Trunk predicted mass	2.4	13.7	24.1	-1.8	-4.9
Whole body water mass	2.4	13.5	25.3	-1.3	-5.0
Arm predicted mass (left)	2.4	12.2	22.8	-1.3	-4.8
Major Depression (MDD)	2.3	2.8	5.0	0.7	-2.2
Body Mass Index (BMI) (2010)	2.3	3.2	6.4	-0.0	-2.5
Allergy or Eczema	2.3	6.0	11.9	0.2	-3.5
Hand grip strength (left)	2.3	6.0	10.3	-1.3	-3.2
Whole body fat-free mass	2.3	13.4	25.0	-1.3	-5.0
Basal metabolic rate	2.3	12.6	24.1	-1.1	-4.9
Ever depressed for a whole week	2.3	2.8	5.3	-0.6	-2.3
Impedance of whole body	2.3	11.7	22.6	0.8	4.8
Type 2 Diabetes (T2D) (2012)	2.2	2.5	4.5	-0.7	-2.1
Financial difficulties in last 2 years	2.2	3.0	3.4	-1.8	-1.6
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	4.6	2.1	1.0
Number of self-reported non-cancer illnesses	2.2	3.9	7.4	0.6	-2.7
Mother’s age at death	2.2	2.8	5.6	-0.1	2.4
Medication for hormone replacement therapy	2.1	2.3	4.2	0.7	2.0
Tense / ‘highly strung’	2.1	3.5	4.9	-1.5	-2.2
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.8	0.8	-2.2
Depressed Affect (Nagel 2018)	2.0	4.1	8.2	-0.2	-2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	4.4	1.0	-2.1
Medication: Levothyroxine sodium	2.0	3.3	5.8	-0.9	-2.4
Medication: Ibuprofen	2.0	2.4	3.4	1.8	1.1
Handedness (chirality/laterality): Left-handed	2.0	2.4	4.3	0.8	2.1
Alzheimer’s Disease (in mother)	1.9	2.3	4.3	0.5	2.1
Leg fat-free mass (left)	1.9	10.1	20.0	-0.4	-4.5
Leg predicted mass (left)	1.9	10.1	20.1	-0.4	-4.5
Time employed in main current job	1.9	2.2	3.7	-1.9	0.8
Qualifications: CSEs or equivalent	1.8	2.4	4.4	0.6	-2.1
Number of incorrect matches in round	1.8	3.0	5.8	-0.3	-2.4
Ever highly irritable/argumentative for 2 days	1.8	2.1	4.2	0.3	2.0
Alcohol drinker status: Never	1.8	2.2	4.3	2.1	-0.0
Relative age voice broke	1.7	2.6	5.2	-0.2	2.3
Hip circumference	1.7	7.2	14.1	-0.5	-3.8
Chronic bronchitis/emphysema (mother)	1.7	2.0	3.8	1.9	-0.5
Fed-up feelings	1.6	2.9	5.8	-0.3	-2.4
Multivitamins +/- minerals	1.6	2.0	2.8	1.1	1.7
High blood pressure (mother)	1.6	2.3	4.2	0.6	-2.0
Headache pain in last month	1.6	2.7	4.5	0.9	2.1
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.9	0.9	-1.7
Osteoporosis (self-reported)	1.6	2.0	3.8	1.9	-0.5
Ever had prostate specific antigen (PSA) test	1.6	1.9	3.2	-1.8	-0.7
Worry (Nagel 2018)	1.5	3.1	5.5	-0.8	-2.4
HbA1C	1.5	1.7	2.0	-1.1	1.4
HDL Cholesterol	1.5	2.5	4.5	0.7	2.1
BMI	1.5	8.4	14.2	1.6	-3.8
Hypothyroidism (self reported)	1.5	3.5	6.5	-0.8	-2.5
Ever had hysterectomy (womb removed)	1.5	1.7	3.4	-1.8	-0.2
Hand grip strength (right)	1.5	4.0	4.5	-1.9	-2.1
Maternal smoking around birth	1.5	2.2	2.8	1.3	1.7
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.7	-0.7	-1.6
Had other major operations	1.5	1.9	3.5	-0.5	1.9
Happiness	1.5	1.8	2.3	1.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	2.5	1.6	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.5	0.0	-1.9
Leg fat mass (right)	1.5	5.7	10.2	1.1	-3.2
Leg fat-free mass (right)	1.5	8.2	16.1	-0.5	-4.0
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.4	-1.6	-0.9
