Best TWAS P=3.2e-12 · Best GWAS P=1.05e-13 conditioned to 0.000305
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | DCAF16 | 0.10 | 0.01 | enet | 6 | 0.02 | 4.7e-02 | 5.6 | -6.5 | 7.5e-11 | -0.69 | 0.16 | 0.32 | FALSE |
| 2 | GTEx | Artery Tibial | DCAF16 | 0.16 | 0.16 | lasso | 5 | 0.13 | 1.5e-10 | -4.7 | -5.2 | 1.5e-07 | -0.31 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | DCAF16 | 0.12 | 0.08 | lasso | 4 | 0.10 | 6.4e-06 | -4.7 | -5.5 | 3.3e-08 | -0.45 | 0.20 | 0.51 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | DCAF16 | 0.24 | 0.03 | enet | 18 | -0.01 | 4.4e-01 | 6.0 | -7.0 | 3.2e-12 | -0.69 | 0.04 | 0.56 | TRUE |
| 5 | GTEx | Esophagus Mucosa | DCAF16 | 0.10 | 0.02 | lasso | 4 | 0.02 | 8.3e-03 | -4.7 | -5.4 | 6.1e-08 | -0.32 | 0.16 | 0.27 | FALSE |
| 6 | GTEx | Spleen | DCAF16 | 0.35 | 0.02 | lasso | 5 | 0.11 | 8.5e-04 | -4.7 | -6.8 | 7.8e-12 | -0.66 | 0.08 | 0.29 | FALSE |
| 7 | GTEx | Thyroid | DCAF16 | 0.11 | 0.02 | lasso | 5 | 0.03 | 2.3e-03 | -4.7 | -6.3 | 3.6e-10 | -0.53 | 0.32 | 0.43 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | DCAF16 | 0.04 | 0.02 | bslmm | 379 | 0.01 | 3.9e-02 | 6.0 | -5.8 | 6.0e-09 | -0.79 | 0.03 | 0.90 | FALSE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | NCAPG | 0.08 | 0.04 | blup | 34 | 0.09 | 1.1e-05 | 5.8 | 5.2 | 1.9e-07 | 0.80 | 0.05 | 0.92 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NCAPG | 0.14 | 0.07 | lasso | 3 | 0.07 | 5.2e-08 | 6.0 | 5.8 | 6.9e-09 | 0.73 | 0.93 | 0.07 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF16 | 0.09 | 0.02 | lasso | 3 | 0.04 | 5.2e-05 | -4.7 | -6.6 | 3.2e-11 | -0.55 | 0.24 | 0.39 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCAPG | 0.02 | 0.03 | lasso | 1 | 0.02 | 9.0e-04 | 5.8 | 5.8 | 6.8e-09 | 0.75 | 0.03 | 0.53 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCAF16 | 0.04 | 0.04 | blup | 31 | 0.04 | 2.2e-05 | -4.7 | -6.6 | 4.1e-11 | -0.60 | 0.21 | 0.40 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NCAPG | 0.02 | 0.02 | blup | 34 | 0.02 | 3.4e-03 | 6.5 | 6.0 | 1.9e-09 | 0.86 | 0.01 | 0.86 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAF16 | 0.07 | 0.04 | blup | 31 | 0.07 | 4.9e-07 | -5.0 | -6.5 | 1.1e-10 | -0.55 | 0.44 | 0.33 | FALSE |