TWAS hub - ACP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1318	0.0358	2.8e-07	0.072	NA	0.088	NA	0.112	2.5e-06	NA	2.2e-07	NA	4.4e-09
2	GTEx	Nerve Tibial	0.0740	0.0374	9.5e-03	0.003	NA	0.004	NA	0.009	2.0e-01	NA	1.5e-01	NA	7.0e-02
3	ROSMAP	Brain Pre-frontal Cortex	0.0338	0.0153	6.0e-03	0.040	0.015	0.021	0.017	0.023	6.7e-06	0.0045	8.4e-04	0.0026	4.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Myopia	6.2	9.0	13.3	3.6	0.8	3.6
Hair/balding pattern: Pattern 3	5.0	7.5	11.9	-3.5	-0.8	-3.1
Past tobacco smoking	4.9	9.0	13.0	-3.1	2.2	-3.6
Comparative height size at age 10	4.9	26.9	53.1	-5.2	1.0	-7.3
Eye problems/disorders: Cataract	4.8	5.6	9.5	-0.5	2.6	-3.1
Ever smoked	4.4	7.8	12.6	2.6	-1.9	3.5
Hayfever, allergic rhinitis or eczema	3.8	8.3	18.6	4.3	1.0	2.3
Fed-up feelings	3.5	6.4	11.0	3.3	-0.3	2.9
Pulse wave Arterial Stiffness index	3.5	4.1	6.5	-2.3	0.7	-2.5
Impedance of arm (right)	3.4	15.9	35.9	-2.5	2.4	-6.0
Knee pain experienced in last month	3.4	5.3	8.6	2.9	-0.7	2.6
Mood swings	3.4	6.1	9.5	2.9	-0.1	3.1
Smoking Status	3.3	7.9	12.0	3.5	-0.1	3.4
Miserableness	3.3	5.6	7.5	2.7	2.4	2.0
Neuroticism score	3.2	6.7	10.2	3.2	1.9	2.5
Impedance of arm (left)	3.2	14.7	31.4	-2.9	2.1	-5.6
Depressed Affect (Nagel 2018)	3.1	6.5	9.4	3.1	1.7	2.7
BMI	3.0	17.3	30.8	2.2	-4.0	5.5
Relative age of first facial hair	3.0	6.2	13.8	3.7	0.7	2.1
Age when periods started (menarche)	3.0	7.3	12.6	3.5	0.4	3.0
Hair/balding pattern: Pattern 2	3.0	3.8	6.7	2.6	0.2	2.2
Breastfed as a baby	2.9	3.6	5.1	-1.7	1.6	-2.3
Worry too long after embarrassment	2.9	4.8	7.5	2.7	1.8	1.9
Impedance of whole body	2.9	14.6	29.4	-2.2	3.1	-5.4
Alcohol intake versus 10 years previously	2.8	4.2	6.8	0.6	-2.6	2.3
Ever highly irritable/argumentative for 2 days	2.8	3.4	5.6	2.4	0.9	1.9
Irritability	2.8	4.7	7.9	2.5	0.3	2.8
HDL Cholesterol	2.7	4.5	6.6	-2.3	-1.3	-2.6
Relative age voice broke	2.7	4.2	7.8	2.8	2.0	0.9
Depression (self-reported)	2.7	3.2	6.4	2.5	0.3	1.8
Medication: Allopurinol	2.6	3.5	5.3	-2.2	-0.4	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.0	6.8	1.5	-0.1	2.6
Pulse wave peak to peak time	2.5	2.9	4.6	2.1	-0.6	1.9
Coronary Artery Disease (CAD)	2.4	2.9	4.2	-2.0	-2.1	-0.6
Allergy	2.4	5.5	12.7	-3.6	-0.8	-1.8
Hypothyroidism (self reported)	2.3	5.3	7.7	2.8	-1.4	2.5
Smoking status: Previous	2.3	3.4	4.5	1.6	-1.8	2.1
Risk taking	2.3	3.4	6.1	2.5	0.2	2.0
Impedance of leg (right)	2.2	10.6	19.8	-1.5	3.1	-4.5
Had other major operations	2.2	2.7	4.9	1.5	0.9	2.2
Father’s age at death	2.2	3.0	5.2	-1.9	0.0	-2.3
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	3.6	-1.5	-1.9	-1.5
Allergy or Eczema	2.1	5.4	11.3	3.4	0.7	2.1
Lung FVC	2.1	10.8	15.3	3.9	3.0	2.8
Neuroticism	2.1	5.1	7.4	2.7	1.2	2.5
