Hub : Genes

MINK1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0917	0.0440	7.9e-03	0.027	NA	0.003	NA	0.011	3.0e-03	NA	1.7e-01	NA	4.0e-02
2	GTEx	Nerve Tibial	0.0731	0.0346	7.7e-03	0.015	NA	-0.004	NA	-0.002	3.0e-02	NA	9.2e-01	NA	5.2e-01
3	METSIM	Adipose	0.0668	0.0255	5.6e-03	0.009	0.001	0.011	0.019	0.010	1.3e-02	2.3e-01	7.4e-03	7.1e-04	9.9e-03
4	NTR	Blood	0.1063	0.0182	0.0e+00	0.152	0.123	0.145	0.147	0.151	1.4e-46	1.5e-37	1.7e-44	5.8e-45	2.1e-46
5	ROSMAP	Brain Pre-frontal Cortex	0.0787	0.0232	2.1e-06	0.056	0.045	0.042	0.047	0.051	1.1e-07	1.7e-06	4.1e-06	1.1e-06	4.0e-07
6	YFS	Blood	0.1786	0.0295	0.0e+00	0.113	0.149	0.160	0.156	0.154	6.4e-35	3.0e-46	4.3e-50	1.5e-48	7.0e-48
7	TCGA	Liver Hepatocellular Carcinoma	0.0710	0.0390	9.2e-03	-0.003	0.018	0.013	NA	0.001	4.7e-01	4.5e-02	7.6e-02	NA	2.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	2.5	1.6	-0.7	-0.8	0.2	-0.2	0.5	0.4
Bipolar Disorder or Schizophrenia	0.3	0.7	2.2	0.2	-0.0	-0.4	1.2	0.7	0.7	1.5
Depressed Affect (Nagel 2018)	0.8	1.8	4.8	0.8	0.3	-0.9	-1.2	-2.2	-1.4	-1.5
Depression (Nagel 2018)	1.2	1.8	4.2	0.6	0.2	-1.2	-1.6	-2.1	-1.3	-1.5
Intelligence (Savage-Jansen 2018)	0.6	1.9	5.3	1.5	0.4	-0.3	1.7	1.7	2.3	0.1
Neuroticism (Nagel 2018)	0.6	1.3	3.9	0.6	0.7	-0.7	-1.1	-2.0	-0.9	-1.4
Schizophrenia (2018)	0.4	0.8	2.2	-0.9	0.6	0.1	1.5	1.1	0.5	1.0
Schizophrenia vs Biploar Disorder	2.0	2.6	4.8	0.0	0.6	1.2	-2.2	-1.6	-2.2	-2.2
Worry (Nagel 2018)	1.4	3.0	8.7	-0.2	0.6	1.0	-2.0	-3.0	-1.7	-2.0
Alzheimer’s Disease (in mother)	1.3	1.6	4.1	-2.0	-2.0	0.1	0.2	1.3	-0.9	0.7
Alzheimer’s Disease (in father)	2.0	2.2	12.6	0.5	-3.5	-0.9	0.7	1.0	0.2	-0.3
Alzheimer’s Disease (including proxy)	4.0	5.8	28.6	-1.6	-5.3	-0.6	1.4	2.3	-0.4	1.2
Crohns Disease (2017)	0.3	0.8	3.8	-0.5	-1.9	-0.1	0.7	0.7	-0.3	0.5
Irritable Bowel Disease (IBD)	0.9	2.1	5.9	-1.4	-1.0	-1.6	-1.1	-1.1	-2.4	-1.1
Ulcerative Colitis (UC)	3.2	6.0	14.8	-1.6	0.3	-2.0	-2.8	-2.8	-3.8	-2.2
Major Depression (MDD)	0.4	0.5	1.2	0.5	0.9	0.8	0.3	-0.3	0.3	1.1
Reaction Time	0.5	1.0	5.6	1.0	-2.4	-0.2	-0.0	-0.3	0.2	-0.0
Verbal and Numeric Reasoning (VNR)	2.2	5.3	10.8	1.5	0.2	2.1	3.1	2.6	3.3	1.9
Breast Cancer	0.8	2.0	5.6	-0.3	2.4	0.3	-1.4	-1.1	-1.4	-1.6
Ovarian Cancer	0.3	0.4	2.2	0.1	0.5	1.5	-0.2	0.2	-0.2	0.2
Prostate Cancer	0.6	0.8	2.1	-0.2	-1.1	-0.1	1.4	1.3	0.5	0.2
Age at First Birth	0.4	0.6	1.2	0.0	-0.6	0.1	-1.1	-1.1	-1.0	-0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	2.0	4.3	-0.0	-1.1	0.2	1.6	2.1	1.8	1.6
Coronary Artery Disease (CAD)	1.7	2.1	4.6	0.0	0.0	1.3	-2.1	-2.0	-2.1	0.0
Crohns Disease (2012)	1.0	1.6	2.9	0.0	-1.6	-0.4	1.7	1.6	1.2	1.1
Mean Putamen Volume	1.2	1.4	3.6	1.9	-0.7	-1.8	0.6	0.4	1.3	0.1
Fasting Glucose	1.4	1.6	5.7	-0.3	-1.2	-0.3	1.2	2.4	1.2	1.1
HbA1C	2.7	2.9	6.9	1.4	0.5	-1.0	2.0	2.6	2.5	0.7
HDL Cholesterol	0.1	0.2	0.5	-0.5	-0.4	-0.4	0.2	-0.7	-0.4	0.3
LDL Cholesterol	0.9	1.4	2.9	-0.9	0.6	-0.5	-1.3	-1.7	-1.2	-1.5
Lupus	1.6	2.4	6.1	-0.8	1.2	1.2	2.5	0.8	2.2	1.3
Neuroticism (2016)	1.9	2.8	6.5	-0.4	-0.3	0.4	-2.0	-2.4	-2.5	-1.7
Primary Biliary Cirrhosis	1.9	2.7	3.8	-1.0	2.0	-1.6	-1.8	-1.3	-1.8	-1.8
Rheumatoid Arthritis	2.0	2.7	4.8	-1.2	0.3	-2.1	2.0	2.2	1.5	1.4
Schizophrenia (2014)	0.3	0.6	1.8	-1.3	1.2	0.4	-0.2	-0.3	-0.7	-0.6
