Hub : Genes

OLFML2A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Caudate basal ganglia 0.1240 0.0630 0.00570 0.102 NA 0.033 NA 0.034 7.7e-04 NA 4.1e-02 NA 3.7e-02
2 GTEx Esophagus Muscularis 0.0760 0.0500 0.00860 -0.004 NA -0.002 NA -0.004 6.5e-01 NA 4.9e-01 NA 7.9e-01
3 GTEx Heart Left Ventricle 0.1686 0.0757 0.00064 0.165 NA 0.076 NA 0.147 4.1e-09 NA 7.4e-05 NA 3.0e-08
4 GTEx Pancreas 0.1520 0.0570 0.00070 0.033 NA 0.086 NA 0.090 1.5e-02 NA 1.8e-04 NA 1.2e-04
5 METSIM Adipose 0.0403 0.0226 0.00200 0.020 0.005 0.002 0.005 0.008 4.1e-04 0.05500 1.6e-01 0.059 1.9e-02
6 TCGA Brain Lower Grade Glioma 0.0563 0.0289 0.00014 0.033 0.031 0.027 NA 0.019 1.0e-04 0.00017 4.0e-04 NA 2.8e-03
7 TCGA Thyroid Carcinoma 0.0240 0.0160 0.00950 0.013 0.017 0.002 NA 0.005 1.8e-02 0.00810 1.7e-01 NA 1.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.9 1.4 2.8 0.7 -0.8 -1.0 0.5 1.7 -1.6 1.5
Bipolar Disorder or Schizophrenia 0.3 0.8 2.8 1.4 -0.4 -0.8 -0.3 0.4 -1.7 0.1
Depressed Affect (Nagel 2018) 0.6 1.3 3.9 -0.1 -0.6 -0.5 -2.0 -1.6 0.6 -1.3
Depression (Nagel 2018) 1.8 2.7 7.0 -1.7 -2.0 -2.6 -0.2 1.1 1.0 1.6
Intelligence (Savage-Jansen 2018) 0.4 1.4 3.1 1.5 0.7 0.1 1.7 0.9 -1.4 1.0
Neuroticism (Nagel 2018) 1.5 3.5 15.0 -0.5 -2.0 -0.5 -3.9 -1.6 1.2 -1.2
Schizophrenia (2018) 0.3 0.7 1.6 1.3 0.2 -0.2 -0.8 -0.9 -0.8 -1.0
Schizophrenia vs Biploar Disorder 1.5 1.9 4.0 -0.6 0.5 2.0 -1.4 -1.7 1.4 -1.5
Worry (Nagel 2018) 2.1 4.4 13.1 -1.1 -2.8 0.4 -3.6 -1.7 2.1 -0.9
Alzheimer’s Disease (in mother) 0.8 0.9 2.8 -1.7 -0.7 0.2 1.2 0.5 1.1 0.6
Alzheimer’s Disease (in father) 2.1 2.3 4.6 1.1 2.1 1.6 -1.1 -1.7 0.0 -2.0
Alzheimer’s Disease (including proxy) 0.3 0.5 0.8 -0.8 0.5 0.7 0.7 -0.6 0.9 -0.5
Crohns Disease (2017) 0.3 0.6 1.0 0.3 0.8 0.8 -1.0 -0.8 -0.3 -0.8
Irritable Bowel Disease (IBD) 0.4 0.9 1.8 0.5 0.4 1.2 -0.9 -1.3 -0.1 -1.2
Ulcerative Colitis (UC) 0.3 0.6 1.7 0.6 -0.1 1.3 -0.1 -1.0 -0.2 -1.0
Major Depression (MDD) 1.8 2.2 6.4 -2.5 -1.6 0.0 0.3 0.9 1.7 1.6
Reaction Time 0.4 0.7 2.6 0.0 -0.2 -1.6 1.0 0.6 -0.6 0.7
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.1 1.1 0.6 0.6 0.7 0.1 -0.9 0.3
Breast Cancer 0.1 0.3 1.2 0.2 0.6 1.1 -0.4 0.2 -0.2 -0.2
Ovarian Cancer 0.8 1.1 3.2 1.7 1.1 0.2 0.8 0.2 -1.8 0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.5 3.7 8.1 2.6 1.0 1.2 -2.8 -1.6 -1.4 -2.0
Bipolar Disorder (2011) 0.5 0.5 1.4 1.2 0.4 0.5 0.4 -0.1 -1.1 -0.5
Body Mass Index (BMI) (2010) 0.2 0.3 1.1 0.1 1.0 -0.4 0.2 0.5 -0.3 0.5
Coronary Artery Disease (CAD) 0.5 0.6 1.9 0.1 -1.4 -1.2 -0.7 -0.4 -0.1 -0.2
Crohns Disease (2012) 0.5 0.8 2.9 1.3 0.7 0.6 -0.3 0.3 -1.7 -0.0
Mean Putamen Volume 0.9 1.0 2.4 -1.4 -0.6 -0.9 1.0 -0.4 1.6 0.3
Fasting Glucose 2.2 2.7 6.9 -0.9 -1.0 -2.6 1.6 1.7 0.0 2.2
HbA1C 1.6 1.8 5.6 -1.7 -0.8 0.3 -1.3 -1.1 2.4 -0.8
HDL Cholesterol 0.2 0.4 1.0 0.5 -1.0 0.2 -0.8 -0.7 0.0 -0.7
LDL Cholesterol 0.2 0.3 0.9 -0.5 -0.3 -0.5 0.3 -0.9 0.5 -0.5
Lupus 0.7 1.1 2.0 -1.2 -0.1 -1.1 1.1 1.4 0.3 1.4
Neuroticism (2016) 2.3 3.4 7.8 -1.6 -2.3 -0.4 -2.8 -1.4 2.2 -0.8
Primary Biliary Cirrhosis 1.6 2.2 7.4 -0.5 -1.3 -1.8 2.7 1.3 -0.5 1.2
Rheumatoid Arthritis 1.9 2.6 4.1 1.3 0.4 -1.4 1.9 2.0 -2.0 1.7
Schizophrenia (2014) 0.4 0.9 1.6 1.3 -1.0 -0.6 -0.8 -1.0 -0.9 -0.9
