Hub : Genes

EFEMP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3060	0.0510	0.0e+00	0.075	0.226	0.236	0.238	0.238	1.9e-09	4.3e-27	2.3e-28	1.4e-28	1.4e-28
2	GTEx	Brain Frontal Cortex BA9	0.1883	0.0755	9.9e-03	0.099	NA	0.035	NA	0.081	1.4e-03	NA	4.1e-02	NA	3.7e-03
3	GTEx	Cells Transformed fibroblasts	0.1120	0.0370	1.1e-04	-0.003	NA	0.051	NA	0.021	6.6e-01	NA	1.1e-04	NA	9.4e-03
4	METSIM	Adipose	0.0305	0.0156	1.5e-02	0.005	0.004	0.001	0.004	0.014	4.6e-02	7.6e-02	2.1e-01	8.1e-02	2.8e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.2945	0.0499	0.0e+00	0.135	0.159	0.194	0.174	0.184	6.5e-17	6.7e-20	2.2e-24	9.1e-22	4.6e-23
6	TCGA	Breast Invasive Carcinoma	0.0201	0.0089	5.5e-05	0.006	0.020	0.017	NA	0.015	1.6e-02	3.9e-05	1.5e-04	NA	3.7e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.3	0.4	-1.0	1.1	-0.3	0.0	-0.6
Bipolar Disorder or Schizophrenia	0.5	1.1	5.3	-0.3	-2.3	0.8	-0.3	-0.8	0.3
Depressed Affect (Nagel 2018)	0.3	0.7	2.1	1.4	-0.6	1.0	0.5	-0.4	0.2
Depression (Nagel 2018)	0.7	1.0	1.7	0.7	0.9	1.3	1.2	0.4	-1.2
Intelligence (Savage-Jansen 2018)	0.8	2.4	3.4	-1.8	-1.8	-0.1	1.7	-1.3	1.7
Neuroticism (Nagel 2018)	0.4	0.9	3.2	0.9	-0.5	1.8	1.0	0.3	-0.1
Schizophrenia (2018)	0.6	1.2	4.6	-0.7	-2.1	0.0	-0.2	-1.1	1.0
Schizophrenia vs Biploar Disorder	0.3	0.5	1.1	-0.3	-0.9	-0.1	0.8	-0.2	1.1
Worry (Nagel 2018)	1.1	2.3	8.1	0.8	1.3	2.8	0.8	1.4	-0.9
Alzheimer’s Disease (in mother)	1.1	1.3	3.8	0.4	-2.0	-1.1	-1.5	0.6	-0.1
Alzheimer’s Disease (in father)	2.0	2.2	6.2	2.5	-0.2	0.2	-0.3	2.1	-1.5
Alzheimer’s Disease (including proxy)	1.1	1.5	2.7	1.6	-1.4	-0.5	-1.1	1.4	-1.1
Crohns Disease (2017)	0.4	0.8	2.2	-0.5	-1.4	-0.4	-0.5	-1.5	-0.5
Irritable Bowel Disease (IBD)	1.2	2.8	7.2	-0.6	-1.9	-2.7	-2.1	-0.7	-0.9
Ulcerative Colitis (UC)	2.3	4.4	14.6	-0.6	-1.5	-3.8	-3.0	-0.1	-0.7
Major Depression (MDD)	0.3	0.4	1.1	0.7	-0.7	-1.0	0.1	0.1	-0.2
Reaction Time	0.2	0.3	0.8	0.6	-0.5	-0.4	-0.9	-0.6	0.2
Verbal and Numeric Reasoning (VNR)	1.3	3.0	9.0	-3.0	-1.7	-0.2	2.1	-1.0	0.9
Breast Cancer	0.0	0.1	0.2	-0.3	0.4	0.1	-0.4	-0.2	-0.5
Ovarian Cancer	2.5	3.3	8.1	1.9	-1.4	-2.9	-2.0	1.1	-0.5
Prostate Cancer	0.3	0.4	0.8	0.7	0.5	0.1	-0.6	0.5	-0.9
Age at First Birth	0.3	0.5	1.8	-0.7	0.1	0.3	-0.2	-1.4	0.5
Bipolar Disorder (2011)	0.8	0.8	2.8	-1.7	0.5	0.9	-0.1	-1.0	0.3
Body Mass Index (BMI) (2010)	0.3	0.5	1.7	0.6	0.2	0.5	1.3	0.6	-0.3
Coronary Artery Disease (CAD)	0.7	0.8	3.6	1.9	0.8	0.0	0.2	0.9	0.1
Crohns Disease (2012)	1.4	2.2	6.2	-1.4	-1.5	-1.6	-0.5	-2.5	0.5
Mean Putamen Volume	0.4	0.5	1.1	-0.4	-0.2	0.5	0.7	-1.1	-0.8
Fasting Glucose	1.9	2.3	7.1	1.7	0.1	-0.4	-0.9	2.7	-1.6
HbA1C	0.1	0.1	0.6	-0.0	0.1	-0.8	-0.2	-0.2	-0.0
HDL Cholesterol	0.6	1.0	4.9	0.3	2.2	0.1	0.3	0.9	-0.4
LDL Cholesterol	0.2	0.4	1.1	0.4	1.1	-0.1	-0.6	0.5	-0.5
Lupus	1.5	2.2	4.3	-1.3	-0.3	1.3	1.9	-2.1	1.4
Neuroticism (2016)	0.2	0.2	0.7	0.1	0.9	0.7	-0.3	0.0	-0.3
Primary Biliary Cirrhosis	0.3	0.4	0.9	-0.4	-0.5	0.3	-0.9	0.4	0.9
Rheumatoid Arthritis	0.4	0.6	3.0	0.1	0.2	-0.2	-0.0	-1.7	0.6
Schizophrenia (2014)	1.0	2.1	8.2	-0.8	-2.9	0.3	0.6	-1.2	1.4
