Hub : Genes

GAPVD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1065 0.0337 7.5e-10 0.157 NA 0.165 NA 0.163 2.3e-12 NA 6.5e-13 NA 9.3e-13
2 GTEx Muscle Skeletal 0.1333 0.0380 7.7e-09 0.098 NA 0.086 NA 0.089 6.9e-10 NA 9.2e-09 NA 4.6e-09
3 GTEx Nerve Tibial 0.1704 0.0572 4.5e-08 0.079 NA 0.087 NA 0.103 3.1e-06 NA 1.0e-06 NA 9.3e-08
4 GTEx Skin Sun Exposed Lower leg 0.0370 0.0180 1.1e-03 0.006 NA -0.003 NA 0.011 8.7e-02 NA 9.9e-01 NA 3.8e-02
5 GTEx Thyroid 0.0530 0.0270 2.2e-03 0.049 NA 0.009 NA -0.001 1.1e-04 NA 6.6e-02 NA 4.1e-01
6 TCGA Prostate Adenocarcinoma 0.0225 0.0136 2.3e-03 0.035 0.006 0.015 NA 0.015 1.2e-04 0.065 9.8e-03 NA 1.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.2 0.5 0.2 -0.5 -0.4 -0.7 0.3 -0.7
Bipolar Disorder or Schizophrenia 0.1 0.3 0.6 0.6 -0.5 0.3 0.3 0.5 -0.8
Depressed Affect (Nagel 2018) 0.7 1.6 3.3 1.3 -1.1 1.8 1.0 1.3 -0.5
Depression (Nagel 2018) 2.3 3.5 5.4 1.9 -1.5 2.3 2.3 1.7 -1.2
Intelligence (Savage-Jansen 2018) 1.8 5.4 7.3 -2.4 2.3 -2.5 -1.6 -2.4 2.7
Neuroticism (Nagel 2018) 7.3 17.1 26.4 4.3 -3.8 5.1 3.9 4.1 -3.3
Schizophrenia (2018) 0.2 0.4 0.8 0.6 -0.1 0.7 0.9 0.4 -0.4
Schizophrenia vs Biploar Disorder 0.2 0.3 0.9 0.5 0.0 0.9 0.8 0.2 -0.3
Worry (Nagel 2018) 7.5 15.9 25.4 4.1 -3.3 5.0 4.2 3.8 -3.1
Alzheimer’s Disease (in mother) 1.5 1.7 2.9 1.1 -1.2 1.3 1.7 1.2 -1.3
Alzheimer’s Disease (in father) 2.4 2.6 6.9 -1.5 1.0 -1.5 -2.6 -1.3 1.3
Alzheimer’s Disease (including proxy) 0.2 0.3 0.9 0.6 -0.9 0.3 0.1 0.6 -0.6
Crohns Disease (2017) 0.1 0.2 0.6 0.4 -0.5 0.8 -0.2 0.4 -0.1
Irritable Bowel Disease (IBD) 0.1 0.3 1.1 -0.4 0.3 -0.0 -1.1 -0.3 0.7
Ulcerative Colitis (UC) 0.7 1.4 2.7 -1.1 0.9 -0.9 -1.7 -1.0 1.2
Major Depression (MDD) 5.0 6.1 9.9 2.4 -2.0 2.6 3.1 2.3 -2.1
Reaction Time 0.2 0.3 0.7 -0.5 0.2 -0.9 -0.7 -0.3 0.3
Verbal and Numeric Reasoning (VNR) 0.9 2.1 3.0 -1.6 1.5 -1.4 -0.6 -1.5 1.7
Breast Cancer 0.0 0.0 0.1 -0.0 -0.1 0.1 -0.1 0.0 -0.4
Ovarian Cancer 0.2 0.2 0.7 -0.2 -0.3 -0.8 -0.7 0.0 -0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.5 2.2 3.2 -1.5 1.8 -0.7 -1.6 -1.6 1.4
Bipolar Disorder (2011) 0.8 0.8 1.1 -0.9 1.0 -0.7 -0.7 -0.9 1.1
Body Mass Index (BMI) (2010) 0.0 0.1 0.1 -0.0 0.1 -0.4 -0.3 -0.1 -0.3
Coronary Artery Disease (CAD) 1.2 1.5 2.4 1.0 -1.0 1.5 1.1 1.3 -1.1
Crohns Disease (2012) 0.1 0.1 0.3 -0.4 0.3 0.0 -0.5 -0.4 0.4
Mean Putamen Volume 1.6 1.9 3.7 1.2 -1.2 1.4 1.9 1.4 -0.7
Fasting Glucose 0.3 0.4 0.8 0.5 -0.5 0.2 0.8 0.4 -0.9
HbA1C 0.2 0.2 0.8 0.5 -0.2 0.9 0.4 0.3 -0.1
HDL Cholesterol 0.0 0.0 0.0 -0.0 0.1 0.2 0.1 -0.1 0.2
LDL Cholesterol 1.6 2.5 3.6 1.7 -1.8 0.8 1.3 1.7 -1.9
Lupus 1.3 1.9 3.2 1.3 -1.2 1.4 1.8 1.3 -1.3
Neuroticism (2016) 7.0 10.1 13.7 3.5 -3.2 3.7 2.7 3.3 -2.6
Primary Biliary Cirrhosis 0.7 0.9 1.4 1.0 -1.2 0.2 1.1 1.0 -0.9
Rheumatoid Arthritis 0.7 0.9 1.6 -0.9 0.5 -1.0 -1.1 -0.7 1.2
Schizophrenia (2014) 1.0 2.1 2.6 1.6 -1.2 1.5 1.5 1.5 -1.5
Triglycerides 0.6 0.9 1.3 0.9 -1.1 0.6 1.1 1.1 -0.8
Type 2 Diabetes (T2D) (2012) 0.7 0.9 1.7 -0.8 1.3 -0.4 0.3 -1.0 1.2