Triglycerides 0.5 0.8 1.5 -1.2 1.0 0.4 0.0 -0.9 1.2 -1.0
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.9 1.0 0.6 1.4 -0.3 -1.1 -0.1 -1.0
Ulcerative Colitis 0.1 0.1 0.2 0.0 -0.5 -0.4 0.5 0.1 -0.0 0.2
Blood Eosinophil Count 0.3 2.1 6.0 1.5 2.5 0.0 1.1 -1.5 -0.8 -1.6
Blood Platelet Count 0.1 0.9 1.6 1.3 0.8 -1.0 0.9 -0.6 -0.8 -1.1
Blood Red Count 0.1 0.6 1.4 -1.0 -0.8 -0.3 0.2 0.5 0.7 1.2
Blood White Count 0.4 2.7 13.3 0.1 2.0 -1.0 3.6 0.3 -0.6 -0.2
Heel T-Score 0.4 2.8 4.9 1.9 1.8 -0.2 -2.2 -1.7 -0.6 -2.2
BMI 0.6 3.2 16.1 0.9 4.0 -0.9 1.7 0.6 -1.0 0.6
Height 1.0 18.7 34.9 4.2 4.0 5.9 -1.9 -4.6 -1.9 -5.8
Waist Hip Ratio (WHR) 2.3 10.1 20.7 -2.8 -4.6 0.4 -2.2 -3.6 3.9 -3.0
Systolic Blood Pressure 1.9 9.6 49.4 0.6 1.9 -0.2 7.0 2.4 -2.2 1.8
Smoking Status 2.8 6.7 20.3 -3.5 -4.5 -0.8 -1.0 -0.8 3.5 0.0
Allergy or Eczema 1.1 2.8 13.4 0.4 3.7 1.9 0.6 -0.9 -0.3 -1.1
Cardiovascular Disease 0.7 2.2 13.0 -1.0 1.0 0.4 3.6 0.6 0.1 0.0
Hypothyroidism (self reported) 1.2 2.8 5.0 1.5 1.6 1.8 -1.5 -2.0 -0.3 -2.2
Respiratory disease 0.8 1.8 5.2 -1.5 1.3 -0.5 2.3 1.1 0.8 1.2
Type 2 Diabetes (T2D) (2018) 1.4 2.7 4.6 2.2 1.2 -1.5 1.1 1.7 -2.1 1.4
Lung FEV1/FVC ratio 0.4 2.0 5.6 2.1 -1.3 -2.4 -0.8 0.2 -1.3 0.0
Lung FVC 0.6 3.0 8.2 2.9 1.6 2.2 -0.0 -0.2 -2.2 -0.5
Neuroticism 2.5 5.9 11.4 -2.4 -2.7 -0.1 -3.4 -2.4 3.1 -1.4
Chronotype (morning person) 2.3 5.2 8.9 1.4 -1.0 -2.3 2.2 3.0 -2.6 2.8
Hair Pigment 0.3 7.8 19.1 1.1 0.5 4.4 -2.2 -3.6 0.3 -3.9
Tanning 0.1 1.6 4.7 -2.2 -0.7 0.5 1.7 -0.2 1.7 -0.0
Hand grip strength (left) 3.8 9.9 31.6 5.6 2.1 1.4 -0.4 1.0 -5.5 -0.6
Number of treatments/medications taken 2.4 4.4 10.2 -3.2 -1.4 -1.5 3.0 0.1 2.5 0.8
Average weekly spirits intake 0.2 0.3 0.7 -0.5 -0.6 0.5 -0.5 -0.5 0.9 -0.3
Sensitivity / hurt feelings 1.2 2.1 5.0 -1.3 -2.1 -1.4 -2.2 -0.5 1.0 -0.5
Frequency of depressed mood in last 2 weeks 0.8 1.1 3.6 -1.9 -1.2 -0.3 -0.2 -0.1 1.6 0.3
Hearing difficulty/problems: Yes 0.9 1.4 4.8 -1.3 0.7 0.1 2.2 0.6 1.0 1.1
Relative age of first facial hair 1.4 2.9 7.2 -1.4 -2.7 -0.2 -1.5 -1.8 1.9 -1.4
Other serious medical condition/disability diagnosed by doctor 3.9 5.1 10.9 -3.3 -1.5 -2.1 2.3 1.8 2.0 2.4
Ever used hormone-replacement therapy (HRT) 1.9 2.5 5.2 -1.5 -2.2 -2.3 0.9 1.1 0.8 1.5
Ever had hysterectomy (womb removed) 0.1 0.1 0.6 -0.1 -0.7 -0.8 0.1 0.1 -0.0 -0.0
Systolic blood pressure, automated reading 1.7 4.8 21.2 1.3 1.6 -0.7 4.6 1.5 -2.1 1.1
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.7 -0.6 0.6 1.5 0.3 -1.6 1.4 -1.4
Angina 1.1 1.5 4.0 -1.4 -2.0 -1.6 0.5 0.4 1.0 0.8
Medication for hormone replacement therapy 1.4 1.5 3.1 -1.3 -1.1 -1.8 1.4 0.9 0.8 1.2
Vitamin and mineral supplements 0.9 1.2 3.2 -0.2 -1.0 -1.6 0.4 1.2 -0.3 1.8
Supplements: Zinc 1.2 1.3 4.8 -0.6 2.2 0.6 1.7 0.7 -0.0 0.6
Medication: Co-codamol 1.4 1.6 5.6 -1.7 -0.3 -0.5 2.4 0.5 1.1 0.9
Medication: Metformin 1.9 2.7 7.0 2.5 1.6 -1.1 0.4 1.3 -2.6 0.6
Diabetes (father) 0.5 0.6 1.7 1.3 -0.7 -0.4 0.8 -0.3 -1.2 -0.2
Diabetes (mother) 0.6 0.8 1.8 1.4 1.0 0.7 -0.2 -0.8 -0.7 -1.0
Severe depression (siblings) 0.5 0.5 1.7 -0.4 0.9 0.1 1.3 0.7 -0.0 0.7
Pack years adult smoking proportion 1.5 2.3 6.4 -2.5 -1.0 0.4 -0.1 -1.3 2.5 -0.6
