Best TWAS P=6.09e-12 · Best GWAS P=2.16e-11 conditioned to 0.179
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DPY19L3 | 0.07 | 0.05 | lasso | 2 | 0.06 | 8.7e-08 | -5.2 | -5.3 | 1.5e-07 | 0.00 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Esophagus Mucosa | PEPD | 0.37 | 0.32 | enet | 20 | 0.39 | 9.5e-28 | 5.1 | 6.0 | 1.5e-09 | 0.90 | 0.02 | 0.98 | FALSE |
| 3 | METSIM | Adipose | CHST8 | 0.22 | 0.17 | lasso | 4 | 0.17 | 3.7e-25 | 5.1 | 5.3 | 1.0e-07 | 0.76 | 0.99 | 0.01 | FALSE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PEPD | 0.06 | 0.01 | blup | 114 | 0.04 | 2.6e-04 | 6.7 | 6.1 | 1.2e-09 | 0.86 | 0.01 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | PEPD | 0.13 | 0.06 | blup | 113 | 0.10 | 1.2e-06 | 4.8 | 6.9 | 6.1e-12 | 0.87 | 0.02 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPY19L3 | 0.04 | 0.03 | blup | 60 | 0.02 | 2.2e-03 | -4.8 | -5.2 | 2.3e-07 | -0.02 | 0.01 | 0.89 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PEPD | 0.16 | 0.07 | lasso | 3 | 0.05 | 3.1e-03 | 6.7 | 6.6 | 5.2e-11 | 0.98 | 0.01 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | DPY19L3 | 0.05 | 0.04 | enet | 9 | 0.05 | 2.1e-05 | -4.8 | -5.3 | 1.3e-07 | -0.01 | 0.02 | 0.97 | TRUE |