TWAS hub - CHST8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.2191	0.0373	4.1e-14	0.168	0.106	0.164	0.171	0.173	2e-24	1.6e-15	9.7e-24	8.7e-25	3.7e-25
2	TCGA	Prostate Adenocarcinoma	0.0798	0.0268	5.9e-05	0.059	0.053	0.038	NA	0.044	8e-07	3.3e-06	7.4e-05	NA	2.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Waist Hip Ratio (WHR)	19.0	85.4	166.4	-12.9	-2.1
Age at last live birth	8.2	11.8	18.6	-4.3	-2.3
Pain all over the body in last month	6.2	6.6	10.2	3.2	1.8
Arm fat mass (right)	5.3	21.7	36.5	6.0	2.6
Arm fat percentage (right)	5.2	20.7	39.2	6.3	1.5
Hip circumference	5.2	22.5	37.8	6.2	2.7
Arm fat percentage (left)	5.1	20.3	38.2	6.2	1.6
Arm fat mass (left)	5.0	20.6	35.2	5.9	2.5
Age at First Birth	4.9	7.2	13.6	-0.8	-3.7
Maternal smoking around birth	4.9	7.1	7.7	2.8	2.5
Body fat percentage	4.8	19.0	35.2	5.9	1.7
Worry (Nagel 2018)	4.7	10.0	19.9	-4.5	0.4
Whole body fat mass	4.7	19.7	34.0	5.8	2.3
Medication: Co-codamol	4.6	5.4	9.4	1.1	3.1
Trunk fat percentage	4.5	18.1	34.2	5.8	1.4
Diverticular disease/diverticulitis (self-reported)	4.4	5.2	9.0	3.0	1.2
Financial difficulties in last 2 years	4.4	6.0	11.0	3.3	0.9
Leg fat mass (right)	4.3	16.7	28.3	5.3	2.3
Coronary Artery Disease (CAD)	4.1	4.9	9.8	-3.1	0.0
Trunk fat mass	4.1	17.7	31.9	5.6	1.9
Alcohol drinker status: Previous	4.0	4.5	7.2	2.7	1.4
Leg fat mass (left)	4.0	15.6	25.4	5.0	2.4
Body mass index (BMI)	3.9	16.7	27.5	5.2	2.4
Age at first live birth	3.9	6.9	8.0	-2.8	-2.4
Alcohol intake frequency.	3.8	8.9	13.7	2.0	3.7
Ever smoked	3.8	6.7	13.3	-0.2	-3.6
Irritability	3.8	6.5	11.3	-3.4	1.3
Number of incorrect matches in round	3.7	6.2	10.6	-3.3	-1.3
Nervous feelings	3.7	6.8	13.2	-3.6	-0.6
Leg fat percentage (right)	3.7	13.6	24.8	5.0	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	7.8	2.8	1.0
Worrier / anxious feelings	3.6	6.8	13.3	-3.6	0.5
Tense / ‘highly strung’	3.6	6.0	8.7	-3.0	1.8
Number of self-reported non-cancer illnesses	3.5	6.0	10.8	3.3	1.1
Mood swings	3.4	6.2	10.8	-1.3	3.3
Leg fat percentage (left)	3.4	12.5	21.7	4.7	1.8
Weight	3.3	16.0	23.1	4.8	3.0
Ever unenthusiastic/disinterested for a whole week	3.2	3.9	4.5	1.8	2.1
Crohns Disease (2017)	3.1	6.8	7.0	2.6	2.6
Angina (self-reported)	3.1	4.0	7.1	-1.0	-2.7
Mean Putamen Volume	3.0	3.4	5.7	2.4	1.1
Neuroticism score	3.0	6.2	8.6	-2.9	1.9
Number of full brothers	3.0	3.7	5.2	1.5	-2.3
Angina	2.9	3.7	6.4	-1.1	-2.5
Suffer from ‘nerves’	2.9	4.6	5.2	-2.0	2.3
Bipolar Disorder or Schizophrenia	2.8	6.8	12.0	-3.5	-1.3
Schizophrenia (2014)	2.6	5.7	10.0	-3.2	-1.2
Multivitamins +/- minerals	2.6	3.3	6.0	0.8	2.4
BMI	2.5	14.6	22.9	4.8	2.5
Loneliness, isolation	2.5	3.4	6.7	-2.6	-0.4
Ever had bowel cancer screening	2.5	2.9	5.4	2.3	0.6
Systolic Blood Pressure	2.4	12.2	21.4	-4.6	-1.7
Neuroticism	2.4	5.8	10.4	-3.2	1.0
Alcohol intake versus 10 years previously	2.4	3.5	5.6	2.4	1.2
Medication: Ibuprofen	2.4	2.9	5.1	0.9	2.2