Systolic blood pressure, automated reading	2.1	6.2	12.3	-3.5	-1.1	-2.2
Medication: Ventolin 100micrograms inhaler	2.1	2.7	4.9	2.2	1.7	0.5
Wears glasses or contact lenses	2.1	2.4	5.1	2.2	0.6	1.3
Height	2.0	38.5	92.5	-3.9	2.7	-9.6
Medication for hormone replacement therapy	2.0	2.2	3.5	1.5	1.0	1.9
Number of incorrect matches in round	2.0	3.3	7.7	-2.8	-1.1	-1.1
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	5.3	2.3	1.2	1.0
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	6.6	-0.8	0.8	-2.6
Medication: Ibuprofen	2.0	2.4	3.9	1.7	-0.7	2.0
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	4.7	2.2	0.8	0.9
Tinnitus: Yes, now most or all of the time	2.0	2.3	4.7	2.2	0.5	1.4
Neuroticism (Nagel 2018)	1.9	4.4	6.9	2.4	0.6	2.6
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	5.7	0.0	2.4	0.6
Body mass index (BMI)	1.9	8.1	13.8	0.8	-3.1	3.7
Suffer from ‘nerves’	1.9	3.0	6.4	2.5	1.1	1.1
Family relationship satisfaction	1.9	2.3	3.6	1.9	1.3	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.3	2.1	0.4	1.6
Alzheimer’s Disease (including proxy)	1.8	2.7	4.8	1.8	0.0	2.2
Triglycerides	1.8	2.9	4.9	1.7	-1.0	2.2
Impedance of leg (left)	1.8	8.8	16.2	-1.5	2.8	-4.0
Alcohol usually taken with meals	1.8	2.9	4.3	-2.1	-0.7	-1.9
Medication: Lisinopril	1.8	2.4	3.6	1.3	-1.3	1.9
Type 2 Diabetes (T2D) (2012)	1.7	2.0	5.0	-0.4	-2.2	0.9
Waist Hip Ratio (WHR)	1.7	7.4	11.9	-3.2	0.6	-3.5
Diabetes (father)	1.7	2.1	3.2	-1.8	0.2	-1.8
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.2	-2.1	-1.1	-0.6
Pain all over the body in last month	1.7	1.8	4.1	-2.0	-1.0	-0.6
Length of working week for main job	1.7	1.9	3.0	-1.5	-1.7	-0.5
Chest pain or discomfort	1.7	2.4	5.8	2.4	0.2	1.2
Medication: Paracetamol	1.7	2.6	4.3	1.8	0.4	2.1
Bipolar Disorder (2018)	1.6	2.5	4.8	-0.6	2.2	-1.6
Systolic Blood Pressure	1.6	8.0	13.6	-3.7	-0.1	-3.2
Stomach or abdominal pain in last month	1.6	1.9	2.9	-1.7	-1.3	-1.1
Had menopause	1.6	2.0	2.8	-1.1	1.4	-1.7
Standing height	1.6	16.1	43.3	-1.4	1.7	-6.6
Friendships satisfaction	1.6	2.0	2.8	1.4	1.1	1.7
Illnesses of father: High blood pressure	1.6	2.0	4.5	-2.1	0.3	-1.1
Breast Cancer	1.5	3.6	7.1	1.8	-0.7	2.7
Nervous feelings	1.5	2.7	5.0	2.2	0.6	1.7
Heart attack	1.5	2.0	2.5	1.4	-1.3	1.6
Pulse rate, automated reading	1.5	4.8	10.8	-3.3	-0.1	-1.9
Heart attack/myocardial infarction (self-reported)	1.5	2.0	2.4	1.3	-1.4	1.6
Hand grip strength (left)	1.4	3.6	7.5	2.7	0.8	1.6
Medication: Lansoprazole	1.4	1.6	3.5	1.1	1.9	-0.1
Illnesses of father: Heart disease	1.4	2.0	2.7	-1.3	-1.6	-1.2
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.0	1.7	0.3	1.5
Commuting to job workplace: Cycle	1.4	1.7	3.1	1.3	0.5	1.8
Multivitamins +/- minerals	1.3	1.6	2.4	0.2	-1.5	1.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	4.6	-0.4	-2.1	0.1
