[Hub]/) : Traits : Leg fat percentage (right) : ← →

chr19:17,473,015-20,313,262

Best TWAS P=3.44e-18 · Best GWAS P=1.16e-19 conditioned to 0.0172

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
24	YFS	Blood	MAST3	0.06	0.04	lasso	5	0.04	4.2e-12	9.05	-8.7	3.4e-18	-0.71	0.00	1.00	TRUE
5	GTEx	Colon Transverse	SSBP4	0.18	0.01	enet	21	0.00	3.6e-01	5.85	-7.2	6.4e-13	-0.57	0.04	0.46	TRUE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JUND	0.11	0.03	blup	58	0.04	1.4e-03	-3.56	7.1	8.9e-13	0.37	0.04	0.08	TRUE
8	GTEx	Esophagus Muscularis	MEF2BNB	0.12	0.00	lasso	4	0.00	7.5e-01	6.39	-6.7	2.5e-11	-0.04	0.02	0.61	TRUE
6	GTEx	Colon Transverse	KIAA1683	0.15	0.02	lasso	3	0.02	3.3e-02	-3.91	6.1	8.1e-10	0.55	0.32	0.17	TRUE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CRTC1	0.33	0.08	lasso	5	0.12	3.6e-05	-3.73	-6.1	9.1e-10	-0.01	0.04	0.52	TRUE
12	GTEx	Testis	AC068499.10	0.38	0.41	lasso	3	0.40	6.8e-19	-5.69	-5.8	6.3e-09	-0.40	1.00	0.00	TRUE
43	The Cancer Genome Atlas	Thyroid Carcinoma	TM6SF2	0.05	0.04	blup	34	0.05	2.8e-05	6.13	5.3	9.0e-08	-0.07	0.01	0.99	TRUE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAST3	0.02	0.02	lasso	3	0.01	1.5e-02	8.36	-8.5	1.8e-17	-0.48	0.02	0.87	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	MAST3	0.04	0.02	lasso	2	0.00	3.4e-01	8.36	-8.4	3.1e-17	-0.48	0.03	0.72	FALSE
13	GTEx	Thyroid	KIAA1683	0.11	0.07	enet	14	0.12	2.1e-09	5.03	8.3	1.2e-16	0.62	0.16	0.83	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	7.18	8.0	8.9e-16	0.57	0.01	0.59	FALSE
16	NTR	Blood	IFI30	0.03	0.02	lasso	6	0.02	8.8e-08	8.60	7.3	2.5e-13	0.82	0.10	0.90	FALSE
14	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	7.18	-7.2	6.8e-13	-0.54	0.04	0.16	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	7.18	7.2	6.8e-13	0.54	0.14	0.13	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	7.18	7.1	1.1e-12	0.54	0.19	0.04	FALSE
40	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IL12RB1	0.10	0.01	enet	10	0.06	2.6e-03	2.08	-6.9	6.4e-12	-0.46	0.01	0.67	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL12RB1	0.07	0.04	blup	58	0.06	4.9e-07	5.01	-6.8	1.2e-11	-0.45	0.87	0.11	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	9.05	-6.6	3.7e-11	-0.60	0.00	0.72	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	JUND	0.17	0.17	lasso	5	0.20	2.7e-25	7.18	6.5	7.7e-11	0.55	1.00	0.00	FALSE
10	GTEx	Pancreas	AC007192.6	0.19	0.00	enet	28	0.01	1.3e-01	9.05	-6.3	3.1e-10	-0.55	0.02	0.72	FALSE
4	GTEx	Brain Hippocampus	DDX49	0.23	-0.01	lasso	4	-0.01	6.6e-01	6.47	-6.2	5.3e-10	0.03	0.02	0.71	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	PDE4C	0.18	0.12	enet	17	0.19	3.3e-24	-3.21	-6.2	7.5e-10	-0.75	0.81	0.19	FALSE
22	YFS	Blood	IFI30	0.08	0.04	bslmm	405	0.08	1.1e-23	-2.21	6.1	8.0e-10	0.70	0.92	0.08	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KIAA1683	0.09	0.06	enet	14	0.10	6.6e-12	-3.79	6.0	1.6e-09	0.60	0.88	0.12	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MAU2	0.09	0.08	blup	369	0.10	1.0e-12	1.83	-6.0	2.0e-09	0.01	0.16	0.84	FALSE
9	GTEx	Nerve Tibial	KIAA1683	0.25	0.22	lasso	9	0.28	5.2e-20	7.18	5.9	3.7e-09	0.52	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	6.13	5.9	4.3e-09	-0.02	0.00	0.99	FALSE
7	GTEx	Esophagus Mucosa	GATAD2A	0.11	0.02	lasso	3	0.02	2.3e-02	6.27	5.8	8.1e-09	-0.05	0.03	0.78	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL12RB1	0.10	0.08	blup	58	0.09	6.9e-10	5.85	-5.7	9.7e-09	-0.46	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	TSSK6	0.07	0.02	blup	32	0.04	2.9e-03	-3.92	-5.7	1.1e-08	-0.03	0.04	0.20	FALSE
11	GTEx	Testis	PDE4C	0.39	0.44	lasso	2	0.43	5.8e-21	-5.69	-5.7	1.3e-08	-0.39	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	AC005253.4	0.11	0.06	enet	23	0.04	1.6e-04	0.24	5.6	1.7e-08	0.46	0.28	0.27	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL12RB1	0.07	0.02	lasso	3	0.01	6.4e-02	5.50	-5.6	1.7e-08	-0.51	0.13	0.15	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	IL12RB1	0.08	0.04	lasso	3	0.05	8.9e-06	3.65	-5.5	4.4e-08	-0.45	0.30	0.51	FALSE
23	YFS	Blood	KIAA1683	0.51	0.40	enet	65	0.46	9.9e-171	7.17	5.4	8.3e-08	0.46	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	IL12RB1	0.10	0.08	enet	13	0.07	3.9e-08	5.85	-5.4	8.4e-08	-0.45	0.99	0.01	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA1683	0.09	0.05	lasso	4	0.06	1.3e-07	7.18	5.3	9.6e-08	0.46	0.84	0.09	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	SUGP1	0.03	0.00	blup	364	0.01	4.3e-02	6.47	5.3	9.7e-08	-0.02	0.02	0.82	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	MAU2	0.17	0.05	bslmm	362	0.06	8.0e-08	5.60	-5.3	1.0e-07	-0.04	0.47	0.45	FALSE
15	METSIM	Adipose	IL12RB1	0.05	0.05	lasso	3	0.04	2.8e-07	5.50	-5.3	1.5e-07	-0.47	0.84	0.15	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL12RB1	0.05	0.03	enet	11	0.05	2.3e-06	-2.47	-5.1	2.7e-07	-0.37	0.55	0.32	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	KIAA1683	0.23	0.14	bslmm	409	0.24	1.4e-30	-1.89	5.1	3.0e-07	0.47	1.00	0.00	FALSE