Hub : Genes

MINK1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0917 0.0440 7.9e-03 0.027 NA 0.003 NA 0.011 3.0e-03 NA 1.7e-01 NA 4.0e-02
2 GTEx Nerve Tibial 0.0731 0.0346 7.7e-03 0.015 NA -0.004 NA -0.002 3.0e-02 NA 9.2e-01 NA 5.2e-01
3 METSIM Adipose 0.0668 0.0255 5.6e-03 0.009 0.001 0.011 0.019 0.010 1.3e-02 2.3e-01 7.4e-03 7.1e-04 9.9e-03
4 NTR Blood 0.1063 0.0182 0.0e+00 0.152 0.123 0.145 0.147 0.151 1.4e-46 1.5e-37 1.7e-44 5.8e-45 2.1e-46
5 ROSMAP Brain Pre-frontal Cortex 0.0787 0.0232 2.1e-06 0.056 0.045 0.042 0.047 0.051 1.1e-07 1.7e-06 4.1e-06 1.1e-06 4.0e-07
6 YFS Blood 0.1786 0.0295 0.0e+00 0.113 0.149 0.160 0.156 0.154 6.4e-35 3.0e-46 4.3e-50 1.5e-48 7.0e-48
7 TCGA Liver Hepatocellular Carcinoma 0.0710 0.0390 9.2e-03 -0.003 0.018 0.013 NA 0.001 4.7e-01 4.5e-02 7.6e-02 NA 2.9e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.6 2.5 1.6 -0.7 -0.8 0.2 -0.2 0.5 0.4
Bipolar Disorder or Schizophrenia 0.3 0.7 2.2 0.2 -0.0 -0.4 1.2 0.7 0.7 1.5
Depressed Affect (Nagel 2018) 0.8 1.8 4.8 0.8 0.3 -0.9 -1.2 -2.2 -1.4 -1.5
Depression (Nagel 2018) 1.2 1.8 4.2 0.6 0.2 -1.2 -1.6 -2.1 -1.3 -1.5
Intelligence (Savage-Jansen 2018) 0.6 1.9 5.3 1.5 0.4 -0.3 1.7 1.7 2.3 0.1
Neuroticism (Nagel 2018) 0.6 1.3 3.9 0.6 0.7 -0.7 -1.1 -2.0 -0.9 -1.4
Schizophrenia (2018) 0.4 0.8 2.2 -0.9 0.6 0.1 1.5 1.1 0.5 1.0
Schizophrenia vs Biploar Disorder 2.0 2.6 4.8 0.0 0.6 1.2 -2.2 -1.6 -2.2 -2.2
Worry (Nagel 2018) 1.4 3.0 8.7 -0.2 0.6 1.0 -2.0 -3.0 -1.7 -2.0
Alzheimer’s Disease (in mother) 1.3 1.6 4.1 -2.0 -2.0 0.1 0.2 1.3 -0.9 0.7
Alzheimer’s Disease (in father) 2.0 2.2 12.6 0.5 -3.5 -0.9 0.7 1.0 0.2 -0.3
Alzheimer’s Disease (including proxy) 4.0 5.8 28.6 -1.6 -5.3 -0.6 1.4 2.3 -0.4 1.2
Crohns Disease (2017) 0.3 0.8 3.8 -0.5 -1.9 -0.1 0.7 0.7 -0.3 0.5
Irritable Bowel Disease (IBD) 0.9 2.1 5.9 -1.4 -1.0 -1.6 -1.1 -1.1 -2.4 -1.1
Ulcerative Colitis (UC) 3.2 6.0 14.8 -1.6 0.3 -2.0 -2.8 -2.8 -3.8 -2.2
Major Depression (MDD) 0.4 0.5 1.2 0.5 0.9 0.8 0.3 -0.3 0.3 1.1
Reaction Time 0.5 1.0 5.6 1.0 -2.4 -0.2 -0.0 -0.3 0.2 -0.0
Verbal and Numeric Reasoning (VNR) 2.2 5.3 10.8 1.5 0.2 2.1 3.1 2.6 3.3 1.9
Breast Cancer 0.8 2.0 5.6 -0.3 2.4 0.3 -1.4 -1.1 -1.4 -1.6
Ovarian Cancer 0.3 0.4 2.2 0.1 0.5 1.5 -0.2 0.2 -0.2 0.2
Prostate Cancer 0.6 0.8 2.1 -0.2 -1.1 -0.1 1.4 1.3 0.5 0.2
Age at First Birth 0.4 0.6 1.2 0.0 -0.6 0.1 -1.1 -1.1 -1.0 -0.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.4 2.0 4.3 -0.0 -1.1 0.2 1.6 2.1 1.8 1.6
Coronary Artery Disease (CAD) 1.7 2.1 4.6 0.0 0.0 1.3 -2.1 -2.0 -2.1 0.0
Crohns Disease (2012) 1.0 1.6 2.9 0.0 -1.6 -0.4 1.7 1.6 1.2 1.1
Mean Putamen Volume 1.2 1.4 3.6 1.9 -0.7 -1.8 0.6 0.4 1.3 0.1
Fasting Glucose 1.4 1.6 5.7 -0.3 -1.2 -0.3 1.2 2.4 1.2 1.1
HbA1C 2.7 2.9 6.9 1.4 0.5 -1.0 2.0 2.6 2.5 0.7
HDL Cholesterol 0.1 0.2 0.5 -0.5 -0.4 -0.4 0.2 -0.7 -0.4 0.3
LDL Cholesterol 0.9 1.4 2.9 -0.9 0.6 -0.5 -1.3 -1.7 -1.2 -1.5
Lupus 1.6 2.4 6.1 -0.8 1.2 1.2 2.5 0.8 2.2 1.3
Neuroticism (2016) 1.9 2.8 6.5 -0.4 -0.3 0.4 -2.0 -2.4 -2.5 -1.7
Primary Biliary Cirrhosis 1.9 2.7 3.8 -1.0 2.0 -1.6 -1.8 -1.3 -1.8 -1.8
Rheumatoid Arthritis 2.0 2.7 4.8 -1.2 0.3 -2.1 2.0 2.2 1.5 1.4
Schizophrenia (2014) 0.3 0.6 1.8 -1.3 1.2 0.4 -0.2 -0.3 -0.7 -0.6
