Hub : Genes

OLFML2A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.1240	0.0630	0.00570	0.102	NA	0.033	NA	0.034	7.7e-04	NA	4.1e-02	NA	3.7e-02
2	GTEx	Esophagus Muscularis	0.0760	0.0500	0.00860	-0.004	NA	-0.002	NA	-0.004	6.5e-01	NA	4.9e-01	NA	7.9e-01
3	GTEx	Heart Left Ventricle	0.1686	0.0757	0.00064	0.165	NA	0.076	NA	0.147	4.1e-09	NA	7.4e-05	NA	3.0e-08
4	GTEx	Pancreas	0.1520	0.0570	0.00070	0.033	NA	0.086	NA	0.090	1.5e-02	NA	1.8e-04	NA	1.2e-04
5	METSIM	Adipose	0.0403	0.0226	0.00200	0.020	0.005	0.002	0.005	0.008	4.1e-04	0.05500	1.6e-01	0.059	1.9e-02
6	TCGA	Brain Lower Grade Glioma	0.0563	0.0289	0.00014	0.033	0.031	0.027	NA	0.019	1.0e-04	0.00017	4.0e-04	NA	2.8e-03
7	TCGA	Thyroid Carcinoma	0.0240	0.0160	0.00950	0.013	0.017	0.002	NA	0.005	1.8e-02	0.00810	1.7e-01	NA	1.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.9	1.4	2.8	0.7	-0.8	-1.0	0.5	1.7	-1.6	1.5
Bipolar Disorder or Schizophrenia	0.3	0.8	2.8	1.4	-0.4	-0.8	-0.3	0.4	-1.7	0.1
Depressed Affect (Nagel 2018)	0.6	1.3	3.9	-0.1	-0.6	-0.5	-2.0	-1.6	0.6	-1.3
Depression (Nagel 2018)	1.8	2.7	7.0	-1.7	-2.0	-2.6	-0.2	1.1	1.0	1.6
Intelligence (Savage-Jansen 2018)	0.4	1.4	3.1	1.5	0.7	0.1	1.7	0.9	-1.4	1.0
Neuroticism (Nagel 2018)	1.5	3.5	15.0	-0.5	-2.0	-0.5	-3.9	-1.6	1.2	-1.2
Schizophrenia (2018)	0.3	0.7	1.6	1.3	0.2	-0.2	-0.8	-0.9	-0.8	-1.0
Schizophrenia vs Biploar Disorder	1.5	1.9	4.0	-0.6	0.5	2.0	-1.4	-1.7	1.4	-1.5
Worry (Nagel 2018)	2.1	4.4	13.1	-1.1	-2.8	0.4	-3.6	-1.7	2.1	-0.9
Alzheimer’s Disease (in mother)	0.8	0.9	2.8	-1.7	-0.7	0.2	1.2	0.5	1.1	0.6
Alzheimer’s Disease (in father)	2.1	2.3	4.6	1.1	2.1	1.6	-1.1	-1.7	0.0	-2.0
Alzheimer’s Disease (including proxy)	0.3	0.5	0.8	-0.8	0.5	0.7	0.7	-0.6	0.9	-0.5
Crohns Disease (2017)	0.3	0.6	1.0	0.3	0.8	0.8	-1.0	-0.8	-0.3	-0.8
Irritable Bowel Disease (IBD)	0.4	0.9	1.8	0.5	0.4	1.2	-0.9	-1.3	-0.1	-1.2
Ulcerative Colitis (UC)	0.3	0.6	1.7	0.6	-0.1	1.3	-0.1	-1.0	-0.2	-1.0
Major Depression (MDD)	1.8	2.2	6.4	-2.5	-1.6	0.0	0.3	0.9	1.7	1.6
Reaction Time	0.4	0.7	2.6	0.0	-0.2	-1.6	1.0	0.6	-0.6	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.1	1.1	0.6	0.6	0.7	0.1	-0.9	0.3
Breast Cancer	0.1	0.3	1.2	0.2	0.6	1.1	-0.4	0.2	-0.2	-0.2
Ovarian Cancer	0.8	1.1	3.2	1.7	1.1	0.2	0.8	0.2	-1.8	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.5	3.7	8.1	2.6	1.0	1.2	-2.8	-1.6	-1.4	-2.0
Bipolar Disorder (2011)	0.5	0.5	1.4	1.2	0.4	0.5	0.4	-0.1	-1.1	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	1.1	0.1	1.0	-0.4	0.2	0.5	-0.3	0.5
Coronary Artery Disease (CAD)	0.5	0.6	1.9	0.1	-1.4	-1.2	-0.7	-0.4	-0.1	-0.2
Crohns Disease (2012)	0.5	0.8	2.9	1.3	0.7	0.6	-0.3	0.3	-1.7	-0.0
Mean Putamen Volume	0.9	1.0	2.4	-1.4	-0.6	-0.9	1.0	-0.4	1.6	0.3
Fasting Glucose	2.2	2.7	6.9	-0.9	-1.0	-2.6	1.6	1.7	0.0	2.2
HbA1C	1.6	1.8	5.6	-1.7	-0.8	0.3	-1.3	-1.1	2.4	-0.8
HDL Cholesterol	0.2	0.4	1.0	0.5	-1.0	0.2	-0.8	-0.7	0.0	-0.7
LDL Cholesterol	0.2	0.3	0.9	-0.5	-0.3	-0.5	0.3	-0.9	0.5	-0.5
Lupus	0.7	1.1	2.0	-1.2	-0.1	-1.1	1.1	1.4	0.3	1.4
Neuroticism (2016)	2.3	3.4	7.8	-1.6	-2.3	-0.4	-2.8	-1.4	2.2	-0.8
Primary Biliary Cirrhosis	1.6	2.2	7.4	-0.5	-1.3	-1.8	2.7	1.3	-0.5	1.2
Rheumatoid Arthritis	1.9	2.6	4.1	1.3	0.4	-1.4	1.9	2.0	-2.0	1.7
Schizophrenia (2014)	0.4	0.9	1.6	1.3	-1.0	-0.6	-0.8	-1.0	-0.9	-0.9
