Best TWAS P=2e-10 · Best GWAS P=6.53e-11 conditioned to 0.00848
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HN1L | 0.08 | 0.01 | blup | 487 | 0.04 | 2.4e-05 | -3.2 | 5.6 | 2.6e-08 | -0.47 | 0.32 | 0.44 | FALSE |
| 2 | GTEx | Artery Tibial | LA16c-316G12.2 | 0.13 | 0.05 | enet | 18 | 0.06 | 1.1e-05 | -6.5 | -6.4 | 2.0e-10 | 0.70 | 0.01 | 0.98 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | TELO2 | 0.16 | 0.03 | lasso | 4 | 0.06 | 3.4e-04 | -4.1 | 5.3 | 1.5e-07 | -0.68 | 0.03 | 0.83 | FALSE |
| 4 | GTEx | Esophagus Muscularis | LA16c-361A3.3 | 0.12 | 0.04 | enet | 7 | 0.05 | 5.1e-04 | -4.9 | -5.5 | 3.1e-08 | 0.82 | 0.32 | 0.52 | FALSE |
| 5 | METSIM | Adipose | TMEM204 | 0.08 | 0.01 | blup | 498 | 0.02 | 2.5e-04 | -4.6 | -5.9 | 4.4e-09 | 0.74 | 0.02 | 0.98 | FALSE |
| 6 | YFS | Blood | CRAMP1L | 0.02 | 0.01 | lasso | 5 | 0.01 | 1.6e-04 | -4.3 | -5.2 | 1.7e-07 | 0.77 | 0.67 | 0.30 | FALSE |
| 7 | YFS | Blood | MLST8 | 0.12 | 0.06 | bslmm | 326 | 0.06 | 4.3e-20 | 4.7 | -5.9 | 3.2e-09 | 0.04 | 0.27 | 0.71 | TRUE |
| 8 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MAPK8IP3 | 0.18 | 0.06 | blup | 77 | 0.10 | 8.7e-06 | -4.9 | -5.8 | 5.0e-09 | 0.75 | 0.06 | 0.89 | FALSE |
| 9 | The Cancer Genome Atlas | Esophageal Carcinoma | CRAMP1L | 0.11 | 0.08 | blup | 60 | 0.07 | 2.2e-03 | -4.9 | -6.0 | 1.6e-09 | 0.87 | 0.02 | 0.84 | FALSE |