Triglycerides	0.2	0.3	0.6	0.5	-0.5	-0.8	-0.6	-0.1	-0.5
Type 2 Diabetes (T2D) (2012)	1.2	1.3	3.3	-0.7	-1.7	-0.5	-0.6	-1.8	0.9
Ulcerative Colitis	1.2	1.7	3.4	-1.5	-1.8	-1.6	-0.4	-1.0	1.0
Blood Eosinophil Count	0.2	1.4	5.9	0.0	-1.2	-0.5	0.4	-0.7	2.4
Blood Platelet Count	0.1	1.5	4.2	2.1	1.2	-0.9	0.5	0.7	1.3
Blood Red Count	0.8	7.5	17.2	-3.0	-0.4	3.0	4.1	-1.3	2.7
Blood White Count	0.2	1.5	5.5	0.6	2.3	-1.7	-0.5	0.4	-0.4
Heel T-Score	0.3	2.5	8.1	-2.8	-0.7	-0.1	0.7	-1.8	1.7
BMI	0.5	2.7	5.2	-0.2	2.0	2.3	1.8	-0.1	-1.9
Height	16.8	324.5	954.8	-5.9	-30.9	-18.2	-8.9	-16.1	17.0
Waist Hip Ratio (WHR)	0.2	0.9	2.7	0.6	-1.6	1.5	0.2	0.2	0.3
Systolic Blood Pressure	3.0	15.2	26.3	1.1	4.5	5.1	3.1	4.4	-3.8
Smoking Status	0.5	1.1	3.3	-0.7	0.5	-0.8	-1.4	-0.3	-1.8
Allergy or Eczema	1.1	2.9	11.2	-0.9	0.3	1.4	3.4	-0.3	1.8
Cardiovascular Disease	0.7	2.3	5.9	0.9	1.3	1.8	0.7	1.3	-2.4
Hypothyroidism (self reported)	1.1	2.5	10.2	1.5	0.3	3.2	1.5	0.1	-0.3
Respiratory disease	0.3	0.8	2.3	1.5	0.7	0.9	0.1	1.0	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.3	1.0	0.3	1.0	0.4	0.4	0.3	-0.4
Lung FEV1/FVC ratio	4.6	23.5	66.3	1.0	7.0	0.1	-3.2	3.8	-8.1
Lung FVC	14.1	71.7	158.8	-6.3	-11.0	-3.4	3.5	-9.3	12.6
Neuroticism	0.6	1.5	4.0	2.0	0.5	1.4	-0.4	1.0	-1.2
Chronotype (morning person)	0.9	2.2	8.9	1.3	-0.2	3.0	1.5	0.3	-0.2
Hair Pigment	0.1	2.4	11.6	3.4	0.4	-0.7	-0.7	0.9	-0.6
Tanning	0.3	4.2	12.3	-2.7	-1.2	0.1	1.9	-3.5	1.0
Hand grip strength (left)	1.6	4.1	10.8	-1.2	-3.3	-2.5	-0.6	-1.9	1.5
Number of treatments/medications taken	0.3	0.6	2.7	0.1	0.2	1.6	0.5	-0.5	0.6
Average weekly spirits intake	0.7	0.9	2.6	1.6	-0.0	0.2	-1.4	0.9	-0.1
Sensitivity / hurt feelings	0.3	0.5	1.7	-0.1	-1.3	-0.3	0.0	-0.8	0.7
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.3	0.6	1.0	0.0	-0.4	-0.2	-1.1
Hearing difficulty/problems: Yes	0.6	1.0	2.8	-1.0	-1.1	-0.7	0.3	-1.7	0.4
Relative age of first facial hair	1.9	4.0	8.3	1.1	2.6	0.7	-1.4	2.2	-2.9
Other serious medical condition/disability diagnosed by doctor	2.1	2.8	5.8	-1.4	-2.0	-1.1	0.6	-1.8	2.4
Ever used hormone-replacement therapy (HRT)	1.4	1.7	4.5	-1.6	-0.9	0.4	1.0	-2.1	1.2
Ever had hysterectomy (womb removed)	1.4	1.6	5.7	-0.5	-2.4	-0.5	-0.2	-1.5	0.9
Systolic blood pressure, automated reading	4.3	12.5	25.1	0.7	4.2	5.0	3.2	3.4	-3.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.5	-0.6	0.6	-0.5	-1.2	0.1	1.1
Angina	1.5	2.0	5.1	0.7	2.3	1.6	1.7	0.8	0.3
Medication for hormone replacement therapy	1.5	1.6	5.0	-2.2	-0.6	-0.9	1.1	-1.2	1.0
Vitamin and mineral supplements	0.5	0.7	2.5	0.4	1.6	0.7	0.7	0.6	-0.3
Supplements: Zinc	0.1	0.1	0.2	0.3	0.2	0.3	-0.4	-0.2	-0.3
Medication: Co-codamol	0.3	0.4	0.9	-0.6	-0.6	-0.7	0.2	-1.0	-0.1
Medication: Metformin	0.3	0.4	0.8	-0.2	0.6	0.9	0.6	-0.9	0.1
Diabetes (father)	0.7	0.9	1.4	1.0	0.7	1.0	-0.7	1.2	-1.0
Diabetes (mother)	3.0	3.8	9.8	2.2	3.1	1.6	-0.8	1.4	-1.9
Severe depression (siblings)	1.5	1.6	4.7	-1.3	-0.6	1.5	2.2	-0.7	0.7
Pack years adult smoking proportion	0.6	0.9	2.0	1.4	0.9	0.7	-0.6	1.2	-0.6
Impedance of leg (right)	0.9	4.5	15.2	-0.7	-3.0	-1.0	0.2	-1.2	3.9
