Best TWAS P=3.64e-09 · Best GWAS P=1.83e-08 conditioned to 0.0601
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Cells EBV-transformed lymphocytes | NEXN | 0.23 | 0.10 | lasso | 3 | 0.08 | 1.4e-03 | 5.3 | 5.5 | 3.5e-08 | 0.89 | 0.04 | 0.82 | FALSE |
2 | GTEx | Lung | GIPC2 | 0.15 | 0.09 | enet | 17 | 0.12 | 2.5e-09 | 5.2 | -5.4 | 7.5e-08 | -0.81 | 0.08 | 0.91 | FALSE |
3 | GTEx | Nerve Tibial | DNAJB4 | 0.08 | 0.07 | lasso | 3 | 0.07 | 1.3e-05 | 5.5 | 5.4 | 6.7e-08 | 0.98 | 0.02 | 0.98 | FALSE |
4 | GTEx | Spleen | GIPC2 | 0.43 | 0.07 | enet | 19 | 0.22 | 2.9e-06 | 5.1 | -5.6 | 2.0e-08 | -0.85 | 0.07 | 0.92 | FALSE |
5 | METSIM | Adipose | DNAJB4 | 0.04 | 0.04 | lasso | 4 | 0.03 | 2.1e-05 | 5.3 | 5.8 | 6.8e-09 | 0.68 | 0.04 | 0.94 | FALSE |
6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DNAJB4 | 0.05 | 0.03 | lasso | 3 | 0.02 | 3.3e-03 | 4.8 | 5.3 | 1.2e-07 | 0.87 | 0.01 | 0.96 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | GIPC2 | 0.04 | 0.01 | blup | 65 | 0.00 | 2.5e-01 | 4.4 | -5.9 | 3.6e-09 | -0.74 | 0.02 | 0.67 | TRUE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIPC2 | 0.02 | 0.02 | lasso | 3 | 0.02 | 1.0e-03 | 5.3 | -5.3 | 1.4e-07 | -0.73 | 0.03 | 0.92 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | DNAJB4 | 0.04 | 0.04 | lasso | 2 | 0.04 | 1.2e-05 | -5.4 | 5.4 | 7.4e-08 | 0.29 | 0.00 | 0.99 | FALSE |