TWAS
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Usage
Models
Genes
Traits
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Traits
:
Impedance of arm (left)
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chr16:11,373,301-13,364,255
Best TWAS P=3.93e-08 · Best GWAS P=2.62e-05 conditioned to 0.000298
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Lung Adenocarcinoma
SNX29
0.10
0.02
enet
18
0.04
2.3e-05
3.2
5.5
3.9e-08
0.11
0.04
0.19
TRUE
1
GTEx
Skin Sun Exposed Lower leg
SNX29
0.22
0.04
enet
22
0.06
2.2e-05
3.3
5.2
1.6e-07
0.28
0.04
0.53
FALSE
2
GTEx
Thyroid
SNX29
0.36
0.14
lasso
10
0.20
6.6e-15
3.8
5.2
2.3e-07
0.48
0.03
0.62
FALSE
3
ROSMAP
Brain Pre-frontal Cortex
SNX29
0.11
0.05
lasso
8
0.06
3.2e-08
3.9
5.2
2.3e-07
0.48
0.03
0.60
FALSE