Happiness	1.3	1.5	3.8	0.5	1.9	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.1	3.7	1.9	1.2	1.1
Comparative body size at age 10	1.3	3.7	10.4	0.8	-0.2	3.2
Qualifications: nursing, teaching	1.3	2.1	2.6	-1.6	-1.6	-1.1
Type 2 Diabetes (T2D) (2018)	1.2	2.3	3.6	1.0	-1.5	1.9
Average weekly spirits intake	1.2	1.4	2.8	1.7	-0.1	1.2
Serious illness, injury or assault to yourself	1.2	1.4	3.7	0.6	1.9	0.5
Medication: Levothyroxine sodium	1.2	2.0	2.8	1.7	-1.1	1.4
Forced vital capacity (FVC)	1.2	4.8	8.6	2.9	2.4	0.3
Financial difficulties in last 2 years	1.2	1.6	2.5	1.5	0.1	1.6
Glaucoma (self-reported)	1.2	1.4	2.2	-1.5	-1.1	-0.9
Medication: Amlodipine	1.2	1.7	3.8	-1.1	0.5	-2.0
Breast cancer (self-reported)	1.2	1.4	2.6	-1.2	0.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	3.6	1.9	1.3	1.6
Ever taken oral contraceptive pill	1.2	1.3	2.8	-1.1	0.1	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.6	1.9	-0.3	0.9
Body Mass Index (BMI) (2010)	1.1	1.5	2.9	0.4	-1.2	1.7
Maternal smoking around birth	1.1	1.6	2.8	1.7	-0.4	1.4
Medication: Ramipril	1.1	1.4	2.3	-1.4	0.2	-1.5
Pulse rate	1.1	1.8	3.6	-1.9	0.8	-1.0
Medication: Paracetamol	1.1	1.9	3.6	1.4	0.3	1.9
Supplements: Zinc	1.0	1.1	2.8	0.6	1.7	-0.3
Pack years adult smoking proportion	1.0	1.6	2.3	1.4	0.6	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	4.6	0.9	-1.1	2.1
Chronic bronchitis/emphysema (father)	1.0	1.2	2.0	1.4	-0.4	1.2
Hair/balding pattern: Pattern 4	1.0	2.5	5.4	-2.3	0.3	-1.4
Headache pain in last month	1.0	1.7	3.2	1.2	1.8	0.6
Mean time to correctly identify matches	1.0	1.8	3.9	-2.0	-1.2	-0.3
Commuting to job workplace: Walk	1.0	1.1	2.8	-0.8	0.2	-1.7
Medication: Gliclazide	1.0	1.1	3.3	-0.1	-1.8	0.2
Eye problems/disorders: Glaucoma	1.0	1.2	3.4	-0.1	-1.8	0.2
Average weekly beer plus cider intake	1.0	1.4	1.6	1.3	1.0	1.2
Heart disease (siblings)	1.0	1.3	1.8	1.0	1.0	1.3
Depression (Nagel 2018)	0.9	1.3	2.0	0.9	1.4	1.2
Major Depression (MDD)	0.9	1.0	1.5	1.2	-1.1	0.7
Blood Platelet Count	0.9	9.9	19.2	-3.2	0.1	-4.4
Sensitivity / hurt feelings	0.9	1.6	4.3	0.6	-0.0	2.1
High blood pressure (mother)	0.9	1.3	2.2	-1.3	-0.1	-1.5
Time employed in main current job	0.9	1.0	2.0	-0.7	0.7	-1.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.7	1.6	-0.6	1.4
Smoking status: Current	0.9	1.5	2.5	1.6	0.4	1.4
Leg fat percentage (left)	0.9	3.3	6.2	-0.3	-2.5	1.9
Unable to work because of sickness or disability	0.9	1.2	2.1	0.9	1.5	0.7
Basal cell carcinoma (self-reported)	0.9	1.1	1.7	-0.0	1.2	-1.3
Alcohol drinker status: Previous	0.9	1.0	2.0	0.2	1.4	1.0
Bipolar Disorder or Schizophrenia	0.8	2.0	3.0	-0.2	1.7	-1.7
Reaction Time	0.8	1.6	3.2	-1.8	-1.0	-0.6
Rheumatoid Arthritis	0.8	1.2	2.0	1.2	1.4	0.3