Triglycerides	0.3	0.4	1.5	0.2	0.8	0.5	0.3	1.2	0.8	0.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.4	0.0	0.0	1.8	1.5	1.4	1.2	0.0
Ulcerative Colitis	4.8	6.9	14.5	0.0	-0.3	-2.7	-2.8	-2.8	-3.8	-3.3
Blood Eosinophil Count	1.0	7.9	18.5	2.3	-2.7	-0.4	4.3	3.6	3.3	0.4
Blood Platelet Count	2.9	33.6	112.4	10.6	-4.1	0.3	4.1	4.1	8.1	2.7
Blood Red Count	0.5	5.2	19.1	-1.7	-4.4	0.1	1.6	1.8	-0.6	2.9
Blood White Count	5.3	38.9	65.6	2.1	-7.3	0.5	7.8	5.9	7.4	8.1
Heel T-Score	0.6	4.9	10.9	-2.6	-3.3	-0.8	2.0	1.8	-0.2	2.9
BMI	3.1	18.1	34.5	1.5	-3.4	0.0	5.9	5.5	5.3	4.6
Height	0.5	9.8	25.1	-0.7	-0.4	0.2	-5.0	-4.2	-4.3	-2.5
Waist Hip Ratio (WHR)	0.3	1.2	2.1	0.1	-1.2	-1.4	-1.0	-1.5	-1.4	0.1
Systolic Blood Pressure	0.1	0.7	3.2	-1.8	-0.3	0.6	0.5	0.2	0.0	0.7
Smoking Status	1.4	3.2	5.9	0.9	-1.0	-2.2	2.1	2.4	2.4	0.6
Allergy or Eczema	0.6	1.6	4.0	2.0	-1.3	-0.0	1.2	1.7	1.2	-0.3
Cardiovascular Disease	0.5	1.7	2.7	-0.8	0.3	1.6	1.4	1.6	1.4	1.4
Hypothyroidism (self reported)	3.2	7.3	17.2	2.7	1.2	4.2	2.5	1.9	2.8	2.7
Respiratory disease	0.3	0.7	1.9	1.4	0.7	0.3	0.2	0.9	1.2	-0.3
Type 2 Diabetes (T2D) (2018)	3.3	6.1	10.3	2.0	-1.7	-0.4	2.9	3.2	2.8	3.1
Lung FEV1/FVC ratio	0.4	2.0	3.2	-1.8	-1.2	-1.6	1.7	1.6	0.2	1.2
Lung FVC	0.5	2.4	5.7	1.1	-0.8	-1.4	2.1	2.4	1.2	1.1
Neuroticism	0.4	0.9	3.3	1.1	-0.1	-1.0	-0.6	-1.8	-0.4	-0.6
Chronotype (morning person)	0.8	1.9	5.7	1.3	2.4	-0.4	-1.2	-0.8	0.5	-2.0
Hair Pigment	0.0	0.5	1.3	-0.7	1.1	-1.1	-0.2	0.2	-0.3	-0.4
Tanning	0.1	1.3	2.3	1.4	-1.5	0.5	1.0	1.3	1.4	0.3
Hand grip strength (left)	0.8	2.1	10.7	-0.4	-3.3	-1.8	0.1	0.8	-0.3	0.4
Number of treatments/medications taken	1.3	2.3	5.2	0.5	1.0	1.6	1.5	1.2	1.8	2.3
Average weekly spirits intake	1.3	1.6	4.2	1.6	-0.6	0.3	0.8	2.0	1.8	0.7
Sensitivity / hurt feelings	0.6	1.0	4.2	2.0	0.8	-0.8	0.2	-0.1	1.2	0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.2	0.9	-0.1	-1.0	-1.1	-1.1	-0.8	-0.5
Hearing difficulty/problems: Yes	0.8	1.2	3.3	1.8	1.7	-0.4	-0.8	-0.1	0.3	-1.2
Relative age of first facial hair	0.3	0.7	2.3	-0.1	1.1	1.5	0.3	-0.7	0.1	-0.7
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	7.7	1.4	-0.4	0.5	2.3	2.8	2.2	1.5
Ever used hormone-replacement therapy (HRT)	1.2	1.5	6.2	0.6	1.6	-2.5	0.5	0.6	0.8	0.2
Ever had hysterectomy (womb removed)	0.7	0.7	1.9	-0.4	1.4	-0.6	-0.9	-0.8	-0.8	-0.9
Systolic blood pressure, automated reading	0.6	1.8	3.9	-0.4	0.6	0.5	2.0	2.0	1.7	1.1
Eye problems/disorders: Diabetes related eye disease	3.6	3.9	6.6	1.3	-1.9	1.2	2.6	1.9	2.2	2.4
Angina	0.2	0.2	0.5	0.5	0.7	-0.6	0.4	0.3	0.4	-0.5
Medication for hormone replacement therapy	1.5	1.6	6.1	1.1	0.3	0.3	1.0	1.0	1.3	2.5
Vitamin and mineral supplements	1.6	2.1	4.5	0.7	-1.0	0.7	2.1	2.0	1.9	0.8
Supplements: Zinc	0.6	0.7	3.8	-0.2	0.6	-1.9	-0.3	-0.4	-0.5	-0.1
Medication: Co-codamol	1.0	1.1	2.8	1.7	0.1	-1.1	-1.3	-1.1	-0.2	-1.0
Medication: Metformin	4.6	6.4	11.3	3.4	-0.8	0.4	3.1	2.2	2.9	3.2
Diabetes (father)	0.6	0.7	3.7	0.2	-0.1	1.9	0.5	0.1	0.7	0.7
Diabetes (mother)	0.2	0.3	0.7	0.4	-0.5	0.6	-0.4	-0.8	0.4	-0.4
Severe depression (siblings)	0.4	0.4	1.2	0.7	-0.6	-0.5	0.5	0.3	1.1	0.4
Pack years adult smoking proportion	0.3	0.5	2.3	-0.5	0.5	-1.5	0.1	-0.1	-0.3	0.7
Impedance of leg (right)	1.0	4.8	11.1	-0.9	0.9	0.7	-3.1	-3.3	-2.5	-2.2
