Hub : Genes

COMMD6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.3257	0.0707	3.0e-06	0.167	NA	0.240	NA	0.265	1.3e-06	NA	3.9e-09	NA	5.0e-10
2	GTEx	Testis	0.4700	0.0740	1.2e-10	0.315	NA	0.337	NA	0.228	1.5e-14	NA	1.3e-15	NA	1.7e-10
3	METSIM	Adipose	0.0322	0.0161	1.8e-02	0.003	0.017	0.001	0.017	0.000	9.6e-02	1.2e-03	2.5e-01	1.0e-03	2.7e-01
4	YFS	Blood	0.0524	0.0135	1.8e-08	0.025	0.034	0.032	0.037	0.031	8.9e-09	2.0e-11	7.1e-11	3.3e-12	2.0e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	3.8	6.0	9.6	-3.1	-2.1	-2.0	-2.4
Bipolar Disorder or Schizophrenia	1.3	3.2	6.2	-2.5	-1.6	-0.8	-1.8
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	0.7	-0.1	0.9	0.6
Depression (Nagel 2018)	0.1	0.2	0.2	0.2	0.4	0.5	0.5
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.8	0.6	-0.6	2.0	0.5
Neuroticism (Nagel 2018)	0.3	0.6	1.7	-0.2	-1.3	0.8	-0.1
Schizophrenia (2018)	0.1	0.3	0.5	-0.7	-0.4	0.6	-0.3
Schizophrenia vs Biploar Disorder	1.5	1.9	3.2	1.7	1.8	1.0	0.8
Worry (Nagel 2018)	1.8	3.8	10.4	-1.6	-3.2	1.0	-1.1
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	-1.1	-0.4	-1.2	-0.4
Alzheimer’s Disease (in father)	1.6	1.7	5.9	-1.0	-2.4	0.3	0.0
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	-1.2	-1.5	-0.3	-0.0
Crohns Disease (2017)	0.5	1.1	1.9	-0.9	-1.0	-1.4	-0.8
Irritable Bowel Disease (IBD)	0.2	0.6	1.3	-0.5	-0.6	-1.1	-0.5
Ulcerative Colitis (UC)	0.3	0.6	1.0	-0.8	-0.4	-0.8	-1.0
Major Depression (MDD)	3.8	4.6	6.2	2.1	2.5	1.9	2.0
Reaction Time	0.3	0.6	1.2	0.6	-0.0	-1.1	0.9
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.3	-0.4	-1.1	0.9	-1.1
Breast Cancer	1.1	2.6	7.2	-2.7	-0.1	-0.9	-1.5
Ovarian Cancer	0.4	0.6	1.9	-0.4	-1.4	-0.3	0.4
Prostate Cancer	2.7	3.8	5.7	-2.4	-1.9	-0.5	-2.4
Age at First Birth	1.1	1.6	2.6	1.6	1.4	-0.7	1.2
Bipolar Disorder (2011)	3.0	2.9	4.9	-1.8	-1.2	-1.3	-2.2
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.9	0.7	-0.5	-0.5
Coronary Artery Disease (CAD)	0.6	0.7	1.8	0.2	1.4	0.1	0.9
Crohns Disease (2012)	1.1	1.8	2.6	-0.7	-1.6	-1.5	-1.4
Mean Putamen Volume	0.3	0.4	0.6	0.7	0.3	0.5	0.8
Fasting Glucose	0.8	1.0	2.2	1.3	0.1	0.2	1.5
HbA1C	0.4	0.4	1.0	-0.4	-1.0	0.4	-0.6
HDL Cholesterol	0.6	1.0	2.0	-1.2	-0.6	0.3	-1.4
LDL Cholesterol	1.5	2.3	4.3	2.1	1.0	0.3	2.0
Lupus	0.5	0.7	1.6	0.6	-0.2	1.2	0.9
Neuroticism (2016)	0.2	0.3	0.6	0.6	0.5	-0.4	0.8
Primary Biliary Cirrhosis	0.5	0.7	1.8	0.4	1.3	-0.9	0.2
Rheumatoid Arthritis	1.4	1.9	3.1	-1.8	-1.0	-1.0	-1.5
Schizophrenia (2014)	0.2	0.4	0.6	-0.5	-0.8	0.4	-0.6
Triglycerides	0.0	0.0	0.0	-0.2	-0.2	0.1	0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.9	0.5	-0.9	1.4	-0.2
