Best TWAS P=1.66e-08 · Best GWAS P=1.16e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DAGLB | 0.09 | 0.09 | lasso | 5 | 0.09 | 5.7e-11 | -5.3 | 5.6 | 1.7e-08 | -0.95 | 0.01 | 0.99 | TRUE |
2 | GTEx | Skin Sun Exposed Lower leg | FAM220A | 0.08 | 0.00 | enet | 14 | 0.01 | 3.5e-02 | -3.2 | -5.5 | 4.6e-08 | 0.73 | 0.04 | 0.78 | FALSE |
3 | METSIM | Adipose | RAC1 | 0.13 | 0.06 | enet | 17 | 0.12 | 1.8e-17 | -5.5 | -5.3 | 1.2e-07 | 0.87 | 0.01 | 0.99 | FALSE |
4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAC1 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.8e-05 | -5.3 | -5.3 | 1.1e-07 | 0.74 | 0.02 | 0.97 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RAC1 | 0.08 | 0.02 | blup | 63 | 0.06 | 7.0e-07 | -5.2 | -5.3 | 1.2e-07 | 0.72 | 0.01 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RAC1 | 0.07 | 0.05 | blup | 59 | 0.03 | 1.1e-02 | -5.3 | -5.4 | 5.9e-08 | 0.90 | 0.01 | 0.87 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | DAGLB | 0.05 | 0.00 | blup | 72 | 0.00 | 1.3e-01 | -3.3 | 5.3 | 9.0e-08 | -0.69 | 0.03 | 0.62 | FALSE |
8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RAC1 | 0.03 | 0.04 | enet | 4 | 0.04 | 7.2e-05 | -5.2 | -5.3 | 1.2e-07 | 0.82 | 0.02 | 0.96 | FALSE |
9 | The Cancer Genome Atlas | Thyroid Carcinoma | RAC1 | 0.06 | 0.06 | lasso | 4 | 0.06 | 9.3e-07 | -5.5 | -5.5 | 3.9e-08 | 0.92 | 0.01 | 0.99 | FALSE |