Leg fat-free mass (left)	1.3	6.8	13.1	1.1	-3.3	-0.0	2.9	3.6	2.4	2.9
Trunk fat percentage	2.8	11.3	20.7	1.4	-2.4	0.5	4.6	4.0	4.2	4.2
Hand grip strength (right)	1.0	2.7	13.4	-1.2	-3.7	-1.7	-0.2	1.1	-0.5	0.1
Townsend deprivation index at recruitment	0.4	0.5	2.3	0.3	-0.1	-1.5	0.1	-0.4	-0.7	0.8
Current tobacco smoking	1.6	2.6	5.1	1.9	-0.4	0.4	1.6	1.8	2.3	1.9
Average weekly fortified wine intake	0.9	1.1	2.1	1.5	-1.1	1.3	0.5	-0.7	0.7	1.1
Maternal smoking around birth	0.5	0.7	2.1	0.1	0.4	-0.4	1.5	1.0	0.6	1.2
Fed-up feelings	1.4	2.5	11.4	-0.8	-1.3	-3.4	-0.4	-1.2	-1.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.3	4.5	0.5	-0.6	-2.1	-0.8	-1.4	-0.8	-0.8
Relative age voice broke	0.4	0.6	2.1	-0.1	0.1	-0.3	-0.7	-1.5	-0.9	-0.6
Taking other prescription medications	2.2	3.4	6.3	1.3	2.5	2.2	1.3	1.1	2.0	2.0
Age when periods started (menarche)	1.7	4.1	7.6	0.6	2.5	-2.4	-1.7	-2.8	-1.7	-1.7
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.2	-0.8	-1.1	-0.1	-0.2	-0.3	-0.7	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	0.1	-1.3	-1.0	0.8	0.8	-0.4	0.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.0	-1.2	-1.1	0.1	0.4	1.1	-0.2	2.0
Qualifications: CSEs or equivalent	2.9	3.8	15.1	-0.1	-1.1	0.5	2.3	1.4	1.8	3.9
Serious illness, injury or assault to yourself	1.0	1.2	2.6	0.1	-0.4	-0.1	1.6	1.6	1.0	1.4
High blood pressure	0.4	1.2	4.0	-0.9	1.7	2.0	-0.1	0.3	-0.0	-0.5
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.7	1.6	-0.8	-0.6	1.0	1.5	1.1	0.0
Multivitamins +/- minerals	2.4	3.1	7.8	-0.1	0.5	-0.3	-2.8	-2.5	-2.3	-1.4
Stomach or abdominal pain in last month	2.1	2.6	8.4	1.7	0.1	0.7	1.7	0.9	2.9	1.7
Supplements: Glucosamine	0.2	0.2	1.4	1.2	-0.1	0.0	0.2	0.1	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.0	0.2	-0.4	-0.8	0.3	0.5	0.3	1.4
Medication: Atenolol	3.0	3.7	8.8	-0.9	0.8	1.8	-1.8	-2.5	-1.7	-3.0
Medication: Levothyroxine sodium	4.2	7.1	16.3	2.5	0.9	4.0	2.3	2.3	3.1	2.6
Sitting height	0.1	0.7	2.1	-0.4	-1.5	-0.4	-1.3	-0.0	-1.0	-0.5
Chronic bronchitis/emphysema (father)	0.1	0.2	0.5	0.5	0.1	0.1	-0.1	0.3	0.4	-0.7
High blood pressure (mother)	0.3	0.5	1.0	0.1	0.9	0.6	0.5	1.0	0.3	-1.0
Body mass index (BMI)	3.7	15.6	29.3	1.3	-3.0	-0.1	5.4	5.3	4.7	4.5
Impedance of leg (left)	1.1	5.1	10.6	-1.2	1.1	0.4	-3.1	-3.2	-2.9	-2.2
Leg predicted mass (left)	1.3	7.1	13.7	1.0	-3.4	-0.1	3.0	3.7	2.4	3.0
Trunk fat mass	2.7	11.5	18.8	1.3	-3.0	0.5	4.3	4.1	4.0	4.3
Waist circumference	2.8	10.1	18.0	1.1	-2.7	-0.1	4.2	4.2	3.4	3.9
Number of incorrect matches in round	0.4	0.6	1.9	0.2	0.6	0.4	-1.4	-1.1	-0.6	-0.6
Past tobacco smoking	1.5	2.7	10.9	0.2	0.3	3.3	-1.6	-1.7	-1.5	-0.6
Alcohol usually taken with meals	1.0	1.7	4.6	0.3	0.4	1.6	-1.4	-1.2	-1.0	-2.1
Nervous feelings	1.4	2.5	3.4	1.2	1.8	1.8	-1.6	-1.8	-0.9	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	5.2	1.0	0.3	-0.5	-1.4	-2.3	-1.4	-1.3
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.4	0.5	0.4	-0.8	-0.0	-0.6	-0.9
Hair/balding pattern: Pattern 2	0.8	1.0	2.7	-1.4	-1.1	-0.2	0.8	1.6	-0.1	0.7
Had menopause	0.9	1.1	7.0	-0.0	2.6	-0.2	-0.3	-0.1	0.2	-0.5
Had other major operations	0.3	0.3	0.8	0.6	0.8	0.9	-0.1	-0.4	0.3	-0.4
