Hub : Genes

GAPVD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1065	0.0337	7.5e-10	0.157	NA	0.165	NA	0.163	2.3e-12	NA	6.5e-13	NA	9.3e-13
2	GTEx	Muscle Skeletal	0.1333	0.0380	7.7e-09	0.098	NA	0.086	NA	0.089	6.9e-10	NA	9.2e-09	NA	4.6e-09
3	GTEx	Nerve Tibial	0.1704	0.0572	4.5e-08	0.079	NA	0.087	NA	0.103	3.1e-06	NA	1.0e-06	NA	9.3e-08
4	GTEx	Skin Sun Exposed Lower leg	0.0370	0.0180	1.1e-03	0.006	NA	-0.003	NA	0.011	8.7e-02	NA	9.9e-01	NA	3.8e-02
5	GTEx	Thyroid	0.0530	0.0270	2.2e-03	0.049	NA	0.009	NA	-0.001	1.1e-04	NA	6.6e-02	NA	4.1e-01
6	TCGA	Prostate Adenocarcinoma	0.0225	0.0136	2.3e-03	0.035	0.006	0.015	NA	0.015	1.2e-04	0.065	9.8e-03	NA	1.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.2	0.5	0.2	-0.5	-0.4	-0.7	0.3	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.6	-0.5	0.3	0.3	0.5	-0.8
Depressed Affect (Nagel 2018)	0.7	1.6	3.3	1.3	-1.1	1.8	1.0	1.3	-0.5
Depression (Nagel 2018)	2.3	3.5	5.4	1.9	-1.5	2.3	2.3	1.7	-1.2
Intelligence (Savage-Jansen 2018)	1.8	5.4	7.3	-2.4	2.3	-2.5	-1.6	-2.4	2.7
Neuroticism (Nagel 2018)	7.3	17.1	26.4	4.3	-3.8	5.1	3.9	4.1	-3.3
Schizophrenia (2018)	0.2	0.4	0.8	0.6	-0.1	0.7	0.9	0.4	-0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	0.9	0.5	0.0	0.9	0.8	0.2	-0.3
Worry (Nagel 2018)	7.5	15.9	25.4	4.1	-3.3	5.0	4.2	3.8	-3.1
Alzheimer’s Disease (in mother)	1.5	1.7	2.9	1.1	-1.2	1.3	1.7	1.2	-1.3
Alzheimer’s Disease (in father)	2.4	2.6	6.9	-1.5	1.0	-1.5	-2.6	-1.3	1.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.6	-0.9	0.3	0.1	0.6	-0.6
Crohns Disease (2017)	0.1	0.2	0.6	0.4	-0.5	0.8	-0.2	0.4	-0.1
Irritable Bowel Disease (IBD)	0.1	0.3	1.1	-0.4	0.3	-0.0	-1.1	-0.3	0.7
Ulcerative Colitis (UC)	0.7	1.4	2.7	-1.1	0.9	-0.9	-1.7	-1.0	1.2
Major Depression (MDD)	5.0	6.1	9.9	2.4	-2.0	2.6	3.1	2.3	-2.1
Reaction Time	0.2	0.3	0.7	-0.5	0.2	-0.9	-0.7	-0.3	0.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.0	-1.6	1.5	-1.4	-0.6	-1.5	1.7
Breast Cancer	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.1	0.0	-0.4
Ovarian Cancer	0.2	0.2	0.7	-0.2	-0.3	-0.8	-0.7	0.0	-0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.5	2.2	3.2	-1.5	1.8	-0.7	-1.6	-1.6	1.4
Bipolar Disorder (2011)	0.8	0.8	1.1	-0.9	1.0	-0.7	-0.7	-0.9	1.1
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	-0.0	0.1	-0.4	-0.3	-0.1	-0.3
Coronary Artery Disease (CAD)	1.2	1.5	2.4	1.0	-1.0	1.5	1.1	1.3	-1.1
Crohns Disease (2012)	0.1	0.1	0.3	-0.4	0.3	0.0	-0.5	-0.4	0.4
Mean Putamen Volume	1.6	1.9	3.7	1.2	-1.2	1.4	1.9	1.4	-0.7
Fasting Glucose	0.3	0.4	0.8	0.5	-0.5	0.2	0.8	0.4	-0.9
HbA1C	0.2	0.2	0.8	0.5	-0.2	0.9	0.4	0.3	-0.1
HDL Cholesterol	0.0	0.0	0.0	-0.0	0.1	0.2	0.1	-0.1	0.2
LDL Cholesterol	1.6	2.5	3.6	1.7	-1.8	0.8	1.3	1.7	-1.9
Lupus	1.3	1.9	3.2	1.3	-1.2	1.4	1.8	1.3	-1.3
Neuroticism (2016)	7.0	10.1	13.7	3.5	-3.2	3.7	2.7	3.3	-2.6
Primary Biliary Cirrhosis	0.7	0.9	1.4	1.0	-1.2	0.2	1.1	1.0	-0.9
Rheumatoid Arthritis	0.7	0.9	1.6	-0.9	0.5	-1.0	-1.1	-0.7	1.2
Schizophrenia (2014)	1.0	2.1	2.6	1.6	-1.2	1.5	1.5	1.5	-1.5
Triglycerides	0.6	0.9	1.3	0.9	-1.1	0.6	1.1	1.1	-0.8