Ulcerative Colitis	0.3	0.5	1.1	-0.5	-1.0	-0.0	-0.7
Blood Eosinophil Count	0.1	1.0	3.5	-0.4	-0.7	-1.9	-0.0
Blood Platelet Count	0.5	5.8	12.0	-2.9	-3.5	0.4	-1.5
Blood Red Count	1.4	13.0	39.9	3.1	0.7	-1.5	6.3
Blood White Count	0.2	1.3	3.5	0.9	-0.2	-0.8	1.9
Heel T-Score	0.1	0.4	0.9	-0.5	-0.4	0.6	-1.0
BMI	0.2	1.2	2.6	0.9	1.6	-1.1	0.3
Height	0.0	0.4	1.0	-0.5	-0.4	0.3	1.0
Waist Hip Ratio (WHR)	0.1	0.4	1.0	-1.0	-0.1	-0.6	0.0
Systolic Blood Pressure	0.3	1.6	4.3	-1.1	-2.1	0.5	-0.8
Smoking Status	0.5	1.2	3.1	-1.8	-0.4	-1.1	-0.8
Allergy or Eczema	0.7	1.8	5.8	1.0	2.4	0.4	0.4
Cardiovascular Disease	0.5	1.5	5.1	-1.0	-2.3	0.1	-0.3
Hypothyroidism (self reported)	0.7	1.6	2.7	1.6	1.6	0.7	0.9
Respiratory disease	0.3	0.6	0.8	-0.9	-0.8	-0.9	-0.5
Type 2 Diabetes (T2D) (2018)	3.2	5.9	11.4	-2.8	-3.4	0.1	-2.1
Lung FEV1/FVC ratio	0.2	1.0	1.8	1.4	0.6	1.1	0.9
Lung FVC	0.1	0.5	0.9	0.7	0.9	-0.7	-0.2
Neuroticism	1.0	2.4	5.9	-1.0	-2.4	1.4	-0.9
Chronotype (morning person)	0.4	0.9	1.6	0.8	1.3	-0.8	0.8
Hair Pigment	0.4	10.3	16.2	-3.6	-3.3	1.2	-4.0
Tanning	0.2	2.7	4.1	-1.7	-0.3	-1.9	-2.0
Hand grip strength (left)	0.2	0.4	0.8	-0.5	-0.9	-0.8	0.0
Number of treatments/medications taken	0.8	1.4	4.4	-1.1	-2.1	-0.0	-0.1
Average weekly spirits intake	1.4	1.7	5.2	1.1	2.3	-0.7	0.2
Sensitivity / hurt feelings	0.1	0.1	0.2	0.1	-0.4	-0.4	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.1	-0.0	0.5	0.5
Hearing difficulty/problems: Yes	1.2	1.8	5.3	-1.3	0.2	-0.5	-2.3
Relative age of first facial hair	0.1	0.1	0.2	0.1	0.5	-0.4	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.4	1.1	0.5	0.3	1.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.2	1.0	1.5	-0.7	0.4
Ever had hysterectomy (womb removed)	1.9	2.1	3.4	-1.1	-1.8	-0.5	-1.9
Systolic blood pressure, automated reading	0.4	1.2	3.4	-1.1	-1.8	0.4	-0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	1.2	0.9	-0.5	0.7
Angina	1.0	1.3	2.0	0.8	1.4	1.0	1.3
Medication for hormone replacement therapy	4.2	4.7	7.3	2.6	2.7	1.3	1.8
Vitamin and mineral supplements	0.2	0.3	1.1	-0.4	-1.0	0.1	-0.3
Supplements: Zinc	1.0	1.1	2.3	0.7	1.5	-0.1	1.3
Medication: Co-codamol	0.9	1.0	2.8	0.4	-0.5	1.7	0.9
Medication: Metformin	0.9	1.3	2.2	-1.5	-1.5	0.3	-0.9
Diabetes (father)	0.3	0.4	1.6	-0.4	0.1	1.3	0.0
Diabetes (mother)	0.4	0.5	1.5	-0.8	-1.2	-0.1	-0.1
Severe depression (siblings)	1.1	1.2	2.8	-0.8	-1.7	-0.2	-1.1
Pack years adult smoking proportion	0.3	0.5	0.9	0.3	1.0	-0.8	0.5
Impedance of leg (right)	1.4	6.7	13.6	2.4	3.7	-0.0	2.7
Leg fat-free mass (left)	0.2	0.9	2.4	-0.8	-1.6	0.0	-0.8
Trunk fat percentage	2.3	9.4	18.2	3.4	4.3	0.1	2.8
Hand grip strength (right)	0.1	0.3	0.6	-0.2	-0.8	-0.7	0.4