Forced vital capacity (FVC)	0.8	3.0	7.0	-2.0	-2.6	-1.6	-1.1	0.7	-2.3	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.2	0.5	-1.1	-1.0	-0.0	0.4	-0.6	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.3	-0.6	-0.7	-1.0	-0.3	-1.5	-0.3	0.1
Qualifications: None of the above	1.0	2.1	10.1	-1.4	3.2	-0.2	-0.6	-1.2	-0.4	-0.5
Financial difficulties in last 2 years	1.0	1.4	4.4	-1.4	-2.1	-1.4	-0.1	0.3	-0.5	0.9
Mouth/teeth dental problems	0.3	0.5	2.5	-1.6	-0.6	0.7	-0.0	0.3	-0.5	-0.3
Heart attack	0.5	0.7	1.4	1.1	1.2	1.1	-0.3	-0.9	0.4	-0.2
Allergy	0.9	2.1	4.7	-2.2	0.5	-0.7	-1.5	-1.3	-2.2	-0.8
Pain all over the body in last month	1.1	1.2	3.6	0.5	-1.4	-0.1	1.2	0.9	1.9	0.5
Diabetes (self-reported)	3.6	5.5	11.8	2.2	-1.7	-0.0	2.8	2.2	2.6	3.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.5	-1.2	-0.3	-0.8	1.0	-0.0	0.5	0.7
Medication: Ramipril	0.6	0.8	2.4	0.9	1.5	1.0	0.5	0.2	0.6	0.8
Medication: Simvastatin	0.5	0.7	3.7	0.6	1.9	0.2	-0.2	-0.6	0.2	-0.6
Fluid intelligence score	1.0	2.0	3.8	1.0	-1.5	0.6	1.9	1.8	1.7	0.5
Illnesses of siblings	1.4	1.9	10.0	0.7	-3.2	-0.1	-0.4	0.6	-0.6	-1.4
Neuroticism score	0.3	0.6	1.4	0.8	-1.2	-1.1	-0.0	-1.1	0.0	0.4
Weight	1.7	8.5	16.0	0.8	-3.4	0.2	3.4	4.0	2.7	3.5
Impedance of arm (right)	1.0	4.9	11.3	0.2	1.9	1.3	-2.7	-3.4	-2.0	-2.6
Arm fat percentage (right)	3.9	15.3	28.7	1.7	-3.0	0.7	5.4	4.7	4.8	4.7
Trunk fat-free mass	0.5	2.9	11.8	-0.4	-3.4	0.1	0.8	2.3	-0.0	1.5
Hip circumference	2.6	11.3	21.7	0.9	-2.8	0.9	4.6	4.7	3.7	3.7
Time employed in main current job	0.5	0.6	2.8	-0.5	-0.5	-1.7	0.6	0.3	-0.4	0.1
Alcohol intake versus 10 years previously	0.5	0.8	1.8	-0.7	0.5	-0.6	-0.9	-1.4	-0.9	1.1
Father’s age at death	2.0	2.7	7.0	-0.8	-0.9	0.1	-2.6	-1.5	-2.6	-1.2
Worrier / anxious feelings	0.3	0.5	1.1	-0.4	-0.9	0.8	-0.6	-1.0	-0.7	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.9	0.3	-0.7	0.0	-0.5	0.2	-0.5
Falls in the last year	1.7	2.2	4.9	1.6	2.2	0.5	1.5	1.4	2.0	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	1.6	0.2	-1.1	1.3	-0.1	0.1	-0.1	0.8
Number of live births	1.5	2.1	5.0	-0.1	0.7	0.4	2.2	1.0	2.0	2.0
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	10.1	-2.1	-3.2	-1.0	-0.2	1.4	-1.8	-0.2
Pulse rate	0.9	1.6	5.9	0.8	0.2	-2.4	-0.5	-1.3	-0.7	-1.4
Happiness	0.9	1.1	2.7	-1.1	1.6	0.3	-0.5	-1.6	-0.9	-0.5
Noisy workplace	1.6	1.9	4.8	-1.5	0.8	-0.1	-2.2	-1.1	-2.1	-0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	4.6	-0.9	-1.1	-2.1	-0.3	0.4	-0.6	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	4.0	0.3	-2.0	-0.2	0.3	1.9	0.3	0.6
Mouth/teeth dental problems: Dentures	0.8	1.4	5.3	2.3	1.0	-1.0	0.2	-0.3	1.4	0.5
Asthma	0.6	1.3	2.5	-0.0	0.3	1.2	1.3	1.6	1.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	6.6	-2.6	-1.9	-2.1	0.2	0.5	-1.6	-0.2
Medication: Cholesterol lowering	0.6	1.0	1.8	1.2	1.3	1.3	0.7	0.1	1.2	0.2
Depression (self-reported)	0.2	0.3	1.3	0.4	-1.2	-0.5	-0.0	-0.4	-0.3	0.1
Medication: Lansoprazole	0.1	0.1	0.1	-0.2	0.4	0.1	0.1	0.1	0.3	0.4
Prospective memory result	1.5	1.9	8.5	0.6	2.9	-0.1	-1.1	-1.7	-0.3	-0.2
Lung cancer (father)	0.8	0.9	3.6	-0.4	0.5	-0.8	-0.4	-0.9	-0.9	-1.9
Illnesses of mother	0.9	1.2	1.8	-1.4	-1.1	-1.3	-1.0	-0.9	-1.2	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.7	-2.2	-1.9	0.1	-0.3	0.5	-1.6	-0.3
