Best TWAS P=6.47e-10 · Best GWAS P=3.95e-08 conditioned to 0.00237
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Putamen basal ganglia | AC012146.7 | 0.30 | 0.03 | enet | 23 | 0.03 | 7.6e-02 | 4.4 | -6.2 | 6.5e-10 | -0.45 | 0.08 | 0.25 | TRUE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | GP1BA | 0.35 | 0.16 | lasso | 11 | 0.18 | 5.9e-07 | 4.0 | 5.6 | 2.6e-08 | 0.56 | 0.19 | 0.68 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | RPAIN | 0.06 | 0.06 | lasso | 3 | 0.06 | 3.1e-08 | 5.4 | -5.5 | 3.0e-08 | -0.98 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | DHX33 | 0.12 | 0.08 | lasso | 5 | 0.07 | 1.8e-03 | 5.5 | -5.4 | 5.2e-08 | -0.96 | 0.02 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GP1BA | 0.02 | 0.02 | blup | 49 | 0.02 | 9.3e-03 | 4.4 | 5.2 | 1.8e-07 | 0.33 | 0.01 | 0.70 | FALSE |
| 4 | NTR | Blood | MINK1 | 0.11 | 0.15 | lasso | 3 | 0.15 | 2.1e-46 | 5.3 | 5.1 | 2.8e-07 | 0.24 | 0.01 | 0.99 | FALSE |