Triglycerides	0.5	0.8	1.5	-1.2	1.0	0.4	0.0	-0.9	1.2	-1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.9	1.0	0.6	1.4	-0.3	-1.1	-0.1	-1.0
Ulcerative Colitis	0.1	0.1	0.2	0.0	-0.5	-0.4	0.5	0.1	-0.0	0.2
Blood Eosinophil Count	0.3	2.1	6.0	1.5	2.5	0.0	1.1	-1.5	-0.8	-1.6
Blood Platelet Count	0.1	0.9	1.6	1.3	0.8	-1.0	0.9	-0.6	-0.8	-1.1
Blood Red Count	0.1	0.6	1.4	-1.0	-0.8	-0.3	0.2	0.5	0.7	1.2
Blood White Count	0.4	2.7	13.3	0.1	2.0	-1.0	3.6	0.3	-0.6	-0.2
Heel T-Score	0.4	2.8	4.9	1.9	1.8	-0.2	-2.2	-1.7	-0.6	-2.2
BMI	0.6	3.2	16.1	0.9	4.0	-0.9	1.7	0.6	-1.0	0.6
Height	1.0	18.7	34.9	4.2	4.0	5.9	-1.9	-4.6	-1.9	-5.8
Waist Hip Ratio (WHR)	2.3	10.1	20.7	-2.8	-4.6	0.4	-2.2	-3.6	3.9	-3.0
Systolic Blood Pressure	1.9	9.6	49.4	0.6	1.9	-0.2	7.0	2.4	-2.2	1.8
Smoking Status	2.8	6.7	20.3	-3.5	-4.5	-0.8	-1.0	-0.8	3.5	0.0
Allergy or Eczema	1.1	2.8	13.4	0.4	3.7	1.9	0.6	-0.9	-0.3	-1.1
Cardiovascular Disease	0.7	2.2	13.0	-1.0	1.0	0.4	3.6	0.6	0.1	0.0
Hypothyroidism (self reported)	1.2	2.8	5.0	1.5	1.6	1.8	-1.5	-2.0	-0.3	-2.2
Respiratory disease	0.8	1.8	5.2	-1.5	1.3	-0.5	2.3	1.1	0.8	1.2
Type 2 Diabetes (T2D) (2018)	1.4	2.7	4.6	2.2	1.2	-1.5	1.1	1.7	-2.1	1.4
Lung FEV1/FVC ratio	0.4	2.0	5.6	2.1	-1.3	-2.4	-0.8	0.2	-1.3	0.0
Lung FVC	0.6	3.0	8.2	2.9	1.6	2.2	-0.0	-0.2	-2.2	-0.5
Neuroticism	2.5	5.9	11.4	-2.4	-2.7	-0.1	-3.4	-2.4	3.1	-1.4
Chronotype (morning person)	2.3	5.2	8.9	1.4	-1.0	-2.3	2.2	3.0	-2.6	2.8
Hair Pigment	0.3	7.8	19.1	1.1	0.5	4.4	-2.2	-3.6	0.3	-3.9
Tanning	0.1	1.6	4.7	-2.2	-0.7	0.5	1.7	-0.2	1.7	-0.0
Hand grip strength (left)	3.8	9.9	31.6	5.6	2.1	1.4	-0.4	1.0	-5.5	-0.6
Number of treatments/medications taken	2.4	4.4	10.2	-3.2	-1.4	-1.5	3.0	0.1	2.5	0.8
Average weekly spirits intake	0.2	0.3	0.7	-0.5	-0.6	0.5	-0.5	-0.5	0.9	-0.3
Sensitivity / hurt feelings	1.2	2.1	5.0	-1.3	-2.1	-1.4	-2.2	-0.5	1.0	-0.5
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.6	-1.9	-1.2	-0.3	-0.2	-0.1	1.6	0.3
Hearing difficulty/problems: Yes	0.9	1.4	4.8	-1.3	0.7	0.1	2.2	0.6	1.0	1.1
Relative age of first facial hair	1.4	2.9	7.2	-1.4	-2.7	-0.2	-1.5	-1.8	1.9	-1.4
Other serious medical condition/disability diagnosed by doctor	3.9	5.1	10.9	-3.3	-1.5	-2.1	2.3	1.8	2.0	2.4
Ever used hormone-replacement therapy (HRT)	1.9	2.5	5.2	-1.5	-2.2	-2.3	0.9	1.1	0.8	1.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.6	-0.1	-0.7	-0.8	0.1	0.1	-0.0	-0.0
Systolic blood pressure, automated reading	1.7	4.8	21.2	1.3	1.6	-0.7	4.6	1.5	-2.1	1.1
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.7	-0.6	0.6	1.5	0.3	-1.6	1.4	-1.4
Angina	1.1	1.5	4.0	-1.4	-2.0	-1.6	0.5	0.4	1.0	0.8
Medication for hormone replacement therapy	1.4	1.5	3.1	-1.3	-1.1	-1.8	1.4	0.9	0.8	1.2
Vitamin and mineral supplements	0.9	1.2	3.2	-0.2	-1.0	-1.6	0.4	1.2	-0.3	1.8
Supplements: Zinc	1.2	1.3	4.8	-0.6	2.2	0.6	1.7	0.7	-0.0	0.6
Medication: Co-codamol	1.4	1.6	5.6	-1.7	-0.3	-0.5	2.4	0.5	1.1	0.9
Medication: Metformin	1.9	2.7	7.0	2.5	1.6	-1.1	0.4	1.3	-2.6	0.6
Diabetes (father)	0.5	0.6	1.7	1.3	-0.7	-0.4	0.8	-0.3	-1.2	-0.2
Diabetes (mother)	0.6	0.8	1.8	1.4	1.0	0.7	-0.2	-0.8	-0.7	-1.0
Severe depression (siblings)	0.5	0.5	1.7	-0.4	0.9	0.1	1.3	0.7	-0.0	0.7
Pack years adult smoking proportion	1.5	2.3	6.4	-2.5	-1.0	0.4	-0.1	-1.3	2.5	-0.6