Leg fat-free mass (left)	4.9	25.8	75.0	-2.6	-8.7	-4.7	-2.8	-5.7	3.3
Trunk fat percentage	2.3	9.4	22.0	-1.2	-4.7	-2.9	-1.8	-3.9	2.5
Hand grip strength (right)	1.1	3.0	10.8	-1.4	-3.3	-1.7	-0.2	-1.4	0.6
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.7	0.1	0.7	-0.3	0.1	-0.1
Current tobacco smoking	0.7	1.1	2.3	0.3	1.1	-0.8	-1.1	1.1	-1.5
Average weekly fortified wine intake	0.4	0.5	0.9	-0.6	-0.4	-0.8	-0.1	-0.9	0.8
Maternal smoking around birth	0.2	0.2	1.0	0.1	-1.0	0.2	-0.2	-0.6	-0.3
Fed-up feelings	0.3	0.6	2.7	1.6	-0.2	-0.2	-0.5	-0.7	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.7	0.6	0.8	0.7	0.1	0.5	-1.3
Relative age voice broke	0.7	1.0	3.9	-0.0	0.8	-0.6	-0.8	0.9	-2.0
Taking other prescription medications	0.3	0.5	1.5	1.2	-0.1	-0.2	0.4	-0.5	1.0
Age when periods started (menarche)	0.2	0.6	2.1	-0.8	1.4	-0.5	-0.4	-0.0	-0.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	-1.2	-0.9	0.1	0.8	-0.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.7	-1.3	-1.6	0.1	0.8	-0.3	0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	-0.9	-0.8	0.4	0.0	-0.5	0.4
Qualifications: CSEs or equivalent	1.6	2.2	5.0	-0.9	0.9	1.9	2.2	-1.1	1.3
Serious illness, injury or assault to yourself	1.1	1.4	3.3	1.8	-0.8	-1.8	-1.0	0.2	-0.3
High blood pressure	1.8	5.0	14.3	1.4	2.2	2.4	0.5	1.7	-3.8
Hayfever, allergic rhinitis or eczema	2.5	5.5	15.0	-2.6	0.8	1.8	3.9	-1.4	2.4
Multivitamins +/- minerals	0.3	0.4	1.5	-0.0	-1.2	-0.3	0.1	-0.6	0.4
Stomach or abdominal pain in last month	0.3	0.4	1.9	0.1	-0.7	-0.3	-0.0	-0.3	1.4
Supplements: Glucosamine	3.7	4.8	7.2	-1.8	-2.5	0.6	2.3	-2.7	2.5
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	4.5	1.8	-2.1	-0.9	-2.1	-0.0	1.1
Medication: Atenolol	1.4	1.7	6.2	-0.0	2.5	1.4	1.0	1.1	-0.1
Medication: Levothyroxine sodium	1.5	2.5	11.4	3.4	0.8	0.7	-0.4	0.8	-1.4
Sitting height	6.1	43.5	136.9	-1.6	-11.7	-6.8	-3.0	-4.8	6.6
Chronic bronchitis/emphysema (father)	1.9	2.2	5.0	1.4	1.4	2.2	0.4	1.3	-1.6
High blood pressure (mother)	0.8	1.1	2.6	1.1	0.3	1.0	-1.1	1.0	-1.6
Body mass index (BMI)	0.6	2.5	6.3	0.8	2.0	1.8	0.6	0.6	-2.5
Impedance of leg (left)	0.6	3.0	11.1	-0.1	-2.4	-1.1	0.3	-0.6	3.3
Leg predicted mass (left)	5.0	26.4	75.3	-2.6	-8.7	-4.9	-2.8	-5.8	3.3
Trunk fat mass	3.9	16.9	44.8	-1.8	-6.7	-3.7	-2.2	-5.0	3.1
Waist circumference	0.8	3.1	12.0	-0.6	-3.5	-0.1	-0.3	-2.4	0.6
Number of incorrect matches in round	0.3	0.5	1.6	0.5	1.2	0.7	0.3	-0.4	-0.8
Past tobacco smoking	0.8	1.5	4.1	1.0	1.8	0.8	0.6	2.0	-0.2
Alcohol usually taken with meals	0.1	0.2	0.7	-0.3	0.8	0.1	-0.2	-0.8	-0.1
Nervous feelings	1.5	2.8	6.2	1.2	2.5	1.5	-0.7	1.9	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.7	0.4	1.1	1.9	1.0	-0.1	-1.1
Hearing difficulty/problems with background noise	0.6	1.0	3.6	1.9	-0.1	-0.2	-0.8	0.8	-1.0
Hair/balding pattern: Pattern 2	0.4	0.5	2.2	1.5	-0.0	0.2	-0.2	0.8	0.2
Had menopause	0.3	0.4	1.3	-0.4	-0.1	0.6	0.6	-1.1	0.1
Had other major operations	0.4	0.5	1.3	-0.3	-1.1	-0.6	-0.6	-0.7	0.6