Leg predicted mass (right)	1.5	8.1	16.1	-0.4	-4.0
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.5	0.5	-1.9
Depression (Nagel 2018)	1.4	2.2	2.8	1.2	-1.7
Schizophrenia vs Biploar Disorder	1.4	1.8	3.5	-0.2	1.9
Type 2 Diabetes (T2D) (2018)	1.4	2.6	5.1	-2.2	-0.5
Neuroticism	1.4	3.3	6.6	0.2	-2.6
Weight	1.4	6.6	13.1	-0.4	-3.6
Exposure to tobacco smoke outside home	1.4	1.9	3.4	-0.7	1.8
Wheeze or whistling in the chest in last year	1.4	2.5	3.1	1.4	-1.8
Body mass index (BMI)	1.3	5.7	11.0	0.6	-3.3
Neuroticism score	1.3	2.8	5.5	0.1	-2.3
Illnesses of mother	1.3	1.6	1.7	-1.3	1.2
Blood clot in the leg (DVT)	1.3	1.7	3.2	0.5	-1.8
Migraine (self-reported)	1.3	1.6	2.2	1.5	1.0
Guilty feelings	1.3	2.0	3.0	1.0	1.7
Leg fat mass (left)	1.3	5.2	8.9	1.2	-3.0
Intelligence (Savage-Jansen 2018)	1.2	3.7	4.4	-1.8	2.1
Blood Red Count	1.2	11.5	20.1	1.7	-4.5
Sitting height	1.2	8.8	14.0	-1.9	-3.7
Impedance of leg (left)	1.2	6.0	11.8	0.5	3.4
Alcohol usually taken with meals	1.2	2.0	2.7	-1.6	-1.2
Medication: Simvastatin	1.2	1.7	2.5	1.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.5	-0.4	-1.9
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	4.6	-0.1	-2.1
Neck or shoulder pain in last month	1.2	1.7	1.7	1.3	1.3
Had major operations	1.2	1.4	2.6	-1.6	-0.3
Commuting to job workplace: Public transport	1.2	1.4	2.1	0.8	1.4
Average weekly spirits intake	1.1	1.4	2.7	0.3	1.6
Average weekly fortified wine intake	1.1	1.3	1.5	-1.2	-1.0
Serious illness, injury or assault to yourself	1.1	1.4	2.7	-0.2	1.6
Worrier / anxious feelings	1.1	2.1	3.4	-0.9	-1.8
Hair/balding pattern: Pattern 3	1.1	1.7	2.2	-1.1	1.5
Qualifications: A levels/AS levels or equivalent	1.1	2.5	3.6	-1.1	1.9
Arm fat mass (right)	1.1	4.5	8.1	1.0	-2.9
Glaucoma (self-reported)	1.1	1.3	2.2	-0.7	-1.5
Leg fat percentage (right)	1.1	3.9	6.7	1.0	-2.6
Comparative body size at age 10	1.1	3.1	5.1	-1.1	-2.3
Emphysema/chronic bronchitis	1.1	1.2	1.9	1.4	-0.7
Heart disease (mother)	1.1	1.4	2.7	-0.3	-1.6
Alcohol intake frequency.	1.1	2.5	5.1	2.2	0.1
Arm fat mass (left)	1.1	4.6	8.5	0.9	-2.9
Medication: Atorvastatin	1.1	1.3	2.6	-1.6	0.1
Myopia	1.1	1.5	1.6	1.3	-1.2
Neuroticism (2016)	1.0	1.5	2.0	-1.0	-1.4
Medication: Atenolol	1.0	1.2	2.4	1.5	-0.1
Chronic bronchitis/emphysema (father)	1.0	1.2	2.3	1.5	-0.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.6	0.2	-1.6
Mean time to correctly identify matches	1.0	2.0	3.9	-0.2	2.0
Whole body fat mass	1.0	4.2	7.8	0.8	-2.8
Number of full sisters	1.0	1.2	2.5	0.0	1.6
Long-standing illness, disability or infirmity	1.0	1.6	3.2	1.8	0.1
Medication: Gliclazide	1.0	1.1	1.8	0.7	1.4
Smoking status: Current	1.0	1.5	1.8	-1.3	1.1
Commuting to job workplace: Cycle	1.0	1.3	1.4	-1.2	1.1
Coronary Artery Disease (CAD)	0.9	1.1	2.2	0.2	-1.5
Fasting Glucose	0.9	1.1	2.2	-0.1	1.5
Blood Eosinophil Count	0.9	6.7	9.9	1.9	-3.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.3	1.1	0.9
High blood pressure	0.9	2.6	5.1	0.1	-2.3
Heart attack	0.9	1.1	2.2	1.5	0.2
Pain all over the body in last month	0.9	0.9	1.5	0.6	-1.2
Father’s age at death	0.9	1.2	2.2	-0.5	1.5