Impedance of leg (right) 1.8 8.8 35.9 -2.9 -6.0 -1.8 -2.0 1.4 2.2 1.9
Leg fat-free mass (left) 1.7 8.7 35.0 3.3 5.9 1.6 1.6 -0.8 -2.7 -1.5
Trunk fat percentage 0.1 0.2 0.8 -0.3 0.9 0.2 0.0 -0.5 0.6 -0.2
Hand grip strength (right) 3.6 9.9 28.9 5.3 3.0 1.0 -0.0 1.3 -5.4 -0.3
Townsend deprivation index at recruitment 4.6 6.5 17.6 -3.4 -1.2 1.0 0.9 -2.8 4.2 -2.2
Current tobacco smoking 3.2 5.3 14.4 -3.7 -2.4 0.4 -0.3 -1.6 3.8 -0.7
Average weekly fortified wine intake 0.7 0.8 1.5 -1.2 -0.2 -0.6 1.1 0.8 0.9 1.1
Maternal smoking around birth 0.4 0.5 1.1 0.2 -1.0 0.3 -0.8 -1.1 0.4 -0.7
Fed-up feelings 0.2 0.4 1.3 -0.2 -0.6 -1.1 -1.0 -0.3 -0.1 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.3 3.1 7.0 -2.6 -1.8 -1.9 1.4 0.6 1.9 1.2
Relative age voice broke 3.4 5.1 9.5 -1.8 -1.1 1.7 -1.8 -3.1 2.8 -2.8
Taking other prescription medications 1.0 1.5 4.4 -2.1 -0.0 -1.2 1.4 0.5 1.3 0.9
Age when periods started (menarche) 8.3 20.0 40.3 -2.9 -2.2 2.7 -3.7 -6.3 5.9 -5.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.7 0.5 0.9 -0.2 -0.5 -0.6 -0.2 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.7 4.0 9.1 -0.8 0.4 1.6 -1.7 -3.0 2.4 -2.6
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.2 -0.6 -0.6 -0.0 0.5 -0.7 1.1 -0.8
Qualifications: CSEs or equivalent 2.1 2.7 7.9 -1.3 1.5 2.8 1.1 -1.4 1.7 -1.2
Serious illness, injury or assault to yourself 0.7 0.9 1.7 -1.3 -1.3 0.3 1.1 0.1 1.1 0.3
High blood pressure 0.7 2.0 10.7 -0.4 1.5 0.5 3.3 -0.1 0.1 -0.6
Hayfever, allergic rhinitis or eczema 1.4 3.0 16.4 0.9 4.1 1.5 0.7 -0.4 -0.9 -0.5
Multivitamins +/- minerals 0.7 0.9 1.6 1.3 0.7 1.2 -0.6 -0.5 -0.8 -1.2
Stomach or abdominal pain in last month 1.9 2.3 6.3 -2.5 0.5 0.3 1.5 -1.2 2.4 -0.6
Supplements: Glucosamine 0.6 0.8 1.8 0.6 -1.3 0.1 -1.1 -1.1 0.1 -1.0
Diverticular disease/diverticulitis (self-reported) 3.1 3.6 6.5 -2.4 -2.3 -2.6 0.6 1.1 1.7 1.7
Medication: Atenolol 1.6 2.0 4.2 -1.0 -0.7 -1.8 2.0 1.4 0.1 1.7
Medication: Levothyroxine sodium 0.7 1.2 2.8 0.5 1.7 1.4 -0.7 -1.1 0.2 -1.3
Sitting height 0.9 6.3 13.6 3.1 3.7 3.1 0.7 -0.5 -2.7 -1.7
Chronic bronchitis/emphysema (father) 0.2 0.2 0.6 -0.3 0.6 0.4 0.8 -0.3 0.2 -0.0
High blood pressure (mother) 2.7 3.8 16.8 -1.2 2.4 -0.3 4.1 1.3 -0.2 1.0
Body mass index (BMI) 0.6 2.8 10.9 0.6 3.3 -1.0 2.1 0.9 -0.9 1.1
Impedance of leg (left) 1.5 7.5 31.3 -2.7 -5.6 -0.9 -2.3 0.6 2.4 1.1
Leg predicted mass (left) 1.7 9.0 35.8 3.4 6.0 1.6 1.7 -0.8 -2.8 -1.6
Trunk fat mass 0.2 0.9 5.1 0.6 2.2 0.3 0.6 -0.4 -0.3 -0.4
Waist circumference 0.2 0.7 3.4 0.0 1.8 -0.6 1.1 -0.4 0.1 -0.3
Number of incorrect matches in round 0.7 1.2 5.0 -0.2 -2.2 -0.9 -1.5 -0.1 0.7 -0.1
Past tobacco smoking 1.0 1.8 4.2 1.9 1.7 -0.1 0.5 1.0 -2.0 0.7
Alcohol usually taken with meals 2.0 3.2 7.6 2.0 1.9 -0.8 1.3 1.8 -2.8 1.1
Nervous feelings 1.5 2.7 7.6 -1.3 -2.8 0.8 -2.5 -0.6 1.6 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 3.3 -1.8 -0.9 -1.0 -0.2 0.1 1.4 0.1
Hearing difficulty/problems with background noise 1.8 2.9 6.0 -0.9 1.3 2.4 -0.9 -2.1 1.9 -1.6
Hair/balding pattern: Pattern 2 0.4 0.5 1.3 1.1 0.2 -0.3 -0.6 0.8 -1.2 -0.0
Had menopause 0.4 0.5 1.3 -0.7 -1.1 -0.6 -0.3 0.6 0.2 0.6
Had other major operations 0.7 0.8 2.3 -1.5 0.2 0.3 0.9 -0.1 1.5 0.5
