[Hub]/) : Traits : Impedance of arm (left) : ← →

chr2:15,703-1,384,725

Best TWAS P=2.76e-15 · Best GWAS P=5.05e-36 conditioned to 5.03e-21

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Artery Tibial	SH3YL1	0.10	0.02	lasso	3	0.01	2.9e-02	5.9	7.9	2.8e-15	0.08	0.65	0.02	TRUE
16	GTEx	Esophagus Muscularis	TMEM18	0.37	0.20	lasso	8	0.18	2.0e-11	-4.8	-6.2	5.8e-10	-0.26	1.00	0.00	TRUE
28	GTEx	Stomach	SH3YL1	0.33	0.21	lasso	6	0.20	3.8e-10	5.8	-5.7	1.3e-08	0.05	1.00	0.00	TRUE
24	GTEx	Ovary	SH3YL1	0.48	0.29	enet	18	0.34	3.2e-09	5.8	7.1	1.1e-12	0.13	0.67	0.03	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	FAM150B	0.06	0.01	bslmm	381	0.03	9.9e-05	-5.5	-7.1	1.7e-12	-0.05	0.40	0.02	FALSE
23	GTEx	Nerve Tibial	SH3YL1	0.33	0.23	enet	35	0.25	5.6e-18	5.9	6.9	3.9e-12	0.07	1.00	0.00	FALSE
19	GTEx	Heart Left Ventricle	SH3YL1	0.14	0.11	enet	16	0.10	8.2e-06	5.8	6.6	5.4e-11	-0.06	0.80	0.01	FALSE
11	GTEx	Colon Transverse	SH3YL1	0.36	0.25	lasso	7	0.26	1.2e-12	5.9	-6.4	1.7e-10	0.05	1.00	0.00	FALSE
30	GTEx	Whole Blood	SH3YL1	0.21	0.17	lasso	6	0.18	2.6e-16	6.0	-6.2	7.5e-10	0.06	1.00	0.00	FALSE
25	GTEx	Pancreas	SH3YL1	0.48	0.43	lasso	11	0.41	6.9e-19	6.0	-6.1	9.4e-10	0.06	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM150B	0.07	0.07	lasso	2	0.06	5.8e-07	6.0	-6.1	1.4e-09	0.07	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Esophageal Carcinoma	SH3YL1	0.16	0.02	blup	67	0.08	1.9e-03	5.8	-6.0	1.6e-09	0.03	0.01	0.93	FALSE
27	GTEx	Skin Sun Exposed Lower leg	SH3YL1	0.42	0.44	lasso	5	0.45	3.3e-41	5.9	-6.0	1.7e-09	0.06	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	SH3YL1	0.32	0.34	lasso	6	0.35	2.8e-21	6.0	-6.0	1.9e-09	0.07	0.01	0.99	FALSE
20	GTEx	Heart Left Ventricle	TMEM18	0.22	0.19	lasso	7	0.16	8.3e-09	-4.6	-5.9	2.8e-09	-0.16	0.99	0.00	FALSE
1	GTEx	Adipose Subcutaneous	SH3YL1	0.08	0.10	lasso	1	0.08	4.1e-07	5.9	5.9	2.9e-09	-0.06	1.00	0.00	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	SH3YL1	0.47	0.53	lasso	2	0.53	2.1e-33	5.9	-5.9	2.9e-09	0.06	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SH3YL1	0.16	0.04	blup	67	0.06	5.6e-07	6.0	-5.9	3.0e-09	0.03	0.01	0.99	FALSE
15	GTEx	Esophagus Muscularis	SH3YL1	0.30	0.23	enet	50	0.28	4.6e-17	5.9	5.9	3.1e-09	-0.05	1.00	0.00	FALSE
13	GTEx	Esophagus Mucosa	SH3YL1	0.60	0.67	lasso	4	0.66	9.2e-58	6.0	-5.9	3.5e-09	0.06	1.00	0.00	FALSE
22	GTEx	Muscle Skeletal	SH3YL1	0.12	0.10	lasso	3	0.09	4.1e-09	5.9	5.9	4.2e-09	-0.08	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	TMEM18	0.32	0.21	lasso	9	0.25	4.7e-20	-4.9	-5.9	4.3e-09	-0.20	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SH3YL1	0.24	0.25	lasso	4	0.25	8.1e-28	5.8	-5.9	4.4e-09	0.07	0.01	0.99	FALSE