Forced vital capacity (FVC)	23.6	91.1	234.1	-4.9	-15.3	-6.9	-0.2	-9.9	11.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.7	-1.6	-1.6	-0.8	-0.6	-1.5	1.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	0.8	0.5	1.0	0.1	0.4	-0.5
Qualifications: None of the above	0.9	1.8	5.7	2.4	0.9	0.5	-0.7	1.5	-1.3
Financial difficulties in last 2 years	0.5	0.6	1.4	0.9	-0.6	-1.2	-1.0	-0.2	0.7
Mouth/teeth dental problems	0.8	1.2	3.5	1.2	0.8	0.8	0.7	1.9	-0.7
Heart attack	0.9	1.2	4.4	0.5	0.1	-1.4	-2.1	0.0	-0.6
Allergy	1.6	3.7	7.7	2.3	-0.9	-1.2	-2.8	1.8	-1.9
Pain all over the body in last month	0.7	0.7	1.4	-0.3	-1.2	-0.9	-0.7	-0.9	0.9
Diabetes (self-reported)	0.5	0.8	1.4	1.1	0.9	1.2	0.2	0.5	-1.0
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.8	-1.2	1.2	1.2	1.9	-0.3	1.2
Medication: Ramipril	0.7	0.9	2.2	0.4	0.4	0.1	-1.5	1.1	-1.3
Medication: Simvastatin	0.7	1.0	3.8	1.1	0.4	-0.1	-0.3	0.8	-2.0
Fluid intelligence score	0.4	0.8	1.8	-1.4	-1.2	-1.1	0.3	0.3	0.2
Illnesses of siblings	3.1	4.4	9.4	-0.1	-3.1	-2.7	-1.2	-2.1	2.0
Neuroticism score	0.2	0.4	1.5	0.6	0.6	1.2	-0.1	0.0	-0.6
Weight	3.9	19.3	61.1	-1.9	-7.8	-3.7	-2.0	-5.0	2.8
Impedance of arm (right)	5.1	23.8	45.4	-1.8	-6.7	-6.0	-2.8	-4.1	5.8
Arm fat percentage (right)	0.3	1.1	3.8	-0.4	-0.9	-1.1	-0.7	-1.9	0.3
Trunk fat-free mass	4.5	25.7	90.6	-2.5	-9.5	-4.0	-2.0	-5.2	3.1
Hip circumference	1.9	8.2	27.1	-1.1	-5.2	-2.4	-0.9	-3.3	1.8
Time employed in main current job	0.8	1.0	4.2	-0.9	-2.0	-0.8	-0.2	-0.4	0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.4	-0.4	0.1	-0.2	-0.7	-0.4	-0.1
Father’s age at death	0.6	0.8	2.7	0.4	0.9	1.6	0.2	0.3	-1.1
Worrier / anxious feelings	1.6	3.0	5.2	1.3	2.3	0.3	-1.7	2.0	-2.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.9	1.7	0.3	-0.3	-1.0	0.4	-1.0
Falls in the last year	1.6	2.2	6.4	-1.1	-2.1	-0.3	0.1	-1.1	2.5
Hair/balding pattern: Pattern 3	6.2	9.2	21.5	-4.6	-0.4	2.4	3.5	-3.0	2.6
Number of live births	1.0	1.5	3.2	-1.6	-1.3	-0.8	-0.0	-1.8	0.9
Forced expiratory volume in 1-second (FEV1)	15.8	53.3	134.6	-4.2	-11.6	-6.1	-1.2	-7.7	8.3
Pulse rate	0.3	0.6	1.0	0.9	-0.7	-0.2	0.9	0.4	1.0
Happiness	1.0	1.2	4.9	2.2	0.5	-0.2	-0.5	1.1	-0.7
Noisy workplace	0.6	0.7	1.9	-0.3	0.2	0.2	1.4	-0.9	1.2
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.8	-1.7	-1.1	-0.5	-0.3	-1.2	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.6	0.6	0.1	-0.4	0.1	-0.4
Mouth/teeth dental problems: Dentures	0.8	1.3	2.4	-0.6	-1.0	-1.3	-0.7	-1.6	1.3
Asthma	0.3	0.6	1.4	0.9	0.9	1.2	0.8	0.4	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	-0.4	0.3	1.0	0.1	-0.8	0.7
Medication: Cholesterol lowering	0.0	0.1	0.2	-0.1	-0.3	-0.1	0.1	-0.0	-0.5
Depression (self-reported)	0.7	0.8	2.4	0.6	0.8	1.6	1.0	-0.2	-0.5
Medication: Lansoprazole	1.1	1.2	3.3	0.8	-0.3	-1.8	-1.8	0.4	0.1
Prospective memory result	0.6	0.7	3.0	-0.6	0.6	0.7	1.7	-0.0	-0.1
Lung cancer (father)	0.6	0.7	1.9	-1.4	0.8	-0.4	-0.5	-0.5	-1.0
Illnesses of mother	2.7	3.3	5.1	-2.3	-1.2	-1.0	1.8	-2.1	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	13.9	44.4	112.4	-3.9	-10.6	-5.4	-1.0	-7.2	7.5
Pulse wave Arterial Stiffness index	0.6	0.7	1.9	-0.1	0.9	1.4	0.2	0.8	-0.9