Medication: Metformin	0.8	1.1	2.1	-0.1	-1.5	1.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.8	2.4	1.6	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.3	1.2	-0.6	1.2
Arm fat mass (right)	0.8	3.1	7.0	-0.1	-2.6	1.5
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.5	0.3	1.6	0.6
High blood pressure (siblings)	0.8	1.2	2.1	-1.4	0.2	-1.2
Forced vital capacity (FVC), Best measure	0.8	2.9	4.6	2.0	2.1	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.4	1.2	0.5	1.2
Medication: Seretide 50 evohaler	0.8	0.9	1.7	1.0	-0.0	1.3
Arm fat percentage (left)	0.8	3.0	6.5	-0.6	-2.5	1.5
Mineral and other dietary supplements	0.8	1.1	1.5	1.0	0.8	1.2
Osteoporosis (self-reported)	0.8	1.0	1.9	0.6	1.4	-0.9
Arm fat mass (left)	0.8	3.3	7.5	-0.1	-2.7	1.6
Leg fat mass (left)	0.8	3.3	6.9	0.1	-2.6	1.7
Alzheimer’s Disease (in mother)	0.7	0.8	0.9	0.9	-0.9	0.8
Mean Putamen Volume	0.7	0.8	1.2	-1.1	-0.4	-1.0
Number of treatments/medications taken	0.7	1.2	2.6	0.7	0.7	1.6
Vitamin and mineral supplements	0.7	0.9	1.6	0.2	1.3	-1.1
Arm fat percentage (right)	0.7	2.8	6.2	-0.6	-2.5	1.3
Mouth/teeth dental problems: Dentures	0.7	1.2	3.3	1.8	-0.2	0.3
Blood clot in the leg (DVT)	0.7	1.0	2.3	1.5	-0.5	0.6
Birth weight	0.7	1.6	2.8	1.7	1.2	0.8
Eye problems/disorders: None of the above	0.7	0.9	1.9	0.7	0.4	1.4
Hypertension (Self-reported)	0.7	1.8	3.0	-1.7	-1.6	-0.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.2	0.4	-1.5	0.4
Mother’s age at death	0.7	0.8	2.3	-0.1	1.5	-0.3
Ever depressed for a whole week	0.7	0.9	1.7	-0.9	0.5	-1.3
Cholesterol lowering medication	0.7	1.0	1.7	-1.3	-0.1	-1.1
Primary Biliary Cirrhosis	0.6	0.8	1.0	-0.8	-1.0	-0.8
Blood Eosinophil Count	0.6	4.6	7.1	2.6	-0.4	2.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.6	0.4	-1.3	0.5
High blood pressure	0.6	1.7	2.9	-1.7	-1.4	-0.3
Medication: Atenolol	0.6	0.7	1.4	0.4	-0.7	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.0	0.9	0.4	1.4
Exposure to tobacco smoke at home	0.6	0.7	1.6	0.6	-0.5	1.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.7	1.6	-0.1	0.4
Leg fat percentage (right)	0.6	2.3	4.2	-0.2	-2.0	1.6
Health satisfaction	0.6	0.7	1.1	-0.8	1.0	-0.6
Neck or shoulder pain in last month	0.6	0.9	2.1	-0.6	-1.4	0.5
Leg fat mass (right)	0.6	2.4	5.2	0.1	-2.3	1.4
Alcohol intake frequency.	0.6	1.4	2.1	-0.9	-1.5	1.2
Had major operations	0.6	0.7	1.1	0.6	1.1	0.8
Loneliness, isolation	0.6	0.9	1.6	0.3	1.2	1.0
Diabetes diagnosed by doctor	0.6	1.1	2.3	0.3	-0.9	1.5
Medication: Bendroflumethiazide	0.6	0.9	2.2	-0.7	0.2	-1.5
Pack years of smoking	0.6	0.9	1.8	0.9	0.3	1.3
Schizophrenia vs Biploar Disorder	0.5	0.6	0.9	-1.0	0.4	-0.9
Crohns Disease (2017)	0.5	1.0	1.5	1.0	1.2	-0.8
Ovarian Cancer	0.5	0.6	1.6	-0.2	0.5	-1.3
