[Hub]/) : Traits : Impedance of arm (left) :

chr2:15,703-1,384,725

Best TWAS P=2.76e-15 · Best GWAS P=5.05e-36 conditioned to 5.03e-21

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous SH3YL1 0.08 0.10 lasso 1 0.08 4.1e-07 5.9 5.9 2.9e-09 -0.06 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous TMEM18 0.32 0.21 lasso 9 0.25 4.7e-20 -4.9 -5.9 4.3e-09 -0.20 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous AC092159.2 0.29 0.14 lasso 14 0.19 4.2e-15 -3.5 -5.3 1.2e-07 -0.15 1.00 0.00 FALSE
4 GTEx Adipose Visceral Omentum SH3YL1 0.15 0.03 lasso 4 0.01 6.5e-02 4.7 5.5 3.1e-08 -0.02 0.17 0.04 FALSE
5 GTEx Artery Aorta TMEM18 0.32 0.16 lasso 5 0.15 1.4e-08 -4.9 -5.4 7.5e-08 -0.17 1.00 0.00 FALSE
6 GTEx Artery Aorta AC092159.2 0.29 0.19 enet 9 0.23 9.7e-13 -4.7 -5.5 3.7e-08 -0.16 1.00 0.00 FALSE
7 GTEx Artery Tibial SH3YL1 0.10 0.02 lasso 3 0.01 2.9e-02 5.9 7.9 2.8e-15 0.08 0.65 0.02 TRUE
8 GTEx Artery Tibial TMEM18 0.35 0.08 enet 28 0.19 9.2e-15 -4.7 -5.3 9.3e-08 -0.17 1.00 0.00 FALSE
9 GTEx Artery Tibial AC092159.2 0.38 0.24 lasso 5 0.30 5.6e-24 -4.8 -5.7 1.2e-08 -0.16 1.00 0.00 FALSE
10 GTEx Colon Sigmoid SH3YL1 0.20 0.14 lasso 3 0.14 1.3e-05 5.9 5.5 3.5e-08 -0.08 0.42 0.03 FALSE
11 GTEx Colon Transverse SH3YL1 0.36 0.25 lasso 7 0.26 1.2e-12 5.9 -6.4 1.7e-10 0.05 1.00 0.00 FALSE
12 GTEx Esophagus Gastroesophageal Junction SH3YL1 0.21 0.09 lasso 7 0.14 1.3e-05 2.2 5.2 2.3e-07 0.03 0.52 0.02 FALSE
13 GTEx Esophagus Mucosa SH3YL1 0.60 0.67 lasso 4 0.66 9.2e-58 6.0 -5.9 3.5e-09 0.06 1.00 0.00 FALSE
14 GTEx Esophagus Mucosa AC092159.2 0.27 0.18 enet 5 0.20 2.5e-13 -4.6 -5.3 1.0e-07 -0.16 1.00 0.00 FALSE
15 GTEx Esophagus Muscularis SH3YL1 0.30 0.23 enet 50 0.28 4.6e-17 5.9 5.9 3.1e-09 -0.05 1.00 0.00 FALSE
16 GTEx Esophagus Muscularis TMEM18 0.37 0.20 lasso 8 0.18 2.0e-11 -4.8 -6.2 5.8e-10 -0.26 1.00 0.00 TRUE
17 GTEx Esophagus Muscularis AC092159.2 0.26 0.16 enet 7 0.20 5.3e-12 -4.8 -5.3 1.1e-07 -0.29 1.00 0.00 FALSE
18 GTEx Heart Atrial Appendage TMEM18 0.26 0.16 lasso 7 0.09 5.0e-05 -4.9 -5.4 6.8e-08 -0.21 0.83 0.07 FALSE
19 GTEx Heart Left Ventricle SH3YL1 0.14 0.11 enet 16 0.10 8.2e-06 5.8 6.6 5.4e-11 -0.06 0.80 0.01 FALSE
20 GTEx Heart Left Ventricle TMEM18 0.22 0.19 lasso 7 0.16 8.3e-09 -4.6 -5.9 2.8e-09 -0.16 0.99 0.00 FALSE
21 GTEx Heart Left Ventricle AC092159.2 0.35 0.24 lasso 6 0.23 2.3e-12 -4.6 -5.5 3.3e-08 -0.17 1.00 0.00 FALSE
22 GTEx Muscle Skeletal SH3YL1 0.12 0.10 lasso 3 0.09 4.1e-09 5.9 5.9 4.2e-09 -0.08 1.00 0.00 FALSE
23 GTEx Nerve Tibial SH3YL1 0.33 0.23 enet 35 0.25 5.6e-18 5.9 6.9 3.9e-12 0.07 1.00 0.00 FALSE
24 GTEx Ovary SH3YL1 0.48 0.29 enet 18 0.34 3.2e-09 5.8 7.1 1.1e-12 0.13 0.67 0.03 FALSE
25 GTEx Pancreas SH3YL1 0.48 0.43 lasso 11 0.41 6.9e-19 6.0 -6.1 9.4e-10 0.06 1.00 0.00 FALSE