Forced vital capacity (FVC) 2.2 8.6 19.1 4.4 2.5 4.2 -1.6 -1.6 -2.5 -2.5
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.6 5.6 -0.2 0.2 1.0 -2.0 -2.4 1.8 -2.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.8 -1.3 0.5 -0.5 0.2 0.6 0.8 0.7
Qualifications: None of the above 3.4 7.4 19.8 -3.9 -3.2 -0.8 -0.5 -2.1 4.5 -0.9
Financial difficulties in last 2 years 2.8 3.8 9.7 -2.7 -1.8 0.7 -1.7 -1.6 3.1 -1.0
Mouth/teeth dental problems 1.0 1.5 6.6 1.6 -0.6 0.6 -2.6 0.2 -0.9 0.2
Heart attack 0.9 1.1 2.9 -1.7 -0.4 0.0 1.2 1.1 0.5 1.4
Allergy 0.9 2.0 8.6 1.1 -2.9 -0.7 -1.7 0.3 -0.8 -0.2
Pain all over the body in last month 1.0 1.0 2.4 -1.6 1.3 0.5 0.9 -0.3 1.4 0.2
Diabetes (self-reported) 0.5 0.7 2.0 1.4 0.5 -0.6 1.0 0.6 -1.0 0.3
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 3.8 0.1 2.0 0.3 0.9 0.2 -0.5 0.0
Medication: Ramipril 0.3 0.4 1.4 0.4 0.6 0.3 1.2 -0.6 -0.2 -0.7
Medication: Simvastatin 1.3 1.9 4.6 -1.5 -1.5 -1.2 2.2 1.0 0.6 1.1
Fluid intelligence score 0.2 0.4 0.7 0.7 0.5 0.4 0.2 0.7 -0.7 0.9
Illnesses of siblings 0.4 0.6 1.8 1.4 0.3 0.3 -0.8 0.3 -1.1 -0.1
Neuroticism score 2.4 5.1 8.7 -2.6 -2.5 -0.2 -2.8 -2.0 2.9 -1.3
Weight 0.9 4.3 20.9 2.0 4.6 0.6 1.4 -0.1 -1.7 -0.4
Impedance of arm (right) 1.7 7.9 22.7 -0.4 -4.8 1.4 -4.2 -2.3 1.8 -2.1
Arm fat percentage (right) 0.1 0.3 1.8 0.2 1.4 -0.1 0.4 -0.2 0.1 0.1
Trunk fat-free mass 1.4 8.1 31.6 3.3 5.6 1.1 1.6 -0.2 -2.9 -1.1
Hip circumference 1.4 6.1 22.8 2.3 4.8 -0.7 1.7 1.4 -2.8 1.0
Time employed in main current job 0.2 0.2 0.8 0.3 -0.1 0.9 -0.4 -0.4 -0.3 -0.5
Alcohol intake versus 10 years previously 1.2 1.8 4.0 1.9 2.0 -0.5 1.1 -0.3 -1.7 -0.7
Father’s age at death 0.3 0.4 2.1 0.1 1.4 0.3 -0.0 -0.5 0.2 -0.2
Worrier / anxious feelings 1.1 2.1 8.9 -0.5 -1.6 0.3 -3.0 -1.2 0.8 -0.9
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.8 12.6 -3.5 -0.6 0.3 0.3 -1.0 3.5 0.4
Falls in the last year 4.0 5.4 10.6 -1.6 -2.0 -2.5 2.2 3.1 -0.2 3.3
Hair/balding pattern: Pattern 3 0.7 1.1 2.2 -0.3 -0.1 -1.5 1.4 1.3 -0.6 1.2
Number of live births 0.7 1.0 4.4 -0.2 -0.5 -2.1 0.2 0.9 -0.3 1.1
Forced expiratory volume in 1-second (FEV1) 2.6 8.6 26.3 5.1 2.2 3.2 -1.6 -1.1 -3.3 -2.0
Pulse rate 1.0 1.7 4.6 1.4 1.6 -0.2 1.0 1.1 -2.1 0.5
Happiness 0.9 1.0 2.6 -1.6 -1.2 -1.1 0.6 -0.1 1.3 0.5
Noisy workplace 1.3 1.6 3.7 -1.7 -1.2 0.3 0.3 -1.2 1.9 -1.0
Qualifications: A levels/AS levels or equivalent 1.2 2.7 6.9 2.6 2.6 0.2 0.1 0.2 -2.2 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.4 -0.0 -0.5 0.1 -1.2 -0.8 0.5 -1.1
Mouth/teeth dental problems: Dentures 1.9 3.3 9.1 -2.6 -1.1 -1.4 3.0 0.5 1.6 0.8
Asthma 0.7 1.4 4.7 -1.3 2.2 0.6 1.2 -0.2 1.2 0.3
Medication: Ibuprofen (e.g. Nurofen) 2.3 3.0 9.6 -2.7 -0.8 0.7 -0.3 -1.5 3.1 -0.6
Medication: Cholesterol lowering 2.9 4.5 8.9 -2.2 -1.6 -2.1 3.0 2.1 0.8 2.5
Depression (self-reported) 0.6 0.7 2.0 -1.1 0.6 0.1 1.4 0.5 0.5 0.9
Medication: Lansoprazole 1.0 1.1 4.8 -0.8 -2.2 -1.1 0.3 0.8 0.1 0.5
Prospective memory result 0.7 0.8 1.2 0.6 -1.0 -0.8 0.4 1.0 -1.1 1.1
Lung cancer (father) 0.6 0.7 2.3 -0.4 -1.3 -1.5 -0.0 -0.4 0.5 -0.1
Illnesses of mother 2.0 2.4 7.3 0.3 0.2 1.1 -2.7 -2.0 1.2 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.1 16.0 4.0 1.0 2.5 -1.9 -0.7 -2.5 -1.5