Triglycerides 0.3 0.4 1.5 0.2 0.8 0.5 0.3 1.2 0.8 0.0
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.4 0.0 0.0 1.8 1.5 1.4 1.2 0.0
Ulcerative Colitis 4.8 6.9 14.5 0.0 -0.3 -2.7 -2.8 -2.8 -3.8 -3.3
Blood Eosinophil Count 1.0 7.9 18.5 2.3 -2.7 -0.4 4.3 3.6 3.3 0.4
Blood Platelet Count 2.9 33.6 112.4 10.6 -4.1 0.3 4.1 4.1 8.1 2.7
Blood Red Count 0.5 5.2 19.1 -1.7 -4.4 0.1 1.6 1.8 -0.6 2.9
Blood White Count 5.3 38.9 65.6 2.1 -7.3 0.5 7.8 5.9 7.4 8.1
Heel T-Score 0.6 4.9 10.9 -2.6 -3.3 -0.8 2.0 1.8 -0.2 2.9
BMI 3.1 18.1 34.5 1.5 -3.4 0.0 5.9 5.5 5.3 4.6
Height 0.5 9.8 25.1 -0.7 -0.4 0.2 -5.0 -4.2 -4.3 -2.5
Waist Hip Ratio (WHR) 0.3 1.2 2.1 0.1 -1.2 -1.4 -1.0 -1.5 -1.4 0.1
Systolic Blood Pressure 0.1 0.7 3.2 -1.8 -0.3 0.6 0.5 0.2 0.0 0.7
Smoking Status 1.4 3.2 5.9 0.9 -1.0 -2.2 2.1 2.4 2.4 0.6
Allergy or Eczema 0.6 1.6 4.0 2.0 -1.3 -0.0 1.2 1.7 1.2 -0.3
Cardiovascular Disease 0.5 1.7 2.7 -0.8 0.3 1.6 1.4 1.6 1.4 1.4
Hypothyroidism (self reported) 3.2 7.3 17.2 2.7 1.2 4.2 2.5 1.9 2.8 2.7
Respiratory disease 0.3 0.7 1.9 1.4 0.7 0.3 0.2 0.9 1.2 -0.3
Type 2 Diabetes (T2D) (2018) 3.3 6.1 10.3 2.0 -1.7 -0.4 2.9 3.2 2.8 3.1
Lung FEV1/FVC ratio 0.4 2.0 3.2 -1.8 -1.2 -1.6 1.7 1.6 0.2 1.2
Lung FVC 0.5 2.4 5.7 1.1 -0.8 -1.4 2.1 2.4 1.2 1.1
Neuroticism 0.4 0.9 3.3 1.1 -0.1 -1.0 -0.6 -1.8 -0.4 -0.6
Chronotype (morning person) 0.8 1.9 5.7 1.3 2.4 -0.4 -1.2 -0.8 0.5 -2.0
Hair Pigment 0.0 0.5 1.3 -0.7 1.1 -1.1 -0.2 0.2 -0.3 -0.4
Tanning 0.1 1.3 2.3 1.4 -1.5 0.5 1.0 1.3 1.4 0.3
Hand grip strength (left) 0.8 2.1 10.7 -0.4 -3.3 -1.8 0.1 0.8 -0.3 0.4
Number of treatments/medications taken 1.3 2.3 5.2 0.5 1.0 1.6 1.5 1.2 1.8 2.3
Average weekly spirits intake 1.3 1.6 4.2 1.6 -0.6 0.3 0.8 2.0 1.8 0.7
Sensitivity / hurt feelings 0.6 1.0 4.2 2.0 0.8 -0.8 0.2 -0.1 1.2 0.3
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.2 0.9 -0.1 -1.0 -1.1 -1.1 -0.8 -0.5
Hearing difficulty/problems: Yes 0.8 1.2 3.3 1.8 1.7 -0.4 -0.8 -0.1 0.3 -1.2
Relative age of first facial hair 0.3 0.7 2.3 -0.1 1.1 1.5 0.3 -0.7 0.1 -0.7
Other serious medical condition/disability diagnosed by doctor 2.5 3.2 7.7 1.4 -0.4 0.5 2.3 2.8 2.2 1.5
Ever used hormone-replacement therapy (HRT) 1.2 1.5 6.2 0.6 1.6 -2.5 0.5 0.6 0.8 0.2
Ever had hysterectomy (womb removed) 0.7 0.7 1.9 -0.4 1.4 -0.6 -0.9 -0.8 -0.8 -0.9
Systolic blood pressure, automated reading 0.6 1.8 3.9 -0.4 0.6 0.5 2.0 2.0 1.7 1.1
Eye problems/disorders: Diabetes related eye disease 3.6 3.9 6.6 1.3 -1.9 1.2 2.6 1.9 2.2 2.4
Angina 0.2 0.2 0.5 0.5 0.7 -0.6 0.4 0.3 0.4 -0.5
Medication for hormone replacement therapy 1.5 1.6 6.1 1.1 0.3 0.3 1.0 1.0 1.3 2.5
Vitamin and mineral supplements 1.6 2.1 4.5 0.7 -1.0 0.7 2.1 2.0 1.9 0.8
Supplements: Zinc 0.6 0.7 3.8 -0.2 0.6 -1.9 -0.3 -0.4 -0.5 -0.1
Medication: Co-codamol 1.0 1.1 2.8 1.7 0.1 -1.1 -1.3 -1.1 -0.2 -1.0
Medication: Metformin 4.6 6.4 11.3 3.4 -0.8 0.4 3.1 2.2 2.9 3.2
Diabetes (father) 0.6 0.7 3.7 0.2 -0.1 1.9 0.5 0.1 0.7 0.7
Diabetes (mother) 0.2 0.3 0.7 0.4 -0.5 0.6 -0.4 -0.8 0.4 -0.4
Severe depression (siblings) 0.4 0.4 1.2 0.7 -0.6 -0.5 0.5 0.3 1.1 0.4
Pack years adult smoking proportion 0.3 0.5 2.3 -0.5 0.5 -1.5 0.1 -0.1 -0.3 0.7
Impedance of leg (right) 1.0 4.8 11.1 -0.9 0.9 0.7 -3.1 -3.3 -2.5 -2.2