Ulcerative Colitis 0.7 1.1 1.6 -1.0 1.1 -0.7 -1.2 -1.1 1.1
Blood Eosinophil Count 0.6 4.6 8.7 -2.1 1.7 -3.0 -2.0 -1.9 1.9
Blood Platelet Count 0.1 0.7 2.9 -0.2 -0.2 -1.7 -1.0 -0.0 0.4
Blood Red Count 0.0 0.4 0.9 0.5 -0.5 0.1 0.8 0.5 -1.0
Blood White Count 0.8 5.8 12.5 -2.2 1.9 -3.5 -1.9 -2.2 2.4
Heel T-Score 0.9 7.1 11.0 -2.6 3.0 -1.8 -2.1 -2.8 3.3
BMI 2.3 13.3 17.1 -3.8 4.1 -3.5 -2.4 -4.1 3.7
Height 1.3 24.2 27.0 -5.0 4.8 -4.6 -5.1 -4.9 5.2
Waist Hip Ratio (WHR) 5.9 26.6 29.7 5.3 -4.9 5.3 5.4 5.1 -4.8
Systolic Blood Pressure 7.0 35.1 41.7 -6.3 5.7 -6.5 -4.9 -6.1 5.9
Smoking Status 21.1 50.6 60.9 7.4 -6.8 7.5 7.8 7.2 -5.8
Allergy or Eczema 1.1 2.8 4.8 -1.6 1.3 -2.2 -2.0 -1.5 1.3
Cardiovascular Disease 2.3 7.4 9.6 -2.9 2.9 -2.8 -1.6 -2.9 3.1
Hypothyroidism (self reported) 2.1 4.8 6.7 -2.3 2.5 -1.4 -1.8 -2.4 2.6
Respiratory disease 1.6 3.7 4.6 -2.2 2.1 -2.0 -1.0 -2.1 1.8
Type 2 Diabetes (T2D) (2018) 2.0 3.7 5.4 -1.9 2.3 -1.4 -1.1 -2.2 2.2
Lung FEV1/FVC ratio 0.1 0.5 0.9 -0.6 0.7 -0.5 -0.9 -0.6 0.8
Lung FVC 1.0 5.3 10.6 -2.2 1.4 -2.7 -3.3 -1.9 1.9
Neuroticism 8.7 21.0 31.4 4.7 -4.0 5.6 4.8 4.5 -3.6
Chronotype (morning person) 0.2 0.4 0.7 -0.6 0.4 -0.8 -0.8 -0.5 -0.6
Hair Pigment 0.1 2.7 3.8 1.9 -1.9 1.1 1.2 1.9 -1.4
Tanning 0.3 3.7 5.7 2.0 -2.4 1.1 1.8 2.1 -1.9
Hand grip strength (left) 3.1 8.1 17.5 -2.7 2.3 -2.6 -4.2 -2.5 2.2
Number of treatments/medications taken 0.3 0.5 2.1 -0.0 0.4 -0.1 1.5 -0.2 0.6
Average weekly spirits intake 0.8 1.0 1.5 1.0 -1.2 0.3 0.7 1.2 -1.1
Sensitivity / hurt feelings 12.0 20.6 23.0 4.7 -4.4 4.8 4.6 4.6 -4.1
Frequency of depressed mood in last 2 weeks 1.7 2.4 5.8 1.3 -0.8 2.1 2.4 1.2 -0.7
Hearing difficulty/problems: Yes 0.3 0.4 1.3 -0.4 0.6 0.2 1.1 -0.3 0.8
Relative age of first facial hair 5.4 11.1 13.7 3.6 -3.7 3.1 2.4 3.6 -3.4
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.1 -0.6 0.9 -0.3 1.4 -0.7 1.2
Ever used hormone-replacement therapy (HRT) 2.7 3.4 4.0 2.0 -1.6 2.0 2.0 1.8 -1.7
Ever had hysterectomy (womb removed) 0.1 0.2 0.5 -0.3 0.4 -0.1 -0.2 -0.4 0.7
Systolic blood pressure, automated reading 6.7 19.6 23.6 -4.7 4.2 -4.9 -3.9 -4.5 4.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.6 -0.4 0.5 -0.4 0.1 -0.5 0.8
Angina 1.3 1.7 3.0 1.5 -1.1 1.2 1.7 1.2 -0.9
Medication for hormone replacement therapy 0.8 0.9 1.6 1.1 -0.9 0.6 1.2 1.0 -0.6
Vitamin and mineral supplements 0.3 0.4 0.5 0.5 -0.6 0.6 0.5 0.7 -0.7
Supplements: Zinc 0.2 0.2 0.3 -0.5 0.5 -0.5 -0.1 -0.6 0.5
Medication: Co-codamol 0.1 0.2 0.5 0.3 -0.3 0.1 0.7 0.3 0.4
Medication: Metformin 2.1 2.9 4.7 -1.6 1.9 -1.2 -1.5 -1.8 2.2
Diabetes (father) 0.9 1.2 3.7 -1.0 1.1 -0.2 -0.2 -0.9 1.9
Diabetes (mother) 1.2 1.5 2.2 -1.3 1.1 -1.1 -1.5 -1.2 1.2
Severe depression (siblings) 0.1 0.1 0.2 0.1 -0.3 0.3 0.4 0.2 -0.5
Pack years adult smoking proportion 4.8 7.3 8.8 2.8 -2.7 2.4 3.0 2.7 -2.7
Impedance of leg (right) 7.9 38.2 43.5 6.6 -6.4 6.2 5.1 6.5 -6.2
Leg fat-free mass (left) 8.5 44.9 50.2 -7.0 7.0 -6.5 -5.4 -7.1 7.0
Trunk fat percentage 0.1 0.5 0.9 -0.5 1.0 -0.5 0.5 -0.8 0.7