Townsend deprivation index at recruitment	0.6	0.8	2.0	-0.2	-1.4	1.1	0.1
Current tobacco smoking	0.9	1.5	3.1	-1.4	0.4	-1.7	-0.9
Average weekly fortified wine intake	0.3	0.4	1.1	-0.3	-0.6	-1.0	0.0
Maternal smoking around birth	2.5	3.6	4.9	-2.2	-1.3	-2.0	-1.9
Fed-up feelings	0.9	1.6	3.7	1.5	0.4	0.7	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	-0.2	-0.7	-0.3	0.4
Relative age voice broke	1.2	1.8	3.2	1.7	1.0	-0.3	1.8
Taking other prescription medications	0.7	1.0	3.3	-0.4	-1.8	0.7	0.0
Age when periods started (menarche)	1.6	3.8	9.0	2.3	0.7	0.7	3.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.2	-0.2	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.0	-1.0	-0.7	-0.6	-1.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.2	-0.3	-0.2	0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.4	-0.1	0.4	-0.1
Serious illness, injury or assault to yourself	0.2	0.3	1.1	-0.0	-1.0	-0.1	-0.1
High blood pressure	0.7	1.8	6.3	-1.0	-2.5	0.3	-0.0
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.3	1.0	1.8	1.0	0.2
Multivitamins +/- minerals	0.5	0.7	1.2	-1.1	-0.6	-0.6	-0.9
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.1	0.3	0.4	0.4
Supplements: Glucosamine	2.6	3.3	5.0	2.2	2.0	-0.3	2.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.6	1.3	0.8	0.1	1.2
Medication: Atenolol	0.3	0.4	0.7	-0.8	-0.2	-0.8	-0.5
Medication: Levothyroxine sodium	0.5	0.9	1.6	1.2	1.3	-0.7	0.1
Sitting height	0.2	1.8	4.2	-1.2	-1.1	2.0	-0.5
Chronic bronchitis/emphysema (father)	2.5	3.0	4.8	-2.2	-1.8	-1.7	-0.9
High blood pressure (mother)	1.8	2.5	4.7	-1.3	-2.2	-0.6	-1.8
Body mass index (BMI)	0.1	0.2	0.4	-0.1	0.4	-0.7	-0.6
Impedance of leg (left)	1.4	6.6	14.4	2.5	3.8	-0.2	2.4
Leg predicted mass (left)	0.2	1.0	2.6	-0.9	-1.6	-0.1	-0.8
Trunk fat mass	0.9	3.7	7.4	2.1	2.7	-0.2	1.8
Waist circumference	0.2	0.8	2.0	0.8	1.4	-0.3	0.7
Number of incorrect matches in round	2.0	3.4	3.8	-1.9	-1.9	-1.7	-1.8
Past tobacco smoking	0.3	0.6	0.8	0.9	0.9	0.8	-0.1
Alcohol usually taken with meals	1.3	2.1	4.0	1.5	1.4	2.0	0.4
Nervous feelings	1.6	3.1	5.8	-1.9	-2.4	-0.0	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.5	0.1	0.1	1.2	0.1
Hearing difficulty/problems with background noise	1.1	1.7	3.2	1.4	1.8	1.3	0.0
Hair/balding pattern: Pattern 2	0.6	0.8	1.9	-0.4	0.8	-0.6	-1.4
Had menopause	1.0	1.2	2.1	1.1	-0.1	1.3	1.5
Had other major operations	0.2	0.3	0.4	0.4	-0.4	0.6	0.5
Forced vital capacity (FVC)	0.1	0.2	0.4	-0.6	-0.2	-0.4	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.9	-0.4	0.1	-1.4	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	-0.8	-0.4	1.1	-0.2
