TWAS
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Models
Genes
Traits
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Traits
:
Leg fat percentage (right)
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chr2:134,928,375-137,323,986
Best TWAS P=1.08e-07 · Best GWAS P=1.76e-08 conditioned to 0.00876
135M
135.5M
136M
136.5M
137M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
LCT
0.02
0.02
enet
3
0.03
7.6e-07
-5.3
5.3
1.1e-07
-0.72
0.00
1.00
TRUE
2
NTR
Blood
CCNT2
0.01
0.00
blup
370
0.00
6.7e-02
-4.5
-5.3
1.4e-07
0.43
0.05
0.76
FALSE
5
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
LCT
0.04
0.02
blup
36
0.02
1.9e-03
-4.4
5.3
1.4e-07
-0.71
0.01
0.96
FALSE
1
CommonMind
Brain Pre-frontal Cortex
LOC100129961
0.17
0.14
enet
9
0.14
2.6e-17
4.9
5.2
1.6e-07
-0.47
0.02
0.97
FALSE
3
YFS
Blood
MCM6
0.18
0.15
enet
20
0.20
8.5e-64
-5.3
-5.2
1.9e-07
0.64
0.01
0.99
FALSE