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.7	-0.8	1.3	-0.4	0.3	-1.0	1.2
Ulcerative Colitis	0.7	1.1	1.6	-1.0	1.1	-0.7	-1.2	-1.1	1.1
Blood Eosinophil Count	0.6	4.6	8.7	-2.1	1.7	-3.0	-2.0	-1.9	1.9
Blood Platelet Count	0.1	0.7	2.9	-0.2	-0.2	-1.7	-1.0	-0.0	0.4
Blood Red Count	0.0	0.4	0.9	0.5	-0.5	0.1	0.8	0.5	-1.0
Blood White Count	0.8	5.8	12.5	-2.2	1.9	-3.5	-1.9	-2.2	2.4
Heel T-Score	0.9	7.1	11.0	-2.6	3.0	-1.8	-2.1	-2.8	3.3
BMI	2.3	13.3	17.1	-3.8	4.1	-3.5	-2.4	-4.1	3.7
Height	1.3	24.2	27.0	-5.0	4.8	-4.6	-5.1	-4.9	5.2
Waist Hip Ratio (WHR)	5.9	26.6	29.7	5.3	-4.9	5.3	5.4	5.1	-4.8
Systolic Blood Pressure	7.0	35.1	41.7	-6.3	5.7	-6.5	-4.9	-6.1	5.9
Smoking Status	21.1	50.6	60.9	7.4	-6.8	7.5	7.8	7.2	-5.8
Allergy or Eczema	1.1	2.8	4.8	-1.6	1.3	-2.2	-2.0	-1.5	1.3
Cardiovascular Disease	2.3	7.4	9.6	-2.9	2.9	-2.8	-1.6	-2.9	3.1
Hypothyroidism (self reported)	2.1	4.8	6.7	-2.3	2.5	-1.4	-1.8	-2.4	2.6
Respiratory disease	1.6	3.7	4.6	-2.2	2.1	-2.0	-1.0	-2.1	1.8
Type 2 Diabetes (T2D) (2018)	2.0	3.7	5.4	-1.9	2.3	-1.4	-1.1	-2.2	2.2
Lung FEV1/FVC ratio	0.1	0.5	0.9	-0.6	0.7	-0.5	-0.9	-0.6	0.8
Lung FVC	1.0	5.3	10.6	-2.2	1.4	-2.7	-3.3	-1.9	1.9
Neuroticism	8.7	21.0	31.4	4.7	-4.0	5.6	4.8	4.5	-3.6
Chronotype (morning person)	0.2	0.4	0.7	-0.6	0.4	-0.8	-0.8	-0.5	-0.6
Hair Pigment	0.1	2.7	3.8	1.9	-1.9	1.1	1.2	1.9	-1.4
Tanning	0.3	3.7	5.7	2.0	-2.4	1.1	1.8	2.1	-1.9
Hand grip strength (left)	3.1	8.1	17.5	-2.7	2.3	-2.6	-4.2	-2.5	2.2
Number of treatments/medications taken	0.3	0.5	2.1	-0.0	0.4	-0.1	1.5	-0.2	0.6
Average weekly spirits intake	0.8	1.0	1.5	1.0	-1.2	0.3	0.7	1.2	-1.1
Sensitivity / hurt feelings	12.0	20.6	23.0	4.7	-4.4	4.8	4.6	4.6	-4.1
Frequency of depressed mood in last 2 weeks	1.7	2.4	5.8	1.3	-0.8	2.1	2.4	1.2	-0.7
Hearing difficulty/problems: Yes	0.3	0.4	1.3	-0.4	0.6	0.2	1.1	-0.3	0.8
Relative age of first facial hair	5.4	11.1	13.7	3.6	-3.7	3.1	2.4	3.6	-3.4
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.1	-0.6	0.9	-0.3	1.4	-0.7	1.2
Ever used hormone-replacement therapy (HRT)	2.7	3.4	4.0	2.0	-1.6	2.0	2.0	1.8	-1.7
Ever had hysterectomy (womb removed)	0.1	0.2	0.5	-0.3	0.4	-0.1	-0.2	-0.4	0.7
Systolic blood pressure, automated reading	6.7	19.6	23.6	-4.7	4.2	-4.9	-3.9	-4.5	4.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.4	0.5	-0.4	0.1	-0.5	0.8
Angina	1.3	1.7	3.0	1.5	-1.1	1.2	1.7	1.2	-0.9
Medication for hormone replacement therapy	0.8	0.9	1.6	1.1	-0.9	0.6	1.2	1.0	-0.6
Vitamin and mineral supplements	0.3	0.4	0.5	0.5	-0.6	0.6	0.5	0.7	-0.7
Supplements: Zinc	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.1	-0.6	0.5
Medication: Co-codamol	0.1	0.2	0.5	0.3	-0.3	0.1	0.7	0.3	0.4
Medication: Metformin	2.1	2.9	4.7	-1.6	1.9	-1.2	-1.5	-1.8	2.2
Diabetes (father)	0.9	1.2	3.7	-1.0	1.1	-0.2	-0.2	-0.9	1.9
Diabetes (mother)	1.2	1.5	2.2	-1.3	1.1	-1.1	-1.5	-1.2	1.2
Severe depression (siblings)	0.1	0.1	0.2	0.1	-0.3	0.3	0.4	0.2	-0.5
Pack years adult smoking proportion	4.8	7.3	8.8	2.8	-2.7	2.4	3.0	2.7	-2.7
Impedance of leg (right)	7.9	38.2	43.5	6.6	-6.4	6.2	5.1	6.5	-6.2