Medication: Seretide 50 evohaler	2.4	2.8	3.3	-1.8	-1.5
Neuroticism (Nagel 2018)	2.3	5.5	10.7	-3.3	0.6
Schizophrenia (2018)	2.3	4.9	9.6	-3.1	-0.3
Medication: Atenolol	2.3	2.8	4.5	-1.1	2.1
Past tobacco smoking	2.3	4.2	7.6	-0.9	2.8
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	4.5	2.1	1.3
Shortness of breath walking on level ground	2.3	2.8	4.1	-1.2	-2.0
Migraine (self-reported)	2.3	2.8	4.9	0.9	2.2
Mouth/teeth dental problems: Mouth ulcers	2.3	3.6	4.5	-1.6	-2.1
Rheumatoid Arthritis	2.2	3.0	3.8	1.5	1.9
Ever used hormone-replacement therapy (HRT)	2.2	2.9	4.9	2.2	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	5.6	-0.4	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	4.8	1.4	2.2
Alzheimer’s Disease (in mother)	2.1	2.5	4.7	2.2	0.6
HbA1C	2.1	2.3	4.3	-0.6	2.1
Chronotype (morning person)	2.1	4.8	9.7	-3.1	-0.0
Qualifications: A levels/AS levels or equivalent	2.1	4.6	7.3	-2.7	-1.4
Illnesses of siblings: Diabetes	2.1	2.6	3.8	1.2	-1.9
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	3.6	1.9	0.8
Headache pain in last month	2.0	3.5	4.1	2.0	1.7
Osteoarthritis (self-reported)	2.0	2.6	2.8	1.7	1.6
Ever depressed for a whole week	2.0	2.5	4.5	0.7	2.1
Body Mass Index (BMI) (2010)	1.9	2.7	2.7	1.6	1.6
Pain type(s) experienced in last month: Hip pain	1.9	2.4	2.4	1.6	1.5
Number of operations (self-reported)	1.9	2.8	5.7	2.4	0.2
Arm predicted mass (left)	1.9	9.4	12.4	2.5	3.5
Age when periods started (menarche)	1.8	4.4	6.5	2.5	-1.5
Crohns Disease (2012)	1.7	2.8	3.4	1.5	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	3.6	0.6	1.9
Arm fat-free mass (left)	1.7	8.6	11.4	2.4	3.4
Bipolar Disorder (2018)	1.6	2.5	2.9	-1.7	-1.5
Relative age of first facial hair	1.6	3.3	6.7	2.6	-0.2
Leg fat-free mass (left)	1.6	8.6	11.3	3.4	2.4
Leg predicted mass (left)	1.6	8.6	11.2	3.4	2.4
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	2.7	-1.7	1.5
High blood pressure (siblings)	1.6	2.3	2.4	1.5	1.6
Vitamin and mineral supplements	1.5	2.0	4.0	-0.1	-2.0
Pack years adult smoking proportion	1.5	2.3	3.8	2.0	0.8
Average weekly fortified wine intake	1.5	1.8	3.5	1.9	0.3
Serious illness, injury or assault to yourself	1.5	1.8	3.1	-0.7	1.8
Mouth/teeth dental problems	1.5	2.3	3.8	0.9	2.0
Arm fat-free mass (right)	1.5	7.4	11.5	1.8	3.4
Medication for pain relief, constipation, heartburn	1.5	2.5	3.3	-1.8	-1.3
Overall health rating	1.5	3.3	5.4	2.3	1.1
Commuting to job workplace: Walk	1.5	1.7	3.3	0.1	-1.8
Wears glasses or contact lenses	1.5	1.7	3.0	-0.6	-1.7
Medication: Paracetamol	1.5	2.4	4.7	2.2	0.0
Basal metabolic rate	1.5	8.5	8.7	3.0	2.9
Primary Biliary Cirrhosis	1.4	2.0	2.9	-1.7	-1.0
Noisy workplace	1.4	1.7	2.7	1.6	0.9
Length of working week for main job	1.4	1.6	2.9	0.5	1.7
Hair/balding pattern: Pattern 4	1.4	3.3	4.8	-2.2	1.4
Medication: Allopurinol	1.4	1.9	3.7	-0.2	-1.9
Mean time to correctly identify matches	1.4	2.8	5.5	-0.1	-2.3
Age started oral contraceptive pill	1.4	1.7	3.4	0.1	-1.8