Hand grip strength (right) 5.1 13.9 25.3 -3.7 3.1 -3.6 -5.0 -3.4 3.2
Townsend deprivation index at recruitment 1.7 2.4 7.6 1.3 -1.1 1.2 2.8 1.2 -1.0
Current tobacco smoking 13.6 22.3 32.9 4.7 -4.4 4.9 5.7 4.7 -3.6
Average weekly fortified wine intake 0.7 0.8 1.8 -0.8 0.9 -0.8 -0.0 -0.9 1.3
Maternal smoking around birth 0.2 0.3 1.1 0.5 -0.1 0.8 1.0 0.2 -0.2
Fed-up feelings 0.4 0.7 1.7 0.8 -0.5 1.3 0.9 0.7 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.1 5.2 1.2 -0.9 1.8 2.3 1.1 -0.6
Relative age voice broke 2.7 4.2 6.1 2.1 -2.0 2.5 1.8 2.1 -1.7
Taking other prescription medications 0.6 1.0 1.6 -0.9 1.3 -0.9 0.2 -1.2 1.2
Age when periods started (menarche) 6.6 15.9 17.0 4.1 -4.0 4.0 4.1 4.1 -3.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.5 -0.6 0.6 -0.5 -0.7 -0.6 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.0 -0.6 1.0 -0.1 0.6 -0.7 0.8
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.5 0.3 -0.2 0.5 0.7 0.2 -0.1
Qualifications: CSEs or equivalent 0.3 0.4 1.0 -0.9 0.5 -1.0 -0.0 -0.6 0.0
Serious illness, injury or assault to yourself 0.3 0.4 2.2 0.2 -0.1 0.4 1.5 0.2 -0.1
High blood pressure 5.0 13.8 16.2 -3.8 4.0 -3.9 -2.3 -3.9 4.0
Hayfever, allergic rhinitis or eczema 2.4 5.2 8.5 -2.2 1.7 -2.9 -2.9 -2.0 1.6
Multivitamins +/- minerals 0.1 0.2 0.4 -0.4 0.3 -0.4 -0.6 -0.4 0.1
Stomach or abdominal pain in last month 0.2 0.3 1.6 0.2 -0.0 0.4 1.3 0.1 0.0
Supplements: Glucosamine 0.0 0.0 0.0 -0.0 0.0 -0.0 -0.0 -0.1 -0.0
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.4 0.8 -0.3 1.8 1.8 0.6 -0.2
Medication: Atenolol 0.3 0.4 2.2 0.1 0.2 0.1 1.5 -0.1 0.6
Medication: Levothyroxine sodium 2.4 4.0 6.1 -2.2 2.5 -1.2 -1.2 -2.4 2.1
Sitting height 3.0 21.5 24.1 -4.7 4.4 -4.6 -4.6 -4.6 4.9
Chronic bronchitis/emphysema (father) 0.2 0.3 0.5 0.4 -0.7 0.0 0.5 0.6 -0.7
High blood pressure (mother) 5.7 7.9 9.9 -3.0 3.1 -3.1 -1.2 -3.1 2.8
Body mass index (BMI) 2.6 10.9 13.6 -3.4 3.7 -3.4 -2.1 -3.6 3.3
Impedance of leg (left) 8.7 42.5 48.6 7.0 -6.8 6.5 5.3 6.9 -6.5
Leg predicted mass (left) 8.8 46.4 51.9 -7.2 7.1 -6.6 -5.5 -7.2 7.1
Trunk fat mass 1.3 5.5 7.6 -2.3 2.8 -2.3 -1.1 -2.6 2.6
Waist circumference 1.0 3.8 5.9 -1.9 2.4 -1.9 -0.6 -2.3 2.0
Number of incorrect matches in round 5.8 9.7 12.0 3.5 -3.1 3.4 2.6 3.3 -2.8
Past tobacco smoking 13.1 24.1 28.4 -5.3 5.0 -4.9 -4.9 -5.1 4.1
Alcohol usually taken with meals 7.3 11.9 13.3 -3.5 3.4 -3.4 -3.6 -3.6 3.2
Nervous feelings 5.5 10.2 18.9 3.1 -2.2 4.3 3.9 2.8 -2.1
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.6 0.9 -0.5 1.4 2.1 0.7 -0.4
Hearing difficulty/problems with background noise 0.8 1.3 2.5 1.0 -0.8 1.5 1.6 0.9 -0.7
Hair/balding pattern: Pattern 2 0.8 1.0 1.6 -1.1 1.2 -0.8 -1.3 -1.1 0.4
Had menopause 0.6 0.7 0.9 0.9 -0.9 1.0 0.3 0.9 -0.9
Had other major operations 1.1 1.4 2.2 1.2 -1.1 0.9 1.5 1.1 -1.2
Forced vital capacity (FVC) 3.1 12.0 20.7 -3.3 2.7 -3.5 -4.5 -3.1 3.3
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 2.6 -1.0 1.6 -0.5 -0.1 -1.3 1.3