Leg fat-free mass (left)	8.5	44.9	50.2	-7.0	7.0	-6.5	-5.4	-7.1	7.0
Trunk fat percentage	0.1	0.5	0.9	-0.5	1.0	-0.5	0.5	-0.8	0.7
Hand grip strength (right)	5.1	13.9	25.3	-3.7	3.1	-3.6	-5.0	-3.4	3.2
Townsend deprivation index at recruitment	1.7	2.4	7.6	1.3	-1.1	1.2	2.8	1.2	-1.0
Current tobacco smoking	13.6	22.3	32.9	4.7	-4.4	4.9	5.7	4.7	-3.6
Average weekly fortified wine intake	0.7	0.8	1.8	-0.8	0.9	-0.8	-0.0	-0.9	1.3
Maternal smoking around birth	0.2	0.3	1.1	0.5	-0.1	0.8	1.0	0.2	-0.2
Fed-up feelings	0.4	0.7	1.7	0.8	-0.5	1.3	0.9	0.7	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.1	5.2	1.2	-0.9	1.8	2.3	1.1	-0.6
Relative age voice broke	2.7	4.2	6.1	2.1	-2.0	2.5	1.8	2.1	-1.7
Taking other prescription medications	0.6	1.0	1.6	-0.9	1.3	-0.9	0.2	-1.2	1.2
Age when periods started (menarche)	6.6	15.9	17.0	4.1	-4.0	4.0	4.1	4.1	-3.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.5	-0.6	0.6	-0.5	-0.7	-0.6	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	-0.6	1.0	-0.1	0.6	-0.7	0.8
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.5	0.3	-0.2	0.5	0.7	0.2	-0.1
Qualifications: CSEs or equivalent	0.3	0.4	1.0	-0.9	0.5	-1.0	-0.0	-0.6	0.0
Serious illness, injury or assault to yourself	0.3	0.4	2.2	0.2	-0.1	0.4	1.5	0.2	-0.1
High blood pressure	5.0	13.8	16.2	-3.8	4.0	-3.9	-2.3	-3.9	4.0
Hayfever, allergic rhinitis or eczema	2.4	5.2	8.5	-2.2	1.7	-2.9	-2.9	-2.0	1.6
Multivitamins +/- minerals	0.1	0.2	0.4	-0.4	0.3	-0.4	-0.6	-0.4	0.1
Stomach or abdominal pain in last month	0.2	0.3	1.6	0.2	-0.0	0.4	1.3	0.1	0.0
Supplements: Glucosamine	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0	-0.1	-0.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.4	0.8	-0.3	1.8	1.8	0.6	-0.2
Medication: Atenolol	0.3	0.4	2.2	0.1	0.2	0.1	1.5	-0.1	0.6
Medication: Levothyroxine sodium	2.4	4.0	6.1	-2.2	2.5	-1.2	-1.2	-2.4	2.1
Sitting height	3.0	21.5	24.1	-4.7	4.4	-4.6	-4.6	-4.6	4.9
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	0.4	-0.7	0.0	0.5	0.6	-0.7
High blood pressure (mother)	5.7	7.9	9.9	-3.0	3.1	-3.1	-1.2	-3.1	2.8
Body mass index (BMI)	2.6	10.9	13.6	-3.4	3.7	-3.4	-2.1	-3.6	3.3
Impedance of leg (left)	8.7	42.5	48.6	7.0	-6.8	6.5	5.3	6.9	-6.5
Leg predicted mass (left)	8.8	46.4	51.9	-7.2	7.1	-6.6	-5.5	-7.2	7.1
Trunk fat mass	1.3	5.5	7.6	-2.3	2.8	-2.3	-1.1	-2.6	2.6
Waist circumference	1.0	3.8	5.9	-1.9	2.4	-1.9	-0.6	-2.3	2.0
Number of incorrect matches in round	5.8	9.7	12.0	3.5	-3.1	3.4	2.6	3.3	-2.8
Past tobacco smoking	13.1	24.1	28.4	-5.3	5.0	-4.9	-4.9	-5.1	4.1
Alcohol usually taken with meals	7.3	11.9	13.3	-3.5	3.4	-3.4	-3.6	-3.6	3.2
Nervous feelings	5.5	10.2	18.9	3.1	-2.2	4.3	3.9	2.8	-2.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.6	0.9	-0.5	1.4	2.1	0.7	-0.4
Hearing difficulty/problems with background noise	0.8	1.3	2.5	1.0	-0.8	1.5	1.6	0.9	-0.7
Hair/balding pattern: Pattern 2	0.8	1.0	1.6	-1.1	1.2	-0.8	-1.3	-1.1	0.4
Had menopause	0.6	0.7	0.9	0.9	-0.9	1.0	0.3	0.9	-0.9
Had other major operations	1.1	1.4	2.2	1.2	-1.1	0.9	1.5	1.1	-1.2