Qualifications: None of the above	0.5	1.0	2.9	0.7	-0.3	-0.8	1.7
Financial difficulties in last 2 years	0.2	0.2	0.6	-0.1	0.3	-0.8	-0.4
Mouth/teeth dental problems	1.0	1.6	3.7	1.3	0.8	1.9	0.5
Heart attack	0.1	0.2	0.6	0.1	0.8	-0.0	0.4
Allergy	0.2	0.5	1.4	-0.5	-1.2	-0.5	0.1
Pain all over the body in last month	0.7	0.7	1.4	-0.5	0.2	-1.0	-1.2
Diabetes (self-reported)	1.1	1.7	2.5	-1.6	-1.6	-0.2	-1.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.3	0.5	0.5	0.6	-0.2
Medication: Ramipril	1.0	1.3	2.0	-1.4	-1.2	-0.2	-1.4
Medication: Simvastatin	1.4	2.0	4.5	1.6	0.5	0.8	2.1
Fluid intelligence score	0.6	1.2	2.1	-0.7	-1.4	-0.6	-1.3
Illnesses of siblings	0.0	0.0	0.0	-0.0	0.2	-0.2	0.1
Neuroticism score	0.5	1.1	3.6	-0.6	-1.9	0.3	-0.6
Weight	0.0	0.0	0.1	0.0	0.3	-0.2	0.1
Impedance of arm (right)	5.8	27.2	49.1	5.9	7.0	1.9	4.7
Arm fat percentage (right)	1.8	6.9	16.4	2.9	4.0	0.1	1.7
Trunk fat-free mass	0.9	5.0	9.9	-2.6	-3.1	-0.6	-1.8
Hip circumference	0.4	1.9	5.4	1.3	2.3	0.5	0.6
Time employed in main current job	0.5	0.5	1.7	-0.6	0.0	0.2	-1.3
Alcohol intake versus 10 years previously	0.4	0.6	1.0	0.8	-0.8	0.4	1.0
Father’s age at death	0.3	0.4	1.5	0.1	-1.2	0.0	0.1
Worrier / anxious feelings	0.7	1.3	3.4	-1.2	-1.9	-0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	-0.2	-0.3	-0.4	-0.1
Falls in the last year	1.1	1.4	2.8	-1.2	-0.7	-1.0	-1.7
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	0.1	-0.7	0.6	0.9
Number of live births	0.3	0.4	1.0	-0.0	-0.0	1.0	0.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.5	-0.5	-0.4	0.1	-0.7
Pulse rate	0.0	0.1	0.2	0.5	0.1	-0.0	0.2
Happiness	0.5	0.6	1.8	-0.4	0.1	0.5	-1.4
Noisy workplace	0.2	0.3	0.6	-0.4	-0.6	-0.8	-0.1
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.1	0.7	0.9	2.3	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	5.2	-1.1	-2.3	0.6	-0.8
Mouth/teeth dental problems: Dentures	1.0	1.6	4.3	-1.1	-0.0	-2.1	-1.0
Asthma	0.9	1.8	3.3	-1.4	-1.0	-1.8	-0.9
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	4.5	-0.9	-0.9	-1.8	-2.1
Medication: Cholesterol lowering	0.5	0.7	2.3	0.6	-0.5	0.4	1.5
Depression (self-reported)	0.3	0.4	1.1	-0.5	-0.2	-0.5	-1.0
Medication: Lansoprazole	1.5	1.8	4.2	1.3	0.8	-0.7	2.1
Prospective memory result	1.1	1.4	5.2	-0.4	-0.3	-2.3	-0.4
Lung cancer (father)	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.0
Illnesses of mother	2.8	3.4	7.2	1.7	2.7	1.0	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.2	-1.1	-0.5	-0.3	-1.1
Pulse wave Arterial Stiffness index	1.5	1.7	4.8	-1.3	-0.6	0.5	-2.2
Impedance of arm (left)	6.1	28.4	48.0	6.1	6.9	1.9	5.0
Arm fat mass (right)	0.4	1.7	4.3	1.2	2.1	-0.5	0.8