Impedance of leg (right)	1.8	8.8	35.9	-2.9	-6.0	-1.8	-2.0	1.4	2.2	1.9
Leg fat-free mass (left)	1.7	8.7	35.0	3.3	5.9	1.6	1.6	-0.8	-2.7	-1.5
Trunk fat percentage	0.1	0.2	0.8	-0.3	0.9	0.2	0.0	-0.5	0.6	-0.2
Hand grip strength (right)	3.6	9.9	28.9	5.3	3.0	1.0	-0.0	1.3	-5.4	-0.3
Townsend deprivation index at recruitment	4.6	6.5	17.6	-3.4	-1.2	1.0	0.9	-2.8	4.2	-2.2
Current tobacco smoking	3.2	5.3	14.4	-3.7	-2.4	0.4	-0.3	-1.6	3.8	-0.7
Average weekly fortified wine intake	0.7	0.8	1.5	-1.2	-0.2	-0.6	1.1	0.8	0.9	1.1
Maternal smoking around birth	0.4	0.5	1.1	0.2	-1.0	0.3	-0.8	-1.1	0.4	-0.7
Fed-up feelings	0.2	0.4	1.3	-0.2	-0.6	-1.1	-1.0	-0.3	-0.1	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	7.0	-2.6	-1.8	-1.9	1.4	0.6	1.9	1.2
Relative age voice broke	3.4	5.1	9.5	-1.8	-1.1	1.7	-1.8	-3.1	2.8	-2.8
Taking other prescription medications	1.0	1.5	4.4	-2.1	-0.0	-1.2	1.4	0.5	1.3	0.9
Age when periods started (menarche)	8.3	20.0	40.3	-2.9	-2.2	2.7	-3.7	-6.3	5.9	-5.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	0.5	0.9	-0.2	-0.5	-0.6	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.7	4.0	9.1	-0.8	0.4	1.6	-1.7	-3.0	2.4	-2.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.2	-0.6	-0.6	-0.0	0.5	-0.7	1.1	-0.8
Qualifications: CSEs or equivalent	2.1	2.7	7.9	-1.3	1.5	2.8	1.1	-1.4	1.7	-1.2
Serious illness, injury or assault to yourself	0.7	0.9	1.7	-1.3	-1.3	0.3	1.1	0.1	1.1	0.3
High blood pressure	0.7	2.0	10.7	-0.4	1.5	0.5	3.3	-0.1	0.1	-0.6
Hayfever, allergic rhinitis or eczema	1.4	3.0	16.4	0.9	4.1	1.5	0.7	-0.4	-0.9	-0.5
Multivitamins +/- minerals	0.7	0.9	1.6	1.3	0.7	1.2	-0.6	-0.5	-0.8	-1.2
Stomach or abdominal pain in last month	1.9	2.3	6.3	-2.5	0.5	0.3	1.5	-1.2	2.4	-0.6
Supplements: Glucosamine	0.6	0.8	1.8	0.6	-1.3	0.1	-1.1	-1.1	0.1	-1.0
Diverticular disease/diverticulitis (self-reported)	3.1	3.6	6.5	-2.4	-2.3	-2.6	0.6	1.1	1.7	1.7
Medication: Atenolol	1.6	2.0	4.2	-1.0	-0.7	-1.8	2.0	1.4	0.1	1.7
Medication: Levothyroxine sodium	0.7	1.2	2.8	0.5	1.7	1.4	-0.7	-1.1	0.2	-1.3
Sitting height	0.9	6.3	13.6	3.1	3.7	3.1	0.7	-0.5	-2.7	-1.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	-0.3	0.6	0.4	0.8	-0.3	0.2	-0.0
High blood pressure (mother)	2.7	3.8	16.8	-1.2	2.4	-0.3	4.1	1.3	-0.2	1.0
Body mass index (BMI)	0.6	2.8	10.9	0.6	3.3	-1.0	2.1	0.9	-0.9	1.1
Impedance of leg (left)	1.5	7.5	31.3	-2.7	-5.6	-0.9	-2.3	0.6	2.4	1.1
Leg predicted mass (left)	1.7	9.0	35.8	3.4	6.0	1.6	1.7	-0.8	-2.8	-1.6
Trunk fat mass	0.2	0.9	5.1	0.6	2.2	0.3	0.6	-0.4	-0.3	-0.4
Waist circumference	0.2	0.7	3.4	0.0	1.8	-0.6	1.1	-0.4	0.1	-0.3
Number of incorrect matches in round	0.7	1.2	5.0	-0.2	-2.2	-0.9	-1.5	-0.1	0.7	-0.1
Past tobacco smoking	1.0	1.8	4.2	1.9	1.7	-0.1	0.5	1.0	-2.0	0.7
Alcohol usually taken with meals	2.0	3.2	7.6	2.0	1.9	-0.8	1.3	1.8	-2.8	1.1
Nervous feelings	1.5	2.7	7.6	-1.3	-2.8	0.8	-2.5	-0.6	1.6	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	3.3	-1.8	-0.9	-1.0	-0.2	0.1	1.4	0.1
Hearing difficulty/problems with background noise	1.8	2.9	6.0	-0.9	1.3	2.4	-0.9	-2.1	1.9	-1.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	1.1	0.2	-0.3	-0.6	0.8	-1.2	-0.0
Had menopause	0.4	0.5	1.3	-0.7	-1.1	-0.6	-0.3	0.6	0.2	0.6
Had other major operations	0.7	0.8	2.3	-1.5	0.2	0.3	0.9	-0.1	1.5	0.5