Crohns Disease (2012)	0.5	0.8	2.2	1.5	0.3	0.1
HbA1C	0.5	0.5	1.2	-1.1	-0.5	0.3
Schizophrenia (2014)	0.5	1.1	2.6	0.0	0.9	-1.6
Ulcerative Colitis	0.5	0.8	1.7	-0.3	0.7	-1.3
Heel T-Score	0.5	4.1	10.6	1.3	0.2	3.3
Chronotype (morning person)	0.5	1.1	1.5	-1.2	1.0	-0.8
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.2	0.6	0.8	1.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.3	0.6	0.4	1.1
Trunk fat percentage	0.5	1.8	2.4	-1.6	-1.5	-0.9
Current tobacco smoking	0.5	0.9	1.3	1.1	0.2	1.2
Hearing difficulty/problems with background noise	0.5	0.7	1.2	0.3	-1.1	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.8	-0.0	-0.9	1.7
Diabetes (self-reported)	0.5	0.8	1.8	-0.2	-0.7	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.0	1.4	1.7	-0.2
Gout (self-reported)	0.5	0.7	1.2	-0.9	0.2	-1.1
Exposure to tobacco smoke outside home	0.5	0.7	1.2	1.1	0.5	0.8
Shortness of breath walking on level ground	0.5	0.6	1.2	1.1	0.9	0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	-0.1	-1.1	0.7
Whole body fat mass	0.5	1.9	5.1	-0.8	-2.2	0.2
Leg pain on walking	0.5	0.6	1.1	0.4	-1.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.9	-0.8	0.4	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	2.0	0.3	0.9	-1.4
Average weekly champagne plus white wine intake	0.5	0.7	1.4	1.2	-0.5	0.6
Number of operations (self-reported)	0.5	0.8	1.2	-0.1	-1.1	1.1
Diastolic blood pressure, automated reading	0.5	1.5	3.2	-0.6	-1.0	1.8
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.4	1.6	1.3	0.5
Prostate Cancer	0.4	0.5	0.8	0.9	0.8	0.3
Age at First Birth	0.4	0.5	0.7	0.5	0.9	0.8
Bipolar Disorder (2011)	0.4	0.3	0.7	0.5	0.8	-0.4
Blood Red Count	0.4	4.2	6.7	-2.6	-2.3	-0.7
Lung FEV1/FVC ratio	0.4	2.2	3.8	-2.0	-1.0	-1.4
Angina	0.4	0.6	0.9	-0.9	-0.7	-0.5
Average weekly fortified wine intake	0.4	0.5	0.7	-0.8	-0.7	-0.4
Taking other prescription medications	0.4	0.7	0.8	0.9	0.6	0.9
Trunk fat mass	0.4	1.9	3.7	-1.2	-1.9	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.8	-0.9	0.8	-0.4
Qualifications: None of the above	0.4	0.8	1.8	0.2	0.7	1.3
Fluid intelligence score	0.4	0.8	1.3	1.1	0.3	1.0
Noisy workplace	0.4	0.5	0.8	0.6	0.9	0.7
Number of full brothers	0.4	0.5	0.9	0.3	0.8	-0.9
Guilty feelings	0.4	0.6	1.3	0.5	-0.3	1.1
Hearing aid user	0.4	0.4	1.0	0.4	1.0	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.2	-1.0	-0.7
Age started oral contraceptive pill	0.4	0.4	1.2	0.3	1.1	0.1
Worry (Nagel 2018)	0.3	0.6	1.6	1.3	0.0	0.6
LDL Cholesterol	0.3	0.5	1.0	-0.6	0.0	-1.0
Lupus	0.3	0.4	1.0	0.3	-1.0	-0.4
Neuroticism (2016)	0.3	0.4	0.9	0.5	1.0	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	0.2	0.3	0.9
Medication: Co-codamol	0.3	0.3	0.9	0.1	-0.2	1.0
Townsend deprivation index at recruitment	0.3	0.4	0.6	0.8	0.5	0.6
