Best TWAS P=2.11e-21 · Best GWAS P=4.33e-23 conditioned to 0.324
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | -6.4 | -7.0 | 2.3e-12 | -0.57 | 0.20 | 0.34 | TRUE |
| 2 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | 9.9 | -9.3 | 1.1e-20 | -0.98 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | 9.9 | -9.2 | 3.7e-20 | -0.97 | 0.01 | 0.99 | FALSE |
| 4 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | 9.8 | -9.2 | 5.8e-20 | -0.96 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SHISA4 | 0.03 | 0.01 | enet | 5 | 0.00 | 2.5e-01 | -7.0 | -6.5 | 1.1e-10 | -0.56 | 0.04 | 0.16 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LMOD1 | 0.02 | 0.01 | blup | 59 | 0.02 | 1.2e-04 | 9.7 | -7.2 | 7.6e-13 | -0.86 | 0.01 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | 9.8 | -9.5 | 2.1e-21 | -0.90 | 0.01 | 0.88 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | -7.0 | -8.3 | 1.2e-16 | -0.75 | 0.24 | 0.75 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | 9.7 | -8.5 | 1.6e-17 | -0.83 | 0.01 | 0.82 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TIMM17A | 0.08 | 0.01 | blup | 65 | 0.04 | 3.0e-05 | 5.1 | 5.4 | 7.3e-08 | 0.51 | 0.07 | 0.54 | FALSE |