Forced vital capacity (FVC)	2.2	8.6	19.1	4.4	2.5	4.2	-1.6	-1.6	-2.5	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.6	5.6	-0.2	0.2	1.0	-2.0	-2.4	1.8	-2.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.8	-1.3	0.5	-0.5	0.2	0.6	0.8	0.7
Qualifications: None of the above	3.4	7.4	19.8	-3.9	-3.2	-0.8	-0.5	-2.1	4.5	-0.9
Financial difficulties in last 2 years	2.8	3.8	9.7	-2.7	-1.8	0.7	-1.7	-1.6	3.1	-1.0
Mouth/teeth dental problems	1.0	1.5	6.6	1.6	-0.6	0.6	-2.6	0.2	-0.9	0.2
Heart attack	0.9	1.1	2.9	-1.7	-0.4	0.0	1.2	1.1	0.5	1.4
Allergy	0.9	2.0	8.6	1.1	-2.9	-0.7	-1.7	0.3	-0.8	-0.2
Pain all over the body in last month	1.0	1.0	2.4	-1.6	1.3	0.5	0.9	-0.3	1.4	0.2
Diabetes (self-reported)	0.5	0.7	2.0	1.4	0.5	-0.6	1.0	0.6	-1.0	0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	3.8	0.1	2.0	0.3	0.9	0.2	-0.5	0.0
Medication: Ramipril	0.3	0.4	1.4	0.4	0.6	0.3	1.2	-0.6	-0.2	-0.7
Medication: Simvastatin	1.3	1.9	4.6	-1.5	-1.5	-1.2	2.2	1.0	0.6	1.1
Fluid intelligence score	0.2	0.4	0.7	0.7	0.5	0.4	0.2	0.7	-0.7	0.9
Illnesses of siblings	0.4	0.6	1.8	1.4	0.3	0.3	-0.8	0.3	-1.1	-0.1
Neuroticism score	2.4	5.1	8.7	-2.6	-2.5	-0.2	-2.8	-2.0	2.9	-1.3
Weight	0.9	4.3	20.9	2.0	4.6	0.6	1.4	-0.1	-1.7	-0.4
Impedance of arm (right)	1.7	7.9	22.7	-0.4	-4.8	1.4	-4.2	-2.3	1.8	-2.1
Arm fat percentage (right)	0.1	0.3	1.8	0.2	1.4	-0.1	0.4	-0.2	0.1	0.1
Trunk fat-free mass	1.4	8.1	31.6	3.3	5.6	1.1	1.6	-0.2	-2.9	-1.1
Hip circumference	1.4	6.1	22.8	2.3	4.8	-0.7	1.7	1.4	-2.8	1.0
Time employed in main current job	0.2	0.2	0.8	0.3	-0.1	0.9	-0.4	-0.4	-0.3	-0.5
Alcohol intake versus 10 years previously	1.2	1.8	4.0	1.9	2.0	-0.5	1.1	-0.3	-1.7	-0.7
Father’s age at death	0.3	0.4	2.1	0.1	1.4	0.3	-0.0	-0.5	0.2	-0.2
Worrier / anxious feelings	1.1	2.1	8.9	-0.5	-1.6	0.3	-3.0	-1.2	0.8	-0.9
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	12.6	-3.5	-0.6	0.3	0.3	-1.0	3.5	0.4
Falls in the last year	4.0	5.4	10.6	-1.6	-2.0	-2.5	2.2	3.1	-0.2	3.3
Hair/balding pattern: Pattern 3	0.7	1.1	2.2	-0.3	-0.1	-1.5	1.4	1.3	-0.6	1.2
Number of live births	0.7	1.0	4.4	-0.2	-0.5	-2.1	0.2	0.9	-0.3	1.1
Forced expiratory volume in 1-second (FEV1)	2.6	8.6	26.3	5.1	2.2	3.2	-1.6	-1.1	-3.3	-2.0
Pulse rate	1.0	1.7	4.6	1.4	1.6	-0.2	1.0	1.1	-2.1	0.5
Happiness	0.9	1.0	2.6	-1.6	-1.2	-1.1	0.6	-0.1	1.3	0.5
Noisy workplace	1.3	1.6	3.7	-1.7	-1.2	0.3	0.3	-1.2	1.9	-1.0
Qualifications: A levels/AS levels or equivalent	1.2	2.7	6.9	2.6	2.6	0.2	0.1	0.2	-2.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.4	-0.0	-0.5	0.1	-1.2	-0.8	0.5	-1.1
Mouth/teeth dental problems: Dentures	1.9	3.3	9.1	-2.6	-1.1	-1.4	3.0	0.5	1.6	0.8
Asthma	0.7	1.4	4.7	-1.3	2.2	0.6	1.2	-0.2	1.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	2.3	3.0	9.6	-2.7	-0.8	0.7	-0.3	-1.5	3.1	-0.6
Medication: Cholesterol lowering	2.9	4.5	8.9	-2.2	-1.6	-2.1	3.0	2.1	0.8	2.5
Depression (self-reported)	0.6	0.7	2.0	-1.1	0.6	0.1	1.4	0.5	0.5	0.9
Medication: Lansoprazole	1.0	1.1	4.8	-0.8	-2.2	-1.1	0.3	0.8	0.1	0.5
Prospective memory result	0.7	0.8	1.2	0.6	-1.0	-0.8	0.4	1.0	-1.1	1.1
Lung cancer (father)	0.6	0.7	2.3	-0.4	-1.3	-1.5	-0.0	-0.4	0.5	-0.1
Illnesses of mother	2.0	2.4	7.3	0.3	0.2	1.1	-2.7	-2.0	1.2	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	16.0	4.0	1.0	2.5	-1.9	-0.7	-2.5	-1.5
