[Hub]/) : Traits : Leg fat-free mass (right) :

chr11:64,407,419-66,333,072

Best TWAS P=3.76e-09 · Best GWAS P=8.36e-10 conditioned to 0.002

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FIBP 0.08 0.11 enet 20 0.12 8.1e-14 3.6 5.2 1.5e-07 -0.42 0.99 0.00 FALSE
2 GTEx Brain Cerebellar Hemisphere EFEMP2 0.35 0.15 enet 5 0.09 2.2e-03 5.5 5.8 6.5e-09 -0.49 0.06 0.84 FALSE
3 GTEx Brain Cerebellum EFEMP2 0.45 0.40 enet 8 0.39 1.6e-12 5.3 5.6 2.2e-08 -0.48 0.08 0.92 FALSE
4 GTEx Cells Transformed fibroblasts EFEMP2 0.06 0.06 lasso 3 0.07 7.8e-06 5.7 5.8 8.2e-09 -0.45 0.07 0.91 FALSE
5 GTEx Colon Transverse DPF2 0.19 0.01 lasso 4 0.05 1.6e-03 3.4 5.5 3.5e-08 -0.08 0.09 0.07 TRUE
6 METSIM Adipose EFEMP2 0.07 0.05 lasso 8 0.04 4.2e-06 4.8 5.2 2.5e-07 -0.48 0.36 0.64 FALSE
7 The Cancer Genome Atlas Breast Invasive Carcinoma EFEMP2 0.04 0.02 lasso 5 0.02 1.4e-05 5.8 5.6 2.3e-08 -0.48 0.04 0.95 FALSE
8 The Cancer Genome Atlas Glioblastoma Multiforme CTSW 0.16 0.18 enet 16 0.19 2.3e-06 5.1 -5.9 3.8e-09 0.52 0.12 0.75 TRUE
9 The Cancer Genome Atlas Glioblastoma Multiforme DKFZp761E198 0.14 0.00 blup 39 0.05 1.4e-02 -4.8 -5.2 1.9e-07 0.62 0.01 0.18 FALSE
10 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma DKFZp761E198 0.07 0.02 blup 39 0.03 5.9e-04 -4.8 -5.8 7.8e-09 0.73 0.02 0.62 FALSE
11 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DPF2 0.07 0.04 blup 28 0.04 2.9e-05 -4.9 5.4 8.5e-08 -0.16 0.00 0.95 FALSE
12 The Cancer Genome Atlas Brain Lower Grade Glioma DPF2 0.03 0.02 blup 28 0.02 1.2e-03 -4.9 5.5 4.6e-08 -0.15 0.00 0.89 FALSE
13 The Cancer Genome Atlas Brain Lower Grade Glioma EFEMP2 0.01 0.00 blup 45 0.01 3.0e-02 2.5 5.2 2.1e-07 -0.45 0.04 0.18 FALSE
14 The Cancer Genome Atlas Lung Adenocarcinoma FIBP 0.02 0.01 blup 45 0.02 1.3e-03 3.8 5.3 1.1e-07 -0.48 0.07 0.38 FALSE
15 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CAPN1 0.03 0.02 blup 39 0.02 2.1e-03 -4.9 -5.2 1.9e-07 0.18 0.00 0.93 FALSE
16 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma POLA2 0.12 0.03 enet 9 0.05 2.5e-04 -4.9 5.3 1.2e-07 -0.13 0.01 0.65 FALSE
17 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CTSW 0.16 0.10 enet 24 0.15 1.9e-06 3.6 -5.2 1.5e-07 0.44 0.57 0.20 FALSE
18 The Cancer Genome Atlas Soft Tissue Sarcoma POLA2 0.09 0.06 blup 34 0.08 1.4e-05 -5.1 5.3 1.2e-07 -0.19 0.01 0.96 FALSE
19 The Cancer Genome Atlas Soft Tissue Sarcoma SNX32 0.08 0.08 lasso 2 0.10 1.5e-06 5.7 5.4 5.6e-08 -0.42 0.08 0.91 FALSE
20 The Cancer Genome Atlas Thyroid Carcinoma DPF2 0.05 0.02 blup 29 0.03 3.7e-04 -4.9 5.3 8.7e-08 -0.14 0.00 0.85 FALSE