Trunk predicted mass	0.9	5.3	10.4	-2.6	-3.2	-0.7	-1.9
Standing height	0.1	0.6	1.6	0.2	0.2	0.7	1.3
Length of working week for main job	0.2	0.2	0.4	0.6	-0.3	0.1	0.5
Exposure to tobacco smoke at home	0.5	0.6	1.0	-0.0	-0.8	0.7	1.0
Breastfed as a baby	2.7	3.4	8.8	-1.8	-3.0	-0.7	-1.1
Tense / ‘highly strung’	0.1	0.1	0.4	-0.2	-0.6	0.4	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	-0.9	-0.6	0.8	-0.3
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.2	0.2	0.2	0.1
Birth weight of first child	0.2	0.3	0.9	0.1	0.6	-0.9	-0.2
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.3	0.7	-0.4	-0.2
Pulse wave reflection index	0.7	0.9	2.4	-0.8	-0.6	-0.5	-1.5
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.8	0.9	1.7	0.9	0.5
Loud music exposure frequency	0.7	0.8	2.2	0.3	0.4	-1.5	0.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.0	0.4	1.1	1.7	0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	-0.0	-0.5	-0.2	0.8
Blood clot in the leg (DVT)	0.3	0.4	1.0	-0.8	-0.1	0.4	-1.0
Medication: Paracetamol	0.6	0.9	3.2	-0.5	-0.1	-0.6	-1.8
Headache pain in last month	0.7	1.2	2.2	1.3	-0.2	0.9	1.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.9	1.0	1.4	0.4	-0.2
Glaucoma (self-reported)	0.8	0.9	1.6	1.0	-0.2	1.2	1.0
Gout (self-reported)	0.6	0.8	2.2	-0.3	-0.1	-1.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.6	1.6	1.1	0.6	1.2
Medication: Amlodipine	0.8	1.2	4.6	0.1	-0.1	-2.1	-0.4
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.3	-0.9	-1.2	-0.5	-1.5
Birth weight	0.5	1.1	1.6	1.2	1.2	-0.1	1.3
Chronic bronchitis/emphysema (mother)	3.1	3.6	7.5	-1.9	-2.7	-0.7	-1.7
High blood pressure (siblings)	0.1	0.2	0.5	-0.3	-0.7	-0.2	0.3
Forced vital capacity (FVC), Best measure	0.3	1.0	1.8	-1.3	-0.5	-0.9	-1.1
Body fat percentage	1.8	7.2	14.4	2.9	3.8	-0.1	2.3
Leg fat percentage (right)	0.5	1.9	4.7	1.2	2.2	-0.5	1.0
Arm fat-free mass (right)	1.1	5.8	11.9	-2.6	-3.5	-1.1	-1.9
Exposure to tobacco smoke outside home	0.1	0.1	0.1	-0.2	0.3	0.3	-0.4
Comparative body size at age 10	0.4	1.0	2.2	-1.1	-1.5	0.0	-0.8
Number of full brothers	0.8	1.0	2.9	-0.6	-0.9	1.7	-0.2
Worry too long after embarrassment	0.1	0.1	0.2	0.5	0.2	0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	-0.4	-0.8	1.0	0.1
Wheeze or whistling in the chest in last year	0.3	0.5	0.7	-0.7	-0.8	-0.7	-0.5
Number of children fathered	1.9	2.2	5.8	1.2	2.4	0.9	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	0.9	0.6	0.5	1.0
Age at first live birth	0.1	0.1	0.4	0.3	0.6	-0.1	-0.1
Pulse wave peak to peak time	1.5	1.8	4.8	1.3	0.7	-0.4	2.2
Health satisfaction	0.3	0.4	1.0	0.1	-1.0	-0.7	0.4
