TWAS
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Models
Genes
Traits
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Traits
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Impedance of arm (left)
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chr2:55,401,562-56,843,605
Best TWAS P=2.05e-11 · Best GWAS P=3.26e-20 conditioned to 0.000811
55.4M
55.6M
55.8M
56M
56.2M
56.4M
56.6M
56.8M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Frontal Cortex BA9
EFEMP1
0.19
0.10
lasso
8
0.08
3.7e-03
-7.4
-6.7
2.1e-11
0.78
0.04
0.69
TRUE
2
GTEx
Cells Transformed fibroblasts
EFEMP1
0.11
0.00
enet
22
0.05
1.1e-04
3.4
-6.0
1.4e-09
0.39
0.16
0.57
TRUE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
EFEMP1
0.02
0.01
blup
79
0.02
3.9e-05
-9.2
5.3
1.5e-07
-0.73
0.00
1.00
FALSE