26 GTEx Skin Not Sun Exposed Suprapubic SH3YL1 0.47 0.53 lasso 2 0.53 2.1e-33 5.9 -5.9 2.9e-09 0.06 1.00 0.00 FALSE
27 GTEx Skin Sun Exposed Lower leg SH3YL1 0.42 0.44 lasso 5 0.45 3.3e-41 5.9 -6.0 1.7e-09 0.06 1.00 0.00 FALSE
28 GTEx Stomach SH3YL1 0.33 0.21 lasso 6 0.20 3.8e-10 5.8 -5.7 1.3e-08 0.05 1.00 0.00 TRUE
29 GTEx Thyroid SH3YL1 0.29 0.32 lasso 4 0.31 2.9e-24 6.0 -5.8 4.8e-09 0.07 1.00 0.00 FALSE
30 GTEx Whole Blood SH3YL1 0.21 0.17 lasso 6 0.18 2.6e-16 6.0 -6.2 7.5e-10 0.06 1.00 0.00 FALSE
31 NTR Blood SH3YL1 0.12 0.17 lasso 5 0.16 6.2e-51 5.9 -5.7 1.1e-08 0.06 1.00 0.00 FALSE
32 ROSMAP Brain Pre-frontal Cortex ACP1 0.03 0.04 lasso 2 0.02 4.7e-04 5.8 -5.6 2.2e-08 0.02 0.61 0.01 FALSE
33 ROSMAP Brain Pre-frontal Cortex FAM150B 0.06 0.01 bslmm 381 0.03 9.9e-05 -5.5 -7.1 1.7e-12 -0.05 0.40 0.02 FALSE
34 The Cancer Genome Atlas Breast Invasive Carcinoma SH3YL1 0.19 0.31 lasso 5 0.32 2.5e-66 5.9 -5.7 1.3e-08 0.07 0.01 0.99 FALSE
35 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma SH3YL1 0.32 0.27 enet 14 0.28 6.6e-14 5.9 -5.2 2.2e-07 0.07 0.01 0.99 FALSE
36 The Cancer Genome Atlas Colon Adenocarcinoma SH3YL1 0.32 0.34 lasso 6 0.35 2.8e-21 6.0 -6.0 1.9e-09 0.07 0.01 0.99 FALSE
37 The Cancer Genome Atlas Esophageal Carcinoma SH3YL1 0.16 0.02 blup 67 0.08 1.9e-03 5.8 -6.0 1.6e-09 0.03 0.01 0.93 FALSE
38 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SH3YL1 0.24 0.25 lasso 4 0.25 8.1e-28 5.8 -5.9 4.4e-09 0.07 0.01 0.99 FALSE
39 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SH3YL1 0.16 0.04 blup 67 0.06 5.6e-07 6.0 -5.9 3.0e-09 0.03 0.01 0.99 FALSE
40 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SH3YL1 0.20 0.05 blup 67 0.09 9.5e-06 6.0 -5.7 9.7e-09 0.05 0.01 0.99 FALSE
41 The Cancer Genome Atlas Brain Lower Grade Glioma FAM150B 0.07 0.07 lasso 2 0.06 5.8e-07 6.0 -6.1 1.4e-09 0.07 0.00 1.00 FALSE
42 The Cancer Genome Atlas Lung Adenocarcinoma SH3YL1 0.17 0.24 enet 15 0.24 5.8e-28 6.0 -5.5 4.0e-08 0.07 0.01 0.99 FALSE
43 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SH3YL1 0.11 0.10 lasso 5 0.10 4.5e-11 6.0 -5.3 1.3e-07 0.07 0.01 0.99 FALSE
44 The Cancer Genome Atlas Pancreatic Adenocarcinoma SH3YL1 0.21 0.18 lasso 1 0.15 9.6e-07 5.8 -5.8 7.0e-09 0.07 0.01 0.99 FALSE
45 The Cancer Genome Atlas Stomach Adenocarcinoma SH3YL1 0.19 0.21 enet 12 0.23 2.1e-16 5.9 -5.3 1.3e-07 0.05 0.01 0.99 FALSE
46 The Cancer Genome Atlas Stomach Adenocarcinoma TMEM18 0.11 0.01 blup 74 0.04 1.3e-03 -4.9 -5.7 1.0e-08 -0.21 0.11 0.04 FALSE
47 The Cancer Genome Atlas Thyroid Carcinoma SH3YL1 0.54 0.56 lasso 4 0.57 1.1e-67 6.0 -5.8 7.2e-09 0.07 0.01 0.99 FALSE
48 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma SH3YL1 0.16 0.14 lasso 2 0.09 1.8e-03 5.9 -5.5 4.5e-08 0.07 0.01 0.93 FALSE