Best TWAS P=5.49e-11 · Best GWAS P=4.28e-11 conditioned to 0.0165
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RALGPS1 | 0.08 | 0.07 | enet | 27 | 0.09 | 3.8e-11 | -6.1 | -6.6 | 5.5e-11 | -0.77 | 0.32 | 0.68 | TRUE |
2 | GTEx | Artery Coronary | RALGPS1 | 0.26 | 0.00 | enet | 26 | 0.07 | 2.9e-03 | 6.3 | 6.1 | 1.1e-09 | 0.62 | 0.04 | 0.71 | FALSE |
3 | GTEx | Esophagus Mucosa | RALGPS1 | 0.05 | 0.01 | lasso | 6 | 0.02 | 2.7e-02 | 6.2 | 6.1 | 1.1e-09 | 0.86 | 0.04 | 0.89 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | RALGPS1 | 0.06 | 0.02 | lasso | 6 | 0.01 | 2.5e-02 | 6.2 | 6.0 | 2.2e-09 | 0.90 | 0.05 | 0.93 | FALSE |
5 | GTEx | Thyroid | RALGPS1 | 0.09 | 0.04 | enet | 12 | 0.01 | 2.7e-02 | 6.1 | -5.8 | 7.6e-09 | -0.64 | 0.04 | 0.95 | FALSE |
6 | METSIM | Adipose | RALGPS1 | 0.04 | 0.04 | lasso | 3 | 0.04 | 2.8e-06 | 6.5 | 6.3 | 3.5e-10 | 0.97 | 0.02 | 0.98 | FALSE |
7 | YFS | Blood | RALGPS1 | 0.08 | 0.13 | lasso | 18 | 0.15 | 1.1e-45 | 6.3 | 5.8 | 5.4e-09 | 0.86 | 0.03 | 0.97 | FALSE |