Number of treatments/medications taken	1.3	2.3	4.0	2.0	0.7
Townsend deprivation index at recruitment	1.3	1.9	3.3	0.7	1.8
Had other major operations	1.3	1.6	2.0	1.4	-1.1
Medication: Ramipril	1.3	1.6	3.3	-0.1	-1.8
Arm predicted mass (right)	1.3	6.6	9.3	2.0	3.1
Number of full sisters	1.3	1.6	2.9	1.7	0.5
Smoking status: Previous	1.3	1.9	3.7	0.4	-1.9
Leg fat-free mass (right)	1.3	7.2	8.5	2.9	2.4
Long-standing illness, disability or infirmity	1.3	2.0	4.0	2.0	0.1
Mineral and other dietary supplements	1.3	1.7	3.4	0.2	-1.9
Leg predicted mass (right)	1.3	7.1	8.7	2.9	2.4
Reaction Time	1.2	2.2	4.3	-0.4	-2.1
HDL Cholesterol	1.2	2.0	3.9	-0.3	-2.0
Fed-up feelings	1.2	2.1	4.2	-0.1	2.0
Happiness	1.2	1.5	1.7	-1.3	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.6	0.7	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.8	-1.7	0.0
Back pain experienced in last month	1.2	1.7	3.5	1.9	-0.0
Whole body water mass	1.2	6.7	8.4	2.2	2.9
Guilty feelings	1.2	1.8	2.0	-1.4	1.3
Illnesses of siblings	1.1	1.6	3.1	-1.8	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.4	0.1	1.9
Mouth/teeth dental problems: Dentures	1.1	1.8	3.4	0.4	-1.8
Number of children fathered	1.1	1.3	2.6	-1.6	0.2
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.6	-0.3	-1.6
Whole body fat-free mass	1.1	6.1	7.6	2.1	2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.5	-1.6	-0.4
Pain experienced in last month	1.1	1.9	3.4	-1.8	-0.6
Irritable Bowel Disease (IBD)	1.0	2.4	4.2	2.0	0.8
Systolic blood pressure, automated reading	1.0	3.0	4.9	-2.2	-1.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	1.7	-1.3	-1.3
Blood clot in the leg (DVT)	1.0	1.3	2.0	0.8	1.4
Medication: Paracetamol	1.0	1.7	3.5	1.9	0.1
Pulse wave peak to peak time	1.0	1.1	1.3	-1.1	-1.0
Eye problems/disorders: None of the above	1.0	1.1	2.3	-1.5	-0.1
Illnesses of father: None of the above (group 1)	1.0	1.3	2.0	-0.7	1.4
Illnesses of father: High blood pressure	1.0	1.2	1.8	0.8	-1.3
Alzheimer’s Disease (including proxy)	0.9	1.3	2.5	1.6	-0.4
Ulcerative Colitis	0.9	1.3	2.4	0.5	-1.5
Chronic bronchitis/emphysema (father)	0.9	1.1	1.5	-1.2	-0.8
Asthma	0.9	1.8	2.3	1.5	-1.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	2.3	1.5	0.9
Gout (self-reported)	0.9	1.2	2.1	-0.5	-1.5
Had major operations	0.9	1.0	2.0	1.4	0.0
Ever taken oral contraceptive pill	0.9	1.1	1.9	0.4	1.4
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.2	0.2	1.5
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.7	0.5	-1.3
Schizophrenia vs Biploar Disorder	0.8	1.1	1.8	-1.3	-0.6
Sensitivity / hurt feelings	0.8	1.4	2.3	-1.5	0.7
Stomach or abdominal pain in last month	0.8	1.0	1.4	-1.2	0.8
Pulse wave Arterial Stiffness index	0.8	0.9	1.0	0.9	1.0
Trunk predicted mass	0.8	4.4	7.1	1.3	2.7
Exposure to tobacco smoke outside home	0.8	1.1	2.2	1.5	0.2
Medication: Omeprazole	0.8	0.9	1.1	0.9	-1.1
Qualifications: nursing, teaching	0.8	1.2	1.8	-0.7	-1.4
