Best TWAS P=8.7e-09 · Best GWAS P=6.06e-08 conditioned to 0.68
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RFWD3 | 0.14 | 0.03 | enet | 15 | 0.04 | 3.0e-03 | 3.9 | 5.5 | 4.0e-08 | -0.73 | 0.08 | 0.85 | FALSE |
| 2 | GTEx | Adrenal Gland | RFWD3 | 0.15 | 0.07 | enet | 20 | 0.12 | 4.6e-05 | -5.2 | 5.3 | 1.0e-07 | -0.76 | 0.03 | 0.94 | FALSE |
| 3 | GTEx | Artery Aorta | RFWD3 | 0.15 | 0.09 | lasso | 3 | 0.05 | 6.2e-04 | -5.2 | 5.1 | 2.8e-07 | -0.78 | 0.03 | 0.91 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | RFWD3 | 0.16 | 0.06 | lasso | 4 | 0.08 | 5.8e-05 | 4.2 | 5.3 | 1.1e-07 | -0.77 | 0.06 | 0.92 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | GLG1 | 0.20 | -0.01 | lasso | 5 | 0.02 | 8.9e-02 | -5.4 | 5.8 | 8.7e-09 | -0.91 | 0.02 | 0.67 | TRUE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | RFWD3 | 0.35 | 0.25 | enet | 31 | 0.27 | 2.5e-09 | -5.2 | 5.4 | 8.0e-08 | -0.74 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Esophagus Mucosa | RFWD3 | 0.20 | 0.18 | lasso | 5 | 0.23 | 3.5e-15 | 4.6 | 5.7 | 1.3e-08 | -0.82 | 0.08 | 0.91 | FALSE |
| 8 | GTEx | Esophagus Muscularis | RFWD3 | 0.18 | 0.07 | lasso | 5 | 0.10 | 1.4e-06 | -5.2 | 5.3 | 1.0e-07 | -0.77 | 0.04 | 0.94 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | RFWD3 | 0.11 | 0.11 | lasso | 1 | 0.07 | 3.8e-04 | -5.2 | 5.2 | 2.6e-07 | -0.84 | 0.02 | 0.96 | FALSE |
| 10 | GTEx | Muscle Skeletal | RFWD3 | 0.08 | 0.11 | lasso | 3 | 0.10 | 3.1e-10 | -5.3 | 5.3 | 9.7e-08 | -0.85 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | RFWD3 | 0.20 | 0.14 | lasso | 5 | 0.15 | 9.2e-09 | -5.2 | 5.5 | 3.7e-08 | -0.83 | 0.01 | 0.98 | FALSE |
| 12 | GTEx | Stomach | RFWD3 | 0.20 | 0.08 | enet | 20 | 0.13 | 1.2e-06 | 4.1 | 5.5 | 4.3e-08 | -0.71 | 0.04 | 0.95 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RFWD3 | 0.06 | 0.07 | enet | 13 | 0.08 | 1.2e-15 | -5.2 | 5.2 | 1.6e-07 | -0.77 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RFWD3 | 0.12 | 0.17 | enet | 6 | 0.18 | 3.0e-18 | -5.2 | 5.1 | 3.0e-07 | -0.81 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RFWD3 | 0.05 | 0.02 | blup | 67 | 0.04 | 1.2e-03 | 4.6 | 5.2 | 2.5e-07 | -0.71 | 0.06 | 0.91 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | RFWD3 | 0.23 | 0.17 | lasso | 5 | 0.23 | 4.1e-22 | 4.3 | 5.3 | 1.0e-07 | -0.76 | 0.08 | 0.91 | FALSE |
| 17 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | RFWD3 | 0.09 | 0.06 | blup | 67 | 0.04 | 2.1e-02 | 4.6 | 5.3 | 1.4e-07 | -0.67 | 0.04 | 0.65 | FALSE |