Pulse wave Arterial Stiffness index	1.8	2.1	6.2	-0.9	2.5	1.1	2.3	-0.7	0.7	-0.2
Impedance of arm (left)	1.6	7.3	16.8	-0.8	-4.1	1.8	-3.7	-2.5	2.2	-2.4
Arm fat mass (right)	0.4	1.5	8.1	1.1	2.9	0.1	0.9	-0.1	-0.8	-0.2
Trunk predicted mass	1.4	8.1	31.5	3.4	5.6	1.0	1.6	-0.2	-3.0	-1.0
Standing height	0.8	8.2	12.8	3.4	3.3	3.6	-1.4	-2.2	-2.0	-3.3
Length of working week for main job	0.3	0.3	1.6	0.4	1.2	0.4	-0.1	-0.4	-0.2	-0.5
Exposure to tobacco smoke at home	1.5	1.7	3.2	-1.8	-1.4	-0.6	1.7	0.1	1.8	0.4
Breastfed as a baby	1.1	1.4	3.3	1.2	0.8	-0.5	-1.3	-1.4	-0.7	-1.8
Tense / ‘highly strung’	1.7	2.7	5.4	-2.1	-2.3	0.8	-1.5	-1.0	2.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.7	-1.6	-0.4	-1.4	1.3	0.4	1.1	0.4
Hair/balding pattern: Pattern 4	0.9	2.2	5.8	-0.7	-2.4	0.4	-2.0	-1.2	1.8	-0.5
Birth weight of first child	0.3	0.6	1.4	1.1	-0.1	0.4	-0.8	-0.9	-0.5	-1.2
Peak expiratory flow (PEF)	2.5	5.9	20.8	4.6	2.5	1.0	-1.1	0.4	-3.5	-0.4
Pulse wave reflection index	1.3	1.5	4.3	-1.2	0.1	0.1	0.3	-1.9	2.1	-1.1
Ever highly irritable/argumentative for 2 days	2.6	3.2	12.0	-3.5	-0.7	-0.0	0.2	-0.3	3.1	0.2
Loud music exposure frequency	1.9	2.1	5.0	-2.2	-1.3	-1.6	0.3	1.4	1.4	1.4
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	8.0	2.5	2.4	-0.4	1.6	1.2	-2.8	0.5
Mouth/teeth dental problems: Bleeding gums	3.4	4.4	8.7	2.0	2.1	2.7	-0.7	-2.2	-1.0	-3.0
Blood clot in the leg (DVT)	0.6	0.8	2.1	-0.8	-0.9	-1.4	0.0	-0.8	1.1	0.0
Medication: Paracetamol	1.3	2.2	8.1	-2.8	-0.9	-0.3	0.1	0.0	2.4	0.9
Headache pain in last month	1.4	2.4	8.4	-2.9	-0.7	-0.1	-0.1	-0.7	2.7	-0.1
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	9.7	1.2	0.5	1.3	-3.1	-1.9	-0.1	-2.0
Glaucoma (self-reported)	0.5	0.6	2.1	-0.8	0.8	1.4	0.2	0.4	0.6	0.5
Gout (self-reported)	0.4	0.5	1.4	-0.8	0.9	-0.5	1.2	-0.5	0.5	-0.4
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	5.4	0.9	1.9	1.9	-1.6	-2.2	0.2	-2.3
Medication: Amlodipine	1.3	1.9	8.7	-0.2	0.1	-0.4	3.0	1.6	-0.6	1.1
Medication: Ventolin 100micrograms inhaler	0.7	0.8	1.8	-1.0	0.6	-0.6	1.3	-0.8	1.2	-0.4
Birth weight	0.2	0.3	1.3	0.2	-0.3	0.0	1.1	0.5	-0.4	0.7
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	0.1	0.1	-0.5	0.0	0.5	-0.6	0.5
High blood pressure (siblings)	0.6	0.8	1.0	-0.8	0.9	1.0	0.8	-1.0	0.9	-0.9
Forced vital capacity (FVC), Best measure	1.6	5.9	14.6	3.3	1.5	3.8	-2.2	-1.3	-1.7	-2.0
Body fat percentage	0.1	0.5	0.7	-0.5	0.8	-0.9	0.7	0.5	0.4	0.9
Leg fat percentage (right)	1.1	4.1	9.4	-1.3	-0.0	-3.1	1.8	2.4	0.2	2.9
Arm fat-free mass (right)	1.4	7.3	33.0	2.5	5.7	0.9	2.1	0.1	-2.5	-0.6
Exposure to tobacco smoke outside home	0.5	0.7	1.8	-0.4	-0.7	-0.2	0.0	-1.3	0.8	-1.4
Comparative body size at age 10	2.0	5.6	11.4	1.4	-0.7	-2.7	0.9	3.3	-2.6	3.4
Number of full brothers	1.1	1.4	3.9	-1.2	-0.7	-0.7	2.0	0.9	0.7	1.4
Worry too long after embarrassment	2.0	3.4	17.9	0.1	-1.8	0.5	-4.2	-1.2	0.6	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	9.3	-3.0	-0.9	-0.7	1.4	0.6	1.9	1.0
Wheeze or whistling in the chest in last year	2.4	4.3	12.5	-3.5	-0.0	-1.4	2.2	0.5	3.0	1.3
Number of children fathered	0.4	0.5	1.9	-0.4	0.2	-0.2	1.4	0.8	-0.3	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.5	1.5	1.3	1.4	-1.6	-0.2	-1.2	-0.5
Age at first live birth	2.1	3.6	6.4	2.2	2.5	2.2	-1.8	-1.3	-1.4	-1.7