Asthma (self-reported)	0.8	1.6	2.0	1.4	-1.1
Osteoporosis (self-reported)	0.8	1.0	1.8	-1.3	-0.5
Medication: Aspirin	0.8	1.0	1.5	1.2	-0.7
Pack years of smoking	0.8	1.2	2.3	1.5	0.3
Average weekly spirits intake	0.7	0.8	1.6	1.3	-0.2
Hearing difficulty/problems: Yes	0.7	1.0	2.0	-1.4	-0.2
Current tobacco smoking	0.7	1.1	2.2	1.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.2	-0.0	1.8
Trunk fat-free mass	0.7	4.1	6.8	1.2	2.6
Impedance of arm (left)	0.7	3.3	6.5	-0.1	-2.6
Comparative height size at age 10	0.7	3.8	6.8	-0.9	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	1.5	-1.2	1.1
Depression (Nagel 2018)	0.6	0.9	1.6	-1.2	0.6
LDL Cholesterol	0.6	1.0	1.0	1.0	1.0
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.2	0.5	1.1
Blood Red Count	0.6	5.5	6.5	2.1	2.5
Supplements: Zinc	0.6	0.6	0.7	0.8	0.8
Hand grip strength (right)	0.6	1.5	3.0	-0.2	1.7
High blood pressure (mother)	0.6	0.8	1.2	-0.7	-1.1
Impedance of leg (left)	0.6	3.0	4.6	-2.1	-1.1
Hearing difficulty/problems with background noise	0.6	1.0	1.9	-0.2	-1.4
Impedance of arm (right)	0.6	2.8	5.4	0.3	-2.3
Time employed in main current job	0.6	0.7	0.7	-0.9	-0.8
Prospective memory result	0.6	0.7	1.1	-0.5	1.0
Pulse wave reflection index	0.6	0.7	0.9	0.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.2	1.1	-0.2
Supplements: Calcium	0.6	0.6	1.3	0.1	1.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.1	0.7	1.0
Depressed Affect (Nagel 2018)	0.5	1.1	2.1	-1.4	0.4
Alzheimer’s Disease (in father)	0.5	0.5	0.8	0.9	-0.6
Ovarian Cancer	0.5	0.7	1.4	-1.2	-0.0
Smoking Status	0.5	1.2	1.4	1.2	-1.0
Impedance of leg (right)	0.5	2.6	3.5	-1.9	-1.3
Qualifications: CSEs or equivalent	0.5	0.6	1.2	1.1	0.1
Medication: Simvastatin	0.5	0.7	1.3	0.4	-1.1
Falls in the last year	0.5	0.7	0.9	0.7	-0.9
Medication: Cholesterol lowering	0.5	0.8	0.9	-1.0	-0.9
Breastfed as a baby	0.5	0.7	1.3	1.2	-0.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.2	0.1	-1.1
Health satisfaction	0.5	0.7	1.4	1.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	-0.1	1.0
Medication: Aspirin	0.5	0.6	1.2	1.1	-0.2
Supplements: Vitamin C	0.5	0.6	1.1	-0.4	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	1.0	-0.4
Mother’s age at death	0.5	0.6	1.3	0.1	-1.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.0	1.0	0.2
Medication: Lisinopril	0.5	0.7	1.1	1.1	0.5
Average weekly beer plus cider intake	0.5	0.7	0.7	0.9	0.9
Commuting to job workplace: Cycle	0.5	0.6	1.1	-0.1	1.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.8	0.9	-0.6
Bipolar Disorder (2011)	0.4	0.4	0.7	0.9	0.0
Hypothyroidism (self reported)	0.4	0.9	1.8	-0.2	1.3
Lung FEV1/FVC ratio	0.4	2.0	2.0	-1.4	1.4
Hand grip strength (left)	0.4	1.2	2.0	-0.6	1.4
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.7	-0.6	0.8
Diabetes (father)	0.4	0.5	1.0	1.0	0.0
Relative age voice broke	0.4	0.7	1.3	1.1	0.2
Taking other prescription medications	0.4	0.6	0.8	0.9	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.0	0.2	1.0
