Best TWAS P=3.99e-10 · Best GWAS P=3.4e-12 conditioned to 0.0033
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | BTBD7 | 0.16 | 0.01 | lasso | 8 | 0.04 | 3.6e-04 | -5.8 | 5.7 | 1.2e-08 | -0.58 | 0.10 | 0.88 | TRUE |
| 2 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | -6.4 | 6.3 | 4.0e-10 | -0.02 | 0.00 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C14orf142 | 0.11 | 0.04 | enet | 7 | 0.05 | 7.2e-07 | 3.5 | -5.4 | 7.9e-08 | 0.22 | 0.50 | 0.08 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | BTBD7 | 0.02 | 0.01 | blup | 72 | 0.02 | 6.8e-03 | -5.7 | 5.6 | 1.7e-08 | -0.80 | 0.01 | 0.88 | FALSE |
| 5 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | BTBD7 | 0.11 | 0.03 | blup | 72 | 0.02 | 8.0e-02 | -5.8 | 5.3 | 9.2e-08 | -0.56 | 0.02 | 0.78 | FALSE |