Health satisfaction	0.9	1.1	2.0	-0.6	-1.4
Medication: Blood pressure	0.9	1.6	3.2	-0.2	-1.8
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.5	0.7	-1.2
Medication: Bendroflumethiazide	0.9	1.4	1.5	1.1	-1.2
Leg fat percentage (left)	0.9	3.2	4.8	1.3	-2.2
Risk taking	0.9	1.2	1.4	-1.2	1.1
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.9	-0.3	2.2
Heart disease (siblings)	0.9	1.0	1.4	1.2	0.8
Lung FEV1/FVC ratio	0.8	3.9	7.7	0.2	2.8
Impedance of leg (right)	0.8	3.8	7.6	0.2	2.8
Age when periods started (menarche)	0.8	1.9	3.8	0.2	1.9
Age at first live birth	0.8	1.5	2.7	-0.5	1.7
Illnesses of siblings: Diabetes	0.8	1.0	1.1	0.9	1.1
Osteoarthritis (self-reported)	0.8	1.1	2.0	0.5	-1.4
Eye problems/disorders: Glaucoma	0.8	0.9	1.4	-0.6	-1.2
Neuroticism (Nagel 2018)	0.7	1.6	3.2	-0.2	-1.8
Crohns Disease (2017)	0.7	1.5	1.6	1.3	-1.1
Ulcerative Colitis	0.7	1.1	1.1	1.1	-1.0
Blood Platelet Count	0.7	8.2	14.1	1.5	3.8
Number of treatments/medications taken	0.7	1.2	1.4	1.0	-1.2
Vitamin and mineral supplements	0.7	1.0	1.5	-0.7	-1.2
Supplements: Zinc	0.7	0.8	0.8	0.9	0.8
Diabetes (mother)	0.7	0.9	1.0	0.8	-1.0
Pack years adult smoking proportion	0.7	1.1	1.6	-1.3	-0.7
Current tobacco smoking	0.7	1.1	1.4	-1.2	0.9
Had menopause	0.7	0.8	1.5	0.4	1.2
Illnesses of siblings	0.7	0.9	1.6	-0.5	-1.3
Comparative height size at age 10	0.7	3.8	4.6	-2.1	-1.7
Hypertension (Self-reported)	0.7	1.9	3.8	0.2	-1.9
Back pain experienced in last month	0.7	1.0	1.8	0.4	-1.4
Number of operations (self-reported)	0.7	1.0	2.0	-1.4	0.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.6	1.3	0.4
Lung FVC	0.6	3.0	6.0	0.3	2.4
Townsend deprivation index at recruitment	0.6	0.8	1.5	-1.2	0.3
Taking other prescription medications	0.6	0.9	1.1	0.9	-1.0
Stomach or abdominal pain in last month	0.6	0.8	1.2	0.7	1.1
Trunk fat mass	0.6	2.8	4.9	0.8	-2.2
Hearing difficulty/problems with background noise	0.6	1.0	1.4	-0.7	-1.2
Falls in the last year	0.6	0.8	1.6	1.2	0.3
Pulse wave Arterial Stiffness index	0.6	0.8	1.2	-0.6	1.1
Length of working week for main job	0.6	0.7	1.4	-0.2	1.2
Peak expiratory flow (PEF)	0.6	1.4	2.8	-0.2	-1.7
Pulse wave peak to peak time	0.6	0.7	1.2	0.4	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.2	0.5	-1.1
Arm fat percentage (left)	0.6	2.3	2.3	1.5	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.6	-0.0	1.6
Medication: Blood pressure	0.6	1.2	1.9	0.6	-1.4
High cholesterol (Self-reported)	0.6	1.1	1.5	0.8	1.2
Illnesses of father: High blood pressure	0.6	0.7	1.3	-0.3	-1.1
Pack years of smoking	0.6	0.9	1.5	-1.2	-0.6
Triglycerides	0.5	0.8	1.7	0.0	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.6	1.3	0.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.9	-0.5	1.0
Arm fat percentage (right)	0.5	1.9	2.0	1.4	-1.3
Medication: Cholesterol lowering	0.5	0.7	0.8	0.9	0.9
Prospective memory result	0.5	0.6	1.1	-1.1	0.2
Loud music exposure frequency	0.5	0.5	1.0	-1.0	0.2
Body fat percentage	0.5	2.0	2.7	1.2	-1.6
Qualifications: College or University degree	0.5	1.5	1.8	-1.1	1.4