Leg fat-free mass (left) 1.3 6.8 13.1 1.1 -3.3 -0.0 2.9 3.6 2.4 2.9
Trunk fat percentage 2.8 11.3 20.7 1.4 -2.4 0.5 4.6 4.0 4.2 4.2
Hand grip strength (right) 1.0 2.7 13.4 -1.2 -3.7 -1.7 -0.2 1.1 -0.5 0.1
Townsend deprivation index at recruitment 0.4 0.5 2.3 0.3 -0.1 -1.5 0.1 -0.4 -0.7 0.8
Current tobacco smoking 1.6 2.6 5.1 1.9 -0.4 0.4 1.6 1.8 2.3 1.9
Average weekly fortified wine intake 0.9 1.1 2.1 1.5 -1.1 1.3 0.5 -0.7 0.7 1.1
Maternal smoking around birth 0.5 0.7 2.1 0.1 0.4 -0.4 1.5 1.0 0.6 1.2
Fed-up feelings 1.4 2.5 11.4 -0.8 -1.3 -3.4 -0.4 -1.2 -1.6 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.3 4.5 0.5 -0.6 -2.1 -0.8 -1.4 -0.8 -0.8
Relative age voice broke 0.4 0.6 2.1 -0.1 0.1 -0.3 -0.7 -1.5 -0.9 -0.6
Taking other prescription medications 2.2 3.4 6.3 1.3 2.5 2.2 1.3 1.1 2.0 2.0
Age when periods started (menarche) 1.7 4.1 7.6 0.6 2.5 -2.4 -1.7 -2.8 -1.7 -1.7
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.2 -0.8 -1.1 -0.1 -0.2 -0.3 -0.7 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.7 0.1 -1.3 -1.0 0.8 0.8 -0.4 0.9
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 4.0 -1.2 -1.1 0.1 0.4 1.1 -0.2 2.0
Qualifications: CSEs or equivalent 2.9 3.8 15.1 -0.1 -1.1 0.5 2.3 1.4 1.8 3.9
Serious illness, injury or assault to yourself 1.0 1.2 2.6 0.1 -0.4 -0.1 1.6 1.6 1.0 1.4
High blood pressure 0.4 1.2 4.0 -0.9 1.7 2.0 -0.1 0.3 -0.0 -0.5
Hayfever, allergic rhinitis or eczema 0.5 1.2 2.7 1.6 -0.8 -0.6 1.0 1.5 1.1 0.0
Multivitamins +/- minerals 2.4 3.1 7.8 -0.1 0.5 -0.3 -2.8 -2.5 -2.3 -1.4
Stomach or abdominal pain in last month 2.1 2.6 8.4 1.7 0.1 0.7 1.7 0.9 2.9 1.7
Supplements: Glucosamine 0.2 0.2 1.4 1.2 -0.1 0.0 0.2 0.1 0.2 0.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 2.0 0.2 -0.4 -0.8 0.3 0.5 0.3 1.4
Medication: Atenolol 3.0 3.7 8.8 -0.9 0.8 1.8 -1.8 -2.5 -1.7 -3.0
Medication: Levothyroxine sodium 4.2 7.1 16.3 2.5 0.9 4.0 2.3 2.3 3.1 2.6
Sitting height 0.1 0.7 2.1 -0.4 -1.5 -0.4 -1.3 -0.0 -1.0 -0.5
Chronic bronchitis/emphysema (father) 0.1 0.2 0.5 0.5 0.1 0.1 -0.1 0.3 0.4 -0.7
High blood pressure (mother) 0.3 0.5 1.0 0.1 0.9 0.6 0.5 1.0 0.3 -1.0
Body mass index (BMI) 3.7 15.6 29.3 1.3 -3.0 -0.1 5.4 5.3 4.7 4.5
Impedance of leg (left) 1.1 5.1 10.6 -1.2 1.1 0.4 -3.1 -3.2 -2.9 -2.2
Leg predicted mass (left) 1.3 7.1 13.7 1.0 -3.4 -0.1 3.0 3.7 2.4 3.0
Trunk fat mass 2.7 11.5 18.8 1.3 -3.0 0.5 4.3 4.1 4.0 4.3
Waist circumference 2.8 10.1 18.0 1.1 -2.7 -0.1 4.2 4.2 3.4 3.9
Number of incorrect matches in round 0.4 0.6 1.9 0.2 0.6 0.4 -1.4 -1.1 -0.6 -0.6
Past tobacco smoking 1.5 2.7 10.9 0.2 0.3 3.3 -1.6 -1.7 -1.5 -0.6
Alcohol usually taken with meals 1.0 1.7 4.6 0.3 0.4 1.6 -1.4 -1.2 -1.0 -2.1
Nervous feelings 1.4 2.5 3.4 1.2 1.8 1.8 -1.6 -1.8 -0.9 -1.8
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 5.2 1.0 0.3 -0.5 -1.4 -2.3 -1.4 -1.3
Hearing difficulty/problems with background noise 0.2 0.3 0.8 -0.4 0.5 0.4 -0.8 -0.0 -0.6 -0.9
Hair/balding pattern: Pattern 2 0.8 1.0 2.7 -1.4 -1.1 -0.2 0.8 1.6 -0.1 0.7
Had menopause 0.9 1.1 7.0 -0.0 2.6 -0.2 -0.3 -0.1 0.2 -0.5
Had other major operations 0.3 0.3 0.8 0.6 0.8 0.9 -0.1 -0.4 0.3 -0.4
