[Hub]/) : Traits : Leg fat-free mass (right) :

chr9:126,844,856-128,824,378

Best TWAS P=9.61e-13 · Best GWAS P=1.27e-12 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous PPP6C 0.06 0.10 lasso 3 0.07 3.2e-06 5.5 -5.5 3.8e-08 0.70 0.96 0.02 FALSE
2 GTEx Artery Aorta PRPS1P2 0.08 0.10 lasso 4 0.08 2.1e-05 -4.5 5.5 4.1e-08 -0.82 0.06 0.89 FALSE
3 GTEx Artery Tibial GAPVD1 0.11 0.16 enet 19 0.16 6.4e-13 -6.7 -7.1 1.2e-12 0.96 0.02 0.98 FALSE
4 GTEx Artery Tibial PRPS1P2 0.06 0.06 enet 6 0.05 9.2e-05 5.3 5.3 1.1e-07 -0.60 0.88 0.09 FALSE
5 GTEx Brain Cerebellum PRPS1P2 0.09 0.08 enet 16 0.04 2.8e-02 -7.1 6.2 6.1e-10 -0.82 0.05 0.80 FALSE
6 GTEx Breast Mammary Tissue (Male) PPP6C 0.12 0.03 enet 12 0.03 6.5e-02 5.3 -5.2 1.7e-07 0.59 0.07 0.10 FALSE
7 GTEx Breast Mammary Tissue (Female) PPP6C 0.14 0.04 lasso 4 0.04 3.1e-02 5.3 -5.7 1.5e-08 0.69 0.08 0.80 FALSE
8 GTEx Cells Transformed fibroblasts PRPS1P2 0.09 0.11 enet 8 0.13 9.6e-10 5.4 5.3 9.6e-08 -0.59 0.96 0.04 FALSE
9 GTEx Colon Transverse PRPS1P2 0.11 0.10 lasso 1 0.08 1.8e-04 5.5 5.5 4.7e-08 -0.63 0.64 0.04 FALSE
10 GTEx Esophagus Mucosa PPP6C 0.07 0.07 enet 21 0.08 7.1e-06 5.0 -5.6 2.6e-08 0.62 0.98 0.02 FALSE
11 GTEx Esophagus Mucosa PRPS1P2 0.07 0.08 lasso 3 0.07 1.5e-05 5.3 5.6 1.6e-08 -0.61 0.52 0.40 FALSE
12 GTEx Esophagus Muscularis OLFML2A 0.08 0.00 enet 27 0.00 4.9e-01 5.1 6.4 1.6e-10 -0.47 0.08 0.24 FALSE
13 GTEx Muscle Skeletal PPP6C 0.03 0.03 enet 6 0.01 3.0e-02 5.2 -5.1 2.7e-07 0.62 0.49 0.12 FALSE
14 GTEx Muscle Skeletal GAPVD1 0.13 0.10 lasso 3 0.09 4.7e-09 -7.1 7.1 1.6e-12 -0.99 0.02 0.98 FALSE
15 GTEx Nerve Tibial GAPVD1 0.17 0.08 lasso 10 0.10 9.3e-08 5.0 -6.5 9.9e-11 0.83 0.15 0.85 FALSE
16 GTEx Pancreas PRPS1P2 0.16 0.13 lasso 6 0.12 8.7e-06 5.3 5.4 6.3e-08 -0.61 0.89 0.08 FALSE
17 GTEx Skin Sun Exposed Lower leg GAPVD1 0.04 0.01 lasso 4 0.01 3.8e-02 5.3 -5.6 1.9e-08 0.74 0.21 0.68 FALSE
18 GTEx Thyroid GAPVD1 0.05 0.05 enet 13 0.01 6.6e-02 -7.0 -7.1 9.6e-13 0.99 0.02 0.98 TRUE
19 GTEx Thyroid PRPS1P2 0.08 0.09 enet 18 0.07 4.0e-06 5.3 5.4 5.9e-08 -0.67 0.92 0.08 FALSE
20 GTEx Whole Blood PPP6C 0.03 0.00 enet 20 0.00 1.0e-01 -6.6 -5.4 7.1e-08 0.66 0.03 0.88 FALSE
21 YFS Blood RABEPK 0.12 0.21 bslmm 317 0.22 2.4e-71 5.4 -5.5 4.8e-08 0.60 1.00 0.00 FALSE
22 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPP6C 0.07 0.08 lasso 3 0.09 5.4e-10 5.3 -5.3 1.1e-07 0.62 0.03 0.97 FALSE
23 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WDR38 0.04 0.01 blup 32 0.02 9.5e-04 -2.1 -5.4 7.5e-08 0.31 0.00 0.07 FALSE
24 The Cancer Genome Atlas Brain Lower Grade Glioma PPP6C 0.02 0.02 lasso 2 0.01 1.5e-02 5.4 -5.4 5.3e-08 0.63 0.02 0.69 FALSE
25 The Cancer Genome Atlas Lung Adenocarcinoma PPP6C 0.02 0.02 lasso 4 0.02 7.6e-04 5.3 -5.3 1.1e-07 0.61 0.03 0.96 FALSE
26 The Cancer Genome Atlas Prostate Adenocarcinoma GAPVD1 0.02 0.04 enet 4 0.01 9.8e-03 -7.0 7.0 2.1e-12 -0.95 0.02 0.90 FALSE
27 The Cancer Genome Atlas Prostate Adenocarcinoma PPP6C 0.06 0.08 lasso 7 0.07 1.8e-07 5.3 -5.1 2.7e-07 0.59 0.02 0.98 FALSE
28 The Cancer Genome Atlas Stomach Adenocarcinoma PPP6C 0.05 0.04 blup 46 0.03 3.8e-03 5.3 -5.3 1.1e-07 0.63 0.02 0.96 FALSE
29 The Cancer Genome Atlas Thyroid Carcinoma PPP6C 0.08 0.13 enet 9 0.13 5.5e-13 5.3 -5.2 1.6e-07 0.63 0.02 0.97 FALSE