Pulse wave Arterial Stiffness index	0.3	0.4	1.3	-0.9	0.1	-0.5	0.4	0.1	0.3	1.1
Impedance of arm (left)	1.0	4.7	10.7	0.4	2.3	1.6	-2.5	-3.3	-1.5	-2.4
Arm fat mass (right)	3.3	13.7	23.2	1.4	-3.3	0.3	4.8	4.6	4.2	4.6
Trunk predicted mass	0.5	2.7	11.2	-0.3	-3.4	0.1	0.7	2.3	0.0	1.5
Standing height	0.5	5.3	13.8	-0.9	-1.6	0.6	-3.7	-2.1	-3.5	-1.6
Length of working week for main job	0.6	0.7	2.1	0.7	-0.3	0.1	0.9	1.4	1.0	0.7
Exposure to tobacco smoke at home	0.2	0.2	0.8	0.0	0.3	-0.9	0.2	-0.5	-0.2	0.4
Breastfed as a baby	0.5	0.6	1.4	0.0	0.8	-0.7	-1.1	-0.4	-1.2	-0.8
Tense / ‘highly strung’	1.9	3.2	5.5	-0.3	0.9	-1.3	-2.3	-2.2	-2.3	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.9	-0.1	-0.6	-1.4	-0.4	-0.9	-0.0	0.3
Hair/balding pattern: Pattern 4	0.3	0.8	3.9	0.2	2.0	-0.5	0.2	0.3	0.9	0.5
Birth weight of first child	0.1	0.1	0.4	0.4	0.1	0.6	-0.3	-0.5	-0.2	-0.2
Peak expiratory flow (PEF)	0.7	1.6	5.2	-1.3	-2.3	-0.2	-0.5	0.4	-1.9	-0.4
Pulse wave reflection index	1.2	1.5	3.7	0.8	-0.1	0.6	1.0	1.9	1.9	1.1
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.9	-1.5	-1.7	-0.7	-0.1	0.4	-0.5	0.8
Loud music exposure frequency	0.4	0.4	1.1	-0.3	0.6	0.5	1.1	0.6	0.5	0.5
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	11.5	0.4	-3.4	-1.0	1.8	2.1	1.2	1.8
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	0.6	0.6	-0.3	0.1	0.0	-0.2	-0.2
Blood clot in the leg (DVT)	1.7	2.2	5.1	1.5	-0.8	1.0	1.3	1.9	2.3	1.1
Medication: Paracetamol	2.2	3.7	4.9	-0.8	-2.1	-1.8	2.2	2.1	1.9	2.2
Headache pain in last month	0.1	0.2	0.5	-0.7	0.3	0.0	0.2	0.7	0.4	0.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.7	-0.6	-1.6	-1.2	-0.5	-0.1	-0.8	0.2
Glaucoma (self-reported)	0.8	1.0	3.0	-1.7	-0.5	-1.7	0.7	0.7	0.2	-0.2
Gout (self-reported)	0.1	0.2	0.6	-0.8	-0.0	-0.2	-0.8	-0.1	-0.3	-0.1
Hypothyroidism/myxoedema (self-reported)	4.0	7.9	23.9	2.6	1.0	4.9	2.1	2.0	2.4	3.0
Medication: Amlodipine	1.0	1.4	3.3	0.3	1.8	-1.2	-0.8	-0.8	-0.7	-1.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.4	0.7	0.4	-0.2	-0.5	-0.8	-0.6
Birth weight	1.0	2.2	5.1	0.3	-1.4	1.5	-1.7	-1.2	-1.1	-2.3
Chronic bronchitis/emphysema (mother)	0.6	0.7	3.5	1.0	-0.1	0.2	0.2	-0.5	0.1	1.9
High blood pressure (siblings)	1.1	1.6	7.3	-0.5	2.7	0.8	0.3	-0.5	0.4	1.7
Forced vital capacity (FVC), Best measure	0.7	2.4	6.2	-1.9	-1.3	-0.6	-1.5	-0.3	-2.5	-1.6
Body fat percentage	3.5	13.7	24.9	1.4	-2.7	0.4	5.0	4.4	4.6	4.5
Leg fat percentage (right)	4.1	14.8	26.4	1.4	-3.1	0.4	5.1	4.7	4.7	4.6
Arm fat-free mass (right)	0.9	4.6	10.8	-0.5	-3.3	-0.5	1.9	3.2	0.9	2.5
Exposure to tobacco smoke outside home	0.4	0.6	1.7	0.5	-0.7	-0.6	0.8	1.3	0.1	0.9
Comparative body size at age 10	0.3	0.8	3.0	0.4	0.3	1.7	-0.7	-0.7	-0.4	-1.1
Number of full brothers	0.9	1.1	4.7	-2.2	-0.2	-1.4	0.3	0.3	-0.6	0.6
Worry too long after embarrassment	0.2	0.4	2.2	0.3	0.0	-0.2	-0.6	-1.5	0.2	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.5	1.0	-1.2	-0.3	-0.1	-0.4	-0.3	-0.2
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	0.9	1.4	0.6	0.3	-0.6	1.1	0.1
Number of children fathered	4.1	4.7	10.1	-0.1	-2.4	-0.3	2.9	3.2	2.2	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.0	1.0	0.1	0.3	-0.8	-0.8	-0.1	0.2
Age at first live birth	0.8	1.5	4.0	-1.0	-0.5	-0.4	-1.3	-0.3	-1.8	-2.0
