[Hub]/) : Traits : Leg fat percentage (right) :

chr19:17,473,015-20,313,262

Best TWAS P=3.44e-18 · Best GWAS P=1.16e-19 conditioned to 0.0172

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex KIAA1683 0.09 0.06 enet 14 0.10 6.6e-12 -3.79 6.0 1.6e-09 0.60 0.88 0.12 FALSE
2 CommonMind Brain Pre-frontal Cortex MAU2 0.09 0.08 blup 369 0.10 1.0e-12 1.83 -6.0 2.0e-09 0.01 0.16 0.84 FALSE
3 GTEx Adipose Subcutaneous AC005253.4 0.11 0.06 enet 23 0.04 1.6e-04 0.24 5.6 1.7e-08 0.46 0.28 0.27 FALSE
4 GTEx Brain Hippocampus DDX49 0.23 -0.01 lasso 4 -0.01 6.6e-01 6.47 -6.2 5.3e-10 0.03 0.02 0.71 FALSE
5 GTEx Colon Transverse SSBP4 0.18 0.01 enet 21 0.00 3.6e-01 5.85 -7.2 6.4e-13 -0.57 0.04 0.46 TRUE
6 GTEx Colon Transverse KIAA1683 0.15 0.02 lasso 3 0.02 3.3e-02 -3.91 6.1 8.1e-10 0.55 0.32 0.17 TRUE
7 GTEx Esophagus Mucosa GATAD2A 0.11 0.02 lasso 3 0.02 2.3e-02 6.27 5.8 8.1e-09 -0.05 0.03 0.78 FALSE
8 GTEx Esophagus Muscularis MEF2BNB 0.12 0.00 lasso 4 0.00 7.5e-01 6.39 -6.7 2.5e-11 -0.04 0.02 0.61 TRUE
9 GTEx Nerve Tibial KIAA1683 0.25 0.22 lasso 9 0.28 5.2e-20 7.18 5.9 3.7e-09 0.52 1.00 0.00 FALSE
10 GTEx Pancreas AC007192.6 0.19 0.00 enet 28 0.01 1.3e-01 9.05 -6.3 3.1e-10 -0.55 0.02 0.72 FALSE
11 GTEx Testis PDE4C 0.39 0.44 lasso 2 0.43 5.8e-21 -5.69 -5.7 1.3e-08 -0.39 1.00 0.00 FALSE
12 GTEx Testis AC068499.10 0.38 0.41 lasso 3 0.40 6.8e-19 -5.69 -5.8 6.3e-09 -0.40 1.00 0.00 TRUE
13 GTEx Thyroid KIAA1683 0.11 0.07 enet 14 0.12 2.1e-09 5.03 8.3 1.2e-16 0.62 0.16 0.83 FALSE
14 GTEx Vagina LRRC25 0.63 0.02 enet 2 0.04 5.3e-02 7.18 -7.2 6.8e-13 -0.54 0.04 0.16 FALSE
15 METSIM Adipose IL12RB1 0.05 0.05 lasso 3 0.04 2.8e-07 5.50 -5.3 1.5e-07 -0.47 0.84 0.15 FALSE
16 NTR Blood IFI30 0.03 0.02 lasso 6 0.02 8.8e-08 8.60 7.3 2.5e-13 0.82 0.10 0.90 FALSE
17 ROSMAP Brain Pre-frontal Cortex PDE4C 0.18 0.12 enet 17 0.19 3.3e-24 -3.21 -6.2 7.5e-10 -0.75 0.81 0.19 FALSE
18 ROSMAP Brain Pre-frontal Cortex SUGP1 0.03 0.00 blup 364 0.01 4.3e-02 6.47 5.3 9.7e-08 -0.02 0.02 0.82 FALSE
19 ROSMAP Brain Pre-frontal Cortex MAU2 0.17 0.05 bslmm 362 0.06 8.0e-08 5.60 -5.3 1.0e-07 -0.04 0.47 0.45 FALSE
20 ROSMAP Brain Pre-frontal Cortex KIAA1683 0.23 0.14 bslmm 409 0.24 1.4e-30 -1.89 5.1 3.0e-07 0.47 1.00 0.00 FALSE
21 ROSMAP Brain Pre-frontal Cortex JUND 0.17 0.17 lasso 5 0.20 2.7e-25 7.18 6.5 7.7e-11 0.55 1.00 0.00 FALSE
22 YFS Blood IFI30 0.08 0.04 bslmm 405 0.08 1.1e-23 -2.21 6.1 8.0e-10 0.70 0.92 0.08 FALSE
23 YFS Blood KIAA1683 0.51 0.40 enet 65 0.46 9.9e-171 7.17 5.4 8.3e-08 0.46 1.00 0.00 FALSE
