Best TWAS P=1.5e-09 · Best GWAS P=8.21e-09 conditioned to 0.00489
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FUT10 | 0.12 | 0.20 | lasso | 11 | 0.21 | 4.2e-25 | 5.0 | 5.8 | 5.0e-09 | 0.62 | 0.09 | 0.90 | FALSE |
2 | GTEx | Adrenal Gland | FUT10 | 0.18 | 0.10 | lasso | 9 | 0.09 | 3.7e-04 | 4.9 | 5.3 | 1.3e-07 | 0.62 | 0.08 | 0.70 | FALSE |
3 | GTEx | Breast Mammary Tissue (Female) | FUT10 | 0.18 | 0.13 | lasso | 5 | 0.13 | 9.5e-05 | 5.8 | 6.0 | 2.3e-09 | 0.86 | 0.01 | 0.97 | FALSE |
4 | GTEx | Liver | FUT10 | 0.16 | 0.05 | lasso | 9 | 0.06 | 9.7e-03 | 5.0 | 5.3 | 9.6e-08 | 0.67 | 0.10 | 0.75 | FALSE |
5 | GTEx | Lung | RP11-722E23.2 | 0.13 | 0.09 | lasso | 6 | 0.10 | 6.1e-08 | 4.6 | 5.2 | 2.5e-07 | 0.53 | 0.29 | 0.70 | FALSE |
6 | GTEx | Nerve Tibial | FUT10 | 0.22 | 0.29 | enet | 18 | 0.32 | 1.3e-23 | 4.6 | 5.2 | 1.7e-07 | 0.60 | 0.14 | 0.85 | FALSE |
7 | GTEx | Pancreas | FUT10 | 0.28 | 0.23 | enet | 20 | 0.22 | 1.4e-09 | 4.8 | 6.0 | 1.5e-09 | 0.57 | 0.13 | 0.86 | TRUE |
8 | GTEx | Pancreas | MAK16 | 0.11 | 0.11 | lasso | 4 | 0.07 | 4.5e-04 | 4.3 | 5.1 | 3.0e-07 | 0.56 | 0.16 | 0.41 | FALSE |
9 | GTEx | Stomach | FUT10 | 0.21 | 0.16 | lasso | 4 | 0.15 | 1.5e-07 | 4.6 | 5.1 | 3.1e-07 | 0.55 | 0.16 | 0.83 | FALSE |
10 | GTEx | Thyroid | FUT10 | 0.22 | 0.20 | enet | 22 | 0.26 | 8.6e-20 | 4.9 | 5.1 | 2.8e-07 | 0.60 | 0.15 | 0.84 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | FUT10 | 0.04 | 0.04 | enet | 11 | 0.04 | 2.1e-05 | 4.6 | 5.4 | 5.6e-08 | 0.67 | 0.13 | 0.86 | FALSE |
12 | The Cancer Genome Atlas | Glioblastoma Multiforme | FUT10 | 0.17 | 0.09 | lasso | 6 | 0.10 | 6.3e-04 | 4.8 | 5.9 | 4.4e-09 | 0.70 | 0.09 | 0.66 | FALSE |
13 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FUT10 | 0.12 | 0.10 | blup | 68 | 0.09 | 2.6e-04 | 5.0 | 5.8 | 5.5e-09 | 0.67 | 0.10 | 0.79 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | FUT10 | 0.18 | 0.24 | lasso | 7 | 0.26 | 2.6e-25 | 4.2 | 5.3 | 1.4e-07 | 0.67 | 0.60 | 0.38 | FALSE |