Sitting height	0.4	2.5	4.9	-0.3	2.2
Waist circumference	0.4	1.4	1.5	1.1	1.2
Allergy	0.4	1.0	1.5	-1.2	-0.7
Depression (self-reported)	0.4	0.5	0.9	0.1	1.0
Exposure to tobacco smoke at home	0.4	0.4	0.6	0.8	0.5
Glaucoma (self-reported)	0.4	0.5	0.9	1.0	-0.0
Worry too long after embarrassment	0.4	0.7	1.3	-0.4	1.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.5	0.6	0.7
Pulse rate, automated reading	0.4	1.4	2.1	0.8	1.4
Family relationship satisfaction	0.4	0.5	1.0	-0.2	1.0
Knee pain experienced in last month	0.4	0.6	1.1	1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.4	-0.4	1.2
Average weekly red wine intake	0.4	0.6	0.9	-1.0	0.6
Medication: Gliclazide	0.4	0.4	0.8	0.0	-0.9
Smoking status: Current	0.4	0.7	1.0	1.0	-0.6
Cholesterol lowering medication	0.4	0.7	1.3	1.1	0.2
Impedance of whole body	0.4	1.9	2.8	-1.0	-1.7
Breast Cancer	0.3	0.7	1.1	1.1	0.6
Triglycerides	0.3	0.5	0.6	-0.8	0.6
Blood Eosinophil Count	0.3	2.6	2.7	1.6	-1.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.6	0.7	0.8
Supplements: Glucosamine	0.3	0.4	0.7	-0.4	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	-0.5	0.8
Had menopause	0.3	0.4	0.7	-0.3	-0.8
Qualifications: None of the above	0.3	0.6	1.1	0.2	-1.1
Lung cancer (father)	0.3	0.3	0.6	-0.0	-0.8
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.5	-0.7	0.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	0.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.1	0.8
Medication: Blood pressure	0.3	0.6	1.0	-0.4	-1.0
Chest pain or discomfort	0.3	0.5	0.9	-0.3	-0.9
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	-0.8	0.3
Friendships satisfaction	0.3	0.3	0.7	-0.8	-0.1
Medication for cholesterol	0.3	0.4	0.8	0.1	0.9
Miserableness	0.3	0.5	1.1	0.2	1.0
Hearing aid user	0.3	0.3	0.6	-0.1	-0.8
Medication: Blood pressure	0.3	0.5	0.6	-0.6	0.8
High cholesterol (Self-reported)	0.3	0.6	1.0	-1.0	-0.4
Alcohol drinker status: Never	0.3	0.4	0.8	0.1	0.9
Unable to work because of sickness or disability	0.3	0.4	0.4	-0.6	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.9	0.4	0.9
Ulcerative Colitis (UC)	0.2	0.4	0.7	0.8	-0.4
Major Depression (MDD)	0.2	0.2	0.5	0.7	0.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.9	1.0	-0.2
Prostate Cancer	0.2	0.2	0.3	-0.4	-0.6
Lupus	0.2	0.4	0.5	0.4	0.7
Blood Platelet Count	0.2	2.8	3.6	1.4	-1.9
Allergy or Eczema	0.2	0.6	1.2	0.1	1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	0.9	-0.2
Lung FVC	0.2	0.9	1.8	-0.1	-1.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	0.7	0.3
Medication for hormone replacement therapy	0.2	0.2	0.3	0.5	-0.5
Diabetes (mother)	0.2	0.3	0.5	0.2	-0.7
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.6	0.4	0.8
Diabetes (self-reported)	0.2	0.4	0.8	-0.1	-0.9
Fluid intelligence score	0.2	0.5	0.9	1.0	0.0
Father’s age at death	0.2	0.3	0.4	0.5	0.6
Number of live births	0.2	0.3	0.3	-0.6	-0.4
