Best TWAS P=1.95e-09 · Best GWAS P=1.51e-09 conditioned to 0.0767
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RNF212 | 0.14 | 0.11 | lasso | 6 | 0.11 | 2.3e-13 | 5.6 | -5.6 | 2.4e-08 | -0.92 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Cortex | RNF212 | 0.15 | 0.03 | lasso | 3 | 0.01 | 1.5e-01 | 5.7 | -6.0 | 2.0e-09 | -0.85 | 0.02 | 0.77 | TRUE |
| 3 | GTEx | Esophagus Muscularis | RP11-20I20.4 | 0.19 | 0.09 | lasso | 3 | 0.10 | 1.9e-06 | -3.9 | 5.8 | 8.2e-09 | 0.79 | 0.01 | 0.99 | FALSE |
| 4 | METSIM | Adipose | SPON2 | 0.06 | 0.06 | lasso | 8 | 0.05 | 2.2e-08 | 5.6 | 5.7 | 1.1e-08 | 0.92 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RNF212 | 0.05 | 0.05 | lasso | 1 | 0.04 | 1.3e-05 | 5.6 | -5.6 | 2.2e-08 | -0.96 | 0.00 | 1.00 | FALSE |