Pulse wave peak to peak time	1.5	1.8	5.6	1.1	-1.9	-0.8	-2.4	0.8	-1.0	0.2
Health satisfaction	1.0	1.3	3.1	-1.8	-1.6	-0.5	1.1	0.1	1.5	0.1
Shortness of breath walking on level ground	1.7	2.1	9.9	0.0	1.2	-0.5	3.1	1.2	-0.8	0.9
Qualifications: College or University degree	1.3	4.1	10.3	2.6	2.9	-0.1	0.6	1.6	-3.2	0.6
Eye problems/disorders: None of the above	0.5	0.6	1.8	0.0	0.7	0.1	-1.3	-1.0	0.4	-0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.5	-1.6	0.2	-1.0	1.1	-0.0	0.8	-0.0
Emphysema/chronic bronchitis	1.5	1.7	5.4	-1.7	-0.2	-0.9	2.3	-0.5	1.5	-0.3
Medication for pain relief, constipation, heartburn	2.5	4.2	13.3	3.6	2.1	1.1	-0.7	-0.7	-2.6	-1.7
Neck or shoulder pain in last month	2.3	3.2	10.5	-2.6	-0.2	1.6	0.3	-1.4	3.2	-0.9
Medication: Blood pressure	1.5	2.6	10.5	-0.1	0.5	-1.0	3.2	1.8	-0.8	1.7
Angina (self-reported)	1.4	1.8	4.4	-1.5	-2.1	-1.8	0.8	0.5	1.1	0.9
Migraine (self-reported)	0.3	0.4	1.4	-0.4	-1.2	-0.2	-0.5	-0.3	0.7	-0.4
Medication: Ibuprofen	2.2	2.6	7.3	-2.5	-0.4	1.0	-0.2	-1.6	2.7	-1.1
Medication: Allopurinol	0.7	0.9	4.7	-1.1	0.0	-0.2	2.2	-0.3	0.7	-0.2
Medication: Omeprazole	1.8	2.1	4.8	-1.6	-0.8	-1.5	2.2	0.8	0.8	1.8
Medication: Seretide 50 evohaler	0.3	0.3	0.9	-0.1	1.0	-0.6	0.5	0.5	-0.3	0.6
Mean time to correctly identify matches	0.4	0.9	3.2	-0.1	-0.3	-1.8	1.3	0.6	-0.6	0.6
Heart disease (mother)	0.9	1.1	1.9	0.2	-0.4	-1.1	1.4	1.3	-1.4	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.1	0.9	1.1	0.0	0.8	1.8	-1.7	1.3
Whole body fat mass	0.3	1.1	5.7	0.6	2.4	-0.3	1.0	0.2	-0.6	0.3
Leg fat mass (right)	0.7	2.7	4.2	0.1	1.8	-1.7	2.0	1.8	-0.9	2.0
Arm predicted mass (right)	1.4	7.1	33.5	2.3	5.8	0.9	2.2	0.1	-2.3	-0.5
Pulse rate, automated reading	0.8	2.7	8.0	1.7	2.8	0.2	1.3	-0.9	-1.8	-1.4
Alcohol intake frequency.	2.0	4.7	9.1	-0.6	-0.5	-3.0	3.0	2.7	-0.8	2.6
Comparative height size at age 10	0.5	2.6	6.3	2.0	1.9	0.6	1.1	1.4	-2.5	0.7
Number of full sisters	2.8	3.5	7.5	-1.5	-0.9	-1.5	2.6	2.2	0.1	2.7
Suffer from ‘nerves’	2.6	4.1	9.9	-1.4	-1.8	0.2	-3.1	-2.2	2.7	-1.3
Overall health rating	4.4	9.5	23.8	-4.9	-2.7	-3.2	2.8	1.2	3.5	2.1
Chest pain or discomfort	2.6	3.7	12.8	-3.6	-1.1	-0.8	0.3	-0.8	3.2	0.1
Had major operations	1.3	1.5	2.6	-1.0	1.6	1.1	1.4	-1.0	1.2	-1.0
Age at last live birth	1.1	1.5	3.3	1.5	1.4	1.0	-1.8	-0.8	-0.8	-1.0
Family relationship satisfaction	0.6	0.7	2.0	1.0	-0.6	-1.4	-0.4	0.5	-1.2	0.2
Leg pain on walking	0.7	0.9	1.8	-1.0	1.3	0.4	-0.0	-0.9	1.3	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.0	-0.9	0.6	0.9	0.7	-0.8	1.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	-0.5	0.8	-0.8	0.7	0.1	0.2	0.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.1	0.6	1.2	-0.6	2.0	1.3	-1.1	1.1
Medication: Aspirin	1.5	1.9	5.3	-0.7	-2.3	-1.7	0.9	1.4	-0.2	1.4
Supplements: Vitamin C	1.7	2.0	4.7	-1.0	-0.1	2.2	-0.1	-1.6	1.5	-1.8
Knee pain experienced in last month	2.4	3.7	8.0	-1.5	-0.2	1.7	0.0	-2.7	2.4	-2.8
Hypertension (Self-reported)	0.6	1.8	9.9	-0.5	1.4	0.4	3.1	-0.0	0.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	2.3	-1.5	-1.5	-0.7	1.5	1.0	0.5	1.5
Illnesses of father: Heart disease	0.6	0.9	2.6	1.3	0.7	-0.5	0.4	0.9	-1.6	0.4
Illnesses of siblings: Diabetes	0.2	0.3	1.1	-0.1	0.0	-0.2	-0.2	-1.0	0.5	-0.8