Impedance of arm (left)	4.9	22.8	44.9	-1.4	-6.7	-6.0	-3.4	-3.8	5.3
Arm fat mass (right)	0.9	3.7	9.0	-0.8	-3.0	-1.5	-1.1	-2.9	0.8
Trunk predicted mass	4.5	25.6	89.7	-2.6	-9.5	-4.0	-1.9	-5.2	3.2
Standing height	15.8	156.8	462.2	-5.6	-21.5	-12.0	-5.6	-12.1	11.2
Length of working week for main job	0.8	0.9	2.7	0.7	1.6	-0.9	-0.9	0.7	0.1
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.1	0.6	-0.2	0.1	-0.1	-0.3
Breastfed as a baby	0.1	0.1	0.2	-0.2	-0.3	-0.5	0.3	0.4	-0.4
Tense / ‘highly strung’	0.9	1.5	3.7	-1.3	1.1	1.9	1.0	-0.7	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.7	0.1	0.6	0.4	-0.3	0.8
Hair/balding pattern: Pattern 4	0.5	1.1	2.1	-0.6	-1.0	-1.4	0.9	-0.8	1.4
Birth weight of first child	2.1	3.8	9.1	-1.7	-3.0	-1.5	-0.8	-2.7	1.0
Peak expiratory flow (PEF)	2.9	6.8	21.6	-0.4	-4.6	-2.4	-1.0	-2.1	2.9
Pulse wave reflection index	1.3	1.6	3.0	0.7	1.3	-0.2	-1.7	1.2	-1.6
Ever highly irritable/argumentative for 2 days	1.8	2.2	2.9	1.7	1.6	1.2	-1.1	1.4	-1.6
Loud music exposure frequency	1.0	1.1	3.2	0.0	0.2	0.3	1.7	-0.5	1.8
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	4.0	-0.7	1.1	-2.0	-0.9	0.6	-0.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.2	-1.2	-1.2	1.1	1.0	-1.5	0.3
Blood clot in the leg (DVT)	3.1	4.0	9.0	-2.1	-2.1	-1.6	-0.6	-3.0	1.8
Medication: Paracetamol	0.3	0.5	1.8	-0.7	-0.8	0.3	-0.1	0.3	1.4
Headache pain in last month	0.4	0.6	1.4	0.4	-1.1	-1.0	0.1	0.5	1.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.2	-0.8	-0.9	-0.7	0.4	-0.2	1.1
Glaucoma (self-reported)	1.2	1.4	2.7	1.3	1.6	-0.2	-0.9	1.0	-1.3
Gout (self-reported)	1.0	1.4	2.4	-1.2	0.3	1.4	1.2	-1.5	1.0
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	5.8	2.0	0.3	2.4	1.1	0.3	-0.4
Medication: Amlodipine	0.8	1.1	3.8	0.6	-0.4	0.6	-1.3	0.6	-2.0
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.6	0.6	0.4	1.7	2.1	-0.4	-0.1
Birth weight	1.4	3.0	8.3	0.3	-2.9	-2.6	-1.7	-0.4	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	0.6	-0.1	0.3	0.3	-0.2	-0.0
High blood pressure (siblings)	2.0	3.0	8.8	-0.2	1.3	3.0	2.1	1.5	-0.8
Forced vital capacity (FVC), Best measure	22.1	80.9	207.4	-4.9	-14.4	-6.5	0.1	-9.6	11.0
Body fat percentage	0.8	3.2	7.0	-0.6	-2.6	-1.6	-1.1	-2.6	1.2
Leg fat percentage (right)	0.1	0.5	1.6	0.2	0.5	1.3	0.6	-0.6	-0.6
Arm fat-free mass (right)	2.9	14.9	53.9	-2.0	-7.3	-2.3	-1.3	-4.4	2.3
Exposure to tobacco smoke outside home	1.6	2.2	5.7	-0.3	-2.0	0.6	0.6	-1.6	2.4
Comparative body size at age 10	0.6	1.8	5.4	-0.4	2.3	1.3	1.0	0.4	-1.5
Number of full brothers	0.3	0.4	1.7	-1.3	-0.0	-0.4	-0.2	-0.8	0.2
Worry too long after embarrassment	0.3	0.6	1.8	-0.4	-1.3	-1.0	0.4	-0.0	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	0.2	-0.0	-0.8	-0.4	-0.6	0.2
Wheeze or whistling in the chest in last year	0.8	1.5	3.2	1.8	1.4	0.4	-0.8	1.3	-1.2
Number of children fathered	0.7	0.7	2.8	-1.7	-0.9	-0.2	0.4	-0.7	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	3.5	1.1	1.0	1.2	-0.6	1.7	-1.9
Age at first live birth	0.8	1.3	5.2	-1.2	-0.4	-2.3	0.2	-1.0	0.4
Pulse wave peak to peak time	2.5	3.0	5.7	-0.4	-2.4	-2.4	-0.8	-1.7	1.6
