Best TWAS P=5.55e-11 · Best GWAS P=4.25e-09 conditioned to 8.21e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | ERAP1 | 0.38 | 0.14 | lasso | 7 | 0.22 | 1.4e-08 | -4.7 | -5.1 | 2.9e-07 | -0.05 | 0.29 | 0.70 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | ERAP1 | 0.29 | 0.18 | lasso | 8 | 0.13 | 2.6e-05 | -4.9 | -5.8 | 7.1e-09 | -0.05 | 0.24 | 0.57 | FALSE |
| 3 | GTEx | Esophagus Muscularis | ERAP1 | 0.19 | 0.06 | enet | 19 | 0.11 | 2.5e-07 | -3.5 | -5.1 | 2.9e-07 | -0.02 | 0.61 | 0.35 | FALSE |
| 4 | GTEx | Liver | CAST | 0.32 | 0.03 | enet | 23 | 0.12 | 4.4e-04 | -4.7 | -6.6 | 5.6e-11 | 0.15 | 0.15 | 0.19 | TRUE |
| 5 | GTEx | Liver | ERAP1 | 0.24 | 0.15 | lasso | 3 | 0.12 | 3.4e-04 | -4.9 | -5.2 | 1.9e-07 | -0.02 | 0.22 | 0.51 | FALSE |
| 6 | GTEx | Liver | CTC-506B8.1 | 0.34 | 0.07 | enet | 22 | 0.05 | 1.9e-02 | -4.5 | -5.2 | 2.4e-07 | -0.04 | 0.13 | 0.16 | FALSE |