Forced vital capacity (FVC) 0.8 3.0 7.0 -2.0 -2.6 -1.6 -1.1 0.7 -2.3 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.2 0.5 -1.1 -1.0 -0.0 0.4 -0.6 -0.6
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 2.3 -0.6 -0.7 -1.0 -0.3 -1.5 -0.3 0.1
Qualifications: None of the above 1.0 2.1 10.1 -1.4 3.2 -0.2 -0.6 -1.2 -0.4 -0.5
Financial difficulties in last 2 years 1.0 1.4 4.4 -1.4 -2.1 -1.4 -0.1 0.3 -0.5 0.9
Mouth/teeth dental problems 0.3 0.5 2.5 -1.6 -0.6 0.7 -0.0 0.3 -0.5 -0.3
Heart attack 0.5 0.7 1.4 1.1 1.2 1.1 -0.3 -0.9 0.4 -0.2
Allergy 0.9 2.1 4.7 -2.2 0.5 -0.7 -1.5 -1.3 -2.2 -0.8
Pain all over the body in last month 1.1 1.2 3.6 0.5 -1.4 -0.1 1.2 0.9 1.9 0.5
Diabetes (self-reported) 3.6 5.5 11.8 2.2 -1.7 -0.0 2.8 2.2 2.6 3.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.5 -1.2 -0.3 -0.8 1.0 -0.0 0.5 0.7
Medication: Ramipril 0.6 0.8 2.4 0.9 1.5 1.0 0.5 0.2 0.6 0.8
Medication: Simvastatin 0.5 0.7 3.7 0.6 1.9 0.2 -0.2 -0.6 0.2 -0.6
Fluid intelligence score 1.0 2.0 3.8 1.0 -1.5 0.6 1.9 1.8 1.7 0.5
Illnesses of siblings 1.4 1.9 10.0 0.7 -3.2 -0.1 -0.4 0.6 -0.6 -1.4
Neuroticism score 0.3 0.6 1.4 0.8 -1.2 -1.1 -0.0 -1.1 0.0 0.4
Weight 1.7 8.5 16.0 0.8 -3.4 0.2 3.4 4.0 2.7 3.5
Impedance of arm (right) 1.0 4.9 11.3 0.2 1.9 1.3 -2.7 -3.4 -2.0 -2.6
Arm fat percentage (right) 3.9 15.3 28.7 1.7 -3.0 0.7 5.4 4.7 4.8 4.7
Trunk fat-free mass 0.5 2.9 11.8 -0.4 -3.4 0.1 0.8 2.3 -0.0 1.5
Hip circumference 2.6 11.3 21.7 0.9 -2.8 0.9 4.6 4.7 3.7 3.7
Time employed in main current job 0.5 0.6 2.8 -0.5 -0.5 -1.7 0.6 0.3 -0.4 0.1
Alcohol intake versus 10 years previously 0.5 0.8 1.8 -0.7 0.5 -0.6 -0.9 -1.4 -0.9 1.1
Father’s age at death 2.0 2.7 7.0 -0.8 -0.9 0.1 -2.6 -1.5 -2.6 -1.2
Worrier / anxious feelings 0.3 0.5 1.1 -0.4 -0.9 0.8 -0.6 -1.0 -0.7 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.7 0.9 0.3 -0.7 0.0 -0.5 0.2 -0.5
Falls in the last year 1.7 2.2 4.9 1.6 2.2 0.5 1.5 1.4 2.0 0.2
Hair/balding pattern: Pattern 3 0.3 0.5 1.6 0.2 -1.1 1.3 -0.1 0.1 -0.1 0.8
Number of live births 1.5 2.1 5.0 -0.1 0.7 0.4 2.2 1.0 2.0 2.0
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 10.1 -2.1 -3.2 -1.0 -0.2 1.4 -1.8 -0.2
Pulse rate 0.9 1.6 5.9 0.8 0.2 -2.4 -0.5 -1.3 -0.7 -1.4
Happiness 0.9 1.1 2.7 -1.1 1.6 0.3 -0.5 -1.6 -0.9 -0.5
Noisy workplace 1.6 1.9 4.8 -1.5 0.8 -0.1 -2.2 -1.1 -2.1 -0.0
Qualifications: A levels/AS levels or equivalent 0.5 1.2 4.6 -0.9 -1.1 -2.1 -0.3 0.4 -0.6 -1.1
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 4.0 0.3 -2.0 -0.2 0.3 1.9 0.3 0.6
Mouth/teeth dental problems: Dentures 0.8 1.4 5.3 2.3 1.0 -1.0 0.2 -0.3 1.4 0.5
Asthma 0.6 1.3 2.5 -0.0 0.3 1.2 1.3 1.6 1.4 1.1
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.5 6.6 -2.6 -1.9 -2.1 0.2 0.5 -1.6 -0.2
Medication: Cholesterol lowering 0.6 1.0 1.8 1.2 1.3 1.3 0.7 0.1 1.2 0.2
Depression (self-reported) 0.2 0.3 1.3 0.4 -1.2 -0.5 -0.0 -0.4 -0.3 0.1
Medication: Lansoprazole 0.1 0.1 0.1 -0.2 0.4 0.1 0.1 0.1 0.3 0.4
Prospective memory result 1.5 1.9 8.5 0.6 2.9 -0.1 -1.1 -1.7 -0.3 -0.2
Lung cancer (father) 0.8 0.9 3.6 -0.4 0.5 -0.8 -0.4 -0.9 -0.9 -1.9
Illnesses of mother 0.9 1.2 1.8 -1.4 -1.1 -1.3 -1.0 -0.9 -1.2 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 4.7 -2.2 -1.9 0.1 -0.3 0.5 -1.6 -0.3