Health satisfaction	0.5	0.7	1.9	0.7	1.4	1.0	-0.2	0.9	0.1
Shortness of breath walking on level ground	1.4	1.6	4.4	1.0	1.1	1.5	0.1	2.1	-1.0
Qualifications: College or University degree	0.5	1.4	5.4	-2.3	-0.6	-0.6	0.0	-1.5	0.7
Eye problems/disorders: None of the above	0.7	0.8	3.5	-0.1	-1.9	0.8	0.5	0.6	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	-0.1	0.3	0.7	0.9	-0.0	0.1
Emphysema/chronic bronchitis	0.9	1.0	3.3	1.8	0.5	0.8	-0.5	1.1	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	-0.2	1.1	0.2	0.6	-0.2	-0.7
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.1	0.4	0.1	0.5	0.4	-0.3
Medication: Blood pressure	0.7	1.2	3.4	1.4	0.5	1.1	-0.3	0.7	-1.9
Angina (self-reported)	1.5	1.9	4.7	0.8	2.2	1.6	1.7	0.8	0.3
Migraine (self-reported)	0.8	1.0	2.3	0.6	-1.2	-0.2	0.7	-1.5	1.0
Medication: Ibuprofen	0.5	0.6	1.9	0.0	0.8	1.4	0.5	-0.3	0.8
Medication: Allopurinol	1.5	2.0	3.5	-1.1	-0.3	1.4	1.9	-1.4	1.8
Medication: Omeprazole	0.3	0.4	1.0	0.8	-0.3	-0.4	-0.7	0.1	1.0
Medication: Seretide 50 evohaler	0.7	0.8	3.4	-0.3	-1.0	0.1	0.7	-0.0	1.8
Mean time to correctly identify matches	0.2	0.5	1.9	-0.2	0.3	-0.4	-0.8	-1.4	-0.0
Heart disease (mother)	0.6	0.7	2.5	-0.2	1.0	1.6	0.3	0.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	2.0	4.9	-0.0	2.1	0.7	-0.3	1.4	-2.2
Whole body fat mass	2.3	9.7	26.8	-1.3	-5.2	-2.6	-1.5	-4.0	2.1
Leg fat mass (right)	0.7	2.7	6.9	-0.8	-2.6	-0.8	-0.5	-2.6	0.9
Arm predicted mass (right)	2.8	14.2	51.4	-1.8	-7.2	-2.5	-1.2	-4.2	2.1
Pulse rate, automated reading	0.5	1.6	4.2	-0.2	-1.5	-0.5	1.4	-0.8	2.0
Alcohol intake frequency.	0.2	0.4	0.9	-0.7	-0.0	-1.0	0.6	-0.4	0.9
Comparative height size at age 10	17.6	97.0	249.6	-5.3	-15.8	-9.6	-4.6	-10.6	8.9
Number of full sisters	1.0	1.2	3.0	-0.3	-1.3	-0.1	1.7	-1.0	1.3
Suffer from ‘nerves’	0.4	0.7	3.1	0.5	-0.1	1.8	0.4	-0.2	-0.6
Overall health rating	0.3	0.7	2.1	1.4	-0.4	0.0	-1.0	1.0	0.0
Chest pain or discomfort	0.4	0.6	2.5	0.5	-1.6	0.5	0.2	0.0	0.6
Had major operations	1.0	1.1	3.3	-0.1	-1.0	-0.9	-0.6	-1.2	1.8
Age at last live birth	1.2	1.7	6.6	-0.7	-0.5	-2.6	-1.6	-0.3	0.2
Family relationship satisfaction	2.6	3.2	6.9	2.4	0.7	0.4	-1.4	2.6	-2.0
Leg pain on walking	1.6	2.0	3.7	-1.4	-1.9	0.9	0.6	-1.5	1.6
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.6	1.2	0.4	0.4	-0.3	0.4
Commuting to job workplace: Car/motor vehicle	3.2	3.7	5.7	2.1	2.4	2.3	0.0	1.8	-1.9
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	4.4	-2.1	-1.3	0.3	1.0	-0.5	0.8
Medication: Aspirin	0.2	0.3	0.8	0.9	-0.1	0.6	0.1	0.4	-0.7
Supplements: Vitamin C	0.5	0.6	1.3	0.9	-0.2	-0.4	-1.2	1.1	-0.5
Knee pain experienced in last month	0.7	1.1	2.8	-1.7	-0.6	0.9	0.8	-1.0	1.1
Hypertension (Self-reported)	1.9	5.3	13.8	1.8	1.9	2.4	0.7	2.1	-3.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	7.6	0.2	-0.1	-0.9	-2.8	1.0	-0.3
Illnesses of father: Heart disease	0.7	0.9	3.6	-0.4	1.9	-0.9	0.8	-0.2	-0.3
Illnesses of siblings: Diabetes	1.5	1.9	4.5	0.9	1.8	0.8	-0.2	1.4	-2.1