Shortness of breath walking on level ground	0.1	0.1	0.2	0.1	-0.1	-0.3	-0.4
Qualifications: College or University degree	0.2	0.5	1.1	-0.3	-1.0	0.9	-0.2
Eye problems/disorders: None of the above	1.9	2.2	3.8	-1.6	-1.2	1.2	-2.0
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.0	0.9	-1.2	1.3	2.0
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.4	-0.2	-0.5	0.8
Medication for pain relief, constipation, heartburn	4.1	7.0	13.3	2.6	1.7	2.3	3.6
Neck or shoulder pain in last month	3.2	4.5	6.5	2.6	2.3	1.7	1.7
Medication: Blood pressure	1.2	2.1	4.8	-1.6	-2.2	-0.9	-0.2
Angina (self-reported)	1.1	1.5	1.8	0.9	1.3	1.3	1.3
Migraine (self-reported)	0.0	0.1	0.1	0.1	-0.4	-0.2	-0.1
Medication: Ibuprofen	2.6	3.1	5.4	-1.4	-1.7	-1.5	-2.3
Medication: Allopurinol	1.8	2.4	4.3	-1.3	-1.1	-2.1	-1.6
Medication: Omeprazole	2.1	2.5	2.9	-1.7	-1.6	-1.7	-1.4
Medication: Seretide 50 evohaler	0.5	0.6	1.1	-0.3	0.4	-1.0	-1.0
Mean time to correctly identify matches	0.3	0.6	1.2	0.9	0.6	-0.2	1.1
Heart disease (mother)	0.8	0.9	2.0	-0.9	-1.4	-0.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	-0.6	0.4	-1.0	0.3
Whole body fat mass	0.5	1.9	4.1	1.4	2.0	-0.4	1.2
Leg fat mass (right)	0.1	0.5	1.3	0.6	1.1	-0.4	0.6
Arm predicted mass (right)	1.0	5.3	11.3	-2.5	-3.4	-0.9	-1.7
Pulse rate, automated reading	0.4	1.4	2.2	-1.5	-1.2	0.7	-1.2
Alcohol intake frequency.	2.2	5.0	7.5	-2.6	-2.7	0.3	-2.3
Comparative height size at age 10	0.4	2.0	3.6	-1.9	-1.8	0.5	-0.9
Number of full sisters	1.7	2.1	3.7	-1.8	-0.6	-0.9	-1.9
Suffer from ‘nerves’	4.3	6.8	12.6	-2.8	-3.6	0.3	-2.6
Overall health rating	1.4	3.0	7.9	-1.6	-2.8	-0.6	-1.0
Chest pain or discomfort	0.2	0.2	0.5	0.4	-0.7	0.2	0.5
Had major operations	1.5	1.7	4.2	0.4	-0.7	-2.1	1.4
Age at last live birth	0.2	0.2	0.5	0.6	0.3	0.0	0.7
Family relationship satisfaction	0.4	0.5	1.6	-0.2	0.2	0.4	-1.3
Leg pain on walking	0.9	1.1	2.8	-0.5	0.7	-1.7	-1.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.7	-0.3	0.6	-1.6	-1.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	-1.1	0.3	0.5	-0.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.0	0.4	1.4	-1.3	0.7
Medication: Aspirin	0.3	0.5	1.1	-0.5	-0.1	-0.6	-1.1
Supplements: Vitamin C	6.6	7.8	12.3	3.5	2.8	1.5	3.0
Knee pain experienced in last month	0.4	0.6	2.0	-0.5	0.2	-1.4	0.0
Hypertension (Self-reported)	0.6	1.6	5.3	-1.1	-2.3	0.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	-0.4	-1.1	0.4	0.3
Illnesses of father: Heart disease	1.2	1.6	3.3	0.7	-1.0	1.8	1.3
Illnesses of siblings: Diabetes	1.2	1.5	3.0	-1.5	0.5	0.4	-1.7
Smoking status: Previous	0.3	0.4	1.0	-0.4	-1.0	-0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.1	-0.0	1.5	-0.2	0.4
