TWAS
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Traits
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Traits
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Leg fat percentage (right)
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chr14:74,424,938-76,089,054
Best TWAS P=1.6e-09 · Best GWAS P=4.03e-10 conditioned to 1
74.4M
74.6M
74.8M
75M
75.2M
75.4M
75.6M
75.8M
76M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
DLST
0.09
0.11
lasso
2
0.11
4.0e-13
-6.3
6.0
1.6e-09
-0.98
0.00
0.99
TRUE
3
GTEx
Testis
AREL1
0.20
0.14
enet
34
0.13
2.1e-06
5.0
5.8
6.0e-09
-0.84
0.23
0.77
FALSE
2
GTEx
Skin Not Sun Exposed Suprapubic
RPS6KL1
0.08
0.08
enet
11
0.07
1.5e-04
5.1
5.8
7.7e-09
-0.94
0.02
0.98
FALSE
4
The Cancer Genome Atlas
Soft Tissue Sarcoma
PROX2
0.07
0.01
blup
41
0.03
4.5e-03
-6.2
5.3
1.2e-07
-0.87
0.00
0.90
FALSE