Smoking status: Previous	1.2	1.8	4.7	-0.5	-2.1	-0.9	-0.5	-2.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	8.1	16.8	42.0	-1.3	-6.5	-4.8	-2.9	-3.3	3.9
Whole body fat-free mass	4.4	25.3	83.2	-2.6	-9.1	-4.2	-2.2	-5.4	3.2
Leg fat-free mass (right)	4.7	24.9	72.8	-2.4	-8.5	-4.8	-2.8	-5.5	3.1
Arm fat percentage (left)	0.3	1.1	3.3	-0.2	-0.7	-1.2	-1.1	-1.8	-0.0
Average weekly red wine intake	0.7	1.1	2.3	-1.5	0.2	0.6	1.2	-1.5	0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.9	1.7	-0.8	-0.1	-0.7	-0.0	-0.0
Mood swings	0.3	0.5	1.4	0.3	-0.8	0.8	-0.0	-1.2	-0.2
Loneliness, isolation	0.6	0.9	2.9	-0.4	-0.3	0.9	0.7	-1.7	0.9
Long-standing illness, disability or infirmity	1.0	1.5	3.4	1.5	-1.9	-0.5	-0.5	0.7	1.4
Ever had bowel cancer screening	0.2	0.2	1.2	0.5	-0.1	0.1	-0.2	-0.0	-1.1
Diabetes diagnosed by doctor	0.3	0.5	1.3	0.8	0.6	1.1	0.4	-0.1	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.8	-1.0	-1.7	-0.3	0.8	-0.4	0.7
Friendships satisfaction	0.9	1.1	3.6	-1.0	-0.4	0.8	1.9	0.2	0.9
Qualifications: nursing, teaching	0.9	1.4	6.2	-2.5	-0.3	-0.9	0.4	-0.8	0.4
Commuting to job workplace: Walk	1.2	1.3	5.2	-0.6	-0.4	-2.3	-1.1	-0.8	0.2
Eye problems/disorders: Cataract	0.4	0.5	2.0	0.3	0.4	-1.4	-0.2	-0.3	0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.7	-0.5	-1.6	-0.5	0.2	-1.0	1.5
Medication for cholesterol	0.7	1.1	3.4	0.2	-1.8	-0.1	-0.1	-0.7	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	7.8	2.2	0.6	-0.9	-2.0	2.8	-1.3
Back pain experienced in last month	2.0	3.0	10.0	0.5	-1.6	1.9	3.2	-0.5	1.1
Mineral and other dietary supplements	2.5	3.4	5.7	1.2	2.2	-1.0	-1.5	2.2	-2.4
Breast cancer (self-reported)	0.8	0.9	1.6	-1.1	-1.2	-0.3	0.6	-1.2	0.9
Asthma (self-reported)	0.4	0.9	2.0	0.6	0.9	1.4	1.2	0.4	0.7
Osteoporosis (self-reported)	0.9	1.1	2.0	-0.8	-1.2	0.9	0.7	-1.4	0.9
Osteoarthritis (self-reported)	1.7	2.2	8.2	-0.3	-2.9	-0.0	0.7	-1.3	1.7
Medication: Aspirin	0.4	0.5	1.1	0.9	0.4	0.7	0.2	0.6	-1.1
Medication: Gliclazide	0.1	0.1	0.5	-0.1	0.1	0.0	-0.7	-0.3	-0.5
Illnesses of father: None of the above (group 1)	2.8	3.5	6.2	-2.0	-2.4	-0.4	-0.0	-2.1	2.5
Smoking status: Current	0.8	1.2	2.7	0.1	1.5	-0.4	-1.0	1.0	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.3	7.1	13.2	-1.6	-3.6	-1.6	0.9	-3.2	3.6
Whole body water mass	4.3	24.3	80.1	-2.4	-8.9	-4.2	-2.3	-5.3	3.0
Leg predicted mass (right)	4.7	25.3	73.1	-2.4	-8.6	-5.0	-2.9	-5.5	3.0
Arm fat mass (left)	1.0	4.2	11.0	-0.6	-3.3	-1.8	-1.3	-2.9	0.9
Number of self-reported non-cancer illnesses	0.5	0.8	1.8	0.7	1.4	1.2	0.5	-0.8	-0.4
Average weekly champagne plus white wine intake	0.6	0.9	2.0	-0.8	-0.7	0.3	1.3	-0.6	1.4
Miserableness	0.2	0.4	1.4	1.2	-0.1	-0.6	-0.8	0.2	0.3
Guilty feelings	0.4	0.7	2.0	0.1	-1.4	-0.1	-0.6	-0.6	1.1
Wears glasses or contact lenses	1.5	1.7	5.9	-0.0	-2.4	0.1	0.2	-1.4	1.6
Ever taken oral contraceptive pill	1.8	2.0	5.3	1.6	-0.6	-2.3	-1.3	1.2	-0.6
Hearing aid user	0.3	0.4	1.1	0.3	0.5	-0.6	-0.6	-0.0	-1.1
Mother’s age at death	0.4	0.5	2.0	0.3	0.7	1.4	0.2	0.0	-0.4
Financial situation satisfaction	4.4	5.5	9.8	2.5	3.1	0.2	-1.6	2.7	-2.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.8	0.2	-1.4	1.0	-0.4	-0.3	0.8