Pulse wave peak to peak time	0.5	0.6	1.8	0.8	-0.1	0.7	-0.8	-0.5	-0.7	-1.3
Health satisfaction	2.2	2.9	5.8	1.5	2.1	-0.2	-1.8	-2.4	-0.9	-2.0
Shortness of breath walking on level ground	0.1	0.2	0.4	-0.3	0.2	-0.6	0.5	-0.6	-0.0	-0.1
Qualifications: College or University degree	0.3	1.1	5.8	-0.2	-0.3	0.8	-0.7	-0.2	-0.6	-2.4
Eye problems/disorders: None of the above	3.1	3.6	8.8	-0.8	-0.2	1.5	-3.0	-1.9	-2.8	-1.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.8	-0.6	0.2	-0.1	-1.1	-0.3	-1.4	-0.2
Emphysema/chronic bronchitis	0.3	0.3	1.4	1.2	-0.1	-0.3	0.3	0.0	0.8	0.0
Medication for pain relief, constipation, heartburn	0.7	1.2	3.0	0.3	-0.1	1.7	-1.4	-1.1	-1.2	-0.9
Neck or shoulder pain in last month	0.9	1.3	4.4	-2.1	1.0	0.0	-0.8	-0.3	-1.3	1.1
Medication: Blood pressure	0.3	0.5	2.8	-0.2	1.7	0.7	0.1	-0.4	0.0	-0.5
Angina (self-reported)	0.1	0.2	0.4	0.5	0.7	-0.4	0.4	0.2	0.4	-0.4
Migraine (self-reported)	0.6	0.8	1.4	-0.9	-0.5	-0.7	-1.1	-1.0	-1.2	-0.7
Medication: Ibuprofen	1.6	1.9	8.3	-2.9	-1.6	-0.7	0.4	0.7	-1.2	-0.0
Medication: Allopurinol	0.5	0.6	2.3	-1.5	0.6	-1.0	-0.4	0.2	-0.7	0.3
Medication: Omeprazole	0.3	0.4	1.6	0.5	0.3	-1.3	-0.5	-0.7	0.1	0.2
Medication: Seretide 50 evohaler	0.7	0.8	1.7	-0.6	0.8	1.2	0.7	1.3	0.5	0.9
Mean time to correctly identify matches	0.2	0.4	1.2	1.1	-0.8	0.1	-0.5	-0.8	0.3	-0.1
Heart disease (mother)	0.6	0.8	3.2	0.4	1.8	1.1	0.4	0.0	0.5	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	-1.2	0.6	-0.5	-0.4	0.4	-0.9	0.0
Whole body fat mass	2.8	11.5	18.9	1.2	-2.9	0.2	4.4	4.3	4.0	4.2
Leg fat mass (right)	4.2	16.2	27.0	1.2	-3.6	0.2	5.2	5.2	4.6	4.9
Arm predicted mass (right)	0.9	4.4	10.0	-0.3	-3.1	-0.3	2.0	3.2	1.1	2.5
Pulse rate, automated reading	2.2	7.2	20.7	-0.3	1.5	-0.9	-3.3	-4.5	-3.0	-2.6
Alcohol intake frequency.	0.6	1.3	2.7	-1.6	0.2	0.6	-0.9	-1.0	-1.5	1.4
Comparative height size at age 10	0.5	2.7	8.4	-0.7	-0.9	0.8	-2.9	-1.4	-2.4	-0.7
Number of full sisters	0.3	0.3	1.1	0.1	0.8	-0.1	-0.4	-1.1	-0.1	-0.6
Suffer from ‘nerves’	1.0	1.6	4.4	-0.7	-0.7	-0.3	-1.3	-2.1	-1.7	-1.2
Overall health rating	0.7	1.6	8.0	1.3	2.8	0.2	-0.3	-0.7	0.7	-0.4
Chest pain or discomfort	0.1	0.2	0.7	-0.3	-0.2	0.2	-0.5	-0.8	-0.2	-0.5
Had major operations	0.5	0.5	1.0	1.0	0.9	0.9	0.2	0.2	1.0	-0.1
Age at last live birth	0.5	0.8	2.0	-0.7	-0.9	-1.1	-0.1	0.5	-0.8	-1.4
Family relationship satisfaction	0.4	0.5	1.8	0.5	0.8	1.4	-0.6	-0.8	0.2	-0.3
Leg pain on walking	0.4	0.4	1.0	-1.0	1.0	0.7	-0.7	-0.1	-0.4	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.4	-1.2	-1.8	0.6	0.5	0.8	-0.0	1.8
Commuting to job workplace: Car/motor vehicle	2.5	2.9	6.5	0.8	-1.0	-0.4	2.3	2.6	1.8	1.7
Illness, injury, bereavement, stress in last 2 years	1.9	2.4	6.3	0.4	2.5	0.8	-1.7	-2.0	-0.9	-1.4
Medication: Aspirin	1.0	1.4	5.0	1.1	2.2	-0.1	0.2	-1.0	1.0	-1.1
Supplements: Vitamin C	0.2	0.2	1.0	-0.3	0.6	-1.0	-0.1	-0.2	-0.3	-0.0
Knee pain experienced in last month	0.5	0.8	2.3	1.5	0.7	-0.1	0.5	0.9	0.9	-0.9
Hypertension (Self-reported)	0.4	1.2	4.0	-0.7	1.1	2.0	0.7	1.2	0.8	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.2	-0.0	0.6	-1.5	-0.4	-0.7	-0.1	0.1
Illnesses of father: Heart disease	1.0	1.3	3.8	1.6	1.9	1.1	-0.1	0.1	1.3	0.1
Illnesses of siblings: Diabetes	2.6	3.2	8.0	0.3	2.0	0.6	1.6	0.3	2.7	2.8