Pulse wave Arterial Stiffness index 0.3 0.4 1.3 -0.9 0.1 -0.5 0.4 0.1 0.3 1.1
Impedance of arm (left) 1.0 4.7 10.7 0.4 2.3 1.6 -2.5 -3.3 -1.5 -2.4
Arm fat mass (right) 3.3 13.7 23.2 1.4 -3.3 0.3 4.8 4.6 4.2 4.6
Trunk predicted mass 0.5 2.7 11.2 -0.3 -3.4 0.1 0.7 2.3 0.0 1.5
Standing height 0.5 5.3 13.8 -0.9 -1.6 0.6 -3.7 -2.1 -3.5 -1.6
Length of working week for main job 0.6 0.7 2.1 0.7 -0.3 0.1 0.9 1.4 1.0 0.7
Exposure to tobacco smoke at home 0.2 0.2 0.8 0.0 0.3 -0.9 0.2 -0.5 -0.2 0.4
Breastfed as a baby 0.5 0.6 1.4 0.0 0.8 -0.7 -1.1 -0.4 -1.2 -0.8
Tense / ‘highly strung’ 1.9 3.2 5.5 -0.3 0.9 -1.3 -2.3 -2.2 -2.3 -2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.9 -0.1 -0.6 -1.4 -0.4 -0.9 -0.0 0.3
Hair/balding pattern: Pattern 4 0.3 0.8 3.9 0.2 2.0 -0.5 0.2 0.3 0.9 0.5
Birth weight of first child 0.1 0.1 0.4 0.4 0.1 0.6 -0.3 -0.5 -0.2 -0.2
Peak expiratory flow (PEF) 0.7 1.6 5.2 -1.3 -2.3 -0.2 -0.5 0.4 -1.9 -0.4
Pulse wave reflection index 1.2 1.5 3.7 0.8 -0.1 0.6 1.0 1.9 1.9 1.1
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.9 -1.5 -1.7 -0.7 -0.1 0.4 -0.5 0.8
Loud music exposure frequency 0.4 0.4 1.1 -0.3 0.6 0.5 1.1 0.6 0.5 0.5
Qualifications: O levels/GCSEs or equivalent 2.2 3.5 11.5 0.4 -3.4 -1.0 1.8 2.1 1.2 1.8
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.4 0.6 0.6 -0.3 0.1 0.0 -0.2 -0.2
Blood clot in the leg (DVT) 1.7 2.2 5.1 1.5 -0.8 1.0 1.3 1.9 2.3 1.1
Medication: Paracetamol 2.2 3.7 4.9 -0.8 -2.1 -1.8 2.2 2.1 1.9 2.2
Headache pain in last month 0.1 0.2 0.5 -0.7 0.3 0.0 0.2 0.7 0.4 0.7
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.7 -0.6 -1.6 -1.2 -0.5 -0.1 -0.8 0.2
Glaucoma (self-reported) 0.8 1.0 3.0 -1.7 -0.5 -1.7 0.7 0.7 0.2 -0.2
Gout (self-reported) 0.1 0.2 0.6 -0.8 -0.0 -0.2 -0.8 -0.1 -0.3 -0.1
Hypothyroidism/myxoedema (self-reported) 4.0 7.9 23.9 2.6 1.0 4.9 2.1 2.0 2.4 3.0
Medication: Amlodipine 1.0 1.4 3.3 0.3 1.8 -1.2 -0.8 -0.8 -0.7 -1.7
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.7 -0.4 0.7 0.4 -0.2 -0.5 -0.8 -0.6
Birth weight 1.0 2.2 5.1 0.3 -1.4 1.5 -1.7 -1.2 -1.1 -2.3
Chronic bronchitis/emphysema (mother) 0.6 0.7 3.5 1.0 -0.1 0.2 0.2 -0.5 0.1 1.9
High blood pressure (siblings) 1.1 1.6 7.3 -0.5 2.7 0.8 0.3 -0.5 0.4 1.7
Forced vital capacity (FVC), Best measure 0.7 2.4 6.2 -1.9 -1.3 -0.6 -1.5 -0.3 -2.5 -1.6
Body fat percentage 3.5 13.7 24.9 1.4 -2.7 0.4 5.0 4.4 4.6 4.5
Leg fat percentage (right) 4.1 14.8 26.4 1.4 -3.1 0.4 5.1 4.7 4.7 4.6
Arm fat-free mass (right) 0.9 4.6 10.8 -0.5 -3.3 -0.5 1.9 3.2 0.9 2.5
Exposure to tobacco smoke outside home 0.4 0.6 1.7 0.5 -0.7 -0.6 0.8 1.3 0.1 0.9
Comparative body size at age 10 0.3 0.8 3.0 0.4 0.3 1.7 -0.7 -0.7 -0.4 -1.1
Number of full brothers 0.9 1.1 4.7 -2.2 -0.2 -1.4 0.3 0.3 -0.6 0.6
Worry too long after embarrassment 0.2 0.4 2.2 0.3 0.0 -0.2 -0.6 -1.5 0.2 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.5 1.0 -1.2 -0.3 -0.1 -0.4 -0.3 -0.2
Wheeze or whistling in the chest in last year 0.4 0.7 1.9 0.9 1.4 0.6 0.3 -0.6 1.1 0.1
Number of children fathered 4.1 4.7 10.1 -0.1 -2.4 -0.3 2.9 3.2 2.2 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.0 1.0 0.1 0.3 -0.8 -0.8 -0.1 0.2
Age at first live birth 0.8 1.5 4.0 -1.0 -0.5 -0.4 -1.3 -0.3 -1.8 -2.0
