Best TWAS P=4.37e-16 · Best GWAS P=3.52e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PSMB7 | 0.05 | 0.01 | lasso | 3 | 0.03 | 3.1e-04 | -7.1 | 6.7 | 2.1e-11 | -0.61 | 0.24 | 0.19 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | -5.9 | 7.6 | 2.8e-14 | -0.84 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Artery Aorta | PSMB7 | 0.15 | 0.03 | enet | 16 | 0.05 | 1.4e-03 | 6.3 | 6.4 | 1.4e-10 | -0.55 | 0.12 | 0.45 | FALSE |
| 4 | GTEx | Artery Tibial | PSMB7 | 0.07 | 0.04 | enet | 7 | 0.03 | 4.1e-03 | -5.9 | 6.0 | 1.9e-09 | -0.66 | 0.47 | 0.18 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | PSMB7 | 0.11 | 0.03 | lasso | 7 | 0.04 | 4.7e-03 | -8.4 | 8.1 | 4.4e-16 | -0.98 | 0.00 | 0.98 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | PSMB7 | 0.09 | 0.07 | enet | 11 | 0.06 | 2.1e-05 | 6.3 | 6.8 | 1.3e-11 | -0.78 | 0.30 | 0.68 | FALSE |
| 7 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | -6.6 | 6.9 | 7.3e-12 | -0.76 | 0.12 | 0.76 | FALSE |
| 8 | GTEx | Colon Transverse | PSMB7 | 0.13 | 0.02 | lasso | 3 | 0.03 | 1.8e-02 | -8.4 | 7.2 | 4.3e-13 | -0.90 | 0.00 | 0.97 | FALSE |
| 9 | GTEx | Nerve Tibial | NEK6 | 0.11 | 0.02 | enet | 40 | 0.03 | 3.9e-03 | -6.8 | 5.6 | 1.8e-08 | -0.37 | 0.08 | 0.40 | FALSE |
| 10 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | -6.5 | 7.0 | 2.0e-12 | -0.78 | 0.72 | 0.28 | FALSE |
| 11 | GTEx | Thyroid | PSMB7 | 0.06 | 0.04 | lasso | 2 | 0.06 | 4.1e-05 | -6.1 | 7.0 | 3.3e-12 | -0.77 | 0.03 | 0.96 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK6 | 0.04 | 0.02 | blup | 87 | 0.02 | 2.5e-05 | 6.8 | 5.7 | 1.0e-08 | -0.37 | 0.79 | 0.13 | FALSE |
| 13 | The Cancer Genome Atlas | Colon Adenocarcinoma | LOC100129034 | 0.12 | 0.00 | lasso | 4 | 0.04 | 1.7e-03 | -7.4 | -5.5 | 3.1e-08 | 0.59 | 0.02 | 0.35 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NEK6 | 0.06 | 0.01 | blup | 87 | 0.04 | 1.0e-04 | 6.8 | 6.8 | 1.4e-11 | -0.51 | 0.18 | 0.45 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB7 | 0.03 | 0.04 | lasso | 4 | 0.04 | 1.2e-04 | -7.1 | 7.3 | 3.1e-13 | -0.78 | 0.04 | 0.91 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB7 | 0.06 | 0.06 | lasso | 4 | 0.04 | 3.7e-05 | -7.2 | 7.2 | 5.7e-13 | -0.84 | 0.08 | 0.92 | FALSE |