Qualifications: CSEs or equivalent	0.3	0.3	0.5	0.6	0.2	0.7
Sitting height	0.3	2.3	4.4	1.2	1.1	-2.1
Leg predicted mass (left)	0.3	1.3	3.5	0.5	-1.9	0.5
Waist circumference	0.3	1.0	2.4	-0.6	-1.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	0.3	1.1	0.5
Mouth/teeth dental problems	0.3	0.4	0.8	-0.4	0.6	0.9
Weight	0.3	1.4	3.6	0.3	-1.9	0.7
Number of live births	0.3	0.5	1.0	1.0	0.7	-0.0
Medication: Cholesterol lowering	0.3	0.5	1.1	-1.1	-0.4	0.3
Pulse wave reflection index	0.3	0.4	0.6	-0.2	-0.8	-0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.3	1.1	0.5	-0.3
Body fat percentage	0.3	1.3	3.1	-0.8	-1.8	0.4
Arm fat-free mass (right)	0.3	1.5	2.3	1.0	-1.5	1.1
Wheeze or whistling in the chest in last year	0.3	0.5	0.8	-0.7	0.9	-0.3
Number of children fathered	0.3	0.3	0.6	-0.8	-0.5	-0.4
Age at first live birth	0.3	0.5	0.8	-0.2	0.9	0.8
Medication for pain relief, constipation, heartburn	0.3	0.6	1.4	0.0	-0.6	-1.2
Medication: Blood pressure	0.3	0.5	1.2	-1.1	-0.5	-0.3
Angina (self-reported)	0.3	0.4	0.7	-0.8	-0.5	-0.5
Arm predicted mass (right)	0.3	1.5	2.2	1.0	-1.5	1.1
Medication: Aspirin	0.3	0.4	0.8	-0.6	0.9	-0.4
Supplements: Vitamin C	0.3	0.3	0.9	-0.1	-0.9	-0.1
Illnesses of siblings: Diabetes	0.3	0.4	0.8	0.9	-0.4	0.3
Leg fat-free mass (right)	0.3	1.4	3.3	0.6	-1.8	0.6
Ever had bowel cancer screening	0.3	0.4	0.7	-0.6	-0.0	-0.9
Medication for cholesterol	0.3	0.4	1.2	0.2	-0.1	-1.1
Osteoarthritis (self-reported)	0.3	0.3	0.6	0.2	-0.7	0.7
Leg predicted mass (right)	0.3	1.4	3.4	0.6	-1.8	0.6
Financial situation satisfaction	0.3	0.4	0.9	0.5	0.3	0.9
Basal metabolic rate	0.3	1.5	3.3	0.9	-1.8	0.6
Arm fat-free mass (left)	0.3	1.4	2.5	0.9	-1.6	0.9
Pain experienced in last month	0.3	0.6	1.2	-0.5	0.5	-1.1
Arm predicted mass (left)	0.3	1.8	2.5	1.2	-1.6	1.2
Schizophrenia (2018)	0.2	0.3	0.8	0.3	0.4	-0.9
Alzheimer’s Disease (in father)	0.2	0.2	0.5	0.2	0.7	0.2
Irritable Bowel Disease (IBD)	0.2	0.4	0.9	0.3	0.4	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.4	1.2	0.1	0.6
Blood White Count	0.2	1.2	1.5	-1.0	-1.2	-1.1
Cardiovascular Disease	0.2	0.7	1.3	-1.2	-0.6	0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.9	0.2	-0.1
Leg fat-free mass (left)	0.2	1.3	3.3	0.6	-1.8	0.5
Hand grip strength (right)	0.2	0.5	1.2	1.1	0.2	0.6
Supplements: Glucosamine	0.2	0.3	0.4	-0.6	-0.3	-0.6
Trunk fat-free mass	0.2	1.1	2.1	1.0	-1.5	0.3
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	-0.3	-0.1	-1.2
Prospective memory result	0.2	0.2	0.4	-0.6	-0.6	0.2
Lung cancer (father)	0.2	0.3	0.3	-0.6	0.6	-0.4
Trunk predicted mass	0.2	1.2	2.0	1.2	-1.4	0.4
Loud music exposure frequency	0.2	0.2	0.4	-0.6	0.1	-0.3
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.6	0.4	-0.1
Migraine (self-reported)	0.2	0.2	0.5	-0.7	-0.2	0.4
