Best TWAS P=1.48e-13 · Best GWAS P=1.82e-17 conditioned to 0.00042
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | MAP2K2 | 0.20 | 0.11 | lasso | 3 | 0.13 | 3.0e-05 | -6.50 | -7.2 | 6.9e-13 | 0.64 | 0.03 | 0.84 | TRUE |
| 2 | GTEx | Heart Left Ventricle | AC007292.4 | 0.18 | 0.00 | enet | 32 | 0.03 | 7.0e-03 | -0.97 | 5.2 | 1.7e-07 | -0.35 | 0.05 | 0.41 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | PIAS4 | 0.14 | 0.12 | lasso | 6 | 0.11 | 1.6e-13 | -6.60 | -6.6 | 4.8e-11 | 0.58 | 1.00 | 0.00 | FALSE |
| 4 | YFS | Blood | MAP2K2 | 0.02 | 0.00 | blup | 373 | 0.01 | 5.9e-03 | 2.30 | 6.0 | 2.1e-09 | -0.51 | 0.08 | 0.46 | FALSE |
| 5 | YFS | Blood | PIAS4 | 0.06 | 0.02 | bslmm | 369 | 0.04 | 4.8e-14 | -6.60 | -7.4 | 1.5e-13 | 0.60 | 0.03 | 0.97 | TRUE |