[Hub]/) : Traits : Leg fat percentage (right) : ← →

chr18:12,090,696-13,822,256

Best TWAS P=1.08e-09 · Best GWAS P=1.25e-09 conditioned to 0.0136

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Brain Nucleus accumbens basal ganglia	PTPN2	0.32	0.02	lasso	10	0.05	2.2e-02	5.7	6.1	1.1e-09	0.71	0.06	0.41	TRUE
4	GTEx	Brain Hippocampus	CEP192	0.43	0.35	lasso	9	0.44	9.8e-12	-4.8	-5.9	2.9e-09	-0.76	0.27	0.72	FALSE
14	GTEx	Pituitary	CEP192	0.51	0.24	enet	29	0.39	1.0e-10	-4.7	-5.7	1.3e-08	-0.79	0.09	0.91	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	CEP192	0.30	0.42	enet	46	0.45	4.1e-64	-4.7	-5.7	1.3e-08	-0.74	0.80	0.20	FALSE
1	GTEx	Adipose Visceral Omentum	CEP192	0.38	0.35	lasso	4	0.43	3.0e-24	-4.8	-5.6	1.6e-08	-0.66	0.80	0.20	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	CEP192	0.09	0.14	blup	85	0.14	8.4e-16	-4.8	-5.5	3.2e-08	-0.72	0.82	0.18	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	SEH1L	0.04	0.05	lasso	1	0.03	2.6e-05	5.5	-5.5	3.8e-08	-0.84	0.08	0.90	FALSE
12	GTEx	Liver	CEP192	0.41	0.29	lasso	6	0.41	1.6e-12	-4.8	-5.5	5.0e-08	-0.72	0.64	0.36	FALSE
3	GTEx	Brain Cortex	CEP192	0.40	0.26	lasso	6	0.26	9.9e-08	-4.8	-5.5	5.1e-08	-0.67	0.60	0.38	FALSE
9	GTEx	Colon Sigmoid	CEP192	0.33	0.32	enet	23	0.32	3.6e-12	-4.8	-5.4	5.3e-08	-0.69	0.77	0.23	FALSE
13	GTEx	Pancreas	CEP192	0.44	0.37	lasso	8	0.44	3.1e-20	-4.7	-5.4	6.2e-08	-0.67	0.74	0.26	FALSE
5	GTEx	Brain Hypothalamus	CEP192	0.35	0.33	enet	29	0.33	1.8e-08	-4.5	-5.4	8.5e-08	-0.70	0.66	0.32	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	CEP192	0.34	0.35	enet	20	0.40	1.6e-23	-4.8	-5.3	1.0e-07	-0.68	0.80	0.19	FALSE
19	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CEP192	0.09	0.07	blup	84	0.09	2.1e-06	-4.5	-5.3	1.0e-07	-0.72	0.37	0.61	FALSE
10	GTEx	Colon Transverse	CEP192	0.45	0.54	lasso	8	0.57	1.2e-32	-4.7	-5.3	1.1e-07	-0.67	0.83	0.17	FALSE
8	GTEx	Brain Putamen basal ganglia	CEP192	0.50	0.39	lasso	5	0.36	2.4e-09	-4.8	-5.3	1.3e-07	-0.66	0.41	0.55	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	CEP192	0.38	0.28	lasso	9	0.28	4.8e-08	-4.8	-5.3	1.4e-07	-0.70	0.32	0.66	FALSE
11	GTEx	Heart Atrial Appendage	CEP192	0.29	0.28	lasso	5	0.26	4.3e-12	-4.7	-5.2	2.2e-07	-0.66	0.80	0.20	FALSE
2	GTEx	Brain Cerebellum	CEP192	0.52	0.44	enet	31	0.52	5.6e-18	-4.8	-5.1	2.8e-07	-0.67	0.79	0.21	FALSE