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chr1:183,961,643-185,416,670

Best TWAS P=3.08e-11 · Best GWAS P=6.25e-09 conditioned to 0.0452

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	GTEx	Uterus	EDEM3	0.27	0.02	enet	20	0.13	1.6e-03	-4.3	-6.6	3.1e-11	-0.64	0.05	0.61	TRUE
15	GTEx	Skin Not Sun Exposed Suprapubic	EDEM3	0.14	0.07	lasso	7	0.08	4.6e-05	5.8	-5.9	3.1e-09	-0.89	0.02	0.98	FALSE
16	GTEx	Skin Sun Exposed Lower leg	EDEM3	0.09	0.09	enet	12	0.10	2.1e-08	5.8	-5.9	3.2e-09	-0.95	0.01	0.99	FALSE
4	GTEx	Artery Aorta	EDEM3	0.19	0.14	enet	12	0.15	9.6e-09	5.8	-5.9	4.2e-09	-0.98	0.01	0.99	FALSE
8	GTEx	Colon Transverse	EDEM3	0.15	0.08	lasso	6	0.09	6.2e-05	5.8	-5.9	4.5e-09	-0.96	0.02	0.98	FALSE
6	GTEx	Cells Transformed fibroblasts	EDEM3	0.15	0.07	lasso	3	0.08	2.4e-06	5.8	-5.9	4.8e-09	-0.98	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EDEM3	0.02	0.02	blup	66	0.03	5.2e-04	5.4	-5.8	5.9e-09	-0.93	0.03	0.94	FALSE
7	GTEx	Colon Sigmoid	EDEM3	0.18	0.17	enet	12	0.13	2.1e-05	5.2	-5.8	6.1e-09	-0.97	0.01	0.99	FALSE
13	GTEx	Nerve Tibial	EDEM3	0.25	0.26	enet	20	0.28	4.8e-20	5.7	-5.8	7.5e-09	-0.99	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	EDEM3	0.15	0.13	lasso	3	0.13	1.0e-10	5.7	-5.8	8.2e-09	-0.99	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EDEM3	0.11	0.08	lasso	14	0.11	2.3e-13	5.2	-5.7	9.1e-09	-0.88	0.02	0.98	FALSE
18	GTEx	Thyroid	EDEM3	0.11	0.07	enet	9	0.07	6.2e-06	-4.9	-5.7	9.2e-09	-0.95	0.02	0.98	FALSE
5	GTEx	Artery Tibial	EDEM3	0.23	0.16	enet	24	0.19	1.7e-14	5.8	-5.7	1.0e-08	-0.91	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	EDEM3	0.08	0.08	blup	66	0.10	1.3e-06	5.4	-5.7	1.0e-08	-0.85	0.05	0.95	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	EDEM3	0.16	0.19	lasso	1	0.15	5.5e-06	5.7	-5.7	1.2e-08	-1.00	0.01	0.99	FALSE
11	GTEx	Esophagus Muscularis	EDEM3	0.14	0.10	enet	16	0.08	1.5e-05	5.7	-5.7	1.2e-08	-0.98	0.01	0.99	FALSE
12	GTEx	Lung	EDEM3	0.15	0.10	lasso	6	0.09	1.5e-07	5.5	-5.7	1.2e-08	-0.96	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	EDEM3	0.04	0.06	lasso	4	0.04	7.3e-06	5.7	-5.7	1.6e-08	-0.99	0.01	0.99	FALSE
17	GTEx	Testis	EDEM3	0.20	0.07	lasso	7	0.08	1.3e-04	4.8	-5.6	1.8e-08	-0.94	0.03	0.97	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EDEM3	0.05	0.06	enet	7	0.08	8.7e-10	4.8	-5.6	1.8e-08	-0.83	0.13	0.87	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	EDEM3	0.04	0.04	blup	66	0.04	2.0e-05	5.2	-5.6	2.1e-08	-0.85	0.05	0.94	FALSE
26	The Cancer Genome Atlas	Rectum Adenocarcinoma	EDEM3	0.23	0.06	blup	67	0.03	6.3e-02	-4.8	-5.6	2.3e-08	-0.85	0.01	0.54	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EDEM3	0.05	0.05	blup	67	0.06	1.0e-04	-4.8	-5.6	2.5e-08	-0.96	0.02	0.97	FALSE
3	GTEx	Adipose Visceral Omentum	EDEM3	0.15	0.07	lasso	4	0.08	7.4e-05	-4.9	-5.5	4.0e-08	-0.91	0.02	0.98	FALSE
14	GTEx	Pancreas	EDEM3	0.19	0.03	lasso	3	0.03	1.4e-02	4.9	-5.3	1.2e-07	-0.86	0.07	0.70	FALSE
10	GTEx	Esophagus Mucosa	EDEM3	0.09	0.02	enet	23	0.02	1.3e-02	-4.8	-5.2	2.5e-07	-0.63	0.03	0.91	FALSE