Best TWAS P=6.06e-09 · Best GWAS P=9.55e-08 conditioned to 0.0131
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | CYP17A1-AS1 | 0.08 | 0.08 | lasso | 8 | 0.06 | 2.8e-05 | 5.1 | 5.2 | 1.9e-07 | 0.95 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Brain Cerebellum | ARL3 | 0.20 | 0.09 | enet | 32 | 0.07 | 3.7e-03 | 5.2 | 5.8 | 6.1e-09 | 0.57 | 0.05 | 0.88 | TRUE |
| 3 | GTEx | Nerve Tibial | CYP17A1-AS1 | 0.14 | 0.08 | lasso | 6 | 0.06 | 7.2e-05 | 5.0 | 5.3 | 1.0e-07 | 0.82 | 0.02 | 0.96 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | CYP17A1-AS1 | 0.15 | 0.18 | lasso | 6 | 0.19 | 1.3e-23 | 5.2 | 5.3 | 1.2e-07 | 0.81 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | AS3MT | 0.06 | 0.09 | enet | 6 | 0.07 | 1.3e-06 | 4.9 | -5.4 | 6.5e-08 | -0.80 | 0.04 | 0.95 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | CYP17A1 | 0.04 | 0.02 | lasso | 1 | 0.02 | 3.9e-03 | 5.3 | -5.3 | 9.6e-08 | -1.00 | 0.01 | 0.88 | FALSE |