Forced vital capacity (FVC)	3.1	12.0	20.7	-3.3	2.7	-3.5	-4.5	-3.1	3.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.6	-1.0	1.6	-0.5	-0.1	-1.3	1.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	0.4	-0.3	0.3	0.7	0.3	-0.7
Qualifications: None of the above	3.6	7.8	8.8	2.9	-2.6	2.6	3.0	2.8	-2.9
Financial difficulties in last 2 years	3.4	4.6	7.6	2.2	-1.7	2.4	2.8	1.9	-1.7
Mouth/teeth dental problems	0.4	0.6	3.1	-0.3	0.2	0.0	-1.8	-0.3	-0.1
Heart attack	3.4	4.4	6.4	2.1	-2.0	1.7	2.5	2.0	-2.1
Allergy	1.1	2.5	4.9	1.6	-1.3	2.2	1.6	1.5	-1.1
Pain all over the body in last month	0.2	0.2	0.8	-0.0	0.3	0.6	0.9	-0.0	0.4
Diabetes (self-reported)	1.4	2.1	3.5	-1.5	1.9	-0.9	-0.3	-1.7	1.8
Hayfever/allergic rhinitis (self-reported)	6.0	7.9	12.0	-2.8	2.9	-3.5	-2.6	-2.9	2.1
Medication: Ramipril	2.0	2.5	3.3	-1.8	1.7	-1.4	-1.0	-1.8	1.7
Medication: Simvastatin	0.2	0.3	0.8	0.5	-0.6	0.2	0.9	0.5	-0.2
Fluid intelligence score	0.5	1.0	1.2	-1.1	0.9	-1.1	-0.8	-1.0	0.9
Illnesses of siblings	0.3	0.4	1.1	0.6	-0.7	0.1	-0.5	0.6	-1.0
Neuroticism score	6.2	12.9	20.9	3.6	-3.0	4.6	3.9	3.4	-2.8
Weight	4.9	24.3	28.4	-5.1	5.3	-4.8	-3.7	-5.3	5.1
Impedance of arm (right)	5.5	25.5	31.5	5.3	-5.0	5.6	4.3	5.2	-4.8
Arm fat percentage (right)	0.3	1.2	2.0	-1.0	1.4	-1.1	-0.0	-1.3	1.1
Trunk fat-free mass	7.8	44.7	48.2	-6.9	6.7	-6.6	-6.0	-6.9	6.9
Hip circumference	5.4	23.1	26.7	-4.9	5.2	-4.8	-3.9	-5.2	4.8
Time employed in main current job	0.3	0.3	1.5	-0.0	-0.2	-0.5	-1.2	0.1	-0.2
Alcohol intake versus 10 years previously	3.4	5.0	6.0	-2.2	2.3	-2.2	-2.0	-2.3	2.4
Father’s age at death	0.8	1.1	1.5	-1.1	1.2	-0.9	-0.6	-1.2	1.2
Worrier / anxious feelings	5.6	10.6	17.4	3.3	-2.7	4.2	3.2	3.1	-2.8
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	8.2	1.0	-0.2	2.0	2.9	0.7	-0.3
Falls in the last year	1.9	2.5	5.4	1.4	-1.5	1.6	2.3	1.4	-1.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.1	-0.2	-0.4	-0.5	0.1	-0.3
Number of live births	0.8	1.1	1.3	1.0	-1.1	0.9	1.0	1.1	-1.2
Forced expiratory volume in 1-second (FEV1)	4.7	16.0	26.2	-4.0	3.4	-4.0	-5.1	-3.7	3.5
Pulse rate	3.7	6.3	7.0	-2.6	2.5	-2.6	-2.7	-2.5	2.3
Happiness	0.8	0.9	1.8	0.9	-1.0	0.8	0.7	0.9	-1.3
Noisy workplace	0.8	1.0	1.7	0.8	-1.0	1.0	1.3	1.0	-0.7
Qualifications: A levels/AS levels or equivalent	4.4	9.7	13.6	-3.1	3.2	-2.7	-2.8	-3.2	3.7
Serious illness, injury or assault of a close relative in last 2 years	3.2	3.7	6.5	-2.0	2.1	-1.3	-1.2	-2.0	2.5
Mouth/teeth dental problems: Dentures	0.3	0.6	2.5	0.3	-0.4	-0.4	1.6	0.4	-0.7
Asthma	0.9	1.9	3.2	-1.4	1.3	-1.8	-1.1	-1.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.1	1.2	-0.8	1.4	2.0	1.1	-1.0
Medication: Cholesterol lowering	0.2	0.3	1.4	0.2	0.1	0.4	1.2	-0.1	0.4
Depression (self-reported)	0.5	0.6	2.5	0.7	-0.4	0.6	1.6	0.6	-0.3
Medication: Lansoprazole	1.6	1.8	2.1	1.4	-1.2	1.4	1.4	1.2	-1.3
Prospective memory result	0.7	0.8	1.4	0.9	-1.2	0.8	0.3	1.0	-1.0
Lung cancer (father)	1.9	2.3	3.7	1.6	-1.3	1.5	1.9	1.4	-1.1
Illnesses of mother	0.7	0.8	1.1	1.0	-1.1	0.9	0.2	1.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.6	8.1	-2.1	1.9	-2.0	-2.8	-2.0	1.9
