TWAS
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Genes
Traits
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Traits
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Leg fat percentage (right)
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chr13:30,336,006-31,886,850
Best TWAS P=2.12e-09 · Best GWAS P=1.13e-11 conditioned to 0.00133
30.4M
30.6M
30.8M
31M
31.2M
31.4M
31.6M
31.8M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Breast Mammary Tissue
HMGB1
0.26
0.02
lasso
6
0.03
9.1e-03
-6.8
6.0
2.1e-09
-0.90
0.00
0.98
TRUE
2
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
HMGB1
0.08
0.04
lasso
1
0.04
6.9e-05
-5.5
5.5
5.0e-08
-0.78
0.06
0.90
FALSE