Illnesses of mother	0.2	0.2	0.2	-0.5	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.3	-1.1	0.0
Standing height	0.2	2.5	4.5	-0.7	2.1
Peak expiratory flow (PEF)	0.2	0.6	0.9	0.5	0.9
Loud music exposure frequency	0.2	0.2	0.2	-0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.9	0.2
Birth weight	0.2	0.5	0.6	0.8	-0.7
Qualifications: College or University degree	0.2	0.7	1.2	-0.5	1.1
Neck or shoulder pain in last month	0.2	0.3	0.5	0.0	-0.7
Heart disease (mother)	0.2	0.2	0.4	-0.0	0.6
Leg pain on walking	0.2	0.3	0.4	0.7	0.3
Illnesses of father: Heart disease	0.2	0.3	0.5	0.4	0.7
Eye problems/disorders: Cataract	0.2	0.3	0.4	0.6	0.4
Breast cancer (self-reported)	0.2	0.3	0.5	0.1	0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.3	-0.7
Myopia	0.2	0.3	0.4	-0.4	0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	0.3	-0.6
Heart disease (siblings)	0.2	0.2	0.4	-0.1	-0.6
Fasting Glucose	0.1	0.2	0.3	-0.2	0.5
Blood White Count	0.1	0.4	0.6	0.7	0.5
Heel T-Score	0.1	0.9	1.4	1.2	0.6
Height	0.1	2.2	3.2	-1.1	1.8
Respiratory disease	0.1	0.3	0.3	0.6	-0.6
Hair Pigment	0.1	2.8	4.2	2.0	1.2
Tanning	0.1	1.2	1.7	-1.3	0.8
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.1	-0.4
Medication: Metformin	0.1	0.1	0.2	0.4	0.2
High blood pressure	0.1	0.4	0.7	-0.3	0.8
Alcohol usually taken with meals	0.1	0.2	0.2	-0.3	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.5	-0.7	0.2
Pulse rate	0.1	0.1	0.2	-0.5	-0.0
Medication: Lansoprazole	0.1	0.1	0.2	0.4	0.3
Birth weight of first child	0.1	0.1	0.1	-0.4	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	-0.4	0.1
Medication: Amlodipine	0.1	0.1	0.2	-0.4	0.3
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.9	-0.0
Comparative body size at age 10	0.1	0.2	0.4	0.2	0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.1	-0.6
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.3	0.5
Hypertension (Self-reported)	0.1	0.4	0.6	0.3	0.8
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.1	-0.7
Average weekly champagne plus white wine intake	0.1	0.1	0.2	0.5	-0.1
Financial situation satisfaction	0.1	0.1	0.2	0.1	-0.5
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.4	0.3
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.6	-0.2
Medication: Atorvastatin	0.1	0.1	0.1	-0.1	0.4
Neuroticism (2016)	0.0	0.0	0.1	-0.2	0.2
Cardiovascular Disease	0.0	0.1	0.2	-0.0	0.5
Ever had hysterectomy (womb removed)	0.0	0.1	0.1	0.2	-0.3
Severe depression (siblings)	0.0	0.0	0.0	0.0	0.2
Forced vital capacity (FVC)	0.0	0.0	0.0	-0.2	-0.1
Heart attack	0.0	0.0	0.0	0.0	-0.0
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	0.1	-0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	0.0	0.2
Risk taking	0.0	0.1	0.1	-0.3	0.0
Diastolic blood pressure, automated reading	0.0	0.1	0.2	0.2	0.4
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.0	-0.5
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.0	-0.2

Hub : Genes

CHST8

Models

Trait associations