Smoking status: Previous	0.2	0.3	1.7	-0.3	-1.3	-0.2	-0.2	-0.1	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.4	0.8	0.0	1.2	0.1	-0.9	-0.4	-0.9
Whole body fat-free mass	1.6	9.1	36.7	3.4	6.1	1.3	1.8	-0.4	-3.0	-1.2
Leg fat-free mass (right)	2.0	10.8	40.9	3.7	6.4	2.2	1.3	-1.3	-2.9	-2.1
Arm fat percentage (left)	0.1	0.6	3.3	0.2	1.8	0.0	0.6	-0.4	0.1	-0.2
Average weekly red wine intake	1.3	1.9	4.0	1.7	2.0	2.0	-0.2	0.4	-1.6	0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	-0.6	-0.4	-0.1	1.0	1.3	0.0	1.4
Mood swings	0.5	0.9	2.0	-1.2	0.2	-0.1	-0.3	-1.4	1.2	-1.1
Loneliness, isolation	2.0	2.7	4.4	-1.4	-1.3	-0.3	-1.6	-2.1	2.1	-2.1
Long-standing illness, disability or infirmity	2.7	4.1	7.0	-2.4	-1.4	-2.3	2.6	1.3	1.5	2.1
Ever had bowel cancer screening	1.8	2.1	5.8	-2.2	-0.9	-1.0	-0.0	-1.3	2.4	-0.7
Diabetes diagnosed by doctor	0.2	0.3	1.3	1.1	0.6	-0.1	0.5	0.2	-0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	4.1	-0.8	0.1	-1.2	1.8	1.8	-0.0	2.0
Friendships satisfaction	0.9	1.1	2.0	-0.2	-0.5	-1.4	1.4	1.4	-0.7	1.2
Qualifications: nursing, teaching	1.6	2.5	6.4	2.1	1.6	-0.3	1.0	1.6	-2.5	0.8
Commuting to job workplace: Walk	0.2	0.3	0.6	0.7	-0.0	-0.1	0.8	-0.3	-0.8	-0.3
Eye problems/disorders: Cataract	0.2	0.3	1.0	0.5	0.4	0.0	1.0	0.2	-0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.6	-1.0	0.5	-1.1	1.6	0.1	0.9	0.5
Medication for cholesterol	0.2	0.4	0.8	-0.3	0.6	0.3	-0.9	0.7	0.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.8	-0.1	-1.9	-0.8	-0.2	0.6	-0.2	0.8
Back pain experienced in last month	1.8	2.6	8.5	-2.9	0.2	0.7	-0.0	-1.0	2.8	-0.6
Mineral and other dietary supplements	0.6	0.7	2.0	0.2	0.6	-1.3	-0.3	0.9	-0.5	1.4
Breast cancer (self-reported)	0.6	0.7	1.7	1.2	-0.7	0.5	-1.3	-0.8	-0.4	-0.6
Asthma (self-reported)	0.8	1.5	4.9	-1.4	2.2	0.6	1.2	-0.1	1.3	0.4
Osteoporosis (self-reported)	0.2	0.3	1.4	-1.2	-0.0	-0.4	0.2	0.0	0.7	-0.2
Osteoarthritis (self-reported)	1.0	1.2	4.4	-2.1	-0.6	-0.1	0.7	-0.2	1.8	0.1
Medication: Aspirin	2.1	2.8	5.5	-1.0	-2.3	-2.2	1.3	1.8	-0.2	1.8
Medication: Gliclazide	0.8	0.9	1.8	0.8	1.2	0.6	1.3	1.0	-1.1	0.4
Illnesses of father: None of the above (group 1)	0.9	1.1	1.6	-1.2	-1.0	-1.0	-0.8	0.9	0.9	1.3
Smoking status: Current	3.5	5.6	16.0	-3.9	-2.0	0.6	-0.0	-1.8	4.0	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	5.4	2.3	1.5	2.0	-1.0	-1.4	-1.0	-1.7
Whole body water mass	1.6	9.2	37.2	3.4	6.1	1.3	1.8	-0.5	-2.9	-1.3
Leg predicted mass (right)	2.0	10.7	40.5	3.7	6.4	2.2	1.4	-1.3	-2.8	-2.1
Arm fat mass (left)	0.5	1.9	10.5	1.0	3.2	0.1	1.2	-0.1	-0.8	-0.1
Number of self-reported non-cancer illnesses	2.4	4.1	10.3	-3.2	-0.4	-0.9	3.2	1.0	2.0	1.5
Average weekly champagne plus white wine intake	0.2	0.3	1.2	-0.0	-0.2	-0.1	-1.1	-0.5	0.3	-0.7
Miserableness	1.1	1.9	3.8	-1.2	-0.1	0.9	-1.5	-1.9	1.7	-1.4
Guilty feelings	0.9	1.3	5.0	-0.9	-2.2	0.1	-1.3	-0.4	1.1	-0.3
Wears glasses or contact lenses	0.4	0.5	0.9	-0.6	-0.4	-0.9	0.8	0.6	0.2	0.8
Ever taken oral contraceptive pill	0.5	0.6	1.2	0.1	1.0	-0.9	0.8	0.6	-0.5	1.1
Hearing aid user	0.6	0.7	1.7	-0.0	0.2	-1.3	0.8	1.0	-0.4	1.1
Mother’s age at death	0.6	0.8	2.0	-0.5	-0.5	-1.4	0.0	1.3	-0.3	1.1
Financial situation satisfaction	2.1	2.6	5.4	-2.3	-2.0	-1.2	1.9	0.7	1.5	1.0