Pulse wave Arterial Stiffness index 1.8 2.1 6.2 -0.9 2.5 1.1 2.3 -0.7 0.7 -0.2
Impedance of arm (left) 1.6 7.3 16.8 -0.8 -4.1 1.8 -3.7 -2.5 2.2 -2.4
Arm fat mass (right) 0.4 1.5 8.1 1.1 2.9 0.1 0.9 -0.1 -0.8 -0.2
Trunk predicted mass 1.4 8.1 31.5 3.4 5.6 1.0 1.6 -0.2 -3.0 -1.0
Standing height 0.8 8.2 12.8 3.4 3.3 3.6 -1.4 -2.2 -2.0 -3.3
Length of working week for main job 0.3 0.3 1.6 0.4 1.2 0.4 -0.1 -0.4 -0.2 -0.5
Exposure to tobacco smoke at home 1.5 1.7 3.2 -1.8 -1.4 -0.6 1.7 0.1 1.8 0.4
Breastfed as a baby 1.1 1.4 3.3 1.2 0.8 -0.5 -1.3 -1.4 -0.7 -1.8
Tense / ‘highly strung’ 1.7 2.7 5.4 -2.1 -2.3 0.8 -1.5 -1.0 2.2 -0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.7 -1.6 -0.4 -1.4 1.3 0.4 1.1 0.4
Hair/balding pattern: Pattern 4 0.9 2.2 5.8 -0.7 -2.4 0.4 -2.0 -1.2 1.8 -0.5
Birth weight of first child 0.3 0.6 1.4 1.1 -0.1 0.4 -0.8 -0.9 -0.5 -1.2
Peak expiratory flow (PEF) 2.5 5.9 20.8 4.6 2.5 1.0 -1.1 0.4 -3.5 -0.4
Pulse wave reflection index 1.3 1.5 4.3 -1.2 0.1 0.1 0.3 -1.9 2.1 -1.1
Ever highly irritable/argumentative for 2 days 2.6 3.2 12.0 -3.5 -0.7 -0.0 0.2 -0.3 3.1 0.2
Loud music exposure frequency 1.9 2.1 5.0 -2.2 -1.3 -1.6 0.3 1.4 1.4 1.4
Qualifications: O levels/GCSEs or equivalent 2.2 3.5 8.0 2.5 2.4 -0.4 1.6 1.2 -2.8 0.5
Mouth/teeth dental problems: Bleeding gums 3.4 4.4 8.7 2.0 2.1 2.7 -0.7 -2.2 -1.0 -3.0
Blood clot in the leg (DVT) 0.6 0.8 2.1 -0.8 -0.9 -1.4 0.0 -0.8 1.1 0.0
Medication: Paracetamol 1.3 2.2 8.1 -2.8 -0.9 -0.3 0.1 0.0 2.4 0.9
Headache pain in last month 1.4 2.4 8.4 -2.9 -0.7 -0.1 -0.1 -0.7 2.7 -0.1
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 9.7 1.2 0.5 1.3 -3.1 -1.9 -0.1 -2.0
Glaucoma (self-reported) 0.5 0.6 2.1 -0.8 0.8 1.4 0.2 0.4 0.6 0.5
Gout (self-reported) 0.4 0.5 1.4 -0.8 0.9 -0.5 1.2 -0.5 0.5 -0.4
Hypothyroidism/myxoedema (self-reported) 1.5 3.0 5.4 0.9 1.9 1.9 -1.6 -2.2 0.2 -2.3
Medication: Amlodipine 1.3 1.9 8.7 -0.2 0.1 -0.4 3.0 1.6 -0.6 1.1
Medication: Ventolin 100micrograms inhaler 0.7 0.8 1.8 -1.0 0.6 -0.6 1.3 -0.8 1.2 -0.4
Birth weight 0.2 0.3 1.3 0.2 -0.3 0.0 1.1 0.5 -0.4 0.7
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.4 0.1 0.1 -0.5 0.0 0.5 -0.6 0.5
High blood pressure (siblings) 0.6 0.8 1.0 -0.8 0.9 1.0 0.8 -1.0 0.9 -0.9
Forced vital capacity (FVC), Best measure 1.6 5.9 14.6 3.3 1.5 3.8 -2.2 -1.3 -1.7 -2.0
Body fat percentage 0.1 0.5 0.7 -0.5 0.8 -0.9 0.7 0.5 0.4 0.9
Leg fat percentage (right) 1.1 4.1 9.4 -1.3 -0.0 -3.1 1.8 2.4 0.2 2.9
Arm fat-free mass (right) 1.4 7.3 33.0 2.5 5.7 0.9 2.1 0.1 -2.5 -0.6
Exposure to tobacco smoke outside home 0.5 0.7 1.8 -0.4 -0.7 -0.2 0.0 -1.3 0.8 -1.4
Comparative body size at age 10 2.0 5.6 11.4 1.4 -0.7 -2.7 0.9 3.3 -2.6 3.4
Number of full brothers 1.1 1.4 3.9 -1.2 -0.7 -0.7 2.0 0.9 0.7 1.4
Worry too long after embarrassment 2.0 3.4 17.9 0.1 -1.8 0.5 -4.2 -1.2 0.6 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.6 9.3 -3.0 -0.9 -0.7 1.4 0.6 1.9 1.0
Wheeze or whistling in the chest in last year 2.4 4.3 12.5 -3.5 -0.0 -1.4 2.2 0.5 3.0 1.3
Number of children fathered 0.4 0.5 1.9 -0.4 0.2 -0.2 1.4 0.8 -0.3 0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 2.5 1.5 1.3 1.4 -1.6 -0.2 -1.2 -0.5
Age at first live birth 2.1 3.6 6.4 2.2 2.5 2.2 -1.8 -1.3 -1.4 -1.7