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.5 0.4 -0.3 0.3 0.7 0.3 -0.7
Qualifications: None of the above 3.6 7.8 8.8 2.9 -2.6 2.6 3.0 2.8 -2.9
Financial difficulties in last 2 years 3.4 4.6 7.6 2.2 -1.7 2.4 2.8 1.9 -1.7
Mouth/teeth dental problems 0.4 0.6 3.1 -0.3 0.2 0.0 -1.8 -0.3 -0.1
Heart attack 3.4 4.4 6.4 2.1 -2.0 1.7 2.5 2.0 -2.1
Allergy 1.1 2.5 4.9 1.6 -1.3 2.2 1.6 1.5 -1.1
Pain all over the body in last month 0.2 0.2 0.8 -0.0 0.3 0.6 0.9 -0.0 0.4
Diabetes (self-reported) 1.4 2.1 3.5 -1.5 1.9 -0.9 -0.3 -1.7 1.8
Hayfever/allergic rhinitis (self-reported) 6.0 7.9 12.0 -2.8 2.9 -3.5 -2.6 -2.9 2.1
Medication: Ramipril 2.0 2.5 3.3 -1.8 1.7 -1.4 -1.0 -1.8 1.7
Medication: Simvastatin 0.2 0.3 0.8 0.5 -0.6 0.2 0.9 0.5 -0.2
Fluid intelligence score 0.5 1.0 1.2 -1.1 0.9 -1.1 -0.8 -1.0 0.9
Illnesses of siblings 0.3 0.4 1.1 0.6 -0.7 0.1 -0.5 0.6 -1.0
Neuroticism score 6.2 12.9 20.9 3.6 -3.0 4.6 3.9 3.4 -2.8
Weight 4.9 24.3 28.4 -5.1 5.3 -4.8 -3.7 -5.3 5.1
Impedance of arm (right) 5.5 25.5 31.5 5.3 -5.0 5.6 4.3 5.2 -4.8
Arm fat percentage (right) 0.3 1.2 2.0 -1.0 1.4 -1.1 -0.0 -1.3 1.1
Trunk fat-free mass 7.8 44.7 48.2 -6.9 6.7 -6.6 -6.0 -6.9 6.9
Hip circumference 5.4 23.1 26.7 -4.9 5.2 -4.8 -3.9 -5.2 4.8
Time employed in main current job 0.3 0.3 1.5 -0.0 -0.2 -0.5 -1.2 0.1 -0.2
Alcohol intake versus 10 years previously 3.4 5.0 6.0 -2.2 2.3 -2.2 -2.0 -2.3 2.4
Father’s age at death 0.8 1.1 1.5 -1.1 1.2 -0.9 -0.6 -1.2 1.2
Worrier / anxious feelings 5.6 10.6 17.4 3.3 -2.7 4.2 3.2 3.1 -2.8
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 8.2 1.0 -0.2 2.0 2.9 0.7 -0.3
Falls in the last year 1.9 2.5 5.4 1.4 -1.5 1.6 2.3 1.4 -1.1
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 0.1 -0.2 -0.4 -0.5 0.1 -0.3
Number of live births 0.8 1.1 1.3 1.0 -1.1 0.9 1.0 1.1 -1.2
Forced expiratory volume in 1-second (FEV1) 4.7 16.0 26.2 -4.0 3.4 -4.0 -5.1 -3.7 3.5
Pulse rate 3.7 6.3 7.0 -2.6 2.5 -2.6 -2.7 -2.5 2.3
Happiness 0.8 0.9 1.8 0.9 -1.0 0.8 0.7 0.9 -1.3
Noisy workplace 0.8 1.0 1.7 0.8 -1.0 1.0 1.3 1.0 -0.7
Qualifications: A levels/AS levels or equivalent 4.4 9.7 13.6 -3.1 3.2 -2.7 -2.8 -3.2 3.7
Serious illness, injury or assault of a close relative in last 2 years 3.2 3.7 6.5 -2.0 2.1 -1.3 -1.2 -2.0 2.5
Mouth/teeth dental problems: Dentures 0.3 0.6 2.5 0.3 -0.4 -0.4 1.6 0.4 -0.7
Asthma 0.9 1.9 3.2 -1.4 1.3 -1.8 -1.1 -1.4 1.1
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 4.1 1.2 -0.8 1.4 2.0 1.1 -1.0
Medication: Cholesterol lowering 0.2 0.3 1.4 0.2 0.1 0.4 1.2 -0.1 0.4
Depression (self-reported) 0.5 0.6 2.5 0.7 -0.4 0.6 1.6 0.6 -0.3
Medication: Lansoprazole 1.6 1.8 2.1 1.4 -1.2 1.4 1.4 1.2 -1.3
Prospective memory result 0.7 0.8 1.4 0.9 -1.2 0.8 0.3 1.0 -1.0
Lung cancer (father) 1.9 2.3 3.7 1.6 -1.3 1.5 1.9 1.4 -1.1
Illnesses of mother 0.7 0.8 1.1 1.0 -1.1 0.9 0.2 1.0 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.6 8.1 -2.1 1.9 -2.0 -2.8 -2.0 1.9
Pulse wave Arterial Stiffness index 2.2 2.6 4.1 -1.8 1.7 -1.6 -0.4 -1.7 2.0