Pulse wave Arterial Stiffness index	2.2	2.6	4.1	-1.8	1.7	-1.6	-0.4	-1.7	2.0
Impedance of arm (left)	4.6	21.2	24.4	4.9	-4.6	4.9	3.9	4.7	-4.5
Arm fat mass (right)	2.2	9.0	11.9	-3.1	3.4	-2.9	-1.8	-3.3	3.2
Trunk predicted mass	7.8	44.6	48.0	-6.9	6.7	-6.6	-6.1	-6.9	6.9
Standing height	1.8	17.7	21.7	-4.2	4.2	-3.7	-4.0	-4.3	4.7
Length of working week for main job	0.1	0.1	0.3	-0.1	-0.2	-0.5	-0.5	0.1	-0.3
Exposure to tobacco smoke at home	0.5	0.5	3.0	0.2	0.0	0.3	1.7	0.1	0.0
Breastfed as a baby	0.2	0.3	0.4	0.7	-0.5	0.5	0.4	0.6	-0.4
Tense / ‘highly strung’	3.1	5.2	7.7	2.3	-1.9	2.8	2.5	2.3	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.3	5.9	1.8	-1.7	1.7	2.4	1.8	-1.2
Hair/balding pattern: Pattern 4	2.7	6.6	9.3	2.7	-2.2	2.8	3.0	2.5	-2.0
Birth weight of first child	0.1	0.2	0.5	-0.1	0.2	0.6	0.3	-0.2	0.7
Peak expiratory flow (PEF)	7.1	16.6	29.5	-4.0	3.4	-3.8	-5.4	-3.8	3.6
Pulse wave reflection index	0.4	0.5	1.7	0.5	-0.7	0.6	1.3	0.6	-0.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.1	1.0	-0.7	1.5	2.0	1.0	-1.2
Loud music exposure frequency	6.9	7.5	9.4	2.8	-3.1	2.4	2.3	2.9	-2.9
Qualifications: O levels/GCSEs or equivalent	8.0	12.7	14.1	-3.5	3.4	-3.6	-3.6	-3.5	3.8
Mouth/teeth dental problems: Bleeding gums	3.1	4.1	5.5	-2.0	2.2	-1.6	-1.7	-2.1	2.4
Blood clot in the leg (DVT)	0.5	0.6	1.7	0.8	-0.4	0.6	1.3	0.5	-0.6
Medication: Paracetamol	3.2	5.3	9.4	2.2	-1.8	2.2	3.1	2.1	-2.3
Headache pain in last month	2.1	3.5	8.3	1.9	-1.5	1.6	2.9	1.7	-1.3
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	3.7	1.6	-1.9	1.5	0.4	1.8	-1.9
Glaucoma (self-reported)	0.1	0.2	0.4	0.4	-0.0	0.6	0.5	0.2	-0.3
Gout (self-reported)	1.1	1.4	3.2	-1.2	1.4	-0.6	-0.2	-1.3	1.8
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	8.4	-2.6	2.9	-1.7	-1.8	-2.8	2.7
Medication: Amlodipine	4.6	6.5	8.2	-2.7	2.6	-2.9	-1.6	-2.6	2.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	0.9	0.9	-0.9	0.7	0.8	0.8	-0.9
Birth weight	0.1	0.2	0.9	-0.1	0.3	0.2	0.0	-0.2	0.9
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.3	-0.3	0.2	0.2	0.3	-0.1
High blood pressure (siblings)	2.0	3.0	5.3	-1.8	1.9	-1.2	-0.7	-1.9	2.3
Forced vital capacity (FVC), Best measure	1.1	4.1	7.4	-1.9	1.7	-1.9	-2.7	-1.8	2.0
Body fat percentage	0.1	0.5	0.9	-0.5	1.0	-0.7	0.4	-0.8	0.6
Leg fat percentage (right)	0.0	0.1	0.3	-0.1	0.4	-0.5	0.5	-0.3	0.0
Arm fat-free mass (right)	7.6	39.0	42.1	-6.5	6.3	-6.3	-5.4	-6.5	6.4
Exposure to tobacco smoke outside home	2.4	3.2	4.1	1.9	-1.8	1.5	2.0	1.8	-1.7
Comparative body size at age 10	0.2	0.6	0.8	-0.7	0.8	-0.6	-0.9	-0.8	0.9
Number of full brothers	1.2	1.5	2.9	1.2	-1.1	1.2	1.7	1.1	-1.0
Worry too long after embarrassment	13.6	22.8	35.4	4.9	-4.2	6.0	4.1	4.7	-4.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	5.0	1.1	-0.8	1.3	2.2	0.9	-0.4
Wheeze or whistling in the chest in last year	0.4	0.6	3.1	-0.1	0.6	0.0	1.8	-0.3	0.5
Number of children fathered	0.2	0.2	0.4	0.3	-0.5	-0.3	0.4	0.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.6	-0.2	0.2	0.2	-0.8	-0.3	0.1
Age at first live birth	2.1	3.8	5.4	-1.9	2.0	-1.5	-2.3	-2.0	1.9