Pulse wave peak to peak time 1.5 1.8 5.6 1.1 -1.9 -0.8 -2.4 0.8 -1.0 0.2
Health satisfaction 1.0 1.3 3.1 -1.8 -1.6 -0.5 1.1 0.1 1.5 0.1
Shortness of breath walking on level ground 1.7 2.1 9.9 0.0 1.2 -0.5 3.1 1.2 -0.8 0.9
Qualifications: College or University degree 1.3 4.1 10.3 2.6 2.9 -0.1 0.6 1.6 -3.2 0.6
Eye problems/disorders: None of the above 0.5 0.6 1.8 0.0 0.7 0.1 -1.3 -1.0 0.4 -0.9
Mouth/teeth dental problems: Loose teeth 0.6 0.8 2.5 -1.6 0.2 -1.0 1.1 -0.0 0.8 -0.0
Emphysema/chronic bronchitis 1.5 1.7 5.4 -1.7 -0.2 -0.9 2.3 -0.5 1.5 -0.3
Medication for pain relief, constipation, heartburn 2.5 4.2 13.3 3.6 2.1 1.1 -0.7 -0.7 -2.6 -1.7
Neck or shoulder pain in last month 2.3 3.2 10.5 -2.6 -0.2 1.6 0.3 -1.4 3.2 -0.9
Medication: Blood pressure 1.5 2.6 10.5 -0.1 0.5 -1.0 3.2 1.8 -0.8 1.7
Angina (self-reported) 1.4 1.8 4.4 -1.5 -2.1 -1.8 0.8 0.5 1.1 0.9
Migraine (self-reported) 0.3 0.4 1.4 -0.4 -1.2 -0.2 -0.5 -0.3 0.7 -0.4
Medication: Ibuprofen 2.2 2.6 7.3 -2.5 -0.4 1.0 -0.2 -1.6 2.7 -1.1
Medication: Allopurinol 0.7 0.9 4.7 -1.1 0.0 -0.2 2.2 -0.3 0.7 -0.2
Medication: Omeprazole 1.8 2.1 4.8 -1.6 -0.8 -1.5 2.2 0.8 0.8 1.8
Medication: Seretide 50 evohaler 0.3 0.3 0.9 -0.1 1.0 -0.6 0.5 0.5 -0.3 0.6
Mean time to correctly identify matches 0.4 0.9 3.2 -0.1 -0.3 -1.8 1.3 0.6 -0.6 0.6
Heart disease (mother) 0.9 1.1 1.9 0.2 -0.4 -1.1 1.4 1.3 -1.4 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 3.1 0.9 1.1 0.0 0.8 1.8 -1.7 1.3
Whole body fat mass 0.3 1.1 5.7 0.6 2.4 -0.3 1.0 0.2 -0.6 0.3
Leg fat mass (right) 0.7 2.7 4.2 0.1 1.8 -1.7 2.0 1.8 -0.9 2.0
Arm predicted mass (right) 1.4 7.1 33.5 2.3 5.8 0.9 2.2 0.1 -2.3 -0.5
Pulse rate, automated reading 0.8 2.7 8.0 1.7 2.8 0.2 1.3 -0.9 -1.8 -1.4
Alcohol intake frequency. 2.0 4.7 9.1 -0.6 -0.5 -3.0 3.0 2.7 -0.8 2.6
Comparative height size at age 10 0.5 2.6 6.3 2.0 1.9 0.6 1.1 1.4 -2.5 0.7
Number of full sisters 2.8 3.5 7.5 -1.5 -0.9 -1.5 2.6 2.2 0.1 2.7
Suffer from ‘nerves’ 2.6 4.1 9.9 -1.4 -1.8 0.2 -3.1 -2.2 2.7 -1.3
Overall health rating 4.4 9.5 23.8 -4.9 -2.7 -3.2 2.8 1.2 3.5 2.1
Chest pain or discomfort 2.6 3.7 12.8 -3.6 -1.1 -0.8 0.3 -0.8 3.2 0.1
Had major operations 1.3 1.5 2.6 -1.0 1.6 1.1 1.4 -1.0 1.2 -1.0
Age at last live birth 1.1 1.5 3.3 1.5 1.4 1.0 -1.8 -0.8 -0.8 -1.0
Family relationship satisfaction 0.6 0.7 2.0 1.0 -0.6 -1.4 -0.4 0.5 -1.2 0.2
Leg pain on walking 0.7 0.9 1.8 -1.0 1.3 0.4 -0.0 -0.9 1.3 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.0 -0.9 0.6 0.9 0.7 -0.8 1.0 -0.4
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.6 -0.5 0.8 -0.8 0.7 0.1 0.2 0.2
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 4.1 0.6 1.2 -0.6 2.0 1.3 -1.1 1.1
Medication: Aspirin 1.5 1.9 5.3 -0.7 -2.3 -1.7 0.9 1.4 -0.2 1.4
Supplements: Vitamin C 1.7 2.0 4.7 -1.0 -0.1 2.2 -0.1 -1.6 1.5 -1.8
Knee pain experienced in last month 2.4 3.7 8.0 -1.5 -0.2 1.7 0.0 -2.7 2.4 -2.8
Hypertension (Self-reported) 0.6 1.8 9.9 -0.5 1.4 0.4 3.1 -0.0 0.3 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.6 2.3 -1.5 -1.5 -0.7 1.5 1.0 0.5 1.5
Illnesses of father: Heart disease 0.6 0.9 2.6 1.3 0.7 -0.5 0.4 0.9 -1.6 0.4
Illnesses of siblings: Diabetes 0.2 0.3 1.1 -0.1 0.0 -0.2 -0.2 -1.0 0.5 -0.8
