[Hub]/) : Traits : Leg fat percentage (right) :

chr9:115,320,787-116,752,771

Best TWAS P=1.42e-09 · Best GWAS P=4.57e-09 conditioned to 0.656

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PRPF4 0.17 0.13 lasso 3 0.11 2.1e-09 5.8 5.6 1.8e-08 0.97 0.00 1.00 FALSE
2 GTEx Adrenal Gland PRPF4 0.28 0.26 lasso 5 0.21 4.2e-08 5.9 5.8 5.0e-09 0.99 0.00 1.00 FALSE
3 GTEx Artery Aorta PRPF4 0.28 0.25 lasso 5 0.22 1.2e-12 5.7 5.7 1.2e-08 0.97 0.00 1.00 FALSE
4 GTEx Brain Cortex PRPF4 0.35 0.05 lasso 7 0.06 7.6e-03 5.7 5.4 6.5e-08 0.86 0.02 0.89 FALSE
5 GTEx Brain Hypothalamus PRPF4 0.35 0.23 lasso 7 0.27 5.9e-07 5.8 5.5 5.0e-08 0.94 0.01 0.99 FALSE
6 GTEx Breast Mammary Tissue PRPF4 0.27 0.22 lasso 3 0.20 1.2e-10 5.8 5.9 3.0e-09 0.97 0.00 1.00 FALSE
7 GTEx Breast Mammary Tissue (Female) PRPF4 0.12 0.04 lasso 1 0.01 1.9e-01 5.8 5.8 7.7e-09 0.98 0.01 0.84 FALSE
8 GTEx Cells EBV-transformed lymphocytes PRPF4 0.23 0.24 lasso 2 0.20 5.7e-07 5.8 5.6 2.3e-08 0.96 0.00 0.99 FALSE
9 GTEx Colon Transverse PRPF4 0.22 0.20 lasso 2 0.17 2.3e-08 5.9 5.9 4.6e-09 1.00 0.00 1.00 FALSE
10 GTEx Esophagus Mucosa PRPF4 0.15 0.18 lasso 2 0.17 3.1e-11 5.8 5.8 7.4e-09 0.98 0.00 1.00 FALSE
11 GTEx Esophagus Muscularis PRPF4 0.20 0.13 enet 7 0.13 1.6e-08 5.8 5.8 5.8e-09 0.97 0.00 1.00 FALSE
12 GTEx Liver PRPF4 0.29 0.14 lasso 7 0.12 4.0e-04 5.8 5.9 3.5e-09 0.93 0.01 0.99 FALSE
13 GTEx Lung PRPF4 0.26 0.27 lasso 4 0.30 2.5e-23 5.8 5.5 3.2e-08 0.98 0.00 1.00 FALSE
14 GTEx Nerve Tibial PRPF4 0.21 0.21 lasso 3 0.23 1.4e-16 5.9 5.8 5.7e-09 1.00 0.00 1.00 FALSE
15 GTEx Pancreas PRPF4 0.38 0.39 lasso 6 0.36 2.6e-16 5.8 5.8 7.4e-09 0.98 0.00 1.00 FALSE
16 GTEx Pituitary PRPF4 0.51 0.38 lasso 5 0.34 1.8e-09 5.7 5.6 1.9e-08 0.98 0.00 1.00 FALSE
17 GTEx Prostate PRPF4 0.46 0.42 lasso 4 0.45 1.3e-12 5.9 5.5 3.4e-08 0.97 0.00 1.00 FALSE
18 GTEx Skin Sun Exposed Lower leg PRPF4 0.17 0.11 lasso 4 0.10 6.0e-09 5.8 5.7 9.6e-09 0.99 0.00 1.00 FALSE
19 GTEx Small Intestine Terminal Ileum PRPF4 0.50 0.30 enet 14 0.33 2.9e-08 5.9 6.1 1.4e-09 0.94 0.00 1.00 TRUE
20 GTEx Spleen PRPF4 0.40 0.37 lasso 1 0.37 1.9e-10 5.7 5.7 9.4e-09 0.98 0.00 1.00 FALSE
21 GTEx Stomach PRPF4 0.47 0.40 lasso 4 0.39 5.8e-20 5.8 5.8 4.9e-09 1.00 0.00 1.00 FALSE
22 GTEx Testis PRPF4 0.33 0.17 enet 7 0.18 1.8e-08 5.7 5.9 4.0e-09 0.99 0.00 1.00 FALSE
23 GTEx Testis CDC26 0.18 0.11 enet 9 0.14 8.7e-07 4.0 -5.3 9.1e-08 -0.89 0.05 0.95 FALSE
24 GTEx Thyroid PRPF4 0.53 0.51 lasso 6 0.52 1.9e-46 5.8 5.8 7.3e-09 0.98 0.00 1.00 FALSE
25 GTEx Thyroid CDC26 0.24 0.19 lasso 7 0.22 7.3e-17 5.7 -5.6 2.6e-08 -0.92 0.01 0.99 FALSE
26 METSIM Adipose PRPF4 0.10 0.10 lasso 8 0.08 1.4e-12 4.7 5.1 3.1e-07 0.87 0.02 0.98 FALSE
27 YFS Blood CDC26 0.07 0.09 lasso 8 0.09 3.9e-27 5.8 -5.8 4.9e-09 -0.97 0.00 1.00 FALSE
28 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PRPF4 0.10 0.07 lasso 6 0.07 7.2e-05 5.9 5.9 4.2e-09 0.99 0.00 1.00 FALSE
29 The Cancer Genome Atlas Prostate Adenocarcinoma PRPF4 0.09 0.13 lasso 3 0.12 3.5e-12 5.8 5.8 5.9e-09 0.99 0.00 1.00 FALSE