Best TWAS P=1.65e-08 · Best GWAS P=8.84e-10 conditioned to 0.00458
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TMEM165 | 0.09 | 0.01 | lasso | 3 | 0.03 | 1.6e-03 | 5.1 | -5.4 | 5.9e-08 | 0.71 | 0.53 | 0.42 | FALSE |
| 2 | GTEx | Brain Cortex | TMEM165 | 0.31 | 0.08 | lasso | 6 | 0.04 | 2.2e-02 | 4.5 | -5.3 | 1.4e-07 | 0.60 | 0.09 | 0.38 | FALSE |
| 3 | GTEx | Colon Sigmoid | SRD5A3-AS1 | 0.16 | 0.14 | enet | 18 | 0.13 | 2.9e-05 | 5.1 | 5.2 | 1.9e-07 | -0.54 | 0.28 | 0.34 | FALSE |
| 4 | GTEx | Nerve Tibial | TMEM165 | 0.18 | 0.22 | enet | 29 | 0.27 | 1.6e-19 | 4.8 | -5.3 | 1.2e-07 | 0.65 | 0.67 | 0.33 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TMEM165 | 0.09 | 0.07 | blup | 404 | 0.08 | 4.9e-11 | 4.8 | -5.6 | 1.6e-08 | 0.76 | 0.73 | 0.26 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM165 | 0.02 | 0.04 | lasso | 3 | 0.03 | 1.0e-07 | 5.1 | -5.4 | 6.5e-08 | 0.70 | 0.21 | 0.78 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SRD5A3 | 0.03 | 0.03 | enet | 4 | 0.05 | 3.1e-06 | -5.5 | 5.4 | 6.2e-08 | -0.74 | 0.02 | 0.96 | FALSE |