Pulse wave peak to peak time 0.5 0.6 1.8 0.8 -0.1 0.7 -0.8 -0.5 -0.7 -1.3
Health satisfaction 2.2 2.9 5.8 1.5 2.1 -0.2 -1.8 -2.4 -0.9 -2.0
Shortness of breath walking on level ground 0.1 0.2 0.4 -0.3 0.2 -0.6 0.5 -0.6 -0.0 -0.1
Qualifications: College or University degree 0.3 1.1 5.8 -0.2 -0.3 0.8 -0.7 -0.2 -0.6 -2.4
Eye problems/disorders: None of the above 3.1 3.6 8.8 -0.8 -0.2 1.5 -3.0 -1.9 -2.8 -1.5
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.8 -0.6 0.2 -0.1 -1.1 -0.3 -1.4 -0.2
Emphysema/chronic bronchitis 0.3 0.3 1.4 1.2 -0.1 -0.3 0.3 0.0 0.8 0.0
Medication for pain relief, constipation, heartburn 0.7 1.2 3.0 0.3 -0.1 1.7 -1.4 -1.1 -1.2 -0.9
Neck or shoulder pain in last month 0.9 1.3 4.4 -2.1 1.0 0.0 -0.8 -0.3 -1.3 1.1
Medication: Blood pressure 0.3 0.5 2.8 -0.2 1.7 0.7 0.1 -0.4 0.0 -0.5
Angina (self-reported) 0.1 0.2 0.4 0.5 0.7 -0.4 0.4 0.2 0.4 -0.4
Migraine (self-reported) 0.6 0.8 1.4 -0.9 -0.5 -0.7 -1.1 -1.0 -1.2 -0.7
Medication: Ibuprofen 1.6 1.9 8.3 -2.9 -1.6 -0.7 0.4 0.7 -1.2 -0.0
Medication: Allopurinol 0.5 0.6 2.3 -1.5 0.6 -1.0 -0.4 0.2 -0.7 0.3
Medication: Omeprazole 0.3 0.4 1.6 0.5 0.3 -1.3 -0.5 -0.7 0.1 0.2
Medication: Seretide 50 evohaler 0.7 0.8 1.7 -0.6 0.8 1.2 0.7 1.3 0.5 0.9
Mean time to correctly identify matches 0.2 0.4 1.2 1.1 -0.8 0.1 -0.5 -0.8 0.3 -0.1
Heart disease (mother) 0.6 0.8 3.2 0.4 1.8 1.1 0.4 0.0 0.5 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.5 -1.2 0.6 -0.5 -0.4 0.4 -0.9 0.0
Whole body fat mass 2.8 11.5 18.9 1.2 -2.9 0.2 4.4 4.3 4.0 4.2
Leg fat mass (right) 4.2 16.2 27.0 1.2 -3.6 0.2 5.2 5.2 4.6 4.9
Arm predicted mass (right) 0.9 4.4 10.0 -0.3 -3.1 -0.3 2.0 3.2 1.1 2.5
Pulse rate, automated reading 2.2 7.2 20.7 -0.3 1.5 -0.9 -3.3 -4.5 -3.0 -2.6
Alcohol intake frequency. 0.6 1.3 2.7 -1.6 0.2 0.6 -0.9 -1.0 -1.5 1.4
Comparative height size at age 10 0.5 2.7 8.4 -0.7 -0.9 0.8 -2.9 -1.4 -2.4 -0.7
Number of full sisters 0.3 0.3 1.1 0.1 0.8 -0.1 -0.4 -1.1 -0.1 -0.6
Suffer from ‘nerves’ 1.0 1.6 4.4 -0.7 -0.7 -0.3 -1.3 -2.1 -1.7 -1.2
Overall health rating 0.7 1.6 8.0 1.3 2.8 0.2 -0.3 -0.7 0.7 -0.4
Chest pain or discomfort 0.1 0.2 0.7 -0.3 -0.2 0.2 -0.5 -0.8 -0.2 -0.5
Had major operations 0.5 0.5 1.0 1.0 0.9 0.9 0.2 0.2 1.0 -0.1
Age at last live birth 0.5 0.8 2.0 -0.7 -0.9 -1.1 -0.1 0.5 -0.8 -1.4
Family relationship satisfaction 0.4 0.5 1.8 0.5 0.8 1.4 -0.6 -0.8 0.2 -0.3
Leg pain on walking 0.4 0.4 1.0 -1.0 1.0 0.7 -0.7 -0.1 -0.4 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 3.4 -1.2 -1.8 0.6 0.5 0.8 -0.0 1.8
Commuting to job workplace: Car/motor vehicle 2.5 2.9 6.5 0.8 -1.0 -0.4 2.3 2.6 1.8 1.7
Illness, injury, bereavement, stress in last 2 years 1.9 2.4 6.3 0.4 2.5 0.8 -1.7 -2.0 -0.9 -1.4
Medication: Aspirin 1.0 1.4 5.0 1.1 2.2 -0.1 0.2 -1.0 1.0 -1.1
Supplements: Vitamin C 0.2 0.2 1.0 -0.3 0.6 -1.0 -0.1 -0.2 -0.3 -0.0
Knee pain experienced in last month 0.5 0.8 2.3 1.5 0.7 -0.1 0.5 0.9 0.9 -0.9
Hypertension (Self-reported) 0.4 1.2 4.0 -0.7 1.1 2.0 0.7 1.2 0.8 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 2.2 -0.0 0.6 -1.5 -0.4 -0.7 -0.1 0.1
Illnesses of father: Heart disease 1.0 1.3 3.8 1.6 1.9 1.1 -0.1 0.1 1.3 0.1
Illnesses of siblings: Diabetes 2.6 3.2 8.0 0.3 2.0 0.6 1.6 0.3 2.7 2.8