Impedance of arm (left) 4.6 21.2 24.4 4.9 -4.6 4.9 3.9 4.7 -4.5
Arm fat mass (right) 2.2 9.0 11.9 -3.1 3.4 -2.9 -1.8 -3.3 3.2
Trunk predicted mass 7.8 44.6 48.0 -6.9 6.7 -6.6 -6.1 -6.9 6.9
Standing height 1.8 17.7 21.7 -4.2 4.2 -3.7 -4.0 -4.3 4.7
Length of working week for main job 0.1 0.1 0.3 -0.1 -0.2 -0.5 -0.5 0.1 -0.3
Exposure to tobacco smoke at home 0.5 0.5 3.0 0.2 0.0 0.3 1.7 0.1 0.0
Breastfed as a baby 0.2 0.3 0.4 0.7 -0.5 0.5 0.4 0.6 -0.4
Tense / ‘highly strung’ 3.1 5.2 7.7 2.3 -1.9 2.8 2.5 2.3 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.3 5.9 1.8 -1.7 1.7 2.4 1.8 -1.2
Hair/balding pattern: Pattern 4 2.7 6.6 9.3 2.7 -2.2 2.8 3.0 2.5 -2.0
Birth weight of first child 0.1 0.2 0.5 -0.1 0.2 0.6 0.3 -0.2 0.7
Peak expiratory flow (PEF) 7.1 16.6 29.5 -4.0 3.4 -3.8 -5.4 -3.8 3.6
Pulse wave reflection index 0.4 0.5 1.7 0.5 -0.7 0.6 1.3 0.6 -0.2
Ever highly irritable/argumentative for 2 days 1.4 1.7 4.1 1.0 -0.7 1.5 2.0 1.0 -1.2
Loud music exposure frequency 6.9 7.5 9.4 2.8 -3.1 2.4 2.3 2.9 -2.9
Qualifications: O levels/GCSEs or equivalent 8.0 12.7 14.1 -3.5 3.4 -3.6 -3.6 -3.5 3.8
Mouth/teeth dental problems: Bleeding gums 3.1 4.1 5.5 -2.0 2.2 -1.6 -1.7 -2.1 2.4
Blood clot in the leg (DVT) 0.5 0.6 1.7 0.8 -0.4 0.6 1.3 0.5 -0.6
Medication: Paracetamol 3.2 5.3 9.4 2.2 -1.8 2.2 3.1 2.1 -2.3
Headache pain in last month 2.1 3.5 8.3 1.9 -1.5 1.6 2.9 1.7 -1.3
Medication for cholesterol, blood pressure or diabetes 1.6 2.6 3.7 1.6 -1.9 1.5 0.4 1.8 -1.9
Glaucoma (self-reported) 0.1 0.2 0.4 0.4 -0.0 0.6 0.5 0.2 -0.3
Gout (self-reported) 1.1 1.4 3.2 -1.2 1.4 -0.6 -0.2 -1.3 1.8
Hypothyroidism/myxoedema (self-reported) 3.1 6.0 8.4 -2.6 2.9 -1.7 -1.8 -2.8 2.7
Medication: Amlodipine 4.6 6.5 8.2 -2.7 2.6 -2.9 -1.6 -2.6 2.7
Medication: Ventolin 100micrograms inhaler 0.5 0.7 0.9 0.9 -0.9 0.7 0.8 0.8 -0.9
Birth weight 0.1 0.2 0.9 -0.1 0.3 0.2 0.0 -0.2 0.9
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 0.3 -0.3 0.2 0.2 0.3 -0.1
High blood pressure (siblings) 2.0 3.0 5.3 -1.8 1.9 -1.2 -0.7 -1.9 2.3
Forced vital capacity (FVC), Best measure 1.1 4.1 7.4 -1.9 1.7 -1.9 -2.7 -1.8 2.0
Body fat percentage 0.1 0.5 0.9 -0.5 1.0 -0.7 0.4 -0.8 0.6
Leg fat percentage (right) 0.0 0.1 0.3 -0.1 0.4 -0.5 0.5 -0.3 0.0
Arm fat-free mass (right) 7.6 39.0 42.1 -6.5 6.3 -6.3 -5.4 -6.5 6.4
Exposure to tobacco smoke outside home 2.4 3.2 4.1 1.9 -1.8 1.5 2.0 1.8 -1.7
Comparative body size at age 10 0.2 0.6 0.8 -0.7 0.8 -0.6 -0.9 -0.8 0.9
Number of full brothers 1.2 1.5 2.9 1.2 -1.1 1.2 1.7 1.1 -1.0
Worry too long after embarrassment 13.6 22.8 35.4 4.9 -4.2 6.0 4.1 4.7 -4.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 5.0 1.1 -0.8 1.3 2.2 0.9 -0.4
Wheeze or whistling in the chest in last year 0.4 0.6 3.1 -0.1 0.6 0.0 1.8 -0.3 0.5
Number of children fathered 0.2 0.2 0.4 0.3 -0.5 -0.3 0.4 0.4 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.6 -0.2 0.2 0.2 -0.8 -0.3 0.1
Age at first live birth 2.1 3.8 5.4 -1.9 2.0 -1.5 -2.3 -2.0 1.9
Pulse wave peak to peak time 1.8 2.1 3.3 1.6 -1.6 1.4 0.1 1.5 -1.8
