Best TWAS P=3.11e-12 · Best GWAS P=4.78e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | UCHL3 | 0.27 | 0.14 | lasso | 10 | 0.26 | 1.1e-31 | -6.8 | -5.4 | 5.8e-08 | 0.78 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adrenal Gland | COMMD6 | 0.33 | 0.17 | lasso | 5 | 0.26 | 5.0e-10 | -4.4 | 6.1 | 1.3e-09 | -0.70 | 0.14 | 0.86 | FALSE |
| 3 | GTEx | Nerve Tibial | RP11-173B14.4 | 0.13 | 0.07 | enet | 26 | 0.04 | 9.7e-04 | -6.9 | -5.7 | 1.1e-08 | 0.76 | 0.00 | 0.99 | FALSE |
| 4 | GTEx | Testis | COMMD6 | 0.47 | 0.32 | enet | 22 | 0.34 | 1.3e-15 | -6.9 | 6.9 | 4.3e-12 | -0.96 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Thyroid | RP11-173B14.4 | 0.08 | 0.09 | lasso | 2 | 0.06 | 1.3e-05 | -6.9 | -7.0 | 3.1e-12 | 1.00 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UCHL3 | 0.04 | 0.04 | lasso | 3 | 0.05 | 2.8e-06 | -6.7 | -6.1 | 9.2e-10 | 0.92 | 0.01 | 0.98 | FALSE |