Smoking status: Previous 1.2 1.9 8.8 -0.9 -0.4 -3.0 1.1 1.1 0.7 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 3.8 -0.6 -1.1 0.3 -1.5 -1.2 -1.9 -0.8
Whole body fat-free mass 0.8 4.6 12.1 0.1 -3.5 -0.1 1.9 3.1 1.1 2.3
Leg fat-free mass (right) 1.1 6.1 12.7 0.9 -3.3 -0.3 2.7 3.6 2.0 2.8
Arm fat percentage (left) 3.9 15.5 29.1 1.7 -2.7 0.9 5.4 4.6 4.9 4.8
Average weekly red wine intake 0.5 0.8 1.7 0.1 -0.7 0.7 -1.3 -1.1 -0.9 -0.8
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.2 1.1 0.8 -0.1 0.5 -0.8 0.7 0.3
Mood swings 1.1 2.0 3.9 0.0 -1.7 -2.0 -1.3 -1.6 -1.7 -0.2
Loneliness, isolation 1.0 1.3 2.8 -1.2 -0.1 0.3 -1.5 -1.5 -1.7 -0.6
Long-standing illness, disability or infirmity 0.3 0.5 2.2 0.6 1.5 0.5 -0.0 0.1 0.7 0.0
Ever had bowel cancer screening 2.0 2.3 14.7 0.6 3.8 0.1 0.1 0.0 1.1 0.3
Diabetes diagnosed by doctor 3.7 6.1 10.8 2.6 -1.3 -0.3 2.8 2.6 2.9 3.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 2.0 1.0 1.4 0.8 -0.9 -1.1 -0.2 -1.2
Friendships satisfaction 0.6 0.8 2.5 0.2 1.1 0.7 -1.0 -1.6 0.1 -0.6
Qualifications: nursing, teaching 0.6 1.0 4.6 2.1 -0.2 -0.0 0.5 0.5 1.1 -0.7
Commuting to job workplace: Walk 2.1 2.3 6.0 -0.7 2.5 0.2 -1.6 -1.8 -1.8 -0.9
Eye problems/disorders: Cataract 0.6 0.7 2.8 0.8 1.7 -0.6 -0.1 0.0 0.8 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 2.2 0.5 0.1 -1.5 -0.1 0.0 0.2 -0.4
Medication for cholesterol 0.5 0.8 2.9 -0.0 -0.4 -1.7 -0.3 -1.0 -0.4 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.9 -1.4 0.6 -0.3 0.1 -0.6 -0.8 -0.1
Back pain experienced in last month 0.7 1.0 2.0 -0.1 1.1 0.1 1.3 1.1 1.0 1.4
Mineral and other dietary supplements 0.6 0.8 1.8 -0.3 -0.6 0.3 1.4 1.1 1.0 1.1
Breast cancer (self-reported) 0.8 0.9 2.0 0.3 0.3 -0.7 -1.4 -0.6 -1.4 -1.3
Asthma (self-reported) 0.6 1.1 2.3 0.0 0.3 1.0 1.1 1.5 1.4 1.2
Osteoporosis (self-reported) 1.7 2.2 8.5 1.6 2.9 1.0 -0.3 -1.5 0.5 0.6
Osteoarthritis (self-reported) 2.0 2.6 5.6 -0.4 0.5 1.5 1.9 1.8 1.9 2.4
Medication: Aspirin 0.9 1.2 4.1 1.1 2.0 0.0 0.3 -0.7 1.0 -1.1
Medication: Gliclazide 2.0 2.2 5.1 2.3 0.9 1.1 1.4 1.6 1.9 0.7
Illnesses of father: None of the above (group 1) 0.7 0.9 2.3 -0.9 -1.0 -0.3 -0.1 -1.5 -1.5 -0.1
Smoking status: Current 1.6 2.6 5.3 2.2 -0.4 0.2 1.4 1.8 2.3 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.0 -0.9 -0.7 -0.4 -0.2 0.5 -1.0 -0.1
Whole body water mass 0.8 4.5 11.8 0.1 -3.4 -0.2 1.8 3.1 1.1 2.4
Leg predicted mass (right) 1.2 6.5 13.2 0.8 -3.4 -0.3 2.8 3.6 2.1 2.8
Arm fat mass (left) 3.4 13.8 23.5 1.3 -3.2 0.5 4.8 4.6 4.2 4.6
Number of self-reported non-cancer illnesses 1.4 2.4 6.0 1.6 0.6 0.9 1.5 1.1 2.5 1.9
Average weekly champagne plus white wine intake 1.0 1.4 4.8 -0.3 2.1 -0.5 -0.6 -0.3 -0.5 -2.2
Miserableness 0.2 0.4 1.4 0.9 0.1 0.4 -0.5 -1.2 -0.0 -0.2
Guilty feelings 0.8 1.2 5.7 0.6 -0.5 -2.4 0.7 -0.4 0.3 1.1
Wears glasses or contact lenses 0.7 0.8 2.8 1.7 0.6 -0.6 0.7 0.1 1.3 -0.0
Ever taken oral contraceptive pill 1.4 1.6 5.3 -0.5 -2.3 -1.5 1.2 0.9 0.5 0.9
Hearing aid user 1.1 1.2 3.3 -1.8 0.9 -0.4 -1.0 -1.2 -1.2 0.7
Mother’s age at death 0.3 0.3 0.7 0.5 0.1 -0.1 0.9 0.3 0.9 -0.7
Financial situation satisfaction 1.8 2.3 5.6 -0.2 -0.2 -0.4 -2.1 -2.4 -1.8 -1.5