29	GTEx	Thyroid	SH3YL1	0.29	0.32	lasso	4	0.31	2.9e-24	6.0	-5.8	4.8e-09	0.07	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SH3YL1	0.21	0.18	lasso	1	0.15	9.6e-07	5.8	-5.8	7.0e-09	0.07	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	SH3YL1	0.54	0.56	lasso	4	0.57	1.1e-67	6.0	-5.8	7.2e-09	0.07	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SH3YL1	0.20	0.05	blup	67	0.09	9.5e-06	6.0	-5.7	9.7e-09	0.05	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM18	0.11	0.01	blup	74	0.04	1.3e-03	-4.9	-5.7	1.0e-08	-0.21	0.11	0.04	FALSE
31	NTR	Blood	SH3YL1	0.12	0.17	lasso	5	0.16	6.2e-51	5.9	-5.7	1.1e-08	0.06	1.00	0.00	FALSE
9	GTEx	Artery Tibial	AC092159.2	0.38	0.24	lasso	5	0.30	5.6e-24	-4.8	-5.7	1.2e-08	-0.16	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	SH3YL1	0.19	0.31	lasso	5	0.32	2.5e-66	5.9	-5.7	1.3e-08	0.07	0.01	0.99	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	ACP1	0.03	0.04	lasso	2	0.02	4.7e-04	5.8	-5.6	2.2e-08	0.02	0.61	0.01	FALSE
4	GTEx	Adipose Visceral Omentum	SH3YL1	0.15	0.03	lasso	4	0.01	6.5e-02	4.7	5.5	3.1e-08	-0.02	0.17	0.04	FALSE
21	GTEx	Heart Left Ventricle	AC092159.2	0.35	0.24	lasso	6	0.23	2.3e-12	-4.6	-5.5	3.3e-08	-0.17	1.00	0.00	FALSE
10	GTEx	Colon Sigmoid	SH3YL1	0.20	0.14	lasso	3	0.14	1.3e-05	5.9	5.5	3.5e-08	-0.08	0.42	0.03	FALSE
6	GTEx	Artery Aorta	AC092159.2	0.29	0.19	enet	9	0.23	9.7e-13	-4.7	-5.5	3.7e-08	-0.16	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	SH3YL1	0.17	0.24	enet	15	0.24	5.8e-28	6.0	-5.5	4.0e-08	0.07	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SH3YL1	0.16	0.14	lasso	2	0.09	1.8e-03	5.9	-5.5	4.5e-08	0.07	0.01	0.93	FALSE
18	GTEx	Heart Atrial Appendage	TMEM18	0.26	0.16	lasso	7	0.09	5.0e-05	-4.9	-5.4	6.8e-08	-0.21	0.83	0.07	FALSE
5	GTEx	Artery Aorta	TMEM18	0.32	0.16	lasso	5	0.15	1.4e-08	-4.9	-5.4	7.5e-08	-0.17	1.00	0.00	FALSE
8	GTEx	Artery Tibial	TMEM18	0.35	0.08	enet	28	0.19	9.2e-15	-4.7	-5.3	9.3e-08	-0.17	1.00	0.00	FALSE
14	GTEx	Esophagus Mucosa	AC092159.2	0.27	0.18	enet	5	0.20	2.5e-13	-4.6	-5.3	1.0e-07	-0.16	1.00	0.00	FALSE
17	GTEx	Esophagus Muscularis	AC092159.2	0.26	0.16	enet	7	0.20	5.3e-12	-4.8	-5.3	1.1e-07	-0.29	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	AC092159.2	0.29	0.14	lasso	14	0.19	4.2e-15	-3.5	-5.3	1.2e-07	-0.15	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SH3YL1	0.11	0.10	lasso	5	0.10	4.5e-11	6.0	-5.3	1.3e-07	0.07	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	SH3YL1	0.19	0.21	enet	12	0.23	2.1e-16	5.9	-5.3	1.3e-07	0.05	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SH3YL1	0.32	0.27	enet	14	0.28	6.6e-14	5.9	-5.2	2.2e-07	0.07	0.01	0.99	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	SH3YL1	0.21	0.09	lasso	7	0.14	1.3e-05	2.2	5.2	2.3e-07	0.03	0.52	0.02	FALSE