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-1.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.7	0.7	-0.8
Qualifications: nursing, teaching	0.5	0.7	0.9	0.7	1.0
Wears glasses or contact lenses	0.5	0.6	0.7	0.7	-0.8
Ever smoked	0.5	0.9	1.1	-1.1	0.8
Pain experienced in last month	0.5	0.8	1.2	-1.1	0.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	0.1	-1.1
Prostate Cancer	0.4	0.5	1.0	-0.2	-1.0
Blood White Count	0.4	3.1	5.5	2.3	0.8
Sensitivity / hurt feelings	0.4	0.6	0.7	-0.7	-0.8
Hearing difficulty/problems: Yes	0.4	0.6	1.2	0.1	1.1
Angina	0.4	0.5	1.0	0.3	-1.0
Trunk fat percentage	0.4	1.4	1.6	1.2	-1.1
Qualifications: None of the above	0.4	0.8	1.5	-1.2	-0.4
Diabetes (self-reported)	0.4	0.7	1.1	-1.0	-0.5
Depression (self-reported)	0.4	0.5	1.0	1.0	0.0
Hair/balding pattern: Pattern 4	0.4	1.1	1.2	-1.1	-1.0
Medication: Amlodipine	0.4	0.6	1.0	-1.0	0.3
Medication: Allopurinol	0.4	0.5	1.0	1.0	-0.1
Diabetes diagnosed by doctor	0.4	0.6	1.0	-1.0	-0.4
Financial situation satisfaction	0.4	0.4	0.8	-0.2	-0.9
Medication: Lisinopril	0.4	0.6	1.1	-1.0	0.2
Average weekly beer plus cider intake	0.4	0.5	1.1	1.0	0.0
Unable to work because of sickness or disability	0.4	0.6	0.6	0.8	0.7
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-0.1	-1.0
Reaction Time	0.3	0.5	0.8	-0.5	0.9
Mean Putamen Volume	0.3	0.4	0.7	-0.1	-0.9
Lupus	0.3	0.4	0.6	0.5	-0.8
Primary Biliary Cirrhosis	0.3	0.4	0.7	0.8	-0.4
Medication: Metformin	0.3	0.4	0.5	0.7	0.7
Fluid intelligence score	0.3	0.5	0.9	-0.4	0.9
Medication: Lansoprazole	0.3	0.4	0.6	0.4	-0.8
Standing height	0.3	2.5	3.3	-1.8	-1.3
Breastfed as a baby	0.3	0.4	0.5	-0.6	-0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	-0.1	0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.3	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	0.8	-0.5	0.9
Angina (self-reported)	0.3	0.4	0.6	0.4	-0.8
Knee pain experienced in last month	0.3	0.5	0.6	0.6	-0.7
Medication for cholesterol	0.3	0.5	0.9	-1.0	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	0.7	0.4
Medication: Aspirin	0.3	0.4	0.7	-0.8	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.9	0.0
Cholesterol lowering medication	0.3	0.4	0.7	0.2	0.9
Irritable Bowel Disease (IBD)	0.2	0.5	0.6	0.8	-0.6
Crohns Disease (2012)	0.2	0.4	0.6	0.3	-0.8
LDL Cholesterol	0.2	0.2	0.3	-0.6	0.4
Smoking Status	0.2	0.5	0.8	-0.9	-0.3
Hair Pigment	0.2	5.8	11.6	0.2	3.4
Tanning	0.2	2.3	2.7	-1.4	-1.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	-0.7	-0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.1	0.7
Medication: Co-codamol	0.2	0.3	0.6	0.7	-0.1
Diabetes (father)	0.2	0.2	0.3	-0.4	-0.6
Severe depression (siblings)	0.2	0.2	0.4	-0.1	0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.2	-0.5	-0.5
Waist circumference	0.2	0.7	1.2	1.1	-0.4
Nervous feelings	0.2	0.4	0.9	-0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	0.9	0.4
Mouth/teeth dental problems	0.2	0.3	0.6	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.9	-0.6	0.9
Medication: Paracetamol	0.2	0.3	0.4	-0.6	-0.4