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.4 0.1 0.4 -0.3 -1.2 -0.9 -0.7 -1.1
Commuting to job workplace: Public transport 0.3 0.3 0.9 1.0 0.5 0.2 -0.8 -0.7 -0.1 -0.3
Eye problems/disorders: Glaucoma 1.2 1.4 3.4 -0.9 -0.5 -1.7 1.9 1.2 1.2 -0.0
Medication: Blood pressure 0.3 0.5 1.7 -0.0 1.3 1.2 -0.3 0.3 0.3 -0.5
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.5 1.6 -0.2 -0.8 0.0 0.3 0.8 0.1
Supplements: Fish oil (including cod liver oil) 1.4 1.8 4.3 0.3 1.4 -0.3 -1.7 -1.4 -1.0 -2.1
High cholesterol (Self-reported) 0.5 1.0 3.5 0.1 0.8 1.9 0.7 0.8 1.1 0.5
Medication: Bendroflumethiazide 0.8 1.3 3.6 1.0 1.9 1.9 -0.4 0.1 0.6 -0.1
Medication: Paracetamol 1.7 2.7 3.5 -1.0 -1.9 -1.6 1.8 1.6 1.6 1.9
Medication: Lisinopril 0.7 0.9 3.5 1.9 -0.1 0.3 0.1 0.5 1.1 -1.2
Medication: Atorvastatin 0.8 1.0 2.7 1.1 1.1 0.6 0.6 1.0 1.6 0.2
Illnesses of father: High blood pressure 1.4 1.8 7.2 0.7 1.9 2.7 -0.6 -0.6 0.5 -0.4
Alcohol drinker status: Never 0.4 0.5 0.9 0.8 0.5 1.0 -0.7 -0.6 0.2 0.9
Ever smoked 1.9 3.3 9.8 -0.5 -0.6 -3.1 1.7 2.1 1.8 1.3
Basal metabolic rate 1.1 5.9 13.7 0.3 -3.7 -0.1 2.4 3.5 1.6 2.8
Leg fat percentage (left) 3.9 14.1 25.9 1.2 -2.9 0.1 5.1 4.8 4.6 4.5
Arm fat-free mass (left) 1.1 5.5 13.0 -0.1 -3.6 -0.6 2.2 3.4 1.3 2.6
Number of operations (self-reported) 0.5 0.7 1.5 0.0 0.8 0.6 1.0 1.2 1.2 0.2
Average weekly beer plus cider intake 1.4 2.0 3.9 0.9 -1.5 -0.1 2.0 1.1 1.9 1.6
Irritability 1.2 2.1 6.3 0.4 -2.5 -2.4 1.0 0.7 0.4 0.8
Risk taking 1.2 1.8 5.6 0.6 -0.2 0.9 1.6 2.4 1.6 0.9
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.8 -0.9 -0.2 -0.1 -0.2 -0.1 -0.3 0.1
Fractured/broken bones in last 5 years 0.7 0.9 1.9 -1.0 0.7 -0.1 1.1 1.0 0.7 1.4
Age started oral contraceptive pill 3.0 3.8 8.0 -0.6 2.4 -2.0 -1.8 -1.4 -1.9 -2.8
Diastolic blood pressure, automated reading 0.5 1.7 3.9 -0.9 0.3 0.4 2.0 1.8 1.4 1.2
Ever depressed for a whole week 0.3 0.4 0.9 0.4 -0.2 -0.5 0.7 -0.2 0.9 0.8
Unable to work because of sickness or disability 0.3 0.4 0.8 -0.5 -0.9 -0.9 0.2 0.2 -0.5 0.8
Commuting to job workplace: Cycle 0.3 0.3 0.9 -0.5 0.8 1.0 0.2 -0.4 0.0 -0.3
Myopia 1.3 2.0 4.2 0.2 2.0 -0.3 -2.0 -1.4 -0.7 -1.7
Vascular/heart problems diagnosed by doctor 0.4 1.2 4.2 1.0 -1.6 -2.0 0.1 -0.6 0.1 0.4
Cholesterol lowering medication 0.1 0.1 0.3 0.5 0.5 0.1 0.1 0.4 0.4 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.3 0.5 0.4 -1.5 -0.7 -0.7 0.1 -0.3
Pain experienced in last month 0.5 0.8 4.7 -0.3 -2.2 0.5 0.1 -0.4 -0.7 0.2
Supplements: Calcium 1.6 1.8 5.1 -1.2 1.0 0.0 -1.7 -2.3 -1.5 0.1
Basal cell carcinoma (self-reported) 0.5 0.6 2.8 0.3 -1.1 -0.5 0.2 1.7 0.2 0.2
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.1 1.2 1.4 1.2 -0.5 -1.2 0.3 -0.4
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 4.8 1.1 -0.8 1.4 1.4 2.0 2.2 1.3
Heart disease (siblings) 0.9 1.1 3.6 -0.3 1.9 0.2 1.3 0.9 1.1 0.6
Alcohol drinker status: Previous 0.3 0.4 0.9 -0.3 -0.9 0.3 0.1 -0.6 -0.6 0.8
Pack years of smoking 0.4 0.5 2.6 -0.3 0.6 -1.6 0.1 -0.2 -0.3 0.7
Impedance of whole body 1.2 6.1 14.7 -0.5 1.9 0.7 -3.1 -3.8 -2.5 -2.8
Leg fat mass (left) 3.9 15.2 25.6 1.3 -3.4 0.2 5.1 5.1 4.4 4.7
Arm predicted mass (left) 1.1 5.4 13.4 -0.1 -3.7 -0.8 2.2 3.4 1.1 2.6