Smoking status: Previous 0.2 0.3 1.7 -0.3 -1.3 -0.2 -0.2 -0.1 0.3 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 1.4 0.8 0.0 1.2 0.1 -0.9 -0.4 -0.9
Whole body fat-free mass 1.6 9.1 36.7 3.4 6.1 1.3 1.8 -0.4 -3.0 -1.2
Leg fat-free mass (right) 2.0 10.8 40.9 3.7 6.4 2.2 1.3 -1.3 -2.9 -2.1
Arm fat percentage (left) 0.1 0.6 3.3 0.2 1.8 0.0 0.6 -0.4 0.1 -0.2
Average weekly red wine intake 1.3 1.9 4.0 1.7 2.0 2.0 -0.2 0.4 -1.6 0.1
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.9 -0.6 -0.4 -0.1 1.0 1.3 0.0 1.4
Mood swings 0.5 0.9 2.0 -1.2 0.2 -0.1 -0.3 -1.4 1.2 -1.1
Loneliness, isolation 2.0 2.7 4.4 -1.4 -1.3 -0.3 -1.6 -2.1 2.1 -2.1
Long-standing illness, disability or infirmity 2.7 4.1 7.0 -2.4 -1.4 -2.3 2.6 1.3 1.5 2.1
Ever had bowel cancer screening 1.8 2.1 5.8 -2.2 -0.9 -1.0 -0.0 -1.3 2.4 -0.7
Diabetes diagnosed by doctor 0.2 0.3 1.3 1.1 0.6 -0.1 0.5 0.2 -0.5 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 4.1 -0.8 0.1 -1.2 1.8 1.8 -0.0 2.0
Friendships satisfaction 0.9 1.1 2.0 -0.2 -0.5 -1.4 1.4 1.4 -0.7 1.2
Qualifications: nursing, teaching 1.6 2.5 6.4 2.1 1.6 -0.3 1.0 1.6 -2.5 0.8
Commuting to job workplace: Walk 0.2 0.3 0.6 0.7 -0.0 -0.1 0.8 -0.3 -0.8 -0.3
Eye problems/disorders: Cataract 0.2 0.3 1.0 0.5 0.4 0.0 1.0 0.2 -0.6 0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.9 2.6 -1.0 0.5 -1.1 1.6 0.1 0.9 0.5
Medication for cholesterol 0.2 0.4 0.8 -0.3 0.6 0.3 -0.9 0.7 0.1 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 3.8 -0.1 -1.9 -0.8 -0.2 0.6 -0.2 0.8
Back pain experienced in last month 1.8 2.6 8.5 -2.9 0.2 0.7 -0.0 -1.0 2.8 -0.6
Mineral and other dietary supplements 0.6 0.7 2.0 0.2 0.6 -1.3 -0.3 0.9 -0.5 1.4
Breast cancer (self-reported) 0.6 0.7 1.7 1.2 -0.7 0.5 -1.3 -0.8 -0.4 -0.6
Asthma (self-reported) 0.8 1.5 4.9 -1.4 2.2 0.6 1.2 -0.1 1.3 0.4
Osteoporosis (self-reported) 0.2 0.3 1.4 -1.2 -0.0 -0.4 0.2 0.0 0.7 -0.2
Osteoarthritis (self-reported) 1.0 1.2 4.4 -2.1 -0.6 -0.1 0.7 -0.2 1.8 0.1
Medication: Aspirin 2.1 2.8 5.5 -1.0 -2.3 -2.2 1.3 1.8 -0.2 1.8
Medication: Gliclazide 0.8 0.9 1.8 0.8 1.2 0.6 1.3 1.0 -1.1 0.4
Illnesses of father: None of the above (group 1) 0.9 1.1 1.6 -1.2 -1.0 -1.0 -0.8 0.9 0.9 1.3
Smoking status: Current 3.5 5.6 16.0 -3.9 -2.0 0.6 -0.0 -1.8 4.0 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 5.4 2.3 1.5 2.0 -1.0 -1.4 -1.0 -1.7
Whole body water mass 1.6 9.2 37.2 3.4 6.1 1.3 1.8 -0.5 -2.9 -1.3
Leg predicted mass (right) 2.0 10.7 40.5 3.7 6.4 2.2 1.4 -1.3 -2.8 -2.1
Arm fat mass (left) 0.5 1.9 10.5 1.0 3.2 0.1 1.2 -0.1 -0.8 -0.1
Number of self-reported non-cancer illnesses 2.4 4.1 10.3 -3.2 -0.4 -0.9 3.2 1.0 2.0 1.5
Average weekly champagne plus white wine intake 0.2 0.3 1.2 -0.0 -0.2 -0.1 -1.1 -0.5 0.3 -0.7
Miserableness 1.1 1.9 3.8 -1.2 -0.1 0.9 -1.5 -1.9 1.7 -1.4
Guilty feelings 0.9 1.3 5.0 -0.9 -2.2 0.1 -1.3 -0.4 1.1 -0.3
Wears glasses or contact lenses 0.4 0.5 0.9 -0.6 -0.4 -0.9 0.8 0.6 0.2 0.8
Ever taken oral contraceptive pill 0.5 0.6 1.2 0.1 1.0 -0.9 0.8 0.6 -0.5 1.1
Hearing aid user 0.6 0.7 1.7 -0.0 0.2 -1.3 0.8 1.0 -0.4 1.1
Mother’s age at death 0.6 0.8 2.0 -0.5 -0.5 -1.4 0.0 1.3 -0.3 1.1
Financial situation satisfaction 2.1 2.6 5.4 -2.3 -2.0 -1.2 1.9 0.7 1.5 1.0