Health satisfaction 0.2 0.2 1.3 0.3 0.1 0.1 1.1 0.0 -0.1
Shortness of breath walking on level ground 5.6 6.7 7.7 -2.8 2.5 -2.7 -2.2 -2.7 2.7
Qualifications: College or University degree 3.0 9.6 13.6 -3.2 2.6 -3.2 -3.7 -2.9 3.0
Eye problems/disorders: None of the above 0.1 0.1 0.3 0.4 -0.3 0.3 0.2 0.5 -0.5
Mouth/teeth dental problems: Loose teeth 3.2 3.7 5.2 2.1 -2.0 1.5 2.3 2.0 -1.6
Emphysema/chronic bronchitis 0.2 0.2 1.4 -0.0 0.0 0.1 1.2 0.2 -0.0
Medication for pain relief, constipation, heartburn 6.5 11.1 13.3 -3.5 3.3 -2.9 -3.6 -3.3 3.3
Neck or shoulder pain in last month 0.8 1.2 2.9 1.0 -0.7 1.3 1.7 0.9 -0.3
Medication: Blood pressure 3.7 6.5 7.6 -2.7 2.7 -2.7 -1.4 -2.8 2.7
Angina (self-reported) 1.1 1.5 2.9 1.4 -1.1 1.1 1.7 1.1 -0.8
Migraine (self-reported) 1.1 1.3 1.6 1.2 -1.3 1.2 0.9 1.3 -1.1
Medication: Ibuprofen 0.2 0.2 0.8 0.1 0.1 0.6 0.9 0.1 -0.2
Medication: Allopurinol 0.4 0.5 0.9 -0.7 0.7 -0.6 0.2 -0.7 1.0
Medication: Omeprazole 0.4 0.4 0.8 -0.6 0.4 -0.9 0.4 -0.5 0.9
Medication: Seretide 50 evohaler 0.5 0.6 1.4 -0.6 0.4 -1.2 -1.0 -0.6 0.6
Mean time to correctly identify matches 0.0 0.1 0.2 0.1 -0.4 -0.3 -0.4 0.2 -0.2
Heart disease (mother) 0.2 0.3 0.5 0.4 -0.6 0.6 0.5 0.5 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.7 -0.2 -0.2 -1.1 -1.3 -0.1 0.1
Whole body fat mass 1.6 6.5 8.9 -2.5 3.0 -2.5 -1.3 -2.9 2.8
Leg fat mass (right) 1.3 5.0 7.1 -2.2 2.7 -2.3 -1.0 -2.5 2.2
Arm predicted mass (right) 7.8 40.0 43.3 -6.6 6.4 -6.4 -5.5 -6.6 6.4
Pulse rate, automated reading 3.0 9.6 10.4 -3.2 3.2 -3.2 -2.8 -3.1 3.0
Alcohol intake frequency. 1.1 2.5 4.2 -1.7 1.6 -2.0 -0.8 -1.6 1.5
Comparative height size at age 10 2.0 10.8 14.8 -3.4 3.6 -2.6 -2.6 -3.5 3.9
Number of full sisters 1.3 1.6 2.5 1.2 -1.3 0.5 1.6 1.3 -1.5
Suffer from ‘nerves’ 2.2 3.5 7.2 1.8 -1.1 2.7 2.5 1.5 -0.9
Overall health rating 1.9 4.1 13.5 1.8 -1.3 1.6 3.7 1.5 -1.2
Chest pain or discomfort 1.4 2.1 4.7 1.4 -1.1 1.6 2.2 1.3 -0.6
Had major operations 0.5 0.6 1.0 -1.0 0.9 -1.0 -0.3 -0.9 0.4
Age at last live birth 2.3 3.3 5.4 -1.8 2.3 -0.9 -1.3 -2.0 2.2
Family relationship satisfaction 0.1 0.1 0.2 0.3 -0.2 0.4 -0.3 0.2 -0.5
Leg pain on walking 0.7 0.8 1.7 -0.9 1.0 -0.6 -0.4 -0.9 1.3
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 2.9 1.3 -1.2 1.0 1.7 1.2 -1.5
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.4 -0.6 0.5 -0.6 -0.5 -0.4 0.5
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 0.2 -0.3 0.1 0.1 0.3 -0.6
Medication: Aspirin 2.5 3.3 4.0 2.0 -2.0 1.7 1.8 1.9 -1.5
Supplements: Vitamin C 0.3 0.3 0.6 -0.6 0.7 -0.4 -0.1 -0.7 0.8
Knee pain experienced in last month 0.3 0.4 1.2 0.6 -0.6 0.0 1.1 0.6 -0.5
Hypertension (Self-reported) 4.9 13.6 16.2 -3.8 4.0 -3.8 -2.2 -3.9 4.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.4 0.6 -0.8 0.5 1.2 0.7 -0.6
Illnesses of father: Heart disease 0.4 0.6 0.9 -0.8 0.9 -0.7 -0.5 -0.9 0.7
Illnesses of siblings: Diabetes 0.4 0.5 1.1 -0.7 0.8 -0.3 -0.2 -0.7 1.1
Smoking status: Previous 6.2 9.3 11.7 3.4 -3.1 3.1 2.9 3.2 -2.6