Medication: Omeprazole	0.2	0.2	0.3	0.5	0.3	0.6
Overall health rating	0.2	0.5	0.7	-0.8	-0.7	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	0.5	0.4	0.6
Whole body fat-free mass	0.2	1.4	2.9	1.0	-1.7	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.5	-0.8	-0.0
Back pain experienced in last month	0.2	0.3	0.6	0.5	-0.3	0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	0.5	0.3	0.7	0.6
Whole body water mass	0.2	1.3	2.9	0.9	-1.7	0.5
Medication: Blood pressure	0.2	0.5	1.0	-0.6	-1.0	0.3
Alcohol drinker status: Never	0.2	0.2	0.4	-0.1	0.4	-0.6
Supplements: Calcium	0.2	0.2	0.3	0.6	0.4	-0.1
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.7	0.4	0.6	-0.9
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.0	-0.4	-0.6
Fasting Glucose	0.1	0.1	0.2	0.2	-0.2	0.4
Hair Pigment	0.1	2.3	3.4	-1.8	0.9	-1.6
Tanning	0.1	1.2	3.0	-0.8	-1.7	-0.2
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	-0.6	-0.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	0.1	0.3	0.4
Medication: Simvastatin	0.1	0.1	0.3	-0.1	-0.1	0.5
Illnesses of siblings	0.1	0.1	0.3	0.3	0.5	-0.1
Hip circumference	0.1	0.6	1.1	0.6	-1.1	0.6
Worrier / anxious feelings	0.1	0.3	0.5	0.1	0.7	-0.5
Falls in the last year	0.1	0.1	0.4	-0.1	-0.6	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.4	0.5	0.0
Asthma	0.1	0.1	0.3	0.6	0.3	0.1
Tense / ‘highly strung’	0.1	0.1	0.3	0.1	-0.2	-0.5
Peak expiratory flow (PEF)	0.1	0.2	0.5	0.7	-0.3	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.5	0.1	-0.2
Qualifications: College or University degree	0.1	0.2	0.3	-0.6	0.1	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	0.3	-0.3	-0.3
Number of full sisters	0.1	0.1	0.3	0.3	-0.6	0.2
Average weekly red wine intake	0.1	0.2	0.4	0.6	0.3	-0.3
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.5	-0.1	0.0
Asthma (self-reported)	0.1	0.2	0.3	0.5	0.5	0.0
Medication: Aspirin	0.1	0.2	0.5	-0.3	0.7	-0.0
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.1	0.5	0.3
Commuting to job workplace: Public transport	0.1	0.1	0.1	0.1	0.2	-0.4
High cholesterol (Self-reported)	0.1	0.1	0.4	-0.6	-0.2	-0.0
Medication: Atorvastatin	0.1	0.1	0.1	-0.4	-0.3	-0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.2	-0.4	-0.1
Fractured/broken bones in last 5 years	0.1	0.2	0.3	-0.6	-0.3	-0.4
Respiratory disease	0.0	0.1	0.1	0.3	0.3	-0.1
Diabetes (mother)	0.0	0.0	0.1	-0.1	-0.2	-0.1
Severe depression (siblings)	0.0	0.0	0.0	-0.1	0.2	0.0
Illnesses of mother	0.0	0.0	0.1	0.2	0.3	-0.1
Birth weight of first child	0.0	0.1	0.2	-0.1	-0.5	-0.0
Heart disease (mother)	0.0	0.0	0.1	0.3	-0.1	-0.0
Age at last live birth	0.0	0.0	0.1	-0.2	-0.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.2	0.0	0.1

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