Whole body fat-free mass	0.6	3.6	7.5	-2.1	-2.7	-0.5	-1.6
Leg fat-free mass (right)	0.3	1.4	3.2	-1.1	-1.8	-0.1	-1.1
Arm fat percentage (left)	1.8	7.1	15.0	3.1	3.9	0.1	2.0
Average weekly red wine intake	0.3	0.5	1.0	1.0	0.4	0.6	0.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.7	0.6	-0.9	0.6
Mood swings	0.2	0.4	1.4	-0.5	-1.2	-0.3	0.3
Loneliness, isolation	0.9	1.3	2.5	1.3	1.6	-0.5	0.7
Long-standing illness, disability or infirmity	1.0	1.5	3.9	-1.3	-2.0	-0.1	-0.8
Ever had bowel cancer screening	0.2	0.2	0.4	-0.5	-0.2	0.4	0.6
Diabetes diagnosed by doctor	1.0	1.7	2.8	-1.5	-1.7	0.4	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	-1.1	-0.2	-0.2	-0.3
Friendships satisfaction	0.4	0.6	1.9	0.5	1.4	0.1	-0.3
Qualifications: nursing, teaching	1.9	2.9	6.3	-2.0	-1.1	0.4	-2.5
Commuting to job workplace: Walk	0.6	0.6	0.9	0.9	-0.2	-0.9	1.0
Eye problems/disorders: Cataract	2.0	2.3	2.8	1.5	1.7	-1.7	1.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.5	-0.4	-0.5	-0.3
Medication for cholesterol	0.9	1.3	2.2	-1.5	-1.1	-0.7	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	4.8	-1.5	-0.6	-1.1	-2.2
Back pain experienced in last month	0.5	0.7	1.0	1.0	0.8	0.9	0.4
Mineral and other dietary supplements	0.1	0.1	0.2	0.1	-0.4	0.3	-0.1
Breast cancer (self-reported)	0.1	0.1	0.2	0.4	0.0	-0.0	0.4
Asthma (self-reported)	1.1	2.2	3.7	-1.6	-1.1	-1.9	-1.2
Osteoporosis (self-reported)	0.2	0.3	0.4	-0.3	-0.6	-0.6	-0.5
Osteoarthritis (self-reported)	0.3	0.4	1.2	-0.7	-1.1	-0.2	-0.2
Medication: Aspirin	0.5	0.7	1.2	-0.9	-0.2	-0.8	-1.1
Medication: Gliclazide	1.5	1.7	3.7	-1.2	-1.9	0.6	-1.1
Illnesses of father: None of the above (group 1)	0.5	0.7	1.9	0.8	1.4	-0.3	0.0
Smoking status: Current	0.7	1.1	2.8	-1.1	0.6	-1.7	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.7	-0.6	0.6	-0.9	-1.3
Whole body water mass	0.7	3.7	8.0	-2.0	-2.8	-0.5	-1.6
Leg predicted mass (right)	0.3	1.6	3.5	-1.2	-1.9	-0.2	-1.3
Arm fat mass (left)	0.5	2.0	4.9	1.4	2.2	-0.4	0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	-0.5	-1.2	0.7	0.0
Average weekly champagne plus white wine intake	0.9	1.2	2.1	-1.2	-0.7	0.8	-1.4
Miserableness	0.6	1.1	2.3	-0.1	-1.5	1.3	-0.6
Guilty feelings	0.8	1.1	2.9	1.7	-0.6	1.0	0.6
Wears glasses or contact lenses	0.5	0.6	2.1	-0.6	-1.4	-0.2	-0.1
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.2	0.1	-0.6	0.5
Hearing aid user	0.3	0.4	0.5	-0.1	0.7	0.7	-0.7
Mother’s age at death	5.3	6.6	10.6	2.9	2.2	1.5	3.2
Financial situation satisfaction	0.8	0.9	2.6	0.1	1.6	0.8	-0.7
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.3	1.2	1.5	0.6	0.1