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.1 0.1 -0.2 0.3 -0.0 0.1 0.3
Whole body fat-free mass 8.4 48.0 52.2 -7.2 7.1 -6.8 -6.0 -7.2 7.2
Leg fat-free mass (right) 8.6 45.7 50.9 -7.1 7.1 -6.5 -5.6 -7.1 7.0
Arm fat percentage (left) 0.5 2.1 3.2 -1.4 1.8 -1.5 -0.4 -1.7 1.4
Average weekly red wine intake 0.5 0.7 2.2 -0.7 0.6 -0.6 -1.5 -0.7 0.7
Handedness (chirality/laterality): Left-handed 0.5 0.6 0.8 0.9 -0.9 0.8 0.6 0.9 -0.8
Mood swings 0.4 0.8 1.7 0.8 -0.6 1.3 1.3 0.7 -0.1
Loneliness, isolation 0.5 0.6 1.1 0.7 -0.5 0.8 1.1 0.7 -0.9
Long-standing illness, disability or infirmity 0.8 1.2 5.6 0.5 0.0 1.0 2.4 0.3 0.1
Ever had bowel cancer screening 1.1 1.3 4.5 1.1 -0.4 1.2 2.1 0.7 -0.4
Diabetes diagnosed by doctor 0.8 1.3 2.5 -1.0 1.6 -0.4 0.2 -1.3 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 0.7 -0.7 0.2 0.5 0.6 -0.3
Friendships satisfaction 0.1 0.1 0.4 -0.1 0.0 -0.6 -0.2 -0.1 -0.4
Qualifications: nursing, teaching 2.2 3.4 4.9 -1.8 1.8 -1.4 -1.9 -1.8 2.2
Commuting to job workplace: Walk 1.2 1.3 2.0 -1.2 0.8 -1.4 -1.2 -1.0 1.2
Eye problems/disorders: Cataract 0.1 0.1 0.2 0.2 -0.5 0.1 0.1 0.3 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.0 0.7 -0.7 0.6 1.4 0.8 -0.5
Medication for cholesterol 0.9 1.4 2.4 1.1 -1.4 1.0 0.3 1.2 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 5.1 6.0 7.3 2.7 -2.7 2.2 2.1 2.6 -2.4
Back pain experienced in last month 2.0 3.0 5.9 1.7 -1.3 1.8 2.4 1.5 -1.3
Mineral and other dietary supplements 0.1 0.1 0.3 0.5 -0.1 0.5 0.4 0.3 -0.3
Breast cancer (self-reported) 0.1 0.1 0.4 0.2 0.0 0.7 0.1 0.1 0.1
Asthma (self-reported) 0.8 1.6 2.7 -1.3 1.3 -1.6 -0.9 -1.4 1.0
Osteoporosis (self-reported) 0.5 0.6 1.6 -0.7 0.7 -1.3 -0.4 -0.8 0.5
Osteoarthritis (self-reported) 2.0 2.7 5.2 1.7 -1.5 1.4 2.3 1.6 -1.1
Medication: Aspirin 3.0 3.9 4.7 2.1 -2.2 1.9 1.9 2.1 -1.5
Medication: Gliclazide 0.7 0.8 1.7 -0.9 0.9 -1.3 -0.8 -0.9 0.5
Illnesses of father: None of the above (group 1) 1.6 2.0 2.7 1.6 -1.2 1.3 1.4 1.3 -1.6
Smoking status: Current 11.9 18.9 29.8 4.3 -4.0 4.5 5.5 4.3 -3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.6 7.6 12.1 -2.7 2.3 -3.1 -3.5 -2.6 2.2
Whole body water mass 8.5 48.4 52.6 -7.2 7.1 -6.8 -6.0 -7.2 7.2
Leg predicted mass (right) 8.5 45.4 50.7 -7.1 7.1 -6.4 -5.6 -7.1 7.0
Arm fat mass (left) 2.3 9.6 11.9 -3.1 3.5 -3.2 -2.0 -3.4 3.2
Number of self-reported non-cancer illnesses 0.3 0.5 1.8 -0.4 0.6 -0.6 1.4 -0.4 0.6
Average weekly champagne plus white wine intake 0.2 0.3 0.7 -0.3 0.4 0.5 -0.9 -0.3 0.6
Miserableness 0.4 0.7 1.4 0.7 -0.6 1.2 0.9 0.8 -0.3
Guilty feelings 6.2 9.3 14.3 3.0 -2.8 3.8 3.1 3.0 -2.4
Wears glasses or contact lenses 1.0 1.1 2.4 -1.0 1.3 -0.5 -0.2 -1.2 1.5
Ever taken oral contraceptive pill 0.9 1.0 1.4 -1.0 0.9 -1.2 -0.9 -1.0 1.1
Hearing aid user 1.6 1.8 2.7 -1.3 1.2 -1.3 -1.6 -1.3 1.0
Mother’s age at death 0.9 1.1 1.6 -1.1 0.9 -1.0 -1.3 -1.0 1.0
Financial situation satisfaction 1.9 2.4 3.9 1.5 -1.4 0.9 1.8 1.4 -2.0
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.9 -0.6 0.3 -0.9 -0.7 -0.5 0.6