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.4	-0.6	-0.5	-1.9	1.1	2.0	-0.5	2.1
Commuting to job workplace: Public transport	1.8	2.1	7.1	0.9	1.3	2.7	-0.7	-1.3	0.1	-1.8
Eye problems/disorders: Glaucoma	0.7	0.8	1.9	-0.1	0.7	0.9	0.9	1.4	-0.6	1.2
Medication: Blood pressure	0.4	0.7	1.8	-0.0	0.6	0.7	1.1	-1.2	0.2	-1.3
Pain type(s) experienced in last month: Hip pain	1.8	2.3	5.7	-1.6	-0.2	0.8	-1.4	-1.8	2.4	-1.3
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.0	-1.2	-1.5	0.7	0.0	-1.2	1.7	-1.3
High cholesterol (Self-reported)	0.3	0.5	2.7	-0.3	-0.1	-0.8	1.6	0.2	0.0	0.1
Medication: Bendroflumethiazide	0.5	0.8	4.8	0.4	0.4	0.1	2.2	0.2	-0.3	-0.4
Medication: Paracetamol	1.3	2.0	7.1	-2.7	-1.1	-0.4	-0.1	-0.3	2.3	0.6
Medication: Lisinopril	0.4	0.6	1.3	0.6	-0.2	-1.1	0.5	0.9	-0.9	0.7
Medication: Atorvastatin	0.3	0.4	1.2	-1.1	-0.4	-0.0	0.2	-0.3	1.1	-0.2
Illnesses of father: High blood pressure	2.2	2.7	4.6	-0.5	-1.3	-1.8	2.0	2.1	-0.7	2.0
Alcohol drinker status: Never	4.3	5.2	13.5	-0.5	-1.6	-1.5	2.1	3.7	-1.1	3.5
Ever smoked	1.5	2.7	7.2	-2.6	-1.1	0.2	-0.6	-1.5	2.7	-1.0
Basal metabolic rate	1.5	8.2	34.1	3.2	5.8	1.2	1.7	-0.3	-2.8	-1.1
Leg fat percentage (left)	0.7	2.6	6.4	-1.2	0.3	-2.5	1.5	1.8	0.3	2.3
Arm fat-free mass (left)	1.3	6.5	30.5	2.2	5.5	0.6	2.1	0.3	-2.3	-0.3
Number of operations (self-reported)	2.0	3.0	8.4	-2.9	-0.6	-0.1	1.9	-0.5	2.8	0.4
Average weekly beer plus cider intake	2.8	4.0	13.0	0.2	-0.7	1.0	-1.3	-3.6	1.5	-3.1
Irritability	2.0	3.3	9.4	-2.9	-0.1	0.4	-0.8	-1.7	3.1	-1.3
Risk taking	1.3	1.9	4.0	-1.9	0.1	1.3	0.6	-1.3	2.0	-1.4
Ever had prostate specific antigen (PSA) test	1.9	2.2	5.3	-2.3	1.0	-1.1	1.8	1.1	1.2	1.4
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.4	-0.6	-0.3	0.5	0.7	0.1	0.7
Age started oral contraceptive pill	0.9	1.2	5.2	0.9	0.1	0.5	-2.3	-0.7	-0.6	-1.1
Diastolic blood pressure, automated reading	0.4	1.3	3.8	1.9	1.5	-0.1	0.5	0.2	-1.6	0.2
Ever depressed for a whole week	0.9	1.1	4.2	-2.0	-0.3	0.1	-0.3	-0.2	1.8	-0.0
Unable to work because of sickness or disability	2.3	2.9	8.1	-1.3	-1.2	-1.1	2.9	2.0	0.3	2.0
Commuting to job workplace: Cycle	0.6	0.7	2.2	0.3	1.1	1.5	0.7	0.7	-0.7	-0.1
Myopia	0.8	1.1	2.6	1.6	1.5	0.5	0.7	0.0	-1.4	0.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	9.7	1.2	-0.2	0.2	-3.1	-0.4	-0.6	-0.0
Cholesterol lowering medication	0.7	1.0	2.5	0.4	-1.2	0.5	-0.7	-1.6	0.4	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	3.6	-1.8	-0.8	-0.9	1.9	1.0	0.8	1.8
Pain experienced in last month	4.4	7.3	18.2	4.0	-0.1	-2.3	-0.1	2.6	-4.3	2.1
Supplements: Calcium	0.5	0.5	1.4	0.0	0.8	1.2	1.2	0.5	-0.4	0.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.5	-0.1	-0.7	-0.2	-0.4	-0.3	0.3	-0.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.9	-1.7	-0.4	-0.1	1.4	1.2	0.4	1.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	4.0	-0.5	-0.9	-2.0	0.5	-0.1	0.4	0.5
Heart disease (siblings)	0.9	1.2	3.7	-0.9	-1.9	-1.1	-0.9	0.0	1.1	0.6
Alcohol drinker status: Previous	0.9	1.0	4.1	-0.2	-2.0	-1.7	0.1	-0.1	0.3	0.1
Pack years of smoking	1.3	2.0	5.5	-2.3	-0.9	0.3	-0.1	-1.3	2.2	-0.8
Impedance of whole body	1.5	7.9	29.8	-2.1	-5.5	0.5	-3.3	-1.2	2.7	-0.8
Leg fat mass (left)	0.5	2.1	4.8	0.3	2.2	-1.3	1.8	1.4	-0.9	1.5
Arm predicted mass (left)	1.3	6.5	28.1	2.5	5.3	0.2	2.1	0.5	-2.6	-0.1