Pulse wave peak to peak time	1.8	2.1	3.3	1.6	-1.6	1.4	0.1	1.5	-1.8
Health satisfaction	0.2	0.2	1.3	0.3	0.1	0.1	1.1	0.0	-0.1
Shortness of breath walking on level ground	5.6	6.7	7.7	-2.8	2.5	-2.7	-2.2	-2.7	2.7
Qualifications: College or University degree	3.0	9.6	13.6	-3.2	2.6	-3.2	-3.7	-2.9	3.0
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.4	-0.3	0.3	0.2	0.5	-0.5
Mouth/teeth dental problems: Loose teeth	3.2	3.7	5.2	2.1	-2.0	1.5	2.3	2.0	-1.6
Emphysema/chronic bronchitis	0.2	0.2	1.4	-0.0	0.0	0.1	1.2	0.2	-0.0
Medication for pain relief, constipation, heartburn	6.5	11.1	13.3	-3.5	3.3	-2.9	-3.6	-3.3	3.3
Neck or shoulder pain in last month	0.8	1.2	2.9	1.0	-0.7	1.3	1.7	0.9	-0.3
Medication: Blood pressure	3.7	6.5	7.6	-2.7	2.7	-2.7	-1.4	-2.8	2.7
Angina (self-reported)	1.1	1.5	2.9	1.4	-1.1	1.1	1.7	1.1	-0.8
Migraine (self-reported)	1.1	1.3	1.6	1.2	-1.3	1.2	0.9	1.3	-1.1
Medication: Ibuprofen	0.2	0.2	0.8	0.1	0.1	0.6	0.9	0.1	-0.2
Medication: Allopurinol	0.4	0.5	0.9	-0.7	0.7	-0.6	0.2	-0.7	1.0
Medication: Omeprazole	0.4	0.4	0.8	-0.6	0.4	-0.9	0.4	-0.5	0.9
Medication: Seretide 50 evohaler	0.5	0.6	1.4	-0.6	0.4	-1.2	-1.0	-0.6	0.6
Mean time to correctly identify matches	0.0	0.1	0.2	0.1	-0.4	-0.3	-0.4	0.2	-0.2
Heart disease (mother)	0.2	0.3	0.5	0.4	-0.6	0.6	0.5	0.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.7	-0.2	-0.2	-1.1	-1.3	-0.1	0.1
Whole body fat mass	1.6	6.5	8.9	-2.5	3.0	-2.5	-1.3	-2.9	2.8
Leg fat mass (right)	1.3	5.0	7.1	-2.2	2.7	-2.3	-1.0	-2.5	2.2
Arm predicted mass (right)	7.8	40.0	43.3	-6.6	6.4	-6.4	-5.5	-6.6	6.4
Pulse rate, automated reading	3.0	9.6	10.4	-3.2	3.2	-3.2	-2.8	-3.1	3.0
Alcohol intake frequency.	1.1	2.5	4.2	-1.7	1.6	-2.0	-0.8	-1.6	1.5
Comparative height size at age 10	2.0	10.8	14.8	-3.4	3.6	-2.6	-2.6	-3.5	3.9
Number of full sisters	1.3	1.6	2.5	1.2	-1.3	0.5	1.6	1.3	-1.5
Suffer from ‘nerves’	2.2	3.5	7.2	1.8	-1.1	2.7	2.5	1.5	-0.9
Overall health rating	1.9	4.1	13.5	1.8	-1.3	1.6	3.7	1.5	-1.2
Chest pain or discomfort	1.4	2.1	4.7	1.4	-1.1	1.6	2.2	1.3	-0.6
Had major operations	0.5	0.6	1.0	-1.0	0.9	-1.0	-0.3	-0.9	0.4
Age at last live birth	2.3	3.3	5.4	-1.8	2.3	-0.9	-1.3	-2.0	2.2
Family relationship satisfaction	0.1	0.1	0.2	0.3	-0.2	0.4	-0.3	0.2	-0.5
Leg pain on walking	0.7	0.8	1.7	-0.9	1.0	-0.6	-0.4	-0.9	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	2.9	1.3	-1.2	1.0	1.7	1.2	-1.5
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	-0.6	0.5	-0.6	-0.5	-0.4	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.2	-0.3	0.1	0.1	0.3	-0.6
Medication: Aspirin	2.5	3.3	4.0	2.0	-2.0	1.7	1.8	1.9	-1.5
Supplements: Vitamin C	0.3	0.3	0.6	-0.6	0.7	-0.4	-0.1	-0.7	0.8
Knee pain experienced in last month	0.3	0.4	1.2	0.6	-0.6	0.0	1.1	0.6	-0.5
Hypertension (Self-reported)	4.9	13.6	16.2	-3.8	4.0	-3.8	-2.2	-3.9	4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.4	0.6	-0.8	0.5	1.2	0.7	-0.6
Illnesses of father: Heart disease	0.4	0.6	0.9	-0.8	0.9	-0.7	-0.5	-0.9	0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.1	-0.7	0.8	-0.3	-0.2	-0.7	1.1