24 YFS Blood MAST3 0.06 0.04 lasso 5 0.04 4.2e-12 9.05 -8.7 3.4e-18 -0.71 0.00 1.00 TRUE
25 The Cancer Genome Atlas Bladder Urothelial Carcinoma IL12RB1 0.07 0.02 lasso 3 0.01 6.4e-02 5.50 -5.6 1.7e-08 -0.51 0.13 0.15 FALSE
26 The Cancer Genome Atlas Colon Adenocarcinoma TSSK6 0.07 0.02 blup 32 0.04 2.9e-03 -3.92 -5.7 1.1e-08 -0.03 0.04 0.20 FALSE
27 The Cancer Genome Atlas Glioblastoma Multiforme JUND 0.17 0.00 blup 57 0.03 5.4e-02 7.18 8.0 8.9e-16 0.57 0.01 0.59 FALSE
28 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IL12RB1 0.05 0.03 enet 11 0.05 2.3e-06 -2.47 -5.1 2.7e-07 -0.37 0.55 0.32 FALSE
29 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IL12RB1 0.10 0.08 blup 58 0.09 6.9e-10 5.85 -5.7 9.7e-09 -0.46 1.00 0.00 FALSE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma JUND 0.05 0.04 lasso 1 0.04 4.3e-05 7.18 7.2 6.8e-13 0.54 0.14 0.13 FALSE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MAST3 0.04 0.02 blup 65 0.01 7.3e-02 9.05 -6.6 3.7e-11 -0.60 0.00 0.72 FALSE
32 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TM6SF2 0.04 0.03 blup 35 0.03 2.5e-04 6.13 5.9 4.3e-09 -0.02 0.00 0.99 FALSE
33 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma JUND 0.11 0.03 blup 58 0.04 1.4e-03 -3.56 7.1 8.9e-13 0.37 0.04 0.08 TRUE
34 The Cancer Genome Atlas Brain Lower Grade Glioma JUND 0.04 0.03 lasso 2 0.02 7.9e-04 7.18 7.1 1.1e-12 0.54 0.19 0.04 FALSE
35 The Cancer Genome Atlas Brain Lower Grade Glioma MAST3 0.02 0.02 lasso 3 0.01 1.5e-02 8.36 -8.5 1.8e-17 -0.48 0.02 0.87 FALSE
36 The Cancer Genome Atlas Lung Adenocarcinoma IL12RB1 0.10 0.08 enet 13 0.07 3.9e-08 5.85 -5.4 8.4e-08 -0.45 0.99 0.01 FALSE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma IL12RB1 0.07 0.04 blup 58 0.06 4.9e-07 5.01 -6.8 1.2e-11 -0.45 0.87 0.11 FALSE
38 The Cancer Genome Atlas Lung Squamous Cell Carcinoma KIAA1683 0.09 0.05 lasso 4 0.06 1.3e-07 7.18 5.3 9.6e-08 0.46 0.84 0.09 FALSE
39 The Cancer Genome Atlas Testicular Germ Cell Tumors CRTC1 0.33 0.08 lasso 5 0.12 3.6e-05 -3.73 -6.1 9.1e-10 -0.01 0.04 0.52 TRUE
40 The Cancer Genome Atlas Testicular Germ Cell Tumors IL12RB1 0.10 0.01 enet 10 0.06 2.6e-03 2.08 -6.9 6.4e-12 -0.46 0.01 0.67 FALSE
41 The Cancer Genome Atlas Thyroid Carcinoma IL12RB1 0.08 0.04 lasso 3 0.05 8.9e-06 3.65 -5.5 4.4e-08 -0.45 0.30 0.51 FALSE
42 The Cancer Genome Atlas Thyroid Carcinoma MAST3 0.04 0.02 lasso 2 0.00 3.4e-01 8.36 -8.4 3.1e-17 -0.48 0.03 0.72 FALSE
43 The Cancer Genome Atlas Thyroid Carcinoma TM6SF2 0.05 0.04 blup 34 0.05 2.8e-05 6.13 5.3 9.0e-08 -0.07 0.01 0.99 TRUE