TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Impedance of arm (left)
:
←
→
chr4:352,955-1,894,092
Best TWAS P=1.95e-09 · Best GWAS P=1.51e-09 conditioned to 0.0767
0.4M
0.6M
0.8M
1M
1.2M
1.4M
1.6M
1.8M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Brain Cortex
RNF212
0.15
0.03
lasso
3
0.01
1.5e-01
5.7
-6.0
2.0e-09
-0.85
0.02
0.77
TRUE
3
GTEx
Esophagus Muscularis
RP11-20I20.4
0.19
0.09
lasso
3
0.10
1.9e-06
-3.9
5.8
8.2e-09
0.79
0.01
0.99
FALSE
4
METSIM
Adipose
SPON2
0.06
0.06
lasso
8
0.05
2.2e-08
5.6
5.7
1.1e-08
0.92
0.01
0.99
FALSE
5
The Cancer Genome Atlas
Brain Lower Grade Glioma
RNF212
0.05
0.05
lasso
1
0.04
1.3e-05
5.6
-5.6
2.2e-08
-0.96
0.00
1.00
FALSE
1
CommonMind
Brain Pre-frontal Cortex
RNF212
0.14
0.11
lasso
6
0.11
2.3e-13
5.6
-5.6
2.4e-08
-0.92
0.01
0.99
FALSE