Smoking status: Previous	1.2	1.9	8.8	-0.9	-0.4	-3.0	1.1	1.1	0.7	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.8	-0.6	-1.1	0.3	-1.5	-1.2	-1.9	-0.8
Whole body fat-free mass	0.8	4.6	12.1	0.1	-3.5	-0.1	1.9	3.1	1.1	2.3
Leg fat-free mass (right)	1.1	6.1	12.7	0.9	-3.3	-0.3	2.7	3.6	2.0	2.8
Arm fat percentage (left)	3.9	15.5	29.1	1.7	-2.7	0.9	5.4	4.6	4.9	4.8
Average weekly red wine intake	0.5	0.8	1.7	0.1	-0.7	0.7	-1.3	-1.1	-0.9	-0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	1.1	0.8	-0.1	0.5	-0.8	0.7	0.3
Mood swings	1.1	2.0	3.9	0.0	-1.7	-2.0	-1.3	-1.6	-1.7	-0.2
Loneliness, isolation	1.0	1.3	2.8	-1.2	-0.1	0.3	-1.5	-1.5	-1.7	-0.6
Long-standing illness, disability or infirmity	0.3	0.5	2.2	0.6	1.5	0.5	-0.0	0.1	0.7	0.0
Ever had bowel cancer screening	2.0	2.3	14.7	0.6	3.8	0.1	0.1	0.0	1.1	0.3
Diabetes diagnosed by doctor	3.7	6.1	10.8	2.6	-1.3	-0.3	2.8	2.6	2.9	3.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.0	1.0	1.4	0.8	-0.9	-1.1	-0.2	-1.2
Friendships satisfaction	0.6	0.8	2.5	0.2	1.1	0.7	-1.0	-1.6	0.1	-0.6
Qualifications: nursing, teaching	0.6	1.0	4.6	2.1	-0.2	-0.0	0.5	0.5	1.1	-0.7
Commuting to job workplace: Walk	2.1	2.3	6.0	-0.7	2.5	0.2	-1.6	-1.8	-1.8	-0.9
Eye problems/disorders: Cataract	0.6	0.7	2.8	0.8	1.7	-0.6	-0.1	0.0	0.8	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	2.2	0.5	0.1	-1.5	-0.1	0.0	0.2	-0.4
Medication for cholesterol	0.5	0.8	2.9	-0.0	-0.4	-1.7	-0.3	-1.0	-0.4	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.9	-1.4	0.6	-0.3	0.1	-0.6	-0.8	-0.1
Back pain experienced in last month	0.7	1.0	2.0	-0.1	1.1	0.1	1.3	1.1	1.0	1.4
Mineral and other dietary supplements	0.6	0.8	1.8	-0.3	-0.6	0.3	1.4	1.1	1.0	1.1
Breast cancer (self-reported)	0.8	0.9	2.0	0.3	0.3	-0.7	-1.4	-0.6	-1.4	-1.3
Asthma (self-reported)	0.6	1.1	2.3	0.0	0.3	1.0	1.1	1.5	1.4	1.2
Osteoporosis (self-reported)	1.7	2.2	8.5	1.6	2.9	1.0	-0.3	-1.5	0.5	0.6
Osteoarthritis (self-reported)	2.0	2.6	5.6	-0.4	0.5	1.5	1.9	1.8	1.9	2.4
Medication: Aspirin	0.9	1.2	4.1	1.1	2.0	0.0	0.3	-0.7	1.0	-1.1
Medication: Gliclazide	2.0	2.2	5.1	2.3	0.9	1.1	1.4	1.6	1.9	0.7
Illnesses of father: None of the above (group 1)	0.7	0.9	2.3	-0.9	-1.0	-0.3	-0.1	-1.5	-1.5	-0.1
Smoking status: Current	1.6	2.6	5.3	2.2	-0.4	0.2	1.4	1.8	2.3	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.0	-0.9	-0.7	-0.4	-0.2	0.5	-1.0	-0.1
Whole body water mass	0.8	4.5	11.8	0.1	-3.4	-0.2	1.8	3.1	1.1	2.4
Leg predicted mass (right)	1.2	6.5	13.2	0.8	-3.4	-0.3	2.8	3.6	2.1	2.8
Arm fat mass (left)	3.4	13.8	23.5	1.3	-3.2	0.5	4.8	4.6	4.2	4.6
Number of self-reported non-cancer illnesses	1.4	2.4	6.0	1.6	0.6	0.9	1.5	1.1	2.5	1.9
Average weekly champagne plus white wine intake	1.0	1.4	4.8	-0.3	2.1	-0.5	-0.6	-0.3	-0.5	-2.2
Miserableness	0.2	0.4	1.4	0.9	0.1	0.4	-0.5	-1.2	-0.0	-0.2
Guilty feelings	0.8	1.2	5.7	0.6	-0.5	-2.4	0.7	-0.4	0.3	1.1
Wears glasses or contact lenses	0.7	0.8	2.8	1.7	0.6	-0.6	0.7	0.1	1.3	-0.0
Ever taken oral contraceptive pill	1.4	1.6	5.3	-0.5	-2.3	-1.5	1.2	0.9	0.5	0.9
Hearing aid user	1.1	1.2	3.3	-1.8	0.9	-0.4	-1.0	-1.2	-1.2	0.7
Mother’s age at death	0.3	0.3	0.7	0.5	0.1	-0.1	0.9	0.3	0.9	-0.7
Financial situation satisfaction	1.8	2.3	5.6	-0.2	-0.2	-0.4	-2.1	-2.4	-1.8	-1.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	0.1	0.4	-0.3	-1.2	-0.9	-0.7	-1.1