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.0	0.6	0.3	-0.6
Eye problems/disorders: Glaucoma	2.6	3.0	4.8	2.2	1.3	1.0	2.2
Medication: Blood pressure	0.5	1.0	2.9	-0.6	-1.7	0.4	-0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	-0.4	0.5	0.3	-1.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.3	-0.2	0.5	0.2
High cholesterol (Self-reported)	0.7	1.2	2.3	1.5	0.8	0.3	1.3
Medication: Bendroflumethiazide	1.0	1.6	2.9	-1.2	-1.7	-0.4	-1.4
Medication: Paracetamol	1.6	2.5	6.2	-1.6	-0.8	-0.6	-2.5
Medication: Lisinopril	0.7	0.9	1.4	-0.5	-1.2	1.1	0.8
Medication: Atorvastatin	1.4	1.7	3.3	-1.8	-1.4	-0.8	-1.1
Illnesses of father: High blood pressure	0.3	0.3	1.0	0.4	1.0	-0.3	0.2
Alcohol drinker status: Never	0.5	0.6	1.8	-0.6	0.5	0.3	-1.3
Ever smoked	0.4	0.7	1.7	-1.3	-0.5	-0.8	-0.5
Basal metabolic rate	0.3	1.7	3.5	-1.4	-1.9	-0.4	-1.1
Leg fat percentage (left)	0.5	1.8	4.6	1.2	2.2	-0.5	0.9
Arm fat-free mass (left)	0.7	3.6	7.6	-2.1	-2.8	-0.4	-1.5
Number of operations (self-reported)	0.6	0.8	2.0	0.7	-0.8	-0.4	1.4
Average weekly beer plus cider intake	0.4	0.5	1.6	0.0	0.7	-1.3	-0.1
Irritability	0.3	0.5	1.1	-0.0	-1.1	0.9	0.2
Risk taking	0.2	0.3	0.5	-0.3	-0.7	-0.7	-0.4
Ever had prostate specific antigen (PSA) test	0.8	1.0	2.2	-0.9	-1.5	0.9	-0.3
Fractured/broken bones in last 5 years	1.0	1.3	4.3	-0.7	-2.1	0.4	-0.1
Age started oral contraceptive pill	0.1	0.1	0.5	-0.1	-0.1	0.7	-0.1
Diastolic blood pressure, automated reading	0.8	2.5	9.1	-1.0	-3.0	-0.1	-0.2
Ever depressed for a whole week	0.3	0.4	0.7	0.5	-0.4	0.9	0.6
Unable to work because of sickness or disability	2.6	3.4	4.9	-1.7	-2.0	-1.3	-2.2
Commuting to job workplace: Cycle	0.2	0.3	0.8	0.2	-0.9	0.1	0.5
Myopia	1.2	1.8	3.6	-1.3	-1.3	0.7	-1.9
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.3	0.8	1.8	-0.3	-0.2
Cholesterol lowering medication	0.7	1.0	1.5	1.0	1.2	-0.7	1.0
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.3	-1.7	-1.8	-1.2	-1.3
Pain experienced in last month	0.5	0.9	2.0	-1.1	-1.4	0.1	-0.4
Supplements: Calcium	0.7	0.8	1.5	-1.1	-1.2	0.3	-0.7
Basal cell carcinoma (self-reported)	0.6	0.8	1.7	1.1	1.3	-0.2	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	0.1	0.7	-0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	-1.0	-0.1	0.1	-1.0
Heart disease (siblings)	0.1	0.2	0.6	0.2	0.3	0.8	0.1
Alcohol drinker status: Previous	3.3	3.8	9.3	-2.0	-3.1	-0.9	-1.0
Pack years of smoking	0.3	0.4	1.0	0.3	1.0	-0.5	0.5
Impedance of whole body	3.8	19.2	35.0	4.8	5.9	1.0	4.1
Leg fat mass (left)	0.1	0.5	1.1	0.5	1.0	-0.6	0.4
Arm predicted mass (left)	0.8	4.0	7.8	-2.2	-2.8	-0.8	-1.7