Smoking status: Previous	6.2	9.3	11.7	3.4	-3.1	3.1	2.9	3.2	-2.6
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	0.1	-0.2	0.3	-0.0	0.1	0.3
Whole body fat-free mass	8.4	48.0	52.2	-7.2	7.1	-6.8	-6.0	-7.2	7.2
Leg fat-free mass (right)	8.6	45.7	50.9	-7.1	7.1	-6.5	-5.6	-7.1	7.0
Arm fat percentage (left)	0.5	2.1	3.2	-1.4	1.8	-1.5	-0.4	-1.7	1.4
Average weekly red wine intake	0.5	0.7	2.2	-0.7	0.6	-0.6	-1.5	-0.7	0.7
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	0.9	-0.9	0.8	0.6	0.9	-0.8
Mood swings	0.4	0.8	1.7	0.8	-0.6	1.3	1.3	0.7	-0.1
Loneliness, isolation	0.5	0.6	1.1	0.7	-0.5	0.8	1.1	0.7	-0.9
Long-standing illness, disability or infirmity	0.8	1.2	5.6	0.5	0.0	1.0	2.4	0.3	0.1
Ever had bowel cancer screening	1.1	1.3	4.5	1.1	-0.4	1.2	2.1	0.7	-0.4
Diabetes diagnosed by doctor	0.8	1.3	2.5	-1.0	1.6	-0.4	0.2	-1.3	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.7	-0.7	0.2	0.5	0.6	-0.3
Friendships satisfaction	0.1	0.1	0.4	-0.1	0.0	-0.6	-0.2	-0.1	-0.4
Qualifications: nursing, teaching	2.2	3.4	4.9	-1.8	1.8	-1.4	-1.9	-1.8	2.2
Commuting to job workplace: Walk	1.2	1.3	2.0	-1.2	0.8	-1.4	-1.2	-1.0	1.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.2	-0.5	0.1	0.1	0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.0	0.7	-0.7	0.6	1.4	0.8	-0.5
Medication for cholesterol	0.9	1.4	2.4	1.1	-1.4	1.0	0.3	1.2	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.1	6.0	7.3	2.7	-2.7	2.2	2.1	2.6	-2.4
Back pain experienced in last month	2.0	3.0	5.9	1.7	-1.3	1.8	2.4	1.5	-1.3
Mineral and other dietary supplements	0.1	0.1	0.3	0.5	-0.1	0.5	0.4	0.3	-0.3
Breast cancer (self-reported)	0.1	0.1	0.4	0.2	0.0	0.7	0.1	0.1	0.1
Asthma (self-reported)	0.8	1.6	2.7	-1.3	1.3	-1.6	-0.9	-1.4	1.0
Osteoporosis (self-reported)	0.5	0.6	1.6	-0.7	0.7	-1.3	-0.4	-0.8	0.5
Osteoarthritis (self-reported)	2.0	2.7	5.2	1.7	-1.5	1.4	2.3	1.6	-1.1
Medication: Aspirin	3.0	3.9	4.7	2.1	-2.2	1.9	1.9	2.1	-1.5
Medication: Gliclazide	0.7	0.8	1.7	-0.9	0.9	-1.3	-0.8	-0.9	0.5
Illnesses of father: None of the above (group 1)	1.6	2.0	2.7	1.6	-1.2	1.3	1.4	1.3	-1.6
Smoking status: Current	11.9	18.9	29.8	4.3	-4.0	4.5	5.5	4.3	-3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.6	7.6	12.1	-2.7	2.3	-3.1	-3.5	-2.6	2.2
Whole body water mass	8.5	48.4	52.6	-7.2	7.1	-6.8	-6.0	-7.2	7.2
Leg predicted mass (right)	8.5	45.4	50.7	-7.1	7.1	-6.4	-5.6	-7.1	7.0
Arm fat mass (left)	2.3	9.6	11.9	-3.1	3.5	-3.2	-2.0	-3.4	3.2
Number of self-reported non-cancer illnesses	0.3	0.5	1.8	-0.4	0.6	-0.6	1.4	-0.4	0.6
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.3	0.4	0.5	-0.9	-0.3	0.6
Miserableness	0.4	0.7	1.4	0.7	-0.6	1.2	0.9	0.8	-0.3
Guilty feelings	6.2	9.3	14.3	3.0	-2.8	3.8	3.1	3.0	-2.4
Wears glasses or contact lenses	1.0	1.1	2.4	-1.0	1.3	-0.5	-0.2	-1.2	1.5
Ever taken oral contraceptive pill	0.9	1.0	1.4	-1.0	0.9	-1.2	-0.9	-1.0	1.1
Hearing aid user	1.6	1.8	2.7	-1.3	1.2	-1.3	-1.6	-1.3	1.0
Mother’s age at death	0.9	1.1	1.6	-1.1	0.9	-1.0	-1.3	-1.0	1.0
Financial situation satisfaction	1.9	2.4	3.9	1.5	-1.4	0.9	1.8	1.4	-2.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.9	-0.6	0.3	-0.9	-0.7	-0.5	0.6