High blood pressure (siblings)	0.2	0.3	0.3	-0.6	0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	0.2	0.7
Average weekly red wine intake	0.2	0.3	0.5	-0.7	0.1
Friendships satisfaction	0.2	0.3	0.5	0.7	-0.2
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.0	-0.6
Ever taken oral contraceptive pill	0.2	0.2	0.5	0.1	-0.7
Medication: Paracetamol	0.2	0.4	0.7	-0.8	0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.3	0.7
Supplements: Calcium	0.2	0.2	0.4	0.2	0.6
Alzheimer’s Disease (in father)	0.1	0.2	0.3	0.2	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	-0.5	-0.0
Heel T-Score	0.1	0.6	1.0	1.0	-0.5
Height	0.1	1.4	2.9	-1.7	0.0
Cardiovascular Disease	0.1	0.4	0.5	0.7	-0.6
Systolic blood pressure, automated reading	0.1	0.4	0.8	-0.1	-0.9
Forced vital capacity (FVC)	0.1	0.3	0.6	0.2	0.8
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.4	-0.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.8	-0.2	0.9
Lung cancer (father)	0.1	0.1	0.1	-0.4	-0.0
Birth weight of first child	0.1	0.1	0.1	-0.4	-0.3
Pulse wave reflection index	0.1	0.1	0.2	-0.3	-0.4
Birth weight	0.1	0.2	0.3	0.5	0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	1.1	-0.1	1.0
Eye problems/disorders: None of the above	0.1	0.2	0.2	-0.4	-0.4
Medication: Omeprazole	0.1	0.1	0.2	-0.2	-0.4
Overall health rating	0.1	0.3	0.3	0.6	0.5
Chest pain or discomfort	0.1	0.1	0.1	-0.2	-0.3
Age at last live birth	0.1	0.2	0.3	-0.3	0.5
Family relationship satisfaction	0.1	0.1	0.2	-0.1	0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	0.2	-0.4
Illnesses of father: Heart disease	0.1	0.2	0.2	0.4	0.5
Smoking status: Previous	0.1	0.2	0.2	0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.4	-0.4	-0.6
Mood swings	0.1	0.1	0.2	-0.3	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	0.0	0.6
Illnesses of father: None of the above (group 1)	0.1	0.2	0.2	0.3	0.5
Irritability	0.1	0.1	0.3	0.5	-0.0
Age started oral contraceptive pill	0.1	0.1	0.3	-0.1	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.0	0.5
Ulcerative Colitis (UC)	0.0	0.0	0.1	0.2	-0.3
Breast Cancer	0.0	0.1	0.1	0.4	0.1
Rheumatoid Arthritis	0.0	0.0	0.0	-0.2	0.0
Systolic Blood Pressure	0.0	0.0	0.1	-0.2	0.2
Relative age of first facial hair	0.0	0.0	0.1	0.1	0.3
Past tobacco smoking	0.0	0.1	0.2	0.1	-0.4
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	-0.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	0.0	-0.1
Noisy workplace	0.0	0.0	0.0	-0.2	0.2
Mouth/teeth dental problems: Dentures	0.0	0.0	0.1	-0.1	-0.3
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.0	0.0	0.0
Gout (self-reported)	0.0	0.0	0.0	0.2	-0.1
Worry too long after embarrassment	0.0	0.0	0.0	0.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.3	0.2
Leg pain on walking	0.0	0.0	0.1	0.0	-0.3
Medication: Aspirin	0.0	0.0	0.0	-0.1	-0.2
Supplements: Vitamin C	0.0	0.0	0.0	-0.2	0.1
Ever had bowel cancer screening	0.0	0.0	0.1	0.3	-0.0
Hearing aid user	0.0	0.0	0.0	0.0	0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.2	0.4	-0.2

Hub : Genes

EGR1

Models

Trait associations