Commuting to job workplace: Public transport 0.2 0.3 0.6 -0.5 0.7 -0.3 -0.2 -0.6 0.8
Eye problems/disorders: Glaucoma 0.0 0.1 0.1 0.2 0.1 0.4 0.3 0.0 0.2
Medication: Blood pressure 3.4 6.5 8.2 -2.7 2.9 -2.4 -1.6 -2.7 2.8
Pain type(s) experienced in last month: Hip pain 1.8 2.2 3.0 1.6 -1.4 1.7 1.7 1.5 -0.8
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.9 0.6 -0.9 0.5 0.6 0.8 -0.6
High cholesterol (Self-reported) 0.0 0.1 0.3 0.2 -0.1 -0.0 0.5 0.1 -0.1
Medication: Bendroflumethiazide 7.6 11.5 14.2 -3.5 3.6 -3.2 -2.6 -3.6 3.8
Medication: Paracetamol 1.6 2.5 4.4 1.5 -1.2 1.3 2.1 1.4 -1.8
Medication: Lisinopril 1.7 2.1 4.0 -1.3 1.1 -1.9 -2.0 -1.3 0.8
Medication: Atorvastatin 1.3 1.6 4.2 1.2 -0.7 1.4 2.1 0.9 -0.6
Illnesses of father: High blood pressure 1.0 1.2 1.8 -1.2 1.1 -1.0 -0.6 -1.1 1.3
Alcohol drinker status: Never 0.2 0.2 0.7 0.5 -0.4 0.2 0.8 0.4 -0.4
Ever smoked 14.4 25.3 29.6 5.4 -5.2 4.8 5.1 5.3 -4.2
Basal metabolic rate 7.8 43.3 47.7 -6.8 6.8 -6.4 -5.5 -6.9 6.8
Leg fat percentage (left) 0.0 0.1 0.3 0.1 0.2 -0.4 0.6 -0.2 -0.2
Arm fat-free mass (left) 7.0 35.3 38.2 -6.2 6.1 -6.0 -5.1 -6.2 6.1
Number of operations (self-reported) 0.3 0.4 2.0 -0.0 0.4 0.1 1.4 -0.2 -0.5
Average weekly beer plus cider intake 0.4 0.6 1.2 0.6 -0.7 0.9 1.1 0.8 -0.4
Irritability 1.0 1.7 2.8 1.4 -1.2 1.4 1.7 1.3 -0.6
Risk taking 0.5 0.8 2.4 -0.8 0.6 -0.9 -0.1 -0.7 1.5
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.8 -0.0 -0.2 -0.9 -0.2 0.0 0.3
Fractured/broken bones in last 5 years 0.3 0.4 0.8 -0.7 0.2 -0.9 -0.9 -0.4 0.3
Age started oral contraceptive pill 1.4 1.7 3.5 -1.2 1.2 -1.1 -1.9 -1.1 1.2
Diastolic blood pressure, automated reading 1.5 4.7 5.8 -2.3 2.4 -1.9 -2.2 -2.3 1.9
Ever depressed for a whole week 1.4 1.7 3.2 1.2 -1.5 0.6 1.0 1.4 -1.8
Unable to work because of sickness or disability 0.6 0.8 1.8 0.8 -1.1 0.5 1.3 0.9 -0.3
Commuting to job workplace: Cycle 1.2 1.4 1.9 -1.3 1.2 -0.9 -1.1 -1.4 1.2
Myopia 8.2 11.9 14.6 -3.5 3.4 -3.3 -3.8 -3.4 3.3
Vascular/heart problems diagnosed by doctor 1.9 5.2 7.0 2.3 -2.6 2.4 0.7 2.5 -2.6
Cholesterol lowering medication 0.3 0.4 0.7 0.6 -0.5 0.6 0.8 0.7 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.4 0.5 -0.5 -0.1 1.2 0.4 -0.1
Pain experienced in last month 4.0 6.6 16.8 -2.5 1.9 -2.5 -4.1 -2.2 1.3
Supplements: Calcium 0.6 0.7 1.8 -0.9 0.5 -1.3 -0.8 -0.7 0.4
Basal cell carcinoma (self-reported) 0.7 0.8 1.3 -0.9 0.8 -1.1 -0.9 -0.8 0.8
Heart attack/myocardial infarction (self-reported) 2.9 3.7 5.9 1.9 -1.8 1.6 2.4 1.8 -1.9
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.3 0.8 -0.6 0.5 1.1 0.6 -0.8
Heart disease (siblings) 5.1 6.2 7.7 2.6 -2.4 2.8 2.6 2.5 -2.1
Alcohol drinker status: Previous 0.3 0.3 0.8 -0.5 0.6 -0.3 -0.3 -0.5 0.9
Pack years of smoking 4.2 6.2 7.2 2.6 -2.5 2.2 2.7 2.5 -2.5
Impedance of whole body 7.6 38.8 44.0 6.6 -6.4 6.5 5.2 6.5 -6.1
Leg fat mass (left) 1.2 4.6 6.6 -2.1 2.6 -2.2 -1.0 -2.5 2.1
Arm predicted mass (left) 7.6 38.6 41.5 -6.4 6.3 -6.2 -5.5 -6.4 6.3