Commuting to job workplace: Public transport	0.2	0.3	0.6	-0.5	0.7	-0.3	-0.2	-0.6	0.8
Eye problems/disorders: Glaucoma	0.0	0.1	0.1	0.2	0.1	0.4	0.3	0.0	0.2
Medication: Blood pressure	3.4	6.5	8.2	-2.7	2.9	-2.4	-1.6	-2.7	2.8
Pain type(s) experienced in last month: Hip pain	1.8	2.2	3.0	1.6	-1.4	1.7	1.7	1.5	-0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.9	0.6	-0.9	0.5	0.6	0.8	-0.6
High cholesterol (Self-reported)	0.0	0.1	0.3	0.2	-0.1	-0.0	0.5	0.1	-0.1
Medication: Bendroflumethiazide	7.6	11.5	14.2	-3.5	3.6	-3.2	-2.6	-3.6	3.8
Medication: Paracetamol	1.6	2.5	4.4	1.5	-1.2	1.3	2.1	1.4	-1.8
Medication: Lisinopril	1.7	2.1	4.0	-1.3	1.1	-1.9	-2.0	-1.3	0.8
Medication: Atorvastatin	1.3	1.6	4.2	1.2	-0.7	1.4	2.1	0.9	-0.6
Illnesses of father: High blood pressure	1.0	1.2	1.8	-1.2	1.1	-1.0	-0.6	-1.1	1.3
Alcohol drinker status: Never	0.2	0.2	0.7	0.5	-0.4	0.2	0.8	0.4	-0.4
Ever smoked	14.4	25.3	29.6	5.4	-5.2	4.8	5.1	5.3	-4.2
Basal metabolic rate	7.8	43.3	47.7	-6.8	6.8	-6.4	-5.5	-6.9	6.8
Leg fat percentage (left)	0.0	0.1	0.3	0.1	0.2	-0.4	0.6	-0.2	-0.2
Arm fat-free mass (left)	7.0	35.3	38.2	-6.2	6.1	-6.0	-5.1	-6.2	6.1
Number of operations (self-reported)	0.3	0.4	2.0	-0.0	0.4	0.1	1.4	-0.2	-0.5
Average weekly beer plus cider intake	0.4	0.6	1.2	0.6	-0.7	0.9	1.1	0.8	-0.4
Irritability	1.0	1.7	2.8	1.4	-1.2	1.4	1.7	1.3	-0.6
Risk taking	0.5	0.8	2.4	-0.8	0.6	-0.9	-0.1	-0.7	1.5
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.8	-0.0	-0.2	-0.9	-0.2	0.0	0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.8	-0.7	0.2	-0.9	-0.9	-0.4	0.3
Age started oral contraceptive pill	1.4	1.7	3.5	-1.2	1.2	-1.1	-1.9	-1.1	1.2
Diastolic blood pressure, automated reading	1.5	4.7	5.8	-2.3	2.4	-1.9	-2.2	-2.3	1.9
Ever depressed for a whole week	1.4	1.7	3.2	1.2	-1.5	0.6	1.0	1.4	-1.8
Unable to work because of sickness or disability	0.6	0.8	1.8	0.8	-1.1	0.5	1.3	0.9	-0.3
Commuting to job workplace: Cycle	1.2	1.4	1.9	-1.3	1.2	-0.9	-1.1	-1.4	1.2
Myopia	8.2	11.9	14.6	-3.5	3.4	-3.3	-3.8	-3.4	3.3
Vascular/heart problems diagnosed by doctor	1.9	5.2	7.0	2.3	-2.6	2.4	0.7	2.5	-2.6
Cholesterol lowering medication	0.3	0.4	0.7	0.6	-0.5	0.6	0.8	0.7	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.4	0.5	-0.5	-0.1	1.2	0.4	-0.1
Pain experienced in last month	4.0	6.6	16.8	-2.5	1.9	-2.5	-4.1	-2.2	1.3
Supplements: Calcium	0.6	0.7	1.8	-0.9	0.5	-1.3	-0.8	-0.7	0.4
Basal cell carcinoma (self-reported)	0.7	0.8	1.3	-0.9	0.8	-1.1	-0.9	-0.8	0.8
Heart attack/myocardial infarction (self-reported)	2.9	3.7	5.9	1.9	-1.8	1.6	2.4	1.8	-1.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.3	0.8	-0.6	0.5	1.1	0.6	-0.8
Heart disease (siblings)	5.1	6.2	7.7	2.6	-2.4	2.8	2.6	2.5	-2.1
Alcohol drinker status: Previous	0.3	0.3	0.8	-0.5	0.6	-0.3	-0.3	-0.5	0.9
Pack years of smoking	4.2	6.2	7.2	2.6	-2.5	2.2	2.7	2.5	-2.5
Impedance of whole body	7.6	38.8	44.0	6.6	-6.4	6.5	5.2	6.5	-6.1
Leg fat mass (left)	1.2	4.6	6.6	-2.1	2.6	-2.2	-1.0	-2.5	2.1
Arm predicted mass (left)	7.6	38.6	41.5	-6.4	6.3	-6.2	-5.5	-6.4	6.3