Commuting to job workplace: Public transport	0.3	0.3	0.9	1.0	0.5	0.2	-0.8	-0.7	-0.1	-0.3
Eye problems/disorders: Glaucoma	1.2	1.4	3.4	-0.9	-0.5	-1.7	1.9	1.2	1.2	-0.0
Medication: Blood pressure	0.3	0.5	1.7	-0.0	1.3	1.2	-0.3	0.3	0.3	-0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.5	1.6	-0.2	-0.8	0.0	0.3	0.8	0.1
Supplements: Fish oil (including cod liver oil)	1.4	1.8	4.3	0.3	1.4	-0.3	-1.7	-1.4	-1.0	-2.1
High cholesterol (Self-reported)	0.5	1.0	3.5	0.1	0.8	1.9	0.7	0.8	1.1	0.5
Medication: Bendroflumethiazide	0.8	1.3	3.6	1.0	1.9	1.9	-0.4	0.1	0.6	-0.1
Medication: Paracetamol	1.7	2.7	3.5	-1.0	-1.9	-1.6	1.8	1.6	1.6	1.9
Medication: Lisinopril	0.7	0.9	3.5	1.9	-0.1	0.3	0.1	0.5	1.1	-1.2
Medication: Atorvastatin	0.8	1.0	2.7	1.1	1.1	0.6	0.6	1.0	1.6	0.2
Illnesses of father: High blood pressure	1.4	1.8	7.2	0.7	1.9	2.7	-0.6	-0.6	0.5	-0.4
Alcohol drinker status: Never	0.4	0.5	0.9	0.8	0.5	1.0	-0.7	-0.6	0.2	0.9
Ever smoked	1.9	3.3	9.8	-0.5	-0.6	-3.1	1.7	2.1	1.8	1.3
Basal metabolic rate	1.1	5.9	13.7	0.3	-3.7	-0.1	2.4	3.5	1.6	2.8
Leg fat percentage (left)	3.9	14.1	25.9	1.2	-2.9	0.1	5.1	4.8	4.6	4.5
Arm fat-free mass (left)	1.1	5.5	13.0	-0.1	-3.6	-0.6	2.2	3.4	1.3	2.6
Number of operations (self-reported)	0.5	0.7	1.5	0.0	0.8	0.6	1.0	1.2	1.2	0.2
Average weekly beer plus cider intake	1.4	2.0	3.9	0.9	-1.5	-0.1	2.0	1.1	1.9	1.6
Irritability	1.2	2.1	6.3	0.4	-2.5	-2.4	1.0	0.7	0.4	0.8
Risk taking	1.2	1.8	5.6	0.6	-0.2	0.9	1.6	2.4	1.6	0.9
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.8	-0.9	-0.2	-0.1	-0.2	-0.1	-0.3	0.1
Fractured/broken bones in last 5 years	0.7	0.9	1.9	-1.0	0.7	-0.1	1.1	1.0	0.7	1.4
Age started oral contraceptive pill	3.0	3.8	8.0	-0.6	2.4	-2.0	-1.8	-1.4	-1.9	-2.8
Diastolic blood pressure, automated reading	0.5	1.7	3.9	-0.9	0.3	0.4	2.0	1.8	1.4	1.2
Ever depressed for a whole week	0.3	0.4	0.9	0.4	-0.2	-0.5	0.7	-0.2	0.9	0.8
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.5	-0.9	-0.9	0.2	0.2	-0.5	0.8
Commuting to job workplace: Cycle	0.3	0.3	0.9	-0.5	0.8	1.0	0.2	-0.4	0.0	-0.3
Myopia	1.3	2.0	4.2	0.2	2.0	-0.3	-2.0	-1.4	-0.7	-1.7
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.2	1.0	-1.6	-2.0	0.1	-0.6	0.1	0.4
Cholesterol lowering medication	0.1	0.1	0.3	0.5	0.5	0.1	0.1	0.4	0.4	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.3	0.5	0.4	-1.5	-0.7	-0.7	0.1	-0.3
Pain experienced in last month	0.5	0.8	4.7	-0.3	-2.2	0.5	0.1	-0.4	-0.7	0.2
Supplements: Calcium	1.6	1.8	5.1	-1.2	1.0	0.0	-1.7	-2.3	-1.5	0.1
Basal cell carcinoma (self-reported)	0.5	0.6	2.8	0.3	-1.1	-0.5	0.2	1.7	0.2	0.2
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.1	1.2	1.4	1.2	-0.5	-1.2	0.3	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.8	1.1	-0.8	1.4	1.4	2.0	2.2	1.3
Heart disease (siblings)	0.9	1.1	3.6	-0.3	1.9	0.2	1.3	0.9	1.1	0.6
Alcohol drinker status: Previous	0.3	0.4	0.9	-0.3	-0.9	0.3	0.1	-0.6	-0.6	0.8
Pack years of smoking	0.4	0.5	2.6	-0.3	0.6	-1.6	0.1	-0.2	-0.3	0.7
Impedance of whole body	1.2	6.1	14.7	-0.5	1.9	0.7	-3.1	-3.8	-2.5	-2.8
Leg fat mass (left)	3.9	15.2	25.6	1.3	-3.4	0.2	5.1	5.1	4.4	4.7
Arm predicted mass (left)	1.1	5.4	13.4	-0.1	-3.7	-0.8	2.2	3.4	1.1	2.6