Tinnitus: Yes, now most or all of the time 1.8 2.1 4.4 -0.6 -0.5 -1.9 1.1 2.0 -0.5 2.1
Commuting to job workplace: Public transport 1.8 2.1 7.1 0.9 1.3 2.7 -0.7 -1.3 0.1 -1.8
Eye problems/disorders: Glaucoma 0.7 0.8 1.9 -0.1 0.7 0.9 0.9 1.4 -0.6 1.2
Medication: Blood pressure 0.4 0.7 1.8 -0.0 0.6 0.7 1.1 -1.2 0.2 -1.3
Pain type(s) experienced in last month: Hip pain 1.8 2.3 5.7 -1.6 -0.2 0.8 -1.4 -1.8 2.4 -1.3
Supplements: Fish oil (including cod liver oil) 1.1 1.5 3.0 -1.2 -1.5 0.7 0.0 -1.2 1.7 -1.3
High cholesterol (Self-reported) 0.3 0.5 2.7 -0.3 -0.1 -0.8 1.6 0.2 0.0 0.1
Medication: Bendroflumethiazide 0.5 0.8 4.8 0.4 0.4 0.1 2.2 0.2 -0.3 -0.4
Medication: Paracetamol 1.3 2.0 7.1 -2.7 -1.1 -0.4 -0.1 -0.3 2.3 0.6
Medication: Lisinopril 0.4 0.6 1.3 0.6 -0.2 -1.1 0.5 0.9 -0.9 0.7
Medication: Atorvastatin 0.3 0.4 1.2 -1.1 -0.4 -0.0 0.2 -0.3 1.1 -0.2
Illnesses of father: High blood pressure 2.2 2.7 4.6 -0.5 -1.3 -1.8 2.0 2.1 -0.7 2.0
Alcohol drinker status: Never 4.3 5.2 13.5 -0.5 -1.6 -1.5 2.1 3.7 -1.1 3.5
Ever smoked 1.5 2.7 7.2 -2.6 -1.1 0.2 -0.6 -1.5 2.7 -1.0
Basal metabolic rate 1.5 8.2 34.1 3.2 5.8 1.2 1.7 -0.3 -2.8 -1.1
Leg fat percentage (left) 0.7 2.6 6.4 -1.2 0.3 -2.5 1.5 1.8 0.3 2.3
Arm fat-free mass (left) 1.3 6.5 30.5 2.2 5.5 0.6 2.1 0.3 -2.3 -0.3
Number of operations (self-reported) 2.0 3.0 8.4 -2.9 -0.6 -0.1 1.9 -0.5 2.8 0.4
Average weekly beer plus cider intake 2.8 4.0 13.0 0.2 -0.7 1.0 -1.3 -3.6 1.5 -3.1
Irritability 2.0 3.3 9.4 -2.9 -0.1 0.4 -0.8 -1.7 3.1 -1.3
Risk taking 1.3 1.9 4.0 -1.9 0.1 1.3 0.6 -1.3 2.0 -1.4
Ever had prostate specific antigen (PSA) test 1.9 2.2 5.3 -2.3 1.0 -1.1 1.8 1.1 1.2 1.4
Fractured/broken bones in last 5 years 0.2 0.3 0.5 -0.4 -0.6 -0.3 0.5 0.7 0.1 0.7
Age started oral contraceptive pill 0.9 1.2 5.2 0.9 0.1 0.5 -2.3 -0.7 -0.6 -1.1
Diastolic blood pressure, automated reading 0.4 1.3 3.8 1.9 1.5 -0.1 0.5 0.2 -1.6 0.2
Ever depressed for a whole week 0.9 1.1 4.2 -2.0 -0.3 0.1 -0.3 -0.2 1.8 -0.0
Unable to work because of sickness or disability 2.3 2.9 8.1 -1.3 -1.2 -1.1 2.9 2.0 0.3 2.0
Commuting to job workplace: Cycle 0.6 0.7 2.2 0.3 1.1 1.5 0.7 0.7 -0.7 -0.1
Myopia 0.8 1.1 2.6 1.6 1.5 0.5 0.7 0.0 -1.4 0.2
Vascular/heart problems diagnosed by doctor 0.6 1.7 9.7 1.2 -0.2 0.2 -3.1 -0.4 -0.6 -0.0
Cholesterol lowering medication 0.7 1.0 2.5 0.4 -1.2 0.5 -0.7 -1.6 0.4 -1.6
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 3.6 -1.8 -0.8 -0.9 1.9 1.0 0.8 1.8
Pain experienced in last month 4.4 7.3 18.2 4.0 -0.1 -2.3 -0.1 2.6 -4.3 2.1
Supplements: Calcium 0.5 0.5 1.4 0.0 0.8 1.2 1.2 0.5 -0.4 0.1
Basal cell carcinoma (self-reported) 0.1 0.2 0.5 -0.1 -0.7 -0.2 -0.4 -0.3 0.3 -0.5
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.9 -1.7 -0.4 -0.1 1.4 1.2 0.4 1.5
Deep venous thrombosis (DVT) (self-reported) 0.7 0.8 4.0 -0.5 -0.9 -2.0 0.5 -0.1 0.4 0.5
Heart disease (siblings) 0.9 1.2 3.7 -0.9 -1.9 -1.1 -0.9 0.0 1.1 0.6
Alcohol drinker status: Previous 0.9 1.0 4.1 -0.2 -2.0 -1.7 0.1 -0.1 0.3 0.1
Pack years of smoking 1.3 2.0 5.5 -2.3 -0.9 0.3 -0.1 -1.3 2.2 -0.8
Impedance of whole body 1.5 7.9 29.8 -2.1 -5.5 0.5 -3.3 -1.2 2.7 -0.8
Leg fat mass (left) 0.5 2.1 4.8 0.3 2.2 -1.3 1.8 1.4 -0.9 1.5
Arm predicted mass (left) 1.3 6.5 28.1 2.5 5.3 0.2 2.1 0.5 -2.6 -0.1