Commuting to job workplace: Public transport	0.3	0.3	1.0	-0.2	-0.2	-1.0	-0.9	0.0	-0.1
Eye problems/disorders: Glaucoma	1.4	1.6	3.4	1.8	0.9	-0.3	-1.1	1.3	-1.7
Medication: Blood pressure	1.0	1.9	5.6	0.7	1.5	1.1	0.2	1.4	-2.4
Pain type(s) experienced in last month: Hip pain	1.9	2.3	6.9	-0.9	-2.6	-0.4	0.0	-2.1	1.2
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.3	-0.5	-1.2	-0.1	-0.0	-1.4	1.5
High cholesterol (Self-reported)	1.3	2.3	4.1	2.0	1.5	0.4	-1.1	1.4	-2.0
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.5	-0.2	-0.2	0.4	0.8	-0.7
Medication: Paracetamol	0.3	0.5	1.3	-0.7	-0.6	0.9	-0.0	0.0	1.2
Medication: Lisinopril	3.7	4.8	8.6	2.6	2.4	-0.9	-2.0	1.8	-2.9
Medication: Atorvastatin	0.4	0.5	1.0	0.2	0.4	1.0	0.9	-0.0	0.9
Illnesses of father: High blood pressure	1.2	1.5	3.5	1.9	1.2	-0.5	-0.5	1.5	-1.2
Alcohol drinker status: Never	4.8	5.8	13.5	-2.3	-2.2	0.8	2.2	-2.4	3.7
Ever smoked	0.8	1.4	3.0	-0.8	-1.1	-1.7	-1.0	-1.6	0.3
Basal metabolic rate	4.6	25.4	82.3	-2.5	-9.1	-4.3	-2.3	-5.5	3.2
Leg fat percentage (left)	0.2	0.7	1.3	0.5	0.9	1.1	0.6	-0.2	-1.0
Arm fat-free mass (left)	2.9	14.9	53.1	-1.8	-7.3	-2.7	-1.4	-4.3	2.3
Number of operations (self-reported)	2.9	4.3	7.1	-1.9	-2.3	-1.6	-0.8	-2.7	2.5
Average weekly beer plus cider intake	0.6	0.8	3.2	-0.3	-1.8	0.9	-0.1	-0.8	0.2
Irritability	0.6	1.0	3.5	-0.3	1.9	1.0	-0.1	0.4	-1.1
Risk taking	0.8	1.1	1.9	1.1	-1.2	1.3	0.7	0.5	1.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.9	-0.4	-0.5	0.0	-0.9	-0.1	-0.1
Fractured/broken bones in last 5 years	0.6	0.8	2.6	-0.1	-0.5	-0.5	-1.6	-1.2	-0.3
Age started oral contraceptive pill	0.4	0.5	1.8	-0.5	0.4	1.4	0.1	0.6	-0.7
Diastolic blood pressure, automated reading	0.7	2.0	5.6	2.4	-0.7	1.2	-0.3	1.9	-1.0
Ever depressed for a whole week	0.5	0.6	1.7	0.3	1.0	-0.2	-1.3	-0.2	-0.9
Unable to work because of sickness or disability	3.8	5.0	12.4	-1.3	-3.1	0.1	2.1	-1.3	3.5
Commuting to job workplace: Cycle	0.4	0.5	1.0	-0.3	-0.6	-0.6	-1.0	1.0	-0.1
Myopia	3.6	5.2	14.8	-0.5	-3.9	-1.4	-0.2	-1.9	3.3
Vascular/heart problems diagnosed by doctor	1.8	4.8	10.9	-1.5	-2.4	-2.7	-0.7	-1.5	3.3
Cholesterol lowering medication	1.4	2.1	3.5	1.6	1.8	1.3	-0.3	1.1	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.5	0.8	-0.2	-0.7	-1.2	0.3	0.6
Pain experienced in last month	0.4	0.7	1.5	0.5	1.2	0.6	-0.4	0.4	-1.2
Supplements: Calcium	0.2	0.2	0.5	0.1	0.7	-0.5	0.5	0.2	-0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.9	-0.8	-1.4	0.7	0.1	-0.7	0.3
Heart attack/myocardial infarction (self-reported)	1.0	1.3	4.9	0.5	0.2	-1.3	-2.2	-0.1	-0.7
Deep venous thrombosis (DVT) (self-reported)	3.5	4.5	9.5	-2.2	-2.2	-1.8	-0.3	-3.1	2.0
Heart disease (siblings)	0.5	0.7	1.9	-0.5	0.8	1.4	1.0	-0.3	-0.4
Alcohol drinker status: Previous	0.5	0.6	2.1	-1.1	-0.1	0.2	-0.2	0.0	1.5
Pack years of smoking	0.4	0.7	1.5	1.2	0.7	0.9	-0.3	0.9	-0.5
Impedance of whole body	2.6	13.2	27.2	-0.9	-5.2	-4.1	-1.8	-2.7	4.9
Leg fat mass (left)	0.6	2.4	6.2	-0.7	-2.5	-1.0	-0.4	-2.5	0.7
Arm predicted mass (left)	2.7	13.8